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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Age-related maculopathy susceptibility 2

ARMS2, age-related maculopathy susceptibility 2
This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: AGE, Complement Factor H, htrA, HAD, fibrillin-1
Papers on ARMS2
Photodynamic therapy in VEGF inhibition non-responders-pharmacogenetic study in age-related macular degeneration assessed with swept-source optical coherence tomography.
New
Wylegala et al., Katowice, Poland. In Photodiagnosis Photodyn Ther, Feb 2016
Greatest linear dimension (GLD) of the lesion, best corrected visual acuity (BCVA), central subfield macular thickness (CSMT) and central choroidal thickness were assessed and compared between CFH and ARMS2 genotype groups.
GENETIC FACTORS ASSOCIATED WITH CHOROIDAL VASCULAR HYPERPERMEABILITY AND SUBFOVEAL CHOROIDAL THICKNESS IN POLYPOIDAL CHOROIDAL VASCULOPATHY.
New
Iijima et al., Kōfu, Japan. In Retina, Feb 2016
Genotyping of three single nubleotide polymorphisms (SNPs), including age-related maculopathy susceptibility 2 (ARMS2) A69S (rs10490924), complement factor H (CFH) I62V (rs800292), and CFH (rs1329428), which are reportedly associated with central serous chorioretinopathy, was conducted using TaqMan technology.
Retinal Pigment Epithelial Atrophy in Neovascular Age-Related Macular Degeneration After Ranibizumab Treatment.
New
Yoshimura et al., Kyoto, Japan. In Am J Ophthalmol, Jan 2016
Baseline characteristics and ARMS2 A69S and CFH I62V polymorphisms were analyzed for their association with development and progression of RPE atrophy.
Reticular Pseudodrusen and Their Association with Age-Related Macular Degeneration: The Melbourne Collaborative Cohort Study.
New
Guymer et al., Melbourne, Australia. In Ophthalmology, Jan 2016
The ARMS2 single nucleotide polymorphism (SNP) rs10490924, HTRA1 SNPs rs11200638 and rs3793917, and CFH SNPs rs393955, rs1061170, and rs2274700 were associated with increased prevalence of RPD (all P < 0.05).
Extramacular drusen are highly associated with age-related macular degeneration, but not with CFH and ARMS2 genotypes.
New
Liakopoulos et al., Köln, Germany. In Br J Ophthalmol, Dec 2015
BACKGROUND: To evaluate the association of extramacular drusen (EMD) with age-related macular degeneration (AMD) and with complement factor H (CFH rs1061170) and age-related maculopathy susceptibility 2 (ARMS2 rs10490924) polymorphisms in individuals with and without AMD.
Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study.
New
Seddon et al., Boston, United States. In Am J Clin Nutr, Nov 2015
Ten genetic loci in 7 genes [complement factor H (CFH), age-related maculopathy susceptibility 2/high-temperature requirement A serine peptidase 1 (ARMS2/HTRA1), complement component 2 (C2), complement factor B (CFB), complement component 3 (C3), collagen type VIII α 1 (COL8A1), and RAD51 paralog B (RAD51B)] were examined.
Association of Genetic Variants with Polypoidal Choroidal Vasculopathy: A Systematic Review and Updated Meta-analysis.
Review
New
Chen et al., Hong Kong, Hong Kong. In Ophthalmology, Sep 2015
In total, 31 polymorphisms in 10 genes/loci (age-related maculopathy susceptibility 2 [ARMS2], high-temperature requirement factor A1 [HTRA1], complement factor H [CFH], complement component 2 [C2], CFB, RDBP, SKIV2L, CETP, 8p21, and 4q12) were significantly associated with PCV.
Age-related macular degeneration: genome-wide association studies to translation.
Review
New
Clark et al., Manchester, United Kingdom. In Genet Med, Jun 2015
Two loci in particular, including genes of the complement cascade on chromosome 1 and the ARMS2/HTRA1 genes on chromosome 10, have been shown to convey significantly increased susceptibility to developing AMD.
Pharmacogenomics of response to anti-VEGF therapy in exudative age-related macular degeneration.
Review
New
Bakri et al., Rochester, United States. In Retina, Mar 2015
Lower-risk genotypes of the CFH, ARMS2, HTRA1, and VEGF-A genes may be associated with improved visual outcomes.
Pharmacogenetics and nutritional supplementation in age-related macular degeneration.
Review
Schwartz et al., Miami, United States. In Clin Ophthalmol, 2014
Recent pharmacogenetic studies have reported differences in treatment outcomes with respect to variants in genes for CFH and ARMS2, although the treatment recommendations based on these differences are controversial.
Pachychoroid neovasculopathy and age-related macular degeneration.
Yoshimura et al., Kyoto, Japan. In Sci Rep, 2014
Their genetic susceptibility to AMD was significantly lower than that of neovascular AMD; ARMS2 rs10490924 (p = 0.029), CFH rs800292 (p = 0.013) and genetic risk score calculated from 11 AMD susceptibility genes (p = 3.8 × 10(-3)).
[Age-related macular degeneration].
Review
Budzinskaia, In Vestn Oftalmol, 2014
The impact of polymorphism in particular genes, including complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2/LOC387715), and serine peptidase (HTRA1), on AMD development is discussed.
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.
GeneRIF
Seddon et al., Boston, United States. In Ophthalmology, 2012
ARMS2/HTRA1 locus confers increased risk for both advanced age-related macular degeneration subtypes, but imparts greater risk for choroid neovascularization than for geographic atrophy.
Association of ARMS2 genotype with bilateral involvement of exudative age-related macular degeneration.
GeneRIF
Yoshimura et al., Kyoto, Japan. In Am J Ophthalmol, 2012
ARMS2 A69S genotype is associated with second-eye involvement of exudative age-related macular degeneration and with the period between first- and second-eye involvements.
Retinal function and CFH-ARMS2 polymorphisms analysis: a pilot study in Italian AMD patients.
GeneRIF
Falsini et al., Roma, Italy. In Neurobiol Aging, 2012
Our findings indicate that CFH (rs1061170) polymorphism impacts significantly on retinal function in early AMD patients.
ARMS2 A69S polymorphism and the risk for age-related maculopathy: the ALIENOR study.
GeneRIF
Korobelnik et al., In Arch Ophthalmol, 2012
TT genotype was associated with very high risk for all types of age-related macular degeneration (ARM), with increasing odds ratios according to the severity of ARM
Genetic associations in polypoidal choroidal vasculopathy: a systematic review and meta-analysis.
GeneRIF
Pang et al., Shantou, China. In Mol Vis, 2011
LOC387715 (ARMS2) rs10490924 was the only variant showing a significant difference between polypoidal choroidal vasculopathy and wet age-related macular degeneration. (Review)
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
Impact
Kubo et al., Yokohama, Japan. In Nat Genet, 2011
In addition to CFH (rs800292, P = 4.23 × 10(-15)) and ARMS2 (rs3750847, P = 8.67 × 10(-29)) loci, we identified two new susceptibility loci for exudative AMD: TNFRSF10A-LOC389641 on chromosome 8p21 (rs13278062, combined P = 1.03 × 10(-12), odds ratio = 0.73) and REST-C4orf14-POLR2B-IGFBP7 on chromosome 4q12 (rs1713985, combined P = 2.34 × 10(-8), odds ratio = 1.30).
Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.
Impact
Lotery et al., Southampton, United Kingdom. In Lancet, 2008
Genetic studies have made advancements in establishing the molecular cause of this disease, identifying mutations in the complement factor H (CFH) gene and a locus on chromosome 10 encompassing the HTRA1/LOC387715/ARMS2 genes.
Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.
Impact
GeneRIF
Weber et al., Regensburg, Germany. In Nat Genet, 2008
a deletion-insertion polymorphism in ARMS2 is strongly associated with AMD, directly affecting the transcript by removing the polyadenylation signal and inserting a 54-bp element known to mediate rapid mRNA turnover.
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