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Shroom family member 2

APXL, Shroom2
The protein encoded by this gene shares significant similarities with the apical protein from Xenopus laevis which is implicated in amiloride-sensitive sodium channel activity. This gene is a strong candidate gene for ocular albinism type 1 syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, OA1, H-2p, HAD, gamma-tubulin
Papers on APXL
Kinase-interacting substrate screening is a novel method to identify kinase substrates.
Kaibuchi et al., Nagoya, Japan. In J Cell Biol, Jul 2015
We found that Scrib plays a crucial role in the regulation of subcellular contractility by assembling into a ternary complex with Rho-kinase and Shroom2 in a phosphorylation-dependent manner.
A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.
Kieran et al., United States. In Clin Cancer Res, Mar 2015
RESULTS: Five differentially expressed genes in medulloblastoma (GLI1, SPHK1, SHROOM2, PDLIM3, and OTX2) were found to associate with Hh pathway activation status.
Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis.
Moreno et al., Barcelona, Spain. In Carcinogenesis, 2014
associated to DIP2B (r = 0.63) and rs5934683 in Xp22.3 associated to SHROOM2 and GPR143 (r = 0.47).
STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas.
Lassmann et al., Freiburg, Germany. In Oncogene, 2014
In contrast, genes promoting cell migration (CTHRC1) were markedly upregulated in OE21 cells, whereas a gene linked to tight-junction stabilization and restricted cell motility (SHROOM2) was downregulated in OE21 but upregulated in OE33 cells.
Congenital nasal pyriform aperture stenosis and ocular albinism co-occurring in a sibship with a maternally-inherited 97 kb Xp22.2 microdeletion.
Stein et al., Sioux Falls, United States. In Am J Med Genet A, 2014
This deletion encompasses a gene known to cause ocular albinism (GPR143), as well as partial deletion of two other genes, TBL1X and SHROOM2.
Comparative organization and gene expression profiles of the porcine pseudoautosomal region.
Raudsepp et al., College Station, United States. In Cytogenet Genome Res, 2012
Here we defined the PAR in SSCXp/Yp by demarcating the sequence of the pseudoautosomal boundary at X:6,743,567 bp in intron 3-4 of SHROOM2 and showed that SHROOM2 is truncated in SSCY.
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
Houlston et al., Edinburgh, United Kingdom. In Nat Genet, 2012
We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 x 10(-10)).
A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort.
Pearlson et al., Hartford, United States. In Neuroimage, 2012
In addition significant novel genes identified included ZNF673, VPS13, SLC9A7, ATP5G2 and SHROOM2.
Shroom2 regulates contractility to control endothelial morphogenesis.
Hildebrand et al., Pittsburgh, United States. In Mol Biol Cell, 2011
Data suggest that Shroom2 facilitates the formation of a contractile network within endothelial cells, the loss of which leads to an increase in endothelial sprouting, migration, and angiogenesis.
Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.
Petit et al., Paris, France. In Development, 2010
During the normal shape transition, myosin VIIa and myosin II (A and B isoforms) displayed polarized redistributions into and out of the developing lobes, respectively, while Shroom2 and F-actin transiently accumulated in the lobes.
Changes in localization and expression levels of Shroom2 and spectrin contribute to variation in amphibian egg pigmentation patterns.
Wallingford et al., Austin, United States. In Dev Genes Evol, 2009
Here, we show that ectopic expression of the gamma-tubulin regulator, Shroom2, is sufficient to induce co-accumulation of pigment granules, spectrin, and dynactin in Xenopus blastomeres.
The shroom family proteins play broad roles in the morphogenesis of thickened epithelial sheets.
Wallingford et al., Austin, United States. In Dev Dyn, 2009
Moreover, we show that ectopic expression of Shroom2, like Shroom3, is able to increase cell height and that loss of Shroom2 function results in a failure of cell elongation in the neural epithelium.
Tackling the characterization of canine chromosomal breakpoints with an integrated in-situ/in-silico approach: the canine PAR and PAB.
Breen et al., Raleigh, United States. In Chromosome Res, 2007
Our characterization of the canine PAR allowed for the comparative study of gene content across previously defined mammalian PARs and indicates that the canine PAB is contained with the gene Shroom2.
Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions.
El-Amraoui et al., Paris, France. In J Cell Sci, 2007
Shroom2 and ZO-1 form a tight-junction-associated scaffolding complex, possibly linked to myosin VIIa, that bridges the junctional membrane to the underlying cytoskeleton, thereby contributing to the stabilization of these junctions.
Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium.
Wallingford et al., Austin, United States. In Development, 2006
Here, we show that the Shroom-family protein, Shroom2 (previously known as APXL) is both necessary and sufficient to govern the localization of pigment granules at the apical surface of epithelial cells.
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