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Actin related protein 2/3 complex, subunit 1A, 41kDa

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: Actin, Arp2, Actin-Related Protein 3, CD99, ARPC1
Papers on ARPC1A
Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
Way et al., Gif-sur-Yvette, France. In Nat Cell Biol, Jan 2016
We found that Arp2/3 complexes containing ARPC1B and ARPC5L are significantly better at promoting actin assembly than those with ARPC1A and ARPC5, both in cells and in vitro.
CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity.
Scotlandi et al., Bologna, Italy. In Oncogene, 2014
In addition, transfection of CD99wt inhibits the expression of several molecules crucial to the remodelling of the actin cytoskeleton, such as ACTR2, ARPC1A, Rho-associated, coiled-coil containing protein kinase 2 (ROCK2) as well as ezrin, an ezrin/radixin/moesin family member that has been clearly associated with tumour progression and metastatic spread in osteosarcoma.
Prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial deletion of 7q (7q22.1→q31.1).
Wang et al., Taipei, Taiwan. In Gene, 2013
We discuss the genotype-phenotype correlation and the consequence of haploinsufficiency of ZKSCAN5, ARPC1A, CYP3A43, RELN, LAMB1, IMMP2L and DOCK4 in this case.
Testing the utility of an integrated analysis of copy number and transcriptomics datasets for inferring gene regulatory relationships.
Fitzgerald et al., Cambridge, United Kingdom. In Plos One, 2012
Three additional predicted ERBB2 regulated interactions were confirmed, as well as interactions regulated by ARPC1A and FANCG.
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
Wallaschofski et al., London, United Kingdom. In Plos Genet, 2011
× 10(-19)), ARPC1A (rs740160; p =  1.56
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
International IBD Genetics Consortium et al., Los Angeles, United States. In Hum Mol Genet, 2010
In addition, we identified associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology [CADM1 (IGSF4)], macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 (a physiological trait that regulates gastrointestinal mucosal expression of blood group A and B antigens) (rs602662, P=3.4x10(-5)).
Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer.
Kallioniemi et al., Tampere, Finland. In Genes Chromosomes Cancer, 2009
data implicate ARPC1A as a novel target for the 7q21-q22 amplification and a regulator of cell migration and invasion in pancreatic cancer
Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.
Segal et al., London, United Kingdom. In Biochem J, 1997
We find that in addition to Arp2 and Arp3, this complex contains a relative of the human (Suppressor of Profilin) SOP2Hs protein and four previously unknown proteins.
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