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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PTI pancreatic trypsin inhibitor

Aprotinin
Top mentioned proteins: HAD, Kallikrein, ACID, CAN, Plasminogen
Papers on Aprotinin
Purification and characterization of tenerplasminin-1, a serine peptidase inhibitor with antiplasmin activity from the coral snake (Micrurus tener tener) venom.
New
Guerrero et al., Caracas, Venezuela. In Comp Biochem Physiol C Toxicol Pharmacol, Jan 2016
Aprotinin (2nM) used as the positive control of inhibition, reduced the plasmin amidolytic activity by 71%.
Use of Clotted Human Plasma and Aprotinin in Skin Tissue Engineering: A Novel Approach to Engineering Composite Skin on a Porous Scaffold.
New
Akbarzadeh et al., Melbourne, Australia. In Tissue Eng Part C Methods, Oct 2015
Skin architecture and basement membrane formation was further improved by the addition of aprotinin (a serine protease inhibitor) to the culture media to inhibit premature clot digestion.
The current place of aprotinin in the management of bleeding.
Review
Royston, London, United Kingdom. In Anaesthesia, 2015
There is a considerable difference between the mechanism of action of the lysine analogues, tranexamic acid and epsilon-aminocaproic acid, and the serine protease inhibitor aprotinin.
The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery.
Pigula et al., Boston, United States. In Plos One, 2014
Aprotinin has attained high efficacy in reducing the requirement for a blood transfusion following a cardiopulmonary bypass, but is seldom studied in the neonatal age group.
Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.
Caughey et al., San Francisco, United States. In Plos One, 2014
To establish relative potencies and modes of action, we compared inactivation of human prostasin, matriptase, airway trypsin-like protease (HAT), and β-tryptase by nafamostat, camostat, bis(5-amidino-2-benzimidazolyl)methane (BABIM), aprotinin, and benzamidine.
Assessment of Aprotinin Loaded Microemulsion Formulations for Parenteral Drug Delivery: Preparation, Characterization, in vitro Release and Cytotoxicity Studies.
Karasulu et al., İzmir, Turkey. In Curr Drug Deliv, 2014
The object of the current study was to prepare novel microemulsion formulations of aprotinin for parenteral delivery and to compare in vitro characteristics and release behaviour of different Technetium-99m ((99m)Tc)-Aprotinin loaded microemulsion formulations.
Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders.
Review
Desai et al., Richmond, United States. In Med Res Rev, 2014
Aprotinin was widely used as an antifibrinolytic drug before its discontinuation in 2008.
Use of aprotinin to reduce blood loss and transfusion in major orthopedic surgery: a meta-analysis.
Review
Wu et al., Hefei, China. In Transfus Apher Sci, 2014
BACKGROUD: Conflicting reports have been published regarding the effectiveness and safety of aprotinin in reducing blood loss and transfusion in patients undergoing orthopedic surgery.
Nuclear imaging of amyloidosis.
Review
Lass et al., Gdańsk, Poland. In Pol J Radiol, 2013
(99m)Tc-Aprotinin was found to be useful in detecting cardiac amyloidosis.
Antifibrinolytics in cardiac surgery.
Review
Dhir, London, Canada. In Ann Card Anaesth, 2013
Nothing has been more controversial in recent times than the aprotinin controversy.
Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations.
GeneRIF
Kuroda et al., Koganei, Japan. In Proteins, 2009
analyzed the mechanisms behind a remarkable 13 degrees stabilization produced by a single A14G and a double A14GA38V mutation
Temperature dependence on structure and dynamics of Bovine Pancreatic Trypsin Inhibitor (BPTI): a neutron scattering study.
GeneRIF
Bellissent-Funel et al., Gif-sur-Yvette, France. In Biochim Biophys Acta, 2009
variation of the radius of gyration and the modification of the shape of BPTI between ambient temperature and 368 K
Structure of a serine protease poised to resynthesize a peptide bond.
GeneRIF
Goldenberg et al., Salt Lake City, United States. In Proc Natl Acad Sci U S A, 2009
insights into the mechanism by which inhibitors like BPTI normally resist hydrolysis when bound to their target proteases.
Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.
GeneRIF
Goldenberg et al., Salt Lake City, United States. In J Mol Biol, 2008
Results describe the functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.
Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines.
GeneRIF
Kuroda et al., Koganei, Japan. In Proc Natl Acad Sci U S A, 2008
high-resolution crystal structures of an extensively simplified variant of bovine pancreatic trypsin inhibitor containing 20 alanines.
The effect of aprotinin on outcome after coronary-artery bypass grafting.
Impact
Newman et al., Durham, United States. In N Engl J Med, 2008
BACKGROUND: Aprotinin has recently been associated with adverse outcomes in patients undergoing cardiac surgery.
Aprotinin during coronary-artery bypass grafting and risk of death.
Impact
Walker et al., Boston, United States. In N Engl J Med, 2008
BACKGROUND: Aprotinin (Trasylol) is used to mitigate bleeding during coronary-artery bypass grafting (CABG).
Effect of aprotinin on renal dysfunction in patients undergoing on-pump and off-pump cardiac surgery: a retrospective observational study.
Impact
Zacharowski et al., Bristol, United Kingdom. In Lancet, 2008
BACKGROUND: Aprotinin is used during cardiac surgery for its blood-saving effects.
Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery.
Impact
Ischemia Research and Education Foundation et al., San Bruno, United States. In Jama, 2007
OBJECTIVE: To contrast long-term all-cause mortality in patients undergoing coronary artery bypass graft (CABG) surgery according to use of 2 lysine analog antifibrinolytics (aminocaproic acid and tranexamic acid), the serine protease inhibitor aprotinin, or no antibleeding agent.
Aprotinin and transfusion requirements in orthotopic liver transplantation: a multicentre randomised double-blind study. EMSALT Study Group.
Impact
Terpstra et al., Leiden, Netherlands. In Lancet, 2000
We aimed to find out whether aprotinin, a potent antifibrinolytic agent, reduces blood loss and transfusion requirements.
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