Molecular dynamics simulations of Arp2/3 complex activation.
New Haven, United States. In Biophys J, 2010
When we applied forces to Arp2 while restraining Arp3, one block of structure (Arp2, subunit ARPC1, the globular domain of ARPC4 and ARPC5) rotated counterclockwise by 30° around a pivot point in an α-helix of ARPC4 (Glu⁸¹-Asn¹⁰⁰) to align Arp2 next to Arp3 in a second block of structure including ARPC3 and the globular domains of ARPC2.
Crystal structure of Arp2/3 complex.
Los Angeles, United States. In Science, 2001
ARPC1 p40 is a seven-blade beta propeller with an insertion that may associate with the side of an actin filament.