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ADP-ribosylation factor 5

ARF5, MONOPTEROS, ADP-ribosylation factor 5
This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: p16, ARF1, ACID, ARF6, ARF3
Papers on ARF5
AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
New
Wagner et al., Beek, Netherlands. In Plant Physiol, Jan 2016
Previously, we reported that the plant hormone auxin induces LFY expression through AUXIN RESPONSE FACTOR5/MONOPTEROS (ARF5/MP).
Auxin responsiveness of the MONOPTEROS-BODENLOS module in primary root initiation critically depends on the nuclear import kinetics of the Aux/IAA inhibitor BODENLOS.
New
Jürgens et al., Tübingen, Germany. In Plant J, Jan 2016
This initial step requires the auxin-dependent release of the transcription factor MONOPTEROS (MP, also known as ARF5) from its inhibition by the Aux/IAA protein BODENLOS (BDL, also known as IAA12).
A Negative Feedback Loop Controlling bHLH Complexes Is Involved in Vascular Cell Division and Differentiation in the Root Apical Meristem.
New
Ohashi-Ito et al., Tokyo, Japan. In Curr Biol, Jan 2016
Two bHLH heterodimers consisting of LONESOME HIGHWAY (LHW) and TARGET OF MONOPTEROS 5 (TMO5)/TMO5-LIKE1 (T5L1) regulate periclinal cell division in vascular cells in the root apical meristem (RAM) [1-5].
PHABULOSA mediates an auxin signaling loop to regulate vascular patterning in Arabidopsis.
New
Carlsbecker et al., Uppsala, Sweden. In Plant Physiol, Jan 2016
We show that one of the HD-ZIP III TFs, PHABULOSA, directly binds the promoter of both MONOPTEROS/AUXIN RESPONSE FACTOR5 (MP/ARF5), a key factor in vascular formation, and IAA20, encoding an AUX/IAA protein which is stable in the presence of auxin and able to interact with and repress MP activity.
Cytokinin-auxin crosstalk in cell type specification.
Review
New
Werr et al., Köln, Germany. In Trends Plant Sci, May 2015
Similarly to auxin, local cytokinin synthesis and response gradients are instructive, and the roles of ARABIDOPSIS RESPONSE REGULATOR 7/15 (ARR7/15) and the negative cytokinin response regulator ARABIDOPSIS HISTIDINE PHOSPHOTRANSFER PROTEIN 6, as well as auxin signalling via MONOPTEROS/BODENLOS, are functionally conserved across different developmental processes.
The PB1 domain in auxin response factor and Aux/IAA proteins: a versatile protein interaction module in the auxin response.
Review
Guilfoyle, United States. In Plant Cell, 2015
Insight into the mechanism of how these transcription factors interact with one another has recently been revealed from crystallographic information on ARF5 and ARF7 C-terminal domains (i.e., a protein-protein interaction domain referred to as domain III/IV that is related to domain III/IV in Aux/IAA proteins).
Constitutive Expression of OsIAA9 Affects Starch Granules Accumulation and Root Gravitropic Response in Arabidopsis.
Wang et al., Changchun, China. In Front Plant Sci, 2014
Protoplast transfection assays showed that OsIAA9 interacted ARF5, but not ARF6, 7, 8 and 19.
Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors.
Impact
Coll et al., Barcelona, Spain. In Cell, 2014
Here, we address this question by solving high-resolution crystal structures of the pivotal Arabidopsis developmental regulator ARF5/MONOPTEROS (MP), its divergent paralog ARF1, and a complex of ARF1 and a generic auxin response DNA element (AuxRE).
A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.
Impact
Sabatini et al., Cambridge, United States. In Nat Cell Biol, 2013
ARF4 depletion preserves viability, Golgi integrity and cargo trafficking in the presence of BFA, and these effects depend on the guanine nucleotide exchange factor GBF1 and other ARF isoforms including ARF1 and ARF5.
BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).
GeneRIF
Casanova et al., Charlottesville, United States. In J Biol Chem, 2012
BRAG2 acts at clathrin-coated pits to promote integrin internalization by activating Arf5 and suggest a previously unrecognized role for Arf5 in clathrin-mediated endocytosis of specific cargoes.
Irrepressible, truncated auxin response factors: natural roles and applications in dissecting auxin gene regulation pathways.
Review
Berleth et al., Toronto, Canada. In Plant Signal Behav, 2012
Using MONOPTEROS (MP)/ARF5, we have generated a truncated version of MP (MPΔ), ( 3) which has lost the target domains for repression by Aux/IAA proteins.
ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5.
GeneRIF
Itoh et al., Kōbe, Japan. In Mol Biol Cell, 2012
a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1/5 pathway.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Deletion of MP/ARF5 domains III and IV reveals a requirement for Aux/IAA regulation in Arabidopsis leaf vascular patterning.
GeneRIF
Berleth et al., Toronto, Canada. In New Phytol, 2012
MP with the domains III and IV eliminated can selectively uncouple a single ARF from regulation by Aux/IAA proteins.
Auxin triggers a genetic switch.
Impact
Jürgens et al., Tübingen, Germany. In Nat Cell Biol, 2011
Here, we demonstrate by experimental and computational analyses that the Arabidopsis ARF protein MONOPTEROS (MP) controls its own expression and the expression of its AUX/IAA inhibitor BODENLOS (BDL), with auxin acting as a threshold-specific trigger by promoting the degradation of the inhibitor.
GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis.
GeneRIF
Nakayama et al., Kyoto, Japan. In Cell Struct Funct, 2010
The lipid droplets deposition and the cellular triacylglycerol content are significantly increased by siRNA-mediated depletion of Arf5.
Transcriptional regulation of vascular cell fates.
Review
Fukuda et al., Tokyo, Japan. In Curr Opin Plant Biol, 2010
The positive feedback loop typically shown in auxin-flow-MONOPTEROS-(HD-ZIP IIIs)-PIN1-auxin-flow in procambial precursor cell determination and VND7-ASL/LBD-VND7 in xylem vessel cell determination, may be a crucial mechanism that determines vascular cell fates, which occurs in stages.
Hormonal control of the shoot stem-cell niche.
Impact
Lohmann et al., Heidelberg, Germany. In Nature, 2010
Whereas ARR7 and ARR15 expression in the shoot apical meristem (SAM) is induced by cytokinin, auxin has a negative effect, which is, at least in part, mediated by the AUXIN RESPONSE FACTOR5/MONOPTEROS (MP) transcription factor.
MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor.
Impact
GeneRIF
Weijers et al., Tübingen, Germany. In Nature, 2010
TARGET OF MP 5 (TMO5) and TMO7 encode basic helix-loop-helix (bHLH) transcription factors that are expressed in the hypophysis-adjacent embryo cells, and are required and partially sufficient for MONOPTEROS-dependent root initiation
Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors.
Review
Vaughan et al., Bethesda, United States. In Mol Cell Biochem, 1999
It preferentially activated class I ARFs 1 and 3 and was not inhibited by BFA but failed to activate ARF5 (class II).
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