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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

ARAP1, centaurindelta 2
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: GAP, p16, Angiotensin II, Rhodopsin, EGFR
Papers on ARAP1
Data interpretation: deciphering the biological function of Type 2 diabetes associated risk loci.
New
Kiani et al., Islamabad, Pakistan. In Acta Diabetol, Aug 2015
Of those 989 SNPs, only 64 returned with RegulomeDB score <3 (evidence of regulatory function), and only four of these were GWAS significant SNPs (THADA/rs10203174, score = 1b; UBE2E2/rs7612463, score = 2a; ARAP1/rs1552224 and TP53INP1/rs8996852, score = 2b).
Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor-associated protein 1 in rats suffering from heat stroke.
Su et al., Guangzhou, China. In Int J Mol Med, 2014
The levels of Ang Ⅱ type 1 (AT1) receptor surface expression and AT1 receptor-associated protein 1 (Arap1) were decreased during HS; however, these effects were attenuated by pre-treatment with XBJ (shown by RT-qPCR and western blot analysis).
A Genome-Wide Screen for Large-Effect Alloimmunization Susceptibility Loci among Red Blood Cell Transfusion Recipients with Sickle Cell Disease.
Chen et al., Houston, United States. In Transfus Med Hemother, 2014
SNPs in the ARAP1/STARD10 region showed suggestive association (p < 1 × 10(-6)), but no association was observed at previously implicated loci TRIM21 or HLA.
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
Review
MAGIC Investigators et al., Athens, Greece. In Diabetes, 2014
ARAP1 constituted a third cluster characterized by defects in insulin processing.
A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.
Mohlke et al., Chapel Hill, United States. In Am J Hum Genet, 2014
Measurement of allele-specific mRNA levels in human pancreatic islet samples heterozygous for rs11603334 showed that the T2D-risk and proinsulin-decreasing allele (C) is associated with increased ARAP1 expression (p < 0.02).
AT1 receptor-associated protein and septic shock-induced vascular hyporeactivity: another 'magic bullet' in the pipe?
Levy et al., In Crit Care, 2012
In a recent study, Katharina Mederle and colleagues explored the impact of angiotensin 1 receptor-associated protein 1 (Arap1) deficiency on vascular hyporesponsiveness in an experimental model of septic shock.
PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study.
Momohara et al., Tokyo, Japan. In Plos One, 2012
Genetic factors regarded as putative risk factors were RA-susceptible polymorphisms identified by the Japanese GWAS meta-analysis, including HLA-DRB1 (shared epitope, SE), rs2240340 (PADI4), rs2230926 (TNFAIP3), rs3093024 (CCR6), rs11900673 (B3GNT2), rs2867461 (ANXA3), rs657075 (CSF2), rs12529514 (CD83), rs2233434 (NFKBIE), rs10821944 (ARID5B), rs3781913 (PDE2A-ARAP1), rs2841277 (PLD4) and rs2847297 (PTPN2).
The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension.
Castrop et al., In Crit Care, 2012
The AT1 receptor-associated protein 1 (Arap1) is expressed in vascular smooth muscle cells and increases the surface expression of the AT1-receptor in vitro.
ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5.
GeneRIF
Itoh et al., Kōbe, Japan. In Mol Biol Cell, 2012
a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1/5 pathway.
Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II.
GeneRIF
Castrop et al., Regensburg, Germany. In Am J Physiol Renal Physiol, 2012
Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
Impact
Yamamoto et al., Yokohama, Japan. In Nat Genet, 2012
Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2.
Expression profiles of signal transduction genes in ex vivo drug-resistant pediatric acute lymphoblastic leukemia.
Styczynski et al., Bydgoszcz, Poland. In Anticancer Res, 2012
The expression of four genes was up-regulated: Gardner-Rasheed feline sarcoma viral oncogene homolog, v-Fgr (FGR), S100 calcium binding protein A11 (S100A11), formyl peptide receptor 1 (FPR1), ArfGAP with RhoGAP domain, ankyrin repeat and PH1 domain (ARAP1), while the expression of growth hormone 1 (GH1) was found to be down-regulated in resistant leukemia blasts.
Exome sequencing and genetic testing for MODY.
Njølstad et al., Bergen, Norway. In Plos One, 2011
Novel variants in the genes ARAP1, GLIS3, MADD, NOTCH2 and WFS1 need further investigation to reveal their possible role in diabetes.
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Florez et al., Stockholm, Sweden. In Diabetes, 2011
Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk.
Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.
GeneRIF
Pedersen et al., Copenhagen, Denmark. In Diabetologia, 2011
Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin release.
ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking.
GeneRIF
Randazzo et al., Bethesda, United States. In Biol Cell, 2011
ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking
Angiotensin II and the vascular phenotype in hypertension.
Review
Touyz et al., Roma, Italy. In Expert Rev Mol Med, 2010
These receptors are regulated by the GPCR-interacting proteins ATRAP, ARAP1 and ATIP.
PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1.
GeneRIF
Lee et al., Seoul, South Korea. In J Biol Chem, 2010
PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells.
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