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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Arachidonate 15-lipoxygenase

Arachidonate 15-Lipoxygenase, 15-LOX, 15-LOX-1
Top mentioned proteins: lysyl oxidase, ACID, LOX-1, 5-lipoxygenase, cyclooxygenase
Papers on Arachidonate 15-Lipoxygenase
How Can Linoleic Acid Be the Preferential Substrate of the Enzyme 15-Lipoxygenase-1? A QM/MM Approach.
New
González-Lafont et al., Barcelona, Spain. In J Phys Chem B, Jan 2016
In this paper, QM(B3LYP)/MM(CHARMM) calculations of the rate-limiting H11-abstraction process of LA catalyzed by rabbit 15-LOX-1 (15-rLOX-1) have been carried out using a complete model of the solvated 15-rLOX-1:LA complex.
Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet.
New
Ozanne et al., Cambridge, United Kingdom. In Faseb J, Jan 2016
Maternal obesogenic diet was associated with increased mitochondrial DNA biogenesis (copy number P < 0.05; transcription factor A, mitochondrial expression P < 0.05), increased mitochondrial antioxidant defenses [manganese superoxide dismutase (MnSOD) P < 0.05; copper/zinc superoxide dismutase P < 0.05; glutathione peroxidase 4 P < 0.01] and increased lipoxygenase expression (arachidonate 12-lipoxygenase P < 0.05; arachidonate 15-lipoxygenase P < 0.05) in the ovary.
The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease.
New
Strosznajder et al., Warsaw, Poland. In Neurochem Res, Jan 2016
Among several isoforms, 5-LOX and 12/15-LOX are especially important in neuroinflammation/neurodegeneration.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Review
New
Okuyama et al., Tokyo, Japan. In Redox Biol, Dec 2015
15-LOX, a prototypical enzyme originally found in reticulocytes shares the similarity of amino acid sequence as well as the biochemical property to plant LOX enzymes.
The role of 12/15-lipoxygenase in production of selected eicosanoids in allergic airway inflammation.
New
Kowal et al., Białystok, Poland. In Adv Med Sci, Dec 2015
MATERIALS AND METHODS: Both C57Bl and 12/15-LOX knockout mice were sensitized by 2 intraperitoneal injections and subsequently challenged by inhalation with Dp allergen extract.
15-Lipoxygenase inhibitors: a patent review.
New
Jabbari et al., Mashhad, Iran. In Expert Opin Ther Pat, Dec 2015
Two types of the enzyme, 15-LOX-1 and 15-LOX-2, have been recognized in mammals to have different abilities in the peroxidation of arachidonic acid and linoleic acid.
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
New
Dekker et al., Groningen, Netherlands. In J Med Chem, Nov 2015
Human 15-lipoxygenase-1 (h-15-LOX-1) is a mammalian lipoxygenase and plays an important role in several inflammatory lung diseases such as asthma, COPD, and chronic bronchitis.
AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages.
New
Brüne et al., Frankfurt am Main, Germany. In J Biol Chem, Nov 2015
Macrophages respond to the Th2 cytokine IL-4 with elevated expression of arachidonate 15-lipoxygenase (ALOX15).
Antineoplastic effects of 15(S)-hydroxyeicosatetraenoic acid and 13-S-hydroxyoctadecadienoic acid in non-small cell lung cancer.
New
Chen et al., Hong Kong, Hong Kong. In Cancer, Oct 2015
BACKGROUND: Previous studies have shown that the levels of 15-lipoxygenase 1 (15-LOX-1) and 15-LOX-2 as well as their metabolites 13-S-hydroxyoctadecadienoic acid (13(S)-HODE) and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) are significantly reduced in smokers with non-small cell lung carcinoma (NSCLC).
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer.
Review
New
Xu et al., Zhenjiang, China. In Inflamm Res, Sep 2015
This article reviews and discusses the role of 15-lipoxygenase-1 (15-LOX-1) in the resolution of colitis and prevention of colitis-associated colorectal cancer.
Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution.
New
Lai et al., San Diego, United States. In J Med Chem, Sep 2015
Previous studies have suggested that activating 15-lipoxygenase (15-LOX) is a promising strategy to intervene the arachidonic acid (AA) metabolite network and control inflammation.
Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b in Alzheimer's disease (AD) and in primary human neuronal-glial (HNG) cells.
Review
Lukiw et al., New Orleans, United States. In Mol Neurobiol, 2014
Bioinformatics analysis indicated that an up-regulated miRNA-125b could potentially target the 3'untranslated region (3'-UTR) of the messenger RNA (mRNA) encoding (a) a 15-lipoxygenase (15-LOX; ALOX15; chr 17p13.3),
[Molecular genetic mechanisms of teratozoospermia].
Review
Wang et al., Changchun, China. In Zhonghua Nan Ke Xue, 2013
Aiming to provide some evidence for the pathogenesis of teratozoospermia, this paper reviews the relevant literature in the past five years addressing such special teratozoospermia as globozoospermia, nuclear vacuoles, decapitated spermatozoa, excessive residual cytoplasm, dysplasia of the fibrous sheath, and primary ciliary dyskinesia, and elaborates on the molecular genetic mechanisms of DPY19L2, AR, PRM1, GBA2, PCI, CREM, TH2A, TH2B, ODF1, Cntrob, OAZ-t, HOOK1, SPEM1, GAT1, PRSS21, 15-LOX, Sptrx, AKAP3, AKAP4, DNAI1, DNAH5, RSPH4A, TXNDC3, CCDC39, LRRC6, LRRC50, KTU and so on.
Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1
Review
Maloney et al., Bethesda, United States. In Unknown Journal, 2013
Lipoxygenases (e.g. 5, 12 and 15-LOX-1) are implicated in a number of human diseases, with reticulocyte 15-Lipoxygenase-1 (15-LOX-1 or 12/15-LOX) being specifically involved in cancer, atherosclerosis, and neurodegenerative conditions, such as stroke [1-9].
Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.
GeneRIF
Newcomer et al., Baton Rouge, United States. In Faseb J, 2012
phosphorylation of 5-LOX at S663 not only down-regulates leukotriene synthesis but also stimulates lipoxin production in inflammatory cells that do not express 15-LOX, redirecting lipid mediator biosynthesis to the production of mediators of inflammation.
High expression of arachidonate 15-lipoxygenase and proinflammatory markers in human ischemic heart tissue.
GeneRIF
Hultén et al., Göteborg, Sweden. In Biochem Biophys Res Commun, 2012
increased ALOX15 in human ischemic heart biopsies was demonstrated.
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
GeneRIF
Shureiqi et al., Houston, United States. In J Natl Cancer Inst, 2012
Mice with human 15-LOX-1 expression in colonic epithelial cells were less susceptible than wild-type mice to AOM-induced colonic tumorigenesis. 15-LOX-1 appears to act as a tumor suppressor and an inhibitor of TNF-alpha-iNOS signaling and NF-kappaB activation.
Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring.
GeneRIF
Zhang et al., Shanghai, China. In Acta Pharmacol Sin, 2012
rs916055 in ALOX15 gene was significantly associated with the percentage of fat mass in Chinese nuclear families with male offspring in the family-based association study using quantitative transmission disequilibrium test approach.
Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.
GeneRIF
Praticò et al., Philadelphia, United States. In Ann Neurol, 2012
12/15-lipoxygenase-overexpressing transgenic mice have elevated levels of BACE1, whereas 12/15-LO-deficient mice have reduced levels.
A function for lipoxygenase in programmed organelle degradation.
Impact
Wiedmann et al., New York City, United States. In Nature, 1998
The expression of 15-lipoxygenase (15-LOX) peaks in reticulocytes immediately before organelle degradation.
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