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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ADP-ribosylation factor-like 4A

ARL4, Arl4a, ADP-ribosylation factor-like 4, ADP-ribosylation factor-like protein 4
ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p16, ARF1, ARL5, HAD, ARF6
Papers on ARL4
PH Domain-Arf G Protein Interactions Localize the Arf-GEF Steppke for Cleavage Furrow Regulation in Drosophila.
Harris et al., Toronto, Canada. In Plos One, 2014
By analyzing GFP-tagged Arf and Arf-like small G proteins, we found that Arf1-GFP, Arf6-GFP and Arl4-GFP, but not Arf4-GFP, localized to furrows.
Functional networks of nucleocytoplasmic transport-related genes differentiate ischemic and dilated cardiomyopathies. A new therapeutic opportunity.
Rivera et al., Valencia, Spain. In Plos One, 2013
Furthermore, the two pathologies shared 6 altered genes: XPO1, ARL4, NFKB2, FHL3, RANBP2, and RHOU showing an identical trend in expression in both ICM and DCM.
ARL4A acts with GCC185 to modulate Golgi complex organization.
Lee et al., Taipei, Taiwan. In J Cell Sci, 2012
Deletion of the ARL4A-interacting region of GCC185 results in inability to maintain Golgi structure and modulate endosome-to-Golgi transport.
GTP-binding-defective ARL4D alters mitochondrial morphology and membrane potential.
Lee et al., Taipei, Taiwan. In Plos One, 2011
ARL4D, ARL4A, and ARL4C are closely related members of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of GTPases.
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.
Deloukas et al., Oxford, United Kingdom. In Plos Genet, 2011
Epigenome-wide association scans (EWAS) identified age-related phenotype DMRs (ap-DMRs) associated with LDL (STAT5A), lung function (WT1), and maternal longevity (ARL4A, TBX20).
The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.
Côté et al., Montréal, Canada. In J Biol Chem, 2011
membrane targeting of ELMO via Arl4A promotes cytoskeletal reorganization including membrane ruffling and stress fiber disassembly via an ELMO-DOCK1800-Rac signaling pathway.
Overexpression of the small GTPase Arl4D suppresses adipogenesis.
Park et al., Chŏnju, South Korea. In Int J Mol Med, 2011
Although Arl4 protein is reported to be expressed in adipose tissue, the function of Arl4D is unknown.
Variants in ZNF365 isoform D are associated with Crohn's disease.
Taylor et al., Los Angeles, United States. In Gut, 2011
A whole-genome microarray expression study further suggested that the Ala62Thr change in ZNF365 isoform D is related to differential expression of the genes ARL4A, MKKS, RRAGD, SUMF2, TDR1 and ZNF148 in CD.
Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop.
Antonny et al., Antibes, France. In J Biol Chem, 2011
Interestingly, the Arno PH domain interacts not only with a phosphoinositide (phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate) but also with an activating Arf family member, such as Arf6 or Arl4.
Fine mapping and association analysis of a quantitative trait locus for milk production traits on Bos taurus autosome 4.
Medrano et al., Davis, United States. In J Dairy Sci, 2009
Single nucleotide polymorphism 9 on ARL4A, SNP10 on XR_027435.1,
Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation.
Parsa et al., San Francisco, United States. In J Neurosurg, 2008
The loss of PTEN was shown to lead to increased levels of ARF4L protein but no change in transcript levels. The ARF4L transcript preferentially localized to the polysomal compartment after PTEN loss in glioma.
The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.
Munro et al., Cambridge, United Kingdom. In Curr Biol, 2007
Study shows that three related Arf-like GTPases Arl4a, Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form.
Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo.
Bramham et al., Bergen, Norway. In Eur J Neurosci, 2006
Of nine cDNAs encoding for known genes and up-regulated more than four-fold, we selected five genes, Narp, neuritin, ADP-ribosylation factor-like protein-4 (ARL4L), TGF-beta-induced immediate early gene-1 (TIEG1) and CARP, for further validation.
Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm.
Fan et al., Baltimore, United States. In Dev Biol, 2003
This gene was a target of WNT signlaing in the dorsal somite.
Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication.
Cherfils et al., Gif-sur-Yvette, France. In Embo Rep, 2002
Here we define the sequence and structural determinants that propagate information across the protein and identify them in all of the Arf family proteins other than Arl6 and Arl4/Arl7.
Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
Joost et al., Aachen, Germany. In Mol Cell Biol, 2002
Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli.
Lee et al., Taipei, Taiwan. In J Biol Chem, 2001
To characterize its molecular properties, we cloned mouse and human ARL4 (mARL4 and hARL4) cDNA.
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