Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling.
Nanchang, China. In Sci Rep, Dec 2015
Blockade of ATP release by carbenoxolone (CBX) treatment, or promoting ATP degradation by ATP diphosphohydrolase (apyrase), decreased extracellular ATP levels in colon tissues, attenuated DSS-induced colitis, whereas inhibition of extracellular ATP degradation by sodium metatungstate (POM-1) exacerbated tissue damage in the mice with colitis.
Schistosomes versus platelets.
Grafton, United States. In Thromb Res, 2014
For example, tegumental apyrase, SmATPDase1 can degrade the platelet-activating molecule ADP in the extracellular environment.
Dynamically analyte-responsive macrocyclic host-fluorophore systems.
Bremen, Germany. In Acc Chem Res, 2014
This includes supramolecular tandem assays in their product- and substrate-selective variants, and in their domino and enzyme-coupled modifications, with assays for amino acid decarboxylases, diamine, and choline oxidase, proteases, methyl transferases, acetylcholineesterase (including an unpublished direct tandem assay), choline oxidase, and potato apyrase as examples.
Purinergic signaling in glioma progression.
Pelotas, Brazil. In Adv Exp Med Biol, 2012
The importance of extracellular ATP for glioma pathobiology was confirmed by the reduction in glioma tumor size by apyrase, which degrades extracellular ATP to AMP, and the striking increase in tumor size by over-expression of an ecto-enzyme that degrades ATP to ADP, suggesting the effect of extracellular ATP on the tumor growth depends on the nucleotide produced by its degradation.
Multiherbicide tolerance conferred by AtPgp1 and apyrase overexpression in Arabidopsis thaliana.
Austin, United States. In Nat Biotechnol, 2003
Recently, we showed that overexpression in Arabidopsis thaliana of either psNTP9, the garden pea apyrase gene, or AtPgp1, the A. thaliana homolog of the plant multidrug resistance (MDR) gene, enabled A. thaliana to germinate on the toxin cycloheximide and to grow better on toxic levels of the plant hormone N6-[2-isopentyl]adenine (2iP).