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Rho GTPase activating protein 22

ARHGAP22, p68RacGAP
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Rhodopsin, Akt, RhoGAP, Actin, GAP
Papers on ARHGAP22
Methylation levels of SLC23A2 and NCOR2 genes correlate with spinal muscular atrophy severity.
Schiöth et al., Uppsala, Sweden. In Plos One, 2014
To investigate the contribution of methylation changes to SMA severity, we compared the methylation level of found CpG sites, designed as "targets", as well as the nearest CpG sites in regulatory regions of ARHGAP22, CDK2AP1, CHML, NCOR2, SLC23A2 and RPL9 in three groups of SMA patients.
ARHGAP22 localizes at endosomes and regulates actin cytoskeleton.
Ohta et al., Japan. In Plos One, 2013
ARHGAP22 is a member of FilGAP family, and implicated in the regulation of tumor cell motility.
Genome-wide analysis shows association of epigenetic changes in regulators of Rab and Rho GTPases with spinal muscular atrophy severity.
Schiöth et al., Saint Petersburg, Russia. In Eur J Hum Genet, 2013
We identified strong significant differences in methylation level between SMA patients and healthy controls in CpG sites close to the genes CHML, ARHGAP22, CYTSB, CDK2AP1 and SLC23A2.
FilGAP and its close relatives: a mediator of Rho-Rac antagonism that regulates cell morphology and migration.
Review
Nakamura, Boston, United States. In Biochem J, 2013
The present review concerns a class of Rho GAPs, FilGAP (ARHGAP24 gene product) and its close relatives (ARHGAP22 and AHRGAP25 gene products).
The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2.
GeneRIF
Sala et al., Milano, Italy. In Hum Mol Genet, 2012
The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling.
The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode.
Martin et al., Brisbane, Australia. In Plos One, 2011
ARHGAP22 is a RhoGAP protein comprising an N-terminal PH domain, a RhoGAP domain and a C-terminal coiled-coil domain.
Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin.
GeneRIF
James et al., Sydney, Australia. In Mol Cell Biol, 2011
Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin
Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis.
Volpert et al., Chicago, United States. In Neoplasia, 2011
These changes in cell shape depended on decreased RhoA and increased Rac1 activation and were mediated by the up-regulation of Rac1-GEF, DOCK3 and down-regulation of Rac1-GAP, ARHGAP22.
Genome-wide association study of diabetic retinopathy in a Taiwanese population.
GeneRIF
Tsai et al., Taiwan. In Ophthalmology, 2011
We identified a genetic association for susceptibility to retinopathy in 5 novel chromosomal regions and PLXDC2 and ARHGAP22, the latter 2 of which are genes implicated in endothelial cell angiogenesis and increased capillary permeability.
Regulating the conversion between rounded and elongated modes of cancer cell movement.
Impact
Olson et al., Glasgow, United Kingdom. In Cancer Cell, 2008
In a recent issue of Cell, Sanz-Moreno et al. identify DOCK3, NEDD9, WAVE2, and ARHGAP22 as key molecules regulating Rac and Rho signaling that determine the mode of movement driving melanoma cell metastasis.
Rac activation and inactivation control plasticity of tumor cell movement.
Impact
Marshall et al., London, United Kingdom. In Cell, 2008
Conversely, in amoeboid movement, Rho-kinase signaling activates a Rac GAP, ARHGAP22, that suppresses mesenchymal movement by inactivating Rac.
Identification and characterization of ARHGAP27 gene in silico.
Katoh et al., Japan. In Int J Mol Med, 2004
ARHGAP1, ARHGAP2, ARHGAP3, ARHGAP4, ARHGAP5, ARHGAP6, ARHGAP7 (DLC1), ARHGAP8, ARHGAP9, ARHGAP10, ARHGAP12, ARHGAP13 (SRGAP1), ARHGAP14 (SRGAP2), ARHGAP15, ARHGAP17 (RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STARD13 (DLC2), HA-1, GMIP, PARG1, RACGAP1, PIK3R1, PIK3R2, and FNBP2 genes encode Rho/Rac/Cdc42-like GTPase activating (RhoGAP) proteins.
Characterization of human ARHGAP10 gene in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2004
ARHGAP gene family was found consisting of at least 32 members, including ARHGAP1, ARHGAP2 (CHN1), ARHGAP3, (CHN2), ARHGAP4, ARHGAP5, ARHGAP6 (STARD8), ARHGAP7 (STARD12 or DLC1), ARHGAP8, ARHGAP9, ARHGAP10, ARHGAP12, ARHGAP13 (SRGAP1), ARHGAP14 (SRGAP2), ARHGAP15, ARHGAP17 (RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STRAD13 (DLC2), HA-1, GMIP, PARG1, PIK3R1, PIK3R2, RACGAP1, and FNBP2.
Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico.
Katoh et al., Narashino, Japan. In Int J Mol Med, 2004
Based on the homology with ARHGAP22, we identified and characterized two novel ARHGAP family genes, ARHGAP24 and ARHGAP25.
p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.
GeneRIF
Patterson et al., Chapel Hill, United States. In J Biol Chem, 2004
a multifunctional regulatory protein with Rac1-specific GTPase-activating activity; regulates transcriptional activity of the endothelin-1 promoter; involved in the signal transduction pathway regulating endothelial cell capillary tube formation
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