The centrosome is an actin-organizing centre.
Grenoble, France. In Nat Cell Biol, Jan 2016
Actin-filament nucleation at the centrosome was mediated by the nucleation-promoting factor WASH in combination with the Arp2/3 complex.
Formins at the Junction.
Marburg an der Lahn, Germany. In Trends Biochem Sci, Jan 2016
The actin regulatory complex Arp2/3 has an established role in the turnover of junctional actin; however, the role of formins, the largest group of actin regulators, is less clear.
Bacterial nucleators: actin' on actin.
Caparica, Portugal. In Pathog Dis, Dec 2015
Many of these effector proteins directly or indirectly target the major eukaryotic actin nucleator, the Arp2/3 complex, by either mimicking nucleation promoting factors or activating upstream small GTPases.
Viruses that ride on the coat-tails of actin nucleation.
Sydney, Australia. In Semin Cell Dev Biol, Oct 2015
Vaccinia virus and baculovirus, Autographa californica multiple nucleopolyhedrovirus, recruit and activate the cellular actin nucleator, the Arp2/3 complex, at the surface of virus particles thereby instigating highly localized actin nucleation.
Signaling networks that regulate cell migration.
Charlottesville, United States. In Cold Spring Harb Perspect Biol, Aug 2015
Their effectors include actin regulators such as formins, members of the WASP/WAVE family and the Arp2/3 complex, and the myosin II motor protein.