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Cytohesin 2

ARNO, cytohesin-2
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: p16, ARF6, Cytoadhesin, GEF, ARF1
Papers using ARNO antibodies
Mitochondria supply membranes for autophagosome biogenesis during starvation.
Supplier
Meurs Eliane F., In PLoS ONE, 2009
... pGBKT7-Sec7-BIG2 was constructed by insertion into sites EcoRI and SalII, and pGBKT7-Sec7-GBF1, pGBKT7-Sec7-EFA6 and pGBKT7-Sec7-ARNO were constructed by insertion into EcoRI and BamHI sites of pGBKT7 (Clontech).
Papers on ARNO
The real-world evidence of heart failure: findings from 41 413 patients of the ARNO database.
New
ARNO Observatory et al., Florence, Italy. In Eur J Heart Fail, Feb 2016
METHODS AND RESULTS: Data came from the ARNO Observatory including inhabitants of five Local Health Units of the Italian National Health Service (INHS).
βarrestin-Mediated Angiotensin II Signaling Controls the Activation of ARF6 and Endocytosis in Migration of Vascular Smooth Muscle Cells.
New
Claing et al., Montréal, Canada. In J Biol Chem, Jan 2016
Interestingly, βarrestin2 can interact with the ARF GEF ARNO, while the C-terminal lacking mutant does not.
PI3K regulates endocytosis after insulin secretion via signaling crosstalk between Arf6 and Rab27a.
New
Kimura et al., Ōita, Japan. In J Cell Sci, Jan 2016
Here, we searched for Rab27a GTPase-activating protein (GAP) EPI64-interacting proteins and identified the Arf6 guanine-nucleotide-exchange factor (GEF) ARNO in pancreatic beta-cells.
RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
New
Goldfinger et al., Duarte, United States. In Biochem Biophys Res Commun, Dec 2015
Here, we report that RLIP76 performs these functions by binding cytohesin-2/ARNO, an Arf GTPase guanine exchange factor, and connecting it to R-Ras at recycling endosomes.
ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment.
New
Santy et al., Paraguay. In Mol Biol Cell, Dec 2015
When expressed in epithelial cells, cytohesin-2/ARNO, a guanine nucleotide exchange factor (GEF) for ARF small GTPases, causes a robust migration response.
Eukaryotic V-ATPase: novel structural findings and functional insights.
Review
Grüber et al., Boston, United States. In Biochim Biophys Acta, 2014
Moreover, it was recently revealed that the V-ATPase itself functions as an evolutionarily conserved pH sensor and receptor for cytohesin-2/Arf-family GTP-binding proteins.
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.
Impact
Li et al., Salt Lake City, United States. In Nature, 2013
Here we show that the direct, immediate and disruptive effects of IL-1β on endothelial stability in a human in vitro cell model are NF-κB independent and are instead the result of signalling through the small GTPase ADP-ribosylation factor 6 (ARF6) and its activator ARF nucleotide binding site opener (ARNO; also known as CYTH2).
Cost of noninfectious comorbidities in patients with HIV.
Review
Palella et al., Reggio nell'Emilia, Italy. In Clinicoecon Outcomes Res, 2012
Antiretroviral therapy (ART)-experienced HIV-infected patients (cases) were compared to age, sex, and race-matched adults from the general population, included in the CINECA ARNO database (controls).
Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion.
GeneRIF
Koronakis et al., Cambridge, United Kingdom. In Cell Host Microbe, 2012
ARNO in turn triggered WAVE regulatory complex recruitment and activation, which was dramatically enhanced when ARNO cooperated with Salmonella SopE.
ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression.
GeneRIF
Krötz et al., München, Germany. In Cardiovasc Res, 2012
role for endothelial ARNO in VEGF-dependent initiation of angiogenesis by regulation of VEGFR-2 internalization in endothelial cells, resulting in the activation of the Akt pathway, vessel permeability, and ultimately endothelial proliferation
Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.
GeneRIF
Marshansky et al., Boston, United States. In Am J Physiol Cell Physiol, 2011
Data that aldolase forms a complex with ARNO/Arf6 and the V-ATPase and that it may contribute to remodeling of the actin cytoskeleton.
From cradle to twilight: the carboxyl terminus directs the fate of the A(2A)-adenosine receptor.
Review
Freissmuth et al., Vienna, Austria. In Biochim Biophys Acta, 2011
The list includes the deubiquinating enzyme USP4, α-actinin, the guanine nucleotide exchange factor for ARF6 ARNO, translin-X-associated protein, calmodulin, the neuronal calcium binding protein NECAB2 and the synapse associated protein SAP102.
Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop.
GeneRIF
Antonny et al., Antibes, France. In J Biol Chem, 2011
Arno behaves as a bistable switch, having an absolute requirement for activation by an Arf protein but, once triggered, becoming highly active through the positive feedback effect of Arf1-GTP.
Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6.
GeneRIF
Tanoue et al., Tokyo, Japan. In J Biol Chem, 2010
cytohesin-2, through a previously unexplored complex formation with paxillin, regulates preadipocyte migration; paxillin plays a previously unknown role as a scaffold protein of Arf guanine-nucleotide exchange factor
[Adjuvant endocrine therapy in postmenopausal hormone-sensitive breast cancer: to start, to switch or to extend?].
Review
Nagykálnai, Budapest, Hungary. In Magy Onkol, 2008
Anastrozole or letrozole should be used upfront for 5 years (ATAC and BIG 1-98), the sequential approach of tamoxifen for 2-3 years, followed by anastrozole or exemestane for 2-3 years is a reasonable alternative (ABCSG8, ARNO 95, IES, ITA), and mostly in patients with node-positive disease completing 5 years of tamoxifen should be offered letrozole up to 4-5 years (MA-17).
The A(2A)-adenosine receptor: a GPCR with unique features?
Review
Freissmuth et al., Vienna, Austria. In Br J Pharmacol, 2008
Established interaction partners include alpha-actinin, ARNO, USP4 and translin-associated protein-X.
Improved overall survival in postmenopausal women with early breast cancer after anastrozole initiated after treatment with tamoxifen compared with continued tamoxifen: the ARNO 95 Study.
Impact
von Minckwitz et al., Frankfurt am Main, Germany. In J Clin Oncol, 2007
PURPOSE: In postmenopausal women with estrogen receptor-positive early breast cancer, surgery is usually followed by a 5-year course of tamoxifen.
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
Impact
Marshansky et al., Boston, United States. In Nat Cell Biol, 2006
The recruitment of the small GTPase Arf6 and ARNO from cytosol to endosomal membranes is driven by V-ATPase-dependent intra-endosomal acidification.
Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and ARNO 95 trial.
Impact
ABCSG and the GABG et al., Vienna, Austria. In Lancet, 2005
BACKGROUND: Tamoxifen has been the standard adjuvant treatment for postmenopausal women with hormone-responsive early breast cancer for more than 20 years.
Structure of the Sec7 domain of the Arf exchange factor ARNO.
Impact
Chardin et al., Gif-sur-Yvette, France. In Nature, 1998
Here we report the crystal structure of the Sec7 domain of human ARNO at 2 A resolution and the identification of the site of interaction of ARNO with Arf.
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