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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Calcium activated nucleotidase 1

This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, P2Y, ATPase
Papers using Apyrase antibodies
Adherence of Acinetobacter baumannii strains to human bronchial epithelial cells.
Xue Chaoyang, In PLoS ONE, 2005
... DNase I and Apyrase were obtained from New England Biolabs.
Papers on Apyrase
Label-free assay based on immobilized capillary enzyme reactor of Leishmania infantum nucleoside triphosphate diphosphohydrolase (LicNTPDase-2-ICER-LC/UV).
Cardoso et al., Ribeirão Preto, Brazil. In J Chromatogr B Analyt Technol Biomed Life Sci, Feb 2016
Nucleoside triphosphate diphosphohydrolase (NTPDase) is an enzyme belonging to the apyrase family that participates in the hydrolysis of the nucleosides di- and triphosphate to the corresponding nucleoside monophosphate.
Five putative nucleoside triphosphate diphosphohydrolase genes are expressed in Trichomonas vaginalis.
Tasca et al., Porto Alegre, Brazil. In Fems Microbiol Lett, Jan 2016
The amino acid alignment predicted the presence of the five crucial apyrase conserved regions, transmembrane domains, signal peptides, phosphorylation and catalytic sites.
Alteration in apyrase enzyme attenuated virulence of Shigella flexneri.
Salleh et al., Malaysia. In Microb Pathog, Jan 2016
The apy gene which is located in the megaplasmid of Shigella species encodes for apyrase enzyme, a pathogenesis-associated enzyme causing mitochondrial damage and host cell death.
Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling.
Bai et al., Nanchang, China. In Sci Rep, Dec 2015
Blockade of ATP release by carbenoxolone (CBX) treatment, or promoting ATP degradation by ATP diphosphohydrolase (apyrase), decreased extracellular ATP levels in colon tissues, attenuated DSS-induced colitis, whereas inhibition of extracellular ATP degradation by sodium metatungstate (POM-1) exacerbated tissue damage in the mice with colitis.
New approaches for improving the production of the 1st and 2nd generation ethanol by yeast.
Sibirny et al., L'viv, Ukraine. In Acta Biochim Pol, Dec 2015
We have developed a method to reduce biomass accumulation of Saccharomyces cerevisiae by the manipulation of the intracellular ATP level due to overexpression of genes of alkaline phosphatase, apyrase or enzymes involved in futile cycles.
Schistosomes versus platelets.
Skelly et al., Grafton, United States. In Thromb Res, 2014
For example, tegumental apyrase, SmATPDase1 can degrade the platelet-activating molecule ADP in the extracellular environment.
Breakthroughs spotlighting roles for extracellular nucleotides and apyrases in stress responses and growth and development.
Roux et al., Austin, United States. In Plant Sci, 2014
These include new findings that document how apyrases and extracellular nucleotides control auxin transport, modulate stomatal aperture, and mediate biotic and abiotic stress responses, and on how apyrase suppression leads to growth inhibition.
Dynamically analyte-responsive macrocyclic host-fluorophore systems.
Nau et al., Bremen, Germany. In Acc Chem Res, 2014
This includes supramolecular tandem assays in their product- and substrate-selective variants, and in their domino and enzyme-coupled modifications, with assays for amino acid decarboxylases, diamine, and choline oxidase, proteases, methyl transferases, acetylcholineesterase (including an unpublished direct tandem assay), choline oxidase, and potato apyrase as examples.
Purinergic signaling in glioma progression.
Battastini et al., Pelotas, Brazil. In Adv Exp Med Biol, 2012
The importance of extracellular ATP for glioma pathobiology was confirmed by the reduction in glioma tumor size by apyrase, which degrades extracellular ATP to AMP, and the striking increase in tumor size by over-expression of an ecto-enzyme that degrades ATP to ADP, suggesting the effect of extracellular ATP on the tumor growth depends on the nucleotide produced by its degradation.
Desbuquois dysplasia type I and fetal hydrops due to novel mutations in the CANT1 gene.
Rehder et al., Vienna, Austria. In Eur J Hum Genet, 2011
Novel mutations in the CANT1 gene are reported in three cases of Desbuquois dysplasia type I and fetal hydrops.
Purinergic signaling involved in Müller cell function in the mammalian retina.
Bringmann et al., Leipzig, Germany. In Prog Retin Eye Res, 2011
In retinopathies, abrogation of the osmotic release of ATP, and the upregulation of ecto-apyrase (NTPDase1), may have neuroprotective effects by preventing the overactivation of neuronal P2X receptors that are implicated in apoptotic cell death.
A founder mutation of CANT1 common in Korean and Japanese Desbuquois dysplasia.
Ikegawa et al., Tokyo, Japan. In J Hum Genet, 2011
estimated the age of the founder mutation as approximately 1420 years
The androgen-regulated Calcium-Activated Nucleotidase 1 (CANT1) is commonly overexpressed in prostate cancer and is tumor-biologically relevant in vitro.
Kristiansen et al., Zürich, Switzerland. In Am J Pathol, 2011
CANT1 is commonly overexpressed in the vast majority of primary prostate carcinomas and in the precursor lesion PIN and may represent a novel prognostic biomarker
CANT1 mutation is also responsible for Desbuquois dysplasia, type 2 and Kim variant.
Ikegawa et al., Tokyo, Japan. In J Med Genet, 2011
The clinical-radiographic spectrum produced by CANT1 mutations must be extended to include Desbuquois dysplasia type 2 and Kim variant.
Identification of CANT1 mutations in Desbuquois dysplasia.
Cormier-Daire et al., Paris, France. In Am J Hum Genet, 2009
Mutations in CANT1 in Desbuquois dysplasia are identified.
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.
Ravichandran et al., Charlottesville, United States. In Nature, 2009
Enzymatic removal of ATP and UTP (by apyrase or the expression of ectopic CD39) abrogated the ability of apoptotic cell supernatants to recruit monocytes in vitro and in vivo.
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells.
Lambrecht et al., Dominican Republic. In Nat Med, 2007
All the cardinal features of asthma, including eosinophilic airway inflammation, Th2 cytokine production and bronchial hyper-reactivity, were abrogated when lung ATP levels were locally neutralized using apyrase or when mice were treated with broad-spectrum P2-receptor antagonists.
[Hirudo medicinalis-leech applications in plastic and reconstructive microsurgery--a literature review].
Vogt et al., Hannover, Germany. In Handchir Mikrochir Plast Chir, 2007
Living in symbiosis with Aeromonas hydrophila, who can digest the sixfold blood meal related to their body weight, and a broad number of anticoagulant agents such as the thrombin inhibitor hirudin, apyrase as well as collagenase, hyaluronidase, Factor Xa inhibitor and fibrinase I and II, leeches decrease venous congestion.
Structure and protein design of a human platelet function inhibitor.
Lu et al., New York City, United States. In Cell, 2004
Hematophagous arthropods secrete a salivary apyrase that inhibits platelet activation by catabolizing ADP released from damaged tissues and blood cells.
Multiherbicide tolerance conferred by AtPgp1 and apyrase overexpression in Arabidopsis thaliana.
Lloyd et al., Austin, United States. In Nat Biotechnol, 2003
Recently, we showed that overexpression in Arabidopsis thaliana of either psNTP9, the garden pea apyrase gene, or AtPgp1, the A. thaliana homolog of the plant multidrug resistance (MDR) gene, enabled A. thaliana to germinate on the toxin cycloheximide and to grow better on toxic levels of the plant hormone N6-[2-isopentyl]adenine (2iP).
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