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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Melanoma antigen family H, 1

APr-1, APRI, Apoptosis-related protein, apoptosis-related protein TFAR19
This gene is thought to be involved in apoptosis. Multiple polyadenylation sites have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, Fib, V1a, bcl-2, PrP
Papers on APr-1
FibroGENE: A gene-based model for staging liver fibrosis.
New
International Liver Disease Genetics Consortium (ILDGC) et al., Sydney, Australia. In J Hepatol, Feb 2016
Model performance was compared to FIB-4 and APRI, and also to the NAFLD fibrosis score (NFS) and Forns' index, in those with NAFLD.
Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits.
New
Yan et al., Xi'an, China. In Oncol Rep, Feb 2016
Previous study suggests that apoptosis-related protein-1 (Apr-1) is involved in cancer cell proliferation and survival.
Progression of Liver Fibrosis and Modern Combination Antiretroviral Therapy Regimens in HIV-Hepatitis C-Coinfected Persons.
New
Canadian Co-infection Cohort Study et al., Montréal, Canada. In Clin Infect Dis, Feb 2016
Both PI and NNRTI use was associated with increases in APRI over time when paired with a backbone of ABC/3TC: 16% per 5 years (95% confidence interval [CI], 4%, 29%) and 11% per 5 years (95% CI, 2%, 20%), respectively.
Aspirin use is associated with lower indices of liver fibrosis among adults in the United States.
New
Mukamal et al., Boston, United States. In Aliment Pharmacol Ther, Feb 2016
RESULTS: The use of aspirin was associated with a significantly lower composite liver fibrosis index calculated from FIB4, APRI, Forns and NFS [0.24 standard deviation (s.d.) units lower; 95% CI -0.42 to -0.06, P = 0.009].
Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease.
New
Yoshioka et al., Japan. In World J Hepatol, Dec 2015
Responses were assessed by liver enzyme levels [aspartate aminotransferase (AST), alanine aminotranferease (ALT), and γ-glutamyl transpeptidase (γ-GTP)], noninvasive scoring systems of hepatic fibrosis-4 [FIB-4 index and aspartate aminotransferase-to-platelet index (APRI)], and liver stiffness [velocity of shear wave (Vs)] measured by acoustic radiation force impulse elastography.
Asymmetric Wnt Pathway Signaling Facilitates Stem Cell-Like Divisions via the Nonreceptor Tyrosine Kinase FRK-1 in Caenorhabditis elegans.
New
Putzke et al., United States. In Genetics, Nov 2015
Specifically, we observe aberrant POP-1 and WRM-1 localization that is dependent on the presence of FRK-1 and APR-1.
Can Serum ST2 Levels Be Used as a Marker of Fibrosis in Chronic Hepatitis B Infection?
New
Kayacetin et al., Ankara, Turkey. In Medicine (baltimore), Nov 2015
The aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on the 4 factors (FIB-4) scores also calculated, and correlations between liver biopsies, sST2 levels, and these scores were analyzed in CHB and cirrhosis patients.The sST2 levels in patients with CHB were significantly higher than those in the control group subjects (median: 1133 pg/mL vs 762.5 pg/mL, respectively [P = 0.035]).
Selected Cytokines Serve as Potential Biomarkers for Predicting Liver Inflammation and Fibrosis in Chronic Hepatitis B Patients With Normal to Mildly Elevated Aminotransferases.
New
China HepB Related Fibrosis Assessment Research Group et al., Guangzhou, China. In Medicine (baltimore), Nov 2015
Compared to existing scores, fib-index was significantly superior to aspartate aminotransferase (AST) to platelet ratio index (APRI) and FIB-4 score for significant fibrosis.In conclusion, CXCL-11 was independently associated with at least moderate inflammation, whereas IL-2R and TGF-α were independent indicators of significant fibrosis in both, total CHB patients and patients with normal or mildly elevated ALT.
Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite.
New
Toth et al., Brisbane, Australia. In Chemmedchem, Oct 2015
We designed new B-cell peptide epitopes based on the aspartic protease of N. americanus (Na-APR-1).
Sevoflurane impairs acquisition learning and memory function in transgenic mice model of Alzheimer's disease by induction of hippocampal neuron apoptosis.
Zhang et al., Zhengzhou, China. In Int J Clin Exp Med, 2014
Apoptosis-related protein (caspase-3 and Bcl-xL) expression in the hippocampus was analyzed by Western blotting.
Short interfering RNA directed against the GOLPH3 gene enhances the effect of chemotherapy against oral squamous cell carcinoma by regulating Caspase3, Bcl2 and cytochrome-c expression.
Wang et al., Zaozhuang, China. In Int J Clin Exp Med, 2014
Apoptosis-related protein expression Cytochrome-C, Caspase3 and Bcl-2 was analyzed by RT-PCR and western blots.
Replication Inhibition of Hepatitis B Virus and Hepatitis C Virus in Co-Infected Patients in Chinese Population.
Niu et al., Changchun, China. In Plos One, 2014
The HBV-HCV co-infection group had higher ALT, AST, ALP, GGT, APRI and FIB-4 levels, but lower ALB and total platelet compared to the HBV mono-infection group, and similar to that of the HCV mono-infected group.
The Human Hookworm Vaccine.
Review
Russell et al., Houston, United States. In Vaccine, 2013
The candidate vaccine is comprised of two recombinant antigens known as Na-GST-1 and Na-APR-1, each of which is an important parasite enzyme required for hookworms to successfully utilize host blood as a source of energy.
Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor.
GeneRIF
Hassan et al., Strasbourg, France. In J Cell Mol Med, 2012
The induction of APR-1 expression caused apoptosis of melanoma cells via the interaction with the juxtamembrane region of p75 neurotrophin receptor.
Wnt regulates spindle asymmetry to generate asymmetric nuclear β-catenin in C. elegans.
Impact
Sawa et al., Kōbe, Japan. In Cell, 2011
Here, we show that during telophase of an asymmetric division in C. elegans, extrinsic Wnt signaling modulates spindle structures through APR-1/APC, which in turn promotes asymmetrical nuclear localization of WRM-1/β-catenin and POP-1/TCF.
Conservation and diversification of Wnt signaling function during the evolution of nematode vulva development.
Impact
Sommer et al., Tübingen, Germany. In Nat Genet, 2005
In addition, mutations in Ppa-lin-17 (encoding Frizzled) and morpholino knock-down of Ppa-lin-44 (encoding Wnt), Ppa-egl-20 (encoding Wnt), Ppa-mig-5 (encoding Dsh), Ppa-apr-1 (encoding APC) and Ppa-bar-1 (encoding beta-catenin) results in gonad-independent vulva differentiation, indicating that these genes have a role in a negative signaling process.
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