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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NUAK family, SNF1-like kinase, 1

Top mentioned proteins: AMPK, LKB1, Akt, CAN, SNARK
Papers on ARK5
MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma.
Cheng et al., Nanjing, China. In Biochem Biophys Res Commun, Oct 2015
In this study, we investigated the regulation of NUAK1 by miR-145 in ICC.
Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer.
Wang et al., Linyi, China. In Oncol Rep, Sep 2015
In the present study, we examined the role of ARK5 in ovarian cancer and normal matched tissues using western blot analysis and migration and invasion, and wound‑healing assays.
New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder.
Sunyer et al., Barcelona, Spain. In Am J Med Genet B Neuropsychiatr Genet, Aug 2015
We detected other genes suggested to be involved in synaptic plasticity, cognitive function, neurological and neuropsychiatric disorders, and smoking behavior such as NUAK1, FGF20, NETO1, BTBD9, DLG2, TOP3B, and CHRNB4.
MiR-204 inhibits human NSCLC metastasis through suppression of NUAK1.
Zhao et al., Weifang, China. In Br J Cancer, 2015
The aim of this study is to determine the roles of NUAK1 (a downstream of Akt) and miR-204 in the invasiveness and metastasis of NSCLC and to reveal the correlation between NUAK1 and miR-204.
Chromodomain Helicase/ATPase DNA-Binding Protein 1-Like Gene (CHD1L) Expression and Implications for Invasion and Metastasis of Breast Cancer.
Ma et al., Qingdao, China. In Plos One, 2014
Western blot analysis was conducted to detect the expression of CHD1L, MMP-2, MMP-9, pAkt/Akt, pARK5/ARK5, and pmTOR/mTOR.
MYC-mediated synthetic lethality for treating tumors.
Huang et al., Wuhan, China. In Curr Cancer Drug Targets, 2014
An SMI can also induce MYC-SL by decreasing MYC expression through the activation of the GSK3β/FBW7 axis, the inactivation of PP2A inhibitors, and the inhibition of ARK5, AUK-A, Brd4, CDK1, CDK2, CHK1, and SAE1/2.
Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers.
Haaf et al., Germany. In Cytogenet Genome Res, 2014
Although, in general, there was no significant overlap between different published data sets or between our top 1,000 DMRs and published data sets, our methylation screen strengthens a number of candidate genes (APLP2, BDNF, HTR1A, NUAK1, PHACTR3, MSMP, SLC6A4, SYN2, and SYNE2) and supports a role for epigenetics in the pathophysiology of suicide.
A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
Recio et al., Barcelona, Spain. In Plos Genet, 2014
We demonstrate that LKB1 and its downstream kinase NUAK1 bind to CDKN1A.
Analysis of NUAK1 and NUAK2 expression during early chick development reveals specific patterns in the developing head.
Thélu et al., Grenoble, France. In Int J Dev Biol, 2013
Several human diseases are associated with the NUAK1 and NUAK2 genes.
The regulation and function of the NUAK family.
Zhao et al., Taipei, Taiwan. In J Mol Endocrinol, 2013
Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently.
Carving axon arbors to fit: master directs one kinase at a time.
Arber et al., Basel, Switzerland. In Cell, 2013
now uncover a later role for LKB1 and its tango with the downstream effector kinase NUAK1 in controlling terminal axonal branching through influencing mitochondrial motility in axons.
Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture.
Polleux et al., Los Angeles, United States. In Cell, 2013
We identified a pathway defined by two kinases, LKB1 and NUAK1, required for cortical axon branching in vivo.
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
Murphy et al., Würzburg, Germany. In Nature, 2012
in human and murine cell lines, oncogenic levels of MYC establish a dependence on AMPK-related kinase 5 for maintaining metabolic homeostasis and for cell survival; ARK5 is an upstream regulator of AMPK and limits protein synthesis via inhibition of the mammalian target of rapamycin 1 (mTORC1) signalling pathway
ARK5 is associated with the invasive and metastatic potential of human breast cancer cells.
Cao et al., Tianjin, China. In J Cancer Res Clin Oncol, 2012
ARK5 enhanced the invasive and metastatic potential of MDA-MB-231 cells under regulation by Akt.
Identification and prioritization of NUAK1 and PPP1CC as positional candidate loci for skeletal muscle strength phenotypes.
Thomis et al., Leuven, Belgium. In Physiol Genomics, 2011
NUAK1 and PPP1CC are identified as positional candidate loci for skeletal muscle strength phenotypes.
A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.
Sun et al., China. In Oncogene, 2011
A novel role for NUAK1 in LKB1-related signaling pathways; NUAK1 can regulate cell proliferation and exert tumor suppression through direct interaction with p53.
Regulation of AMPK by the ubiquitin proteasome system.
Willis et al., Durban, South Africa. In Am J Pathol, 2011
Other investigators found that AMPK regulatory components, including the AMPK α subunit and AMPK kinases NUAK1 and MARK4, can be ubiquitinated with atypical ubiquitin chains.
New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.
Alessi et al., Dundee, United Kingdom. In Sci Signal, 2009
the LKB1-NUAK pathway has roles in controlling myosin phosphatase complexes and cell adhesion
The regulation and function of mammalian AMPK-related kinases.
Carling et al., London, United Kingdom. In Acta Physiol (oxf), 2009
Recently, 12 AMPK-related kinases (BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) were identified that are closely related by sequence homology to the catalytic domain of AMPK.
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