[CK2beta promotes Pink1/Parkin-mediated MIRO1 degradation].
In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2014
Studies have suggested that PINK1FL can selectively accumulate at the surface of damaged mitochondria and cooperate with another Parkinson's Disease-related protein PARKIN to trigger the degradation of MIRO1, a mitochondria trafficking regulator.
Miro1: new wheels for transferring mitochondria.
Boston, United States. In Embo J, 2014
In this issue of The EMBO Journal, the group of Anurag Agrawal shows that mitochondrial transfer is dependent on the levels of Miro1, a mitochondrial Rho-GTPase that regulates intercellular mitochondrial movement.
Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins.
London, United Kingdom. In Biochem Soc Trans, 2013
One of the core components of this machinery, the mitochondrial Rho GTPases Miro1 (mitochondrial Rho 1) and Miro2 have received special attention due to their Ca2+-sensing and GTPase abilities, marking Miro an exceptional candidate for co-ordinating mitochondrial dynamics and intracellular signalling pathways.