Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.
Salt Lake City, United States. In Nature, 2013
Here we show that the direct, immediate and disruptive effects of IL-1β on endothelial stability in a human in vitro cell model are NF-κB independent and are instead the result of signalling through the small GTPase ADP-ribosylation factor 6 (ARF6) and its activator ARF nucleotide binding site opener (ARNO; also known as CYTH2).
Cost of noninfectious comorbidities in patients with HIV.
Reggio nell'Emilia, Italy. In Clinicoecon Outcomes Res, 2012
Antiretroviral therapy (ART)-experienced HIV-infected patients (cases) were compared to age, sex, and race-matched adults from the general population, included in the CINECA ARNO database (controls).