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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Argininosuccinate lyase

Argininosuccinate Lyase
Top mentioned proteins: ACID, CAN, Arginase, HAD, iNOS
Papers on Argininosuccinate Lyase
Argininosuccinic Aciduria-A Rare Indication for Liver Transplant: Report of Two Cases.
New
Kalayoglu et al., İstanbul, Turkey. In Exp Clin Transplant, Feb 2016
UNASSIGNED: Argininosuccinic aciduria is a urea cycle disorder caused by an argininosuccinate lyase enzyme deficiency that ends with nitrogen accumulation as ammonia.
Effect of Cysteamine on Mutant ASL Proteins with Cysteine for Arginine Substitutions.
New
Häberle et al., Zürich, Switzerland. In Mol Diagn Ther, Feb 2016
OBJECTIVES: We investigated the effect of cysteamine on mutant argininosuccinate lyase (ASL), the second most common defect in the urea cycle.
Lys-315 at the Interfaces of Diagonal Subunits of δ-Crystallin Plays a Critical Role in the Reversibility of Folding and Subunit Assembly.
New
Lee et al., Kao-hsiung, Taiwan. In Plos One, Dec 2015
δ-Crystallin is the major structural protein in avian eye lenses and is homologous to the urea cycle enzyme argininosuccinate lyase.
Argininosuccinate lyase is a potential therapeutic target in breast cancer.
New
Lai et al., Tainan City, Taiwan. In Oncol Rep, Dec 2015
In our previous study, we observed that blocking argininosuccinate lyase (ASL) attenuates tumor progression in liver cancer.
The phenotypic spectrum of organic acidurias and urea cycle disorders. Part 2: the evolving clinical phenotype.
New
Garcia Cazorla et al., Heidelberg, Germany. In J Inherit Metab Dis, Nov 2015
Cardiomyopathy [methylmalonic (MMA) and propionic aciduria (PA)], prolonged QTc interval (PA), optic nerve atrophy [MMA, isovaleric aciduria (IVA)], pancytopenia (PA), and macrocephaly [glutaric aciduria type 1 (GA1)] were exclusively found in OAD patients, whereas hepatic involvement was more frequent in UCD patients, in particular in argininosuccinate lyase (ASL) deficiency.
Report of 3 Patients With Urea Cycle Defects Treated With Related Living-Donor Liver Transplant.
New
Haberal et al., Ankara, Turkey. In Exp Clin Transplant, Nov 2015
Patients presented with late-onset ornithine transcarbamylase deficiency, argininosuccinate lyase deficiency, and citrullinemia.
Candidate effectors contribute to race differentiation and virulence of the lentil anthracnose pathogen Colletotrichum lentis.
Banniza et al., Saskatoon, Canada. In Bmc Genomics, 2014
Furthermore, an EST encoding argininosuccinate lyase (Arg) was identified as a bacterial gene.
Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges.
Review
Szlosarek et al., London, United Kingdom. In Cancer Res Treat, 2013
More recently, dysregulation of argininosuccinate lyase has been documented in a subset of arginine auxotrophic glioblastoma multiforme, HCC and in fumarate hydratase-mutant renal cancers.
Regulation of endothelial nitric oxide synthase activity by protein-protein interaction.
Review
Su, Augusta, United States. In Curr Pharm Des, 2013
In addition, eNOS associations with cationic amino acid transporter-1 (CAT-1), argininosuccinate synthase (ASS), argininosuccinate lyase (ASL), and soluble guanylate cyclase (sGC) facilitate directed delivery of substrate (L-arginine) to eNOS and optimizing NO production and NO action on its target.
Molecular diagnosis of urea cycle disorders: current global scenario.
Review
Vaidyanathan, In Indian J Biochem Biophys, 2013
This encompasses 5 major disorders, corresponding with deficiency of each step in the urea cycle, namely ornithine transcarbamoylase (OTC) deficiency, argininosuccinate lyase (ASL) deficiency, carbamoyl phosphate synthetase (CPS) deficiency, citrullinemia and argininemia.
Optimizing therapy for argininosuccinic aciduria.
Review
Erez et al., Houston, United States. In Mol Genet Metab, 2012
In this article, we discuss the natural history of ASA and the recent mechanistic insights from animal studies that have shown the requirement of argininosuccinate lyase, the enzyme deficient in ASA, for systemic nitric oxide production.
Aspartase/fumarase superfamily: a common catalytic strategy involving general base-catalyzed formation of a highly stabilized aci-carboxylate intermediate.
Review
Poelarends et al., Groningen, Netherlands. In Biochemistry, 2012
Members of the aspartase/fumarase superfamily share a common tertiary and quaternary fold, as well as a similar active site architecture; the superfamily includes aspartase, fumarase, argininosuccinate lyase, adenylosuccinate lyase, δ-crystallin, and 3-carboxy-cis,cis-muconate lactonizing enzyme (CMLE).
Requirement of argininosuccinate lyase for systemic nitric oxide production.
Impact
Lee et al., Houston, United States. In Nat Med, 2011
We show that a hypomorphic mouse model of argininosuccinate lyase (encoded by Asl) deficiency has a distinct phenotype of multiorgan dysfunction and NO deficiency.
Regulation of cellular metabolism by protein lysine acetylation.
Impact
Guan et al., Shanghai, China. In Science, 2010
Acetylation activated enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase in fatty acid oxidation and malate dehydrogenase in the TCA cycle, inhibited argininosuccinate lyase in the urea cycle, and destabilized phosphoenolpyruvate carboxykinase in gluconeogenesis.
Recruitment of enzymes as lens structural proteins.
Impact
Piatigorsky et al., In Science, 1987
In terms of sequence similarity, size, and other physical characteristics delta-crystallin is closely related to argininosuccinate lyase, tau-crystallin to enolase, and SIII-crystallin to glutathione S-transferase; moreover, it has recently been demonstrated that epsilon-crystallin is an active lactate dehydrogenase.
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