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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Amyloid beta

APP, Abeta
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Presenilin-1, CAN, AGE, V1a, beta-secretase
Papers using APP antibodies
The anti-cholinesterase phenserine and its enantiomer Posiphen as 5′ untranslated region directed translation blockers of the Parkinson's alpha synuclein expression
Greig Nigel H et al., In Journal of Neurology, Neurosurgery, and Psychiatry, 2011
... Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of ...
TrkB and protein kinase Mzeta regulate synaptic localization of PSD-95 in developing cortex
Rivest Serge et al., In Frontiers in Cellular Neuroscience, 2010
... (B6.129S4-Ccr2tm1Ifc/J) and APP transgenic mice (APP ...
The projected effect of risk factor reduction on Alzheimer's disease prevalence.
Ginsberg Stephen D., In PLoS ONE, 2010
... Rabbit polyclonal antibody against amyloid precursor protein (APP) was from Novus Biologicals (Littleton, CO) ...
Neurogenesis and Alzheimer's disease: At the crossroads.
Gaetani Silvana, In PLoS ONE, 2008
... For all experiments, we used age-matched littermate female mice obtained from heterozygous APPSw,Ind x non-transgenic (WT) crossings ...
Beta-secretase-1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
Gutierrez Antonia et al., In Acta Neuropathologica, 2008
... The generation and characterization of PS1/APP transgenic (tg) mice has been ...
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Papers on APP
Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.
Tomita et al., Japan. In J Biol Chem, 11 Dec 2015
Familial Alzheimer's disease (FAD) mutations within PS1 were analyzed in yeast cells artificially expressing membrane bound substrate, amyloid precursor protein (APP) or Notch fused to Gal4 transcriptional activator.
Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.
Ehrlich et al., New York City, United States. In Mol Psychiatry, 10 Dec 2015
The first line expresses oligomerogenic mutant APP(E693Q) inside neurons, leading to the accumulation of amyloid beta (Aβ) oligomers and behavioral impairment, but never develops parenchymal fibrillar amyloid deposits.
Differential effect of intranasally administrated kinin B1 and B2 receptor antagonists in Alzheimer's disease mice.
Fleisher-Berkovich et al., In Biol Chem, 10 Dec 2015
We also showed that intranasal treatment with R-715 but not HOE-140 of Alzheimer's mice enhanced amyloid beta burden and microglia/macrophages activation.
Comparative Neuroregenerative Effects of C-Phycocyanin and IFN-Beta in a Model of Multiple Sclerosis in Mice.
Pentón-Arias et al., Havana, Cuba. In J Neuroimmune Pharmacol, 10 Dec 2015
Histological and immunohistochemistry (anti-Mac-3, anti-CD3 and anti-APP) assessments were performed in spinal cord in the postinduction time.
Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways.
McCarthy et al., Cork, Ireland. In Cell Signal, 21 Nov 2015
More that 90 transmembrane proteins have been reported to be γ-secretase substrates, including the widely studied amyloid precursor protein (APP) and the Notch receptor, which are precursors for the generation of amyloid-β peptides and biologically active APP intracellular domain (AICD) and Notch intracellular domain (NICD).
η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Haass et al., München, Germany. In Nature, 15 Nov 2015
Two principal physiological pathways either prevent or promote amyloid-β generation from its precursor, β-amyloid precursor protein (APP), in a competitive manner.
Protein structures in Alzheimer's disease: The basis for rationale therapeutic design.
Villegas et al., Barcelona, Spain. In Arch Biochem Biophys, 13 Nov 2015
Thus, structural information available for APP, α- β- and γ-secretases, CTFβ and derived Aβ peptides, AICDs, apoE and apoJ, LRP-1 and RAGE, and neprilysin and insulin-degrading enzyme is provided.
Understanding the function of ABCA7 in Alzheimer's disease.
Garner et al., Wollongong, Australia. In Biochem Soc Trans, 01 Nov 2015
Our initial studies showed that transient overexpression of ABCA7 in Chinese hamster ovary cells stably expressing human amyloid precursor protein (APP) resulted in an approximate 50% inhibition in the production of the AD-related amyloid-β (Aβ) peptide as compared with mock-transfected cells.
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.
Strydom et al., London, United Kingdom. In Nat Rev Neurosci, Sep 2015
It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP)--an Alzheimer disease risk factor--although the possession of extra copies of other chromosome 21 genes may also play a part.
APP intracellular domain-WAVE1 pathway reduces amyloid-β production.
Kim et al., New York City, United States. In Nat Med, Sep 2015
Here we report that the amyloid precursor protein (APP) intracellular domain (AICD) downregulates Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous protein 1 (WAVE1 or WASF1) as part of a negative feedback mechanism to limit Aβ production.
SUMOylation: Novel Neuroprotective Approach for Alzheimer's Disease?
Cimarosti et al., Porto Alegre, Brazil. In Aging Dis, Sep 2015
Interestingly, some of the main proteins involved in AD, including amyloid precursor protein (APP) and tau, have recently been shown to be SUMOylated.
Inhibition of amyloid-β plaque formation by α-synuclein.
Meyer-Luehmann et al., München, Germany. In Nat Med, Jul 2015
Here we performed intracerebral injections of α-syn-containing preparations into amyloid precursor protein (APP) transgenic mice (expressing APP695(KM670/671NL) and PSEN1(L166P) under the control of the neuron-specific Thy-1 promoter; referred to here as 'APPPS1').
Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.
Goldstein et al., San Diego, United States. In Cell Stem Cell, May 2015
We found that human neurons carrying SORL1 variants associated with an increased SAD risk show a reduced response to treatment with BDNF, at the level of both SORL1 expression and APP processing.
Imaging the Intracellular Trafficking of APP with Photoactivatable GFP.
Pasternak et al., Kenya. In J Vis Exp, Dec 2014
Aβ is derived from the sequential cleavage of Amyloid Precursor Protein (APP) by β and γ-secretases.
The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid- β Production in Alzheimer's Disease.
Best et al., Columbus, United States. In Oxid Med Cell Longev, Dec 2014
Analyzing the ROS response of essential proteins in the amyloidogenic pathway, such as amyloid-beta precursor protein (APP) and beta-secretase (BACE1), along with influential signaling programs of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and c-Jun N-terminal kinase (JNK), has helped visualize the path between OS and Aβ overproduction.
Structural origin of polymorphism of Alzheimer's amyloid β-fibrils.
Guo et al., Los Angeles, United States. In Biochem J, 2012
propose that the strength of inter-strand side-chain interactions determines the degree of beta-sheet twist, which then leads to the different association patterns between different cross beta-units and thus distinct fibril morphologies
Down's syndrome and Alzheimer's disease: towards secondary prevention.
Manji et al., Trenton, United States. In Nat Rev Drug Discov, 2012
[review] Based on the apparent common pathogenic role of amyloid precursor protein in both Down's syndrome and Alzheimer's disease (AD), the idea that the dementia associated with Down's syndrome is in fact AD is supported on many levels.
Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.
Boehning et al., Galveston, United States. In Proc Natl Acad Sci U S A, 2012
These results reveal the mechanistic basis by which ubiquilin-1 regulates APP maturation.
Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment.
Fändrich et al., Halle, Germany. In Proc Natl Acad Sci U S A, 2012
Molecular basis of beta-amyloid oligomer recognition with a conformational antibody fragment.
Neurologic and motor dysfunctions in APP transgenic mice.
Strazielle et al., Mont-Saint-Aignan, France. In Rev Neurosci, 2011
In APP transgenic mice models showed Neurologic and motor dysfunctions.
More papers using APP antibodies
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
da Cruz e Silva Odete AB et al., In Molecular Neurodegeneration, 2007
... Primary monoclonal antibodies used were 22C11 (Chemicon) against the APP ectodomain, JL-8 (BD Biosciences) for detection of the ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
Liu Jian-xun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... = 10), controlled for age (5 months, range 4–6), were separated into 4 groups: APP/PS1+tap water (transgenic group), ...
Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells
Jutila Mark A. et al., In Genes and immunity, 2006
... For transcript stabilization studies, cells in X-VIVO were treated with APP (Apple PolyR, Littleton, CO, USA) at 54μg/mL, recombinant human TNFα (PeproTech, Rocky Hill, NJ, USA) at 50ng/mL, recombinant bovine TNFα (Thermo Scientific, Waltham, MA), PC1 (Phytolab, ...
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD
Suzuki Toshiharu et al., In Molecular Neurodegeneration, 2005
... The APP-ibl transgenic mouse was generated ...
Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice
Shen Yong et al., In The Journal of Cell Biology, 2004
... Generation of APP transgenic AD mice with deletion ...
Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent
Li Feng et al., In Molecular therapy. Nucleic acids, 2003
... polyvinylidene fluoride membranes were incubated with antibody (BACE1 polyclonal antibody (1:1,000): AB5940; Millipore (Billerica, MA); APP monoclonal antibody (1:2,000): catalog number 1565-1; Epitomics (Burlingame, CA); β-actin monoclonal ...
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
Morgan Dave et al., In Journal of Neuroinflammation, 2002
... For the 5-month treatment study, 13 APP-transgenic mice, aged 23 months, ...
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Grutzendler Jaime et al., In Scientific Reports, 2002
... Imaging Abeta plaques in living transgenic mice with multiphoton microscopy ...
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
Chang N-S et al., In Cell Death & Disease, 1999
... Antibody against phospho-APP at Thr668 was from Cell Signaling Technology (Danvers, MA, USA) ...
Sunday Driver links axonal transport to damage signaling
Goldstein Lawrence S.B. et al., In The Journal of Cell Biology, 1998
... Brady, University of Illinois, Chicago, IL), anti-DIC and anti-APP (Chemicon), anti-syntaxin13 (Synaptic Systems GmbH), anti-myelin basic protein ...
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
Liebman Susan W. et al., In Disease Models & Mechanisms, 1998
... Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice ...
Coordinated transport of phosphorylated amyloid-β precursor protein and c-Jun NH2-terminal kinase–interacting protein-1
Muresan Virgil et al., In The Journal of Cell Biology, 1998
... 22C11; CHEMICON International, Inc.); mouse anti–human amyloid-β protein (clones 4G8 and 6E10; Signet Laboratories); rabbit anti-APP (raised against a polypeptide from the cytoplasmic domain of APP; Cell Signaling Technology); mouse anti–human APP ...
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
Finkelstein David I., In PLoS ONE, 1996
... The APP mice were heterozygous transgenic mice (C57B6/SJL, I.D ...
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