Seizures in Alzheimer's disease.
Houston, United States. In Neuroscience, 04 Jan 2015
The amyloid-β peptide has been identified as a possible link between Alzheimer's disease and seizures, and while amyloid-β is known to affect neuronal activity, the full-length amyloid precursor protein (APP) and other APP cleavage products may be important for the development and maintenance of cortical network hyperexcitability.
Emerging roles of the γ-secretase-notch axis in inflammation.
Singapore, Singapore. In Pharmacol Ther, 08 Dec 2014
Two of the most widely known and studied of these substrates are the amyloid precursor protein (APP) and the Notch receptor, which are precursors for the generation of amyloid-β (Aβ) and the Notch intracellular domain (NICD), respectively.
Three-dimensional structure of human γ-secretase.
Beijing, China. In Nature, Sep 2014
Aberrant cleavage of the amyloid precursor protein (APP) results in aggregation of amyloid-β, which accumulates in the brain and consequently causes Alzheimer's disease.
New Type of BACE1 siRNA Delivery to Cells.
Łódź, Poland. In Med Sci Monit, Dec 2013
Material and Methods An INR-32 human neuroblastoma cell line was stably transfected to express the APP cDNA coding fragment containing the predicted sites for cleavage by α, β, or γ-secretase.
Structural origin of polymorphism of Alzheimer's amyloid β-fibrils.
Los Angeles, United States. In Biochem J, 2012
propose that the strength of inter-strand side-chain interactions determines the degree of beta-sheet twist, which then leads to the different association patterns between different cross beta-units and thus distinct fibril morphologies
Down's syndrome and Alzheimer's disease: towards secondary prevention.
More papers using
Trenton, United States. In Nat Rev Drug Discov, 2012
[review] Based on the apparent common pathogenic role of amyloid precursor protein in both Down's syndrome and Alzheimer's disease (AD), the idea that the dementia associated with Down's syndrome is in fact AD is supported on many levels.
Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells
In Genes and immunity, 2006
... For transcript stabilization studies, cells in X-VIVO were treated with APP (Apple PolyR, Littleton, CO, USA) at 54μg/mL, recombinant human TNFα (PeproTech, Rocky Hill, NJ, USA) at 50ng/mL, recombinant bovine TNFα (Thermo Scientific, Waltham, MA), PC1 (Phytolab, ...