GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Amyloid beta
APP, Abeta
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
APP
antibodies
The anti-cholinesterase phenserine and its enantiomer Posiphen as 5′ untranslated region directed translation blockers of the Parkinson's alpha synuclein expression
Supplier
In Journal of Neurology, Neurosurgery, and Psychiatry, 2011
... Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of ...
The projected effect of risk factor reduction on Alzheimer's disease prevalence.
Supplier
In PLoS ONE, 2010
... Rabbit polyclonal antibody against amyloid precursor protein (APP) was from Novus Biologicals (Littleton, CO) ...
TrkB and protein kinase Mzeta regulate synaptic localization of PSD-95 in developing cortex
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In Frontiers in Cellular Neuroscience, 2010
... (B6.129S4-Ccr2tm1Ifc/J) and APP transgenic mice (APP ...
Beta-secretase-1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
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In Acta Neuropathologica, 2008
... The generation and characterization of PS1/APP transgenic (tg) mice has been ...
Neurogenesis and Alzheimer's disease: At the crossroads.
more suppliersSupplier
In PLoS ONE, 2008
... For all experiments, we used age-matched littermate female mice obtained from heterozygous APPSw,Ind x non-transgenic (WT) crossings ...
Papers on
APP
EvaGreen Real-time PCR protocol for specific 'Candidatus Phytoplasma mali' detection and quantification in insects.
New
Grugliasco, Italy. In Mol Cell Probes, 06 Apr 2013
Phytoplasma mali' (apple proliferation phytoplasma, APP) in insects.
Early cognitive stimulation compensates for memory and pathological changes in Tg2576 mice.
New
Pamplona, Spain. In Biochim Biophys Acta, 05 Apr 2013
CS appeared to affect the APP processing since differences in levels of ADAM17, BACE1 and C99/C83 ratio were found.
Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.
New
Leuven, Belgium. In Neurobiol Aging, 05 Apr 2013
Lowering the production and accumulation of Aβ has been explored as treatment for Alzheimer's disease (AD), because Aβ is postulated to play an important role in the pathogenesis of AD. 5-HT4 receptors are an interesting drug target in this regard, as their activation might stimulate α-secretase processing, which increases sAPPα and reduces Aβ, at least according to the central dogma in APP processing.
[Personal genomics for Alzheimer's disease].
New
Niigata, Japan. In Brain Nerve, 31 Mar 2013
The amyloid precursor protein (APP), presenilin1 (PSEN1), and presenilin2 (PSEN2) genes were identified as causative genes in a small number of families with autosomal dominant early-onset forms of AD (ADEOAD).
Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness.
New
Impact
Kyoto, Japan. In Cell Stem Cell, 19 Mar 2013
Aβ oligomers accumulated in iPSC-derived neurons and astrocytes in cells from patients with a familial amyloid precursor protein (APP)-E693Δ mutation and sporadic AD, leading to endoplasmic reticulum (ER) and oxidative stress.
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
New
Impact
Bonn, Germany. In Nature, 03 Mar 2013
Furthermore, NLRP3 inflammasome deficiency skewed microglial cells to an M2 phenotype and resulted in the decreased deposition of amyloid-β in the APP/PS1 model of Alzheimer's disease.
Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?
Review
New
Beaverton, United States. In Biochim Biophys Acta, Jan 2013
Recent research using AD postmortem brains, and AD mouse and cell models revealed that amyloid beta (Aβ) and tau hyperphosphorylation are involved in mitochondrial dysfunction and synaptic damage in AD.
Chronic Administration of Anti-Stroke Herbal Medicine TongLuoJiuNao Reduces Amyloidogenic Processing of Amyloid Precursor Protein in a Mouse Model of Alzheimer's Disease.
New
Sarasota, United States. In Plos One, Dec 2012
In this study, we chronically administered TLJN in amyloid precursor protein (APP) Swedish mutant transgenic mice (APP23) from 6 months old of age, which is at the onset of Aβ plaques, to 12 months old.
Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer's disease.
Review
New
United States. In Discov Med, Sep 2012
Aβ is generated through a sequential proteolytic process initiated by BACE1, or β-secretase, from the amyloid-β precursor protein (APP).
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.
New
Impact
Reykjavík, Iceland. In Nature, Sep 2012
Here, to search for low-frequency variants in the amyloid-β precursor protein (APP) gene with a significant effect on the risk of Alzheimer's disease, we studied coding variants in APP in a set of whole-genome sequence data from 1,795 Icelanders.
[Mitochondrial enzyme ABAD and its role in the development and treatment of Alzheimer's disease].
Review
New
Hradec Králové, Czech Republic. In Ceska Slov Farm, Aug 2012
The amyloid-beta peptide (Abeta) has been associated with Alzheimer's disease (AD) for some time.
[Gamma-secretase inhibitors in Alzheimer's disease therapy].
Review
New
Hradec Králové, Czech Republic. In Ceska Slov Farm, Jun 2012
The Aß peptide is the result of the enzymatic cleavage of the amyloid precursor protein (APP).
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
New
Impact
San Diego, United States. In Nature, Mar 2012
Here we reprogrammed primary fibroblasts from two patients with familial Alzheimer's disease, both caused by a duplication of the amyloid-β precursor protein gene (APP; termed APP(Dp)), two with sporadic Alzheimer's disease (termed sAD1, sAD2) and two non-demented control individuals into iPSC lines.
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.
New
Impact
Melbourne, Australia. In Nat Med, Feb 2012
Amyloid precursor protein (APP) ferroxidase activity couples with surface ferroportin to export iron, but its activity is inhibited in Alzheimer's disease, thereby causing neuronal iron accumulation.
Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort.
New
GeneRIF
Amsterdam, Netherlands. In Neurology, Feb 2012
Cerebrospinal fluid amyloid beta42 protein, total tau, and phosphorylated tau are useful biomarkers in differential dementia diagnosis.
Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease.
GeneRIF
Halifax, Canada. In J Neuropathol Exp Neurol, 2012
Butyrylcholinesterase-positive plaques are Abeta positive, and butyrylcholinesterase may play a role in Alzheimer's disease maturation. plaque maturation.
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.
Impact
GeneRIF
Cambridge, United States. In Science, 2012
study found links between Abeta, endocytosis, and human Alzheimer's disease risk factors can be ascertained with yeast as a model system
Neurologic and motor dysfunctions in APP transgenic mice.
Review
Mont-Saint-Aignan, France. In Rev Neurosci, 2011
APP transgenic mutants have also been investigated with respect to survival rates, neurologic functions, and motor coordination, which are all susceptible to alteration in Alzheimer dementia.
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.
GeneRIF
Boston, United States. In J Neurosci, 2011
The results of thia study illuminated the in vivo dynamics of soluble Abeta during the development of AD-type neuropathology and after gamma-secretase inhibition and help explain the apparent paradox that CSF Abeta(42) levels fall as humans develop AD.
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.
More papers using
APP
antibodies
Impact
GeneRIF
Baltimore, United States. In Cell, 2011
Study reports that the immediate early gene Arc is required for activity-dependent generation of Abeta. Arc is a postsynaptic protein that recruits endophilin2/3 and dynamin to early/recycling endosomes that traffic
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
Supplier
In Molecular Neurodegeneration, 2007
... Primary monoclonal antibodies used were 22C11 (Chemicon) against the APP ectodomain, JL-8 (BD Biosciences) for detection of the ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... = 10), controlled for age (5 months, range 4–6), were separated into 4 groups: APP/PS1+tap water (transgenic group), ...
Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells
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In Genes and immunity, 2006
... For transcript stabilization studies, cells in X-VIVO were treated with APP (Apple PolyR, Littleton, CO, USA) at 54μg/mL, recombinant human TNFα (PeproTech, Rocky Hill, NJ, USA) at 50ng/mL, recombinant bovine TNFα (Thermo Scientific, Waltham, MA), PC1 (Phytolab, ...
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD
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In Molecular Neurodegeneration, 2005
... The APP-ibl transgenic mouse was generated ...
Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice
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In The Journal of Cell Biology, 2004
... Generation of APP transgenic AD mice with deletion ...
Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent
Supplier
In Molecular therapy. Nucleic acids, 2003
... polyvinylidene fluoride membranes were incubated with antibody (BACE1 polyclonal antibody (1:1,000): AB5940; Millipore (Billerica, MA); APP monoclonal antibody (1:2,000): catalog number 1565-1; Epitomics (Burlingame, CA); β-actin monoclonal ...
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
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In Journal of Neuroinflammation, 2002
... For the 5-month treatment study, 13 APP-transgenic mice, aged 23 months, ...
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
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In Scientific Reports, 2002
... Imaging Abeta plaques in living transgenic mice with multiphoton microscopy ...
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
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In Cell Death & Disease, 1999
Sunday Driver links axonal transport to damage signaling
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In The Journal of Cell Biology, 1998
... Brady, University of Illinois, Chicago, IL), anti-DIC and anti-APP (Chemicon), anti-syntaxin13 (Synaptic Systems GmbH), anti-myelin basic protein ...
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
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In Disease Models & Mechanisms, 1998
... Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice ...
Coordinated transport of phosphorylated amyloid-β precursor protein and c-Jun NH2-terminal kinase–interacting protein-1
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In The Journal of Cell Biology, 1998
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
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In PLoS ONE, 1996
... The APP mice were heterozygous transgenic mice (C57B6/SJL, I.D ...
