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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Arginase, liver

Arginase, CAR, calcium-sensing receptor
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: CAR, CAN, V1a, HAD, ACID
Papers using Arginase antibodies
Identification of local and circulating cancer stem cells in human liver cancer
Supplier
Bright J J et al., In British Journal of Cancer, 2007
... The human CAR agonist CITCO was obtained from BioMol (Plymouth Meeting, PA, USA) ...
Termination of cAMP signals by Ca2+ and Gαi via extracellular Ca2+ sensors
Supplier
Hofer Aldebaran M. et al., In The Journal of Cell Biology, 1999
... HEK 293 cells stably expressing the human CaR and WT HEK 293 were grown in high-glucose DME + glutamax (Life Technologies) supplemented with 10% FBS ...
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene.
Supplier
Appanna Vasu D., In PLoS ONE, 1999
... including pregnenolone 16α-carbonitrile (PCN, 10 µM; Sigma) for PXR, 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP, 250 nM; Sigma) for CAR, β-estradiol (10 nM; Sigma) for ER, T0901317 (1 µM; Cayman Chemical) for LXRα, calcipotriol ...
Papers on Arginase
Nuclear receptors and drug metabolism for the personalization of cancer therapy.
New
Toffoli et al., Italy. In Expert Opin Drug Metab Toxicol, Feb 2016
The study of the host genetic background of Pregnane X Receptor (PXR; NR1I2) and Constitutive Androstane Receptor (CAR; NR1I3 and NR1I4), represents a new and attractive strategy to discern variability in ADME of antineoplastic drugs.
p-Cresyl sulfate suppresses lipopolysaccharide-induced anti-bacterial immune responses in murine macrophages in vitro.
New
Kaneko et al., Kunitachi, Japan. In Toxicol Lett, Feb 2016
We evaluated the effects of pCS on cytokine production, nitric oxide (NO) production, arginase activity, expression of cell-surface molecules, and phagocytosis in the macrophage-like cell line, RAW264.7.
Deciphering cd137 (4-1bb) signaling in T-cell costimulation for translation into successful cancer immunotherapy.
Review
New
Melero et al., Pamplona, Spain. In Eur J Immunol, Feb 2016
Furthermore, the signaling cytoplasmic tail of CD137 is a key component of anti-CD19 chimeric antigen receptors (CAR) which are used to redirect T cells against leukemia and lymphoma in the clinic.
The potential role of polyamines in gill epithelial remodeling during extreme hypoosmotic challenges in the gulf killifish, Fundulus grandis.
New
Galvez et al., Baton Rouge, United States. In Comp Biochem Physiol B Biochem Mol Biol, Feb 2016
UNASSIGNED: Polyamines are a family of low molecular weight organic cations produced in part by the coordinated actions of arginase II (Arg II) and ornithine decarboxylase (Odc).
Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy.
New
Impact
Eshhar et al., Qiryat Gat, Israel. In Annu Rev Pharmacol Toxicol, Feb 2016
A chimeric antigen receptor (CAR) is a recombinant fusion protein combining an antibody-derived targeting fragment with signaling domains capable of activating T cells.
Targeted therapies for CLL: Practical issues with the changing treatment paradigm.
Review
New
O'Brien et al., Houston, United States. In Blood Rev, Jan 2016
Strategies targeting the immune system such as lenalidomide, chimeric antigen receptor (CAR) T cells, and more recently, checkpoint inhibitors, are in clinical development.
The role of the calcium-sensing receptor in gastrointestinal inflammation.
Review
New
Mohamadzadeh et al., Gainesville, United States. In Semin Cell Dev Biol, Jan 2016
Observations that a deficiency in the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific receptor knockout mice resulted in diminished intestinal barrier integrity, altered composition of the gut microbiota, modified expression of intestinal pattern recognition receptors, and a skewing of local and systemic innate responses from regulatory to stimulatory, may change the way that this receptor is considered as a potential immunotherapeutic target in gut homeostasis.
Efavirenz pharmacogenetics in a cohort of Italian patients.
New
D'Avolio et al., Torino, Italy. In Int J Antimicrob Agents, Jan 2016
Whole blood was used to identify SNPs in ABCB1, MRP2, CYP2B6, CYP2A6, UGT2B7, NR1I2 (PXR), NR1I3 (CAR) and HNF4α by real-time PCR.
Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors.
Review
New
Kranz et al., Urbana, United States. In Trends Pharmacol Sci, Jan 2016
While CAR-based adoptive cell therapies are already showing great promise, their basic mechanistic properties have been studied in less detail compared with those of αβ TCRs.
Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis.
New
Rocco et al., Rio de Janeiro, Brazil. In Plos One, Dec 2015
Additionally, dasatinib reduced expression of iNOS and increased expression of arginase and metalloproteinase-9 in silicotic macrophages.
Shifting the Evolving CAR T Cell Platform into Higher Gear.
New
Impact
Bluestone et al., San Francisco, United States. In Cancer Cell, Nov 2015
In this issue of Cancer Cell, Zhao and colleagues test various chimeric antigen receptor (CAR) T cells to show that CD28-CD3ζ CAR T cells that constitutively express 4-1BBL promote T cell expansion and tumor eradication while reducing exhaustion.
Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells.
New
Impact
Maini et al., London, United Kingdom. In Nat Med, Jun 2015
In persistent infection, arginase-expressing gMDSCs (and circulating arginase) increased most in disease phases characterized by HBV replication without immunopathology, whilst L-arginine decreased.
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors.
New
Impact
Mackall et al., Bethesda, United States. In Nat Med, Jun 2015
It remains unknown whether the impressive effects of CD19 CARs relate to greater susceptibility of hematologic malignancies to CAR therapies, or superior functionality of the CD19 CAR itself.
Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.
New
Impact
Dotti et al., Houston, United States. In Nat Med, May 2015
Adoptive transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less striking therapeutic effects in solid tumors than in lymphoid malignancies.
Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia.
Review
Sobrevia et al., Santiago, Chile. In Oxid Med Cell Longev, 2014
The fetal and placental endothelial dysfunction is related to alterations in the L-arginine/nitric oxide (NO) pathway and the arginase/urea pathway and results in reduced NO production.
Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes.
GeneRIF
Pratesi et al., Brasília, Brazil. In Gene, 2012
Three previously reported mutations were found (p.R21X; p.I11T and p.W122X), and five novel mutations were identified (p.G27D; p.G74V; p.T134I; p.R308Q; p.I174fs179).
Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor.
GeneRIF
Christopoulos et al., Australia. In Endocrinology, 2012
Data indicate that mutations in the HHD and ECL of the CaSR induce pathway-selective bias that favors the preferential activation (gain of function) or inhibition (loss of function) of one signaling pathway over another.
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
GeneRIF
Yuan et al., Nagoya, Japan. In Circ Res, 2012
The extracellular calcium-induced increase in cytosolic Ca(2+) due to upregulated CaSR, contributes to the augmented Ca(2+) influx and excessive pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension.
Binding of the unreactive substrate analog L-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I.
GeneRIF
Christianson et al., Philadelphia, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
X-ray crystal structures are now reported of the complexes of Mn(2)(2+)-human arginase I (HAI) and Co(2)(2+)-HAI with L-2-amino-3-guanidinopropionic acid an amino acid bearing a guanidinium side chain two methylene groups shorter than that of L-arginine
Resection of multiple recurrent cardiac myxomas in an adult man with Carney's complex.
GeneRIF
Schaff et al., Rochester, United States. In Ann Thorac Surg, 2012
We treated a 40-year-old man who presented with an embolic stroke. He had a family history of cardiac myxoma and underwent resection of a right atrial myxoma 7 years ago. Genetic evaluation revealed a heterozygous mutation in the PRKAR1A gene.
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