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ADP-ribosylation factor 6

ARF6, ADP-ribosylation factor 6
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p16, Actin, ARF1, CAN, V1a
Papers using ARF6 antibodies
G protein-coupled receptor endocytosis in ADP-ribosylation factor 6-depleted cells.
Supplier
Keen James, In PLoS ONE, 2004
... MA); mouse anti-phospho-FGFR, rabbit anti-phospho-FRS2α (Y196), rabbit anti-MAPK (p42/p44), mouse anti-phospho-MAPK (p42/p44), rabbit anti-Cdc42, rabbit anti-Arf6 (Cell Signaling Technology, Danvers, MA); rabbit ...
The requirement of both extracellular regulated kinase and p38 mitogen-activated protein kinase for stimulation of cytosolic phospholipase A2 activity by either FcγRIIA or FcγRIIIB in human neutrophils
Supplier
Sabe Hisataka et al., In The Journal of Experimental Medicine, 1999
... Anti–influenza hemagglutinin (HA) mAb was purchased from BAbCO, anti-ARF6 mAb was from Santa Cruz Biotechnology, Inc., and Cy2-, Cy3-, ...
The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation
Supplier
Etienne-Manneville Sandrine et al., In The Journal of Cell Biology, 1999
... obtained from Sigma-Aldrich, phalloidin-rhodamine from Invitrogen, anti-pericentrin from BabCO, anti-GM130, anti-EEA1, and anti-Rac1 from BD, anti-Arf6 from AbCam, anti-Cdc42, anti-Par6, and anti-PKCζ ...
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration
Supplier
Ginsberg Mark H. et al., In The Journal of Cell Biology, 1995
... , mouse monoclonal anti-Arf6, and rabbit H-15 anti–His tag antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Papers on ARF6
Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking.
New
Whiteheart et al., Lexington, United States. In Blood, Feb 2016
ADP-ribosylation factor 6 (Arf6) is a small GTP-binding protein known to regulate endocytic trafficking, especially of integrins.
Excessive Selenium Supplementation Induced Oxidative Stress and Endoplasmic Reticulum Stress in Chicken Spleen.
New
He et al., Mianyang, China. In Biol Trace Elem Res, Feb 2016
Then, the levels of antioxidative enzymes, GPx, SOD, and MDA as well as the expression levels of GRP78, ARF6, caspase 3, caspase 12, and Bcl 2 in the spleen were determined at days 15, 30, and 45, respectively.
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.
New
Ganju et al., United States. In Mol Oncol, Nov 2015
Treatment with SecinH3, a small molecule drug which deactivates ARF6 downstream of Robo4, can enhance Robo4 signaling and thus inhibit breast cancer growth and metastasis.
Genome-wide association studies in biliary atresia.
Review
New
Sindhi et al., Pittsburgh, United States. In Wiley Interdiscip Rev Syst Biol Med, Sep 2015
Although distinct, these susceptibility genes share several functions including roles in mechanisms for organogenesis (glypican 1 or GPC1, and adenosine diphosphate ribosylation factor 6, or ARF6) or a greater expression in fetal liver than in adult liver (adducin 3 or ADD3).
Molecular and physiological mechanisms regulating tissue reunion in incised plant tissues.
Review
New
Satoh et al., Utsunomiya, Japan. In J Plant Res, May 2015
Ethylene and jasmonic acid modulate the expression of ANAC071 and RAP2.6L, respectively, and auxin signaling via ARF6/8 is essential for the expression of these transcription factors.
Constitutive Expression of OsIAA9 Affects Starch Granules Accumulation and Root Gravitropic Response in Arabidopsis.
Wang et al., Changchun, China. In Front Plant Sci, 2014
Protoplast transfection assays showed that OsIAA9 interacted ARF5, but not ARF6, 7, 8 and 19.
Identification of Novel and Conserved miRNAs in Leaves of In vitro Grown Citrus reticulata "Lugan" Plantlets by Solexa Sequencing.
Lai et al., Fuzhou, China. In Front Plant Sci, 2014
After analyzing the expression level of their targets during the reservation of the ponkan in vitro plantlet, development-associated cre-ARF6 and stress-related cre-CSD modules exhibited negative correlation with miR167 and miR398, respectively, indicating an involvement of the miRNAs in the in vitro development of ponkan and function in the conservation of ponkan germplasm.
Rab-mediated trafficking role in neurite formation.
Review
Gonzalez-Billault et al., Santiago, Chile. In J Neurochem, 2014
Finally, we also discuss the participation of the ADP-ribosylation factor 6, a member of the ArfGTPase family, in neurite formation since it seems to have an important cross-talk with RabGTPases.
Activation machinery of the small GTPase Arf6.
Review
Kanaho et al., Tsukuba, Japan. In Adv Biol Regul, 2014
The small GTPase ADP-ribosylation factor 6 (Arf6) plays pivotal roles in a wide variety of cellular events, including exocytosis, endocytosis, actin cytoskeleton reorganization and phosphoinositide metabolism, in various types of cells.
A Wnt-er migration: the confusing role of β-catenin in melanoma metastasis.
Review
Weeraratna et al., Philadelphia, United States. In Sci Signal, 2013
The role of β-catenin in melanoma metastasis remains unclear; however, a new study points to the roles of Wnt5A and ARF6 in driving β-catenin expression and melanoma metastasis.
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.
Impact
Li et al., Salt Lake City, United States. In Nature, 2013
Here we show that the direct, immediate and disruptive effects of IL-1β on endothelial stability in a human in vitro cell model are NF-κB independent and are instead the result of signalling through the small GTPase ADP-ribosylation factor 6 (ARF6) and its activator ARF nucleotide binding site opener (ARNO; also known as CYTH2).
ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation.
GeneRIF
Annaert et al., Leuven, Belgium. In Embo J, 2012
A specific microenvironment facilitating ARF6-mediated mobilization of telencephalin that contributes to promotion of dendritic spine development.
ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons.
GeneRIF
Fawcett et al., Cambridge, United Kingdom. In J Neurosci, 2012
Our data suggest a novel mechanism of integrin traffic and transport in peripheral axons, regulated by the activation state of ARF6
ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration.
GeneRIF
Mishima et al., Cambridge, United Kingdom. In Embo J, 2012
It was shown that ARF6 competes with 14-3-3 for binding to centralspindlin such that midbodies formed by centralspindlin mutants that can bind 14-3-3 but not ARF6 frequently collapse before abscission.
ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies.
GeneRIF
López Bernal et al., Swansea, United Kingdom. In Plos One, 2011
a functional ARF6 system in human myometrium and a correlation between ARF6 level and activity in uterine and abnormal pregnancy
GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells.
GeneRIF
Lu et al., Nanjing, China. In Plos One, 2011
GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells.
The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.
Impact
Alto et al., Dallas, United States. In Nature, 2011
The 2.5 Å crystal structure of EspG in complex with ARF6 shows how EspG blocks GTPase-activating-protein-assisted GTP hydrolysis, revealing a potent mechanism of GTPase signalling inhibition at organelle membranes.
Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex.
Impact
Bowerman et al., Eugene, United States. In Nat Cell Biol, 2010
EFA-6 orthologues activate ARF6-type GTPases to regulate vesicle trafficking.
Mechanisms of endocytosis.
Review
Impact
McMahon et al., Cambridge, United Kingdom. In Annu Rev Biochem, 2008
These clathrin-independent pathways include the CLIC/GEEC endocytic pathway, arf6-dependent endocytosis, flotillin-dependent endocytosis, macropinocytosis, circular doral ruffles, phagocytosis, and trans-endocytosis.
ARF proteins: roles in membrane traffic and beyond.
Review
Impact
Chavrier et al., United States. In Nat Rev Mol Cell Biol, 2006
Recent advances in our understanding of the signalling pathways that are regulated by ARF1 and ARF6, two of the best characterized ARF proteins, provide a molecular context for ARF protein function in fundamental biological processes, such as secretion, endocytosis, phagocytosis, cytokinesis, cell adhesion and tumour-cell invasion.
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