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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Low density lipoprotein receptor adaptor protein 1

ARH, ARH1
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, LDL receptor, Neuropeptide, ACID
Papers on ARH
Role of estradiol in intrinsic hindbrain AMPK regulation of hypothalamic AMPK, metabolic neuropeptide, and norepinephrine activity and food intake in the female rat.
New
Briski et al., Monroe, United States. In Neuroscience, Mar 2016
Cc decreased PVH corticotropin-releasing hormone and arcuate (ARH) proopiomelanocortin (POMC) and neuropeptide Y in O, but suppressed only POMC in E. O/Cc exhibited both augmented (PVH, VMH) and decreased (LHA, ARH) hypothalamic NE content, whereas Cc treatment of E elevated preoptic and dorsomedial hypothalamic nucleus NE.
Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.
New
Wagner et al., Pomona, United States. In Neuroendocrinology, Feb 2016
UNASSIGNED: Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis.
Network of hypothalamic neurons that control appetite.
Review
New
Sohn, Taejŏn, South Korea. In Bmb Rep, Apr 2015
Specifically, two distinct neuronal populations exist in the arcuate nucleus of hypothalamus (ARH): the anorexigenic (appetite-suppressing) pro-opiomelanocortin (POMC) neurons and the orexigenic (appetite-increasing) neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons.
The history of Autosomal Recessive Hypercholesterolemia (ARH). From clinical observations to gene identification.
Review
New
Bertolini et al., Ferrara, Italy. In Gene, Feb 2015
The loss of function of this protein is the cause of Autosomal Recessive Hypercholesterolemia (ARH).
Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice.
O'Connell et al., Wuhan, China. In Sci Rep, 2014
Long-term consumption of high-fat diet (HFD) leads to persistent activation and leptin resistance in AgRP neurons in the arcuate nucleus of the hypothalamus (ARH).
Expression patterns of Doppel in differential ovine PRNP genotypes: quantification using real-time RT-PCR.
Zhang et al., Lanzhou, China. In Genet Mol Res, 2014
Different tissue samples were collected from the central nervous system plus four regions of lymphoid system, eleven regions of digestive tract and two reproductive organs from four ARR/ARQ and four ARH/ARQ sheep, genotypes of the PrP gene.
Autosomal recessive hypercholesterolemia: a mild phenotype of familial hypercholesterolemia: insight from the kinetic study using stable isotope and animal studies.
Review
Yamagishi et al., Kanazawa, Japan. In J Atheroscler Thromb, 2014
Autosomal recessive hypercholesterolemia (ARH) is an extremely rare inherited disorder, the cause of which is mutations in the low-density lipoprotein (LDL) receptor adaptor protein 1 (LDLRAP1) gene.
Orphanin FQ-ORL-1 regulation of reproduction and reproductive behavior in the female.
Review
Sanathara et al., Long Beach, United States. In Vitam Horm, 2014
The arcuate nucleus of the hypothalamus (ARH) is a brain region that expresses OFQ/N and ORL-1 important for both sexual behavior and modulating estradiol feedback loops.
Microsomal transfer protein (MTP) inhibition-a novel approach to the treatment of homozygous hypercholesterolemia.
Review
Bertolini et al., Milano, Italy. In Ann Med, 2014
In certain geographical areas a significant number of patients may be affected by an autosomal recessive hypercholesterolemia (ARH).
Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.
GeneRIF
Zajonc et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2012
report the crystal structure at 1.37-A resolution of the phosphotyrosine-binding (PTB) domain of ARH in complex with an LDLR tail peptide containing the FxNPxY(0) internalization signal
A novel type of familial hypercholesterolemia: double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene.
GeneRIF
Yamagishi et al., Kanazawa, Japan. In Atherosclerosis, 2011
LDL receptor/LDLRAP1 double heterozygous mutations may account for severer phenotype in terms of xanthoma and atherosclerotic cardiovascular disease in familial hypercholesterolemia patients.
Premature senescence in cells from patients with autosomal recessive hypercholesterolemia (ARH): evidence for a role for ARH in mitosis.
GeneRIF
Soutar et al., London, United Kingdom. In Arterioscler Thromb Vasc Biol, 2011
ARH protein is involved in cell cycle progression, possibly by affecting nuclear membrane formation through interaction with lamin B1 or other mitotic proteins, and its absence affects cell proliferation and induces premature senescence.
ADP-ribosylarginine hydrolase regulates cell proliferation and tumorigenesis.
GeneRIF
Moss et al., Bethesda, United States. In Cancer Res, 2011
ARH1(-/-) and ARH1(+/-) mice spontaneously develop lymphomas, adenocarcinomas, & metastases more frequently than wild-type. Proper control of protein ADP-ribosylation levels affected by ARH1 is essential for cancer suppression.
ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells.
GeneRIF
Fölsch et al., Chicago, United States. In J Cell Biol, 2011
Knockdown of ARH in polarized epithelial cells leads to specific apical missorting of truncated LDLR, which encodes only the FxNPxY motif (LDLR-CT27).
Hypothalamic neural projections are permanently disrupted in diet-induced obese rats.
Impact
Simerly et al., Los Angeles, United States. In Cell Metab, 2008
The arcuate nucleus of the hypothalamus (ARH) is a key component of hypothalamic pathways regulating energy balance, and leptin is required for normal development of ARH projections.
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
Impact
Kadowaki et al., Tokyo, Japan. In Cell Metab, 2007
Here, we show that adiponectin enhances AMPK activity in the arcuate hypothalamus (ARH) via its receptor AdipoR1 to stimulate food intake; this stimulation of food intake by adiponectin was attenuated by dominant-negative AMPK expression in the ARH.
The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.
Impact
Elmquist et al., Boston, United States. In Cell Metab, 2005
The hypothalamic arcuate nucleus (ARH) has been proposed as an important site of leptin action.
Trophic action of leptin on hypothalamic neurons that regulate feeding.
Impact
Simerly et al., Beaverton, United States. In Science, 2004
In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus (ARH).
Effect of Arsenic Trioxide in TRAIL (Tumor Necrosis Factor-related Apoptosis Inducing Ligand)-Mediated Apoptosis in Multiple Myeloma Cell Lines.
Park et al., In Cancer Res Treat, 2003
MATERIALS AND METHODS: Using TRAIL-sensitive (RPMI- 8226) and TRAIL-resistant (ARH-77 and IM-9) MM cell lines, the cell viability, induction of apoptosis, and change in the caspases were examined after treatment with TRAIL alone, or in combination with various concentrations of As2O3.
Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysis.
Impact
Hobbs et al., Roma, Italy. In Lancet, 2002
FINDINGS: Two ARH mutations, a frameshift mutation (c432insA) in exon 4 (ARH1) and a nonsense mutation (c65G-->A) in exon 1 (ARH2), were present in all of the 17 unrelated families with ARH.
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