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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

Amyloid beta

APP, Abeta
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Presenilin-1, CAN, AGE, beta-secretase, V1a
Papers using APP antibodies
The anti-cholinesterase phenserine and its enantiomer Posiphen as 5′ untranslated region directed translation blockers of the Parkinson's alpha synuclein expression
Greig Nigel H et al., In Journal of Neurology, Neurosurgery, and Psychiatry, 2011
... Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of ...
TrkB and protein kinase Mzeta regulate synaptic localization of PSD-95 in developing cortex
Rivest Serge et al., In Frontiers in Cellular Neuroscience, 2010
... (B6.129S4-Ccr2tm1Ifc/J) and APP transgenic mice (APP ...
The projected effect of risk factor reduction on Alzheimer's disease prevalence.
Ginsberg Stephen D., In PLoS ONE, 2010
... Rabbit polyclonal antibody against amyloid precursor protein (APP) was from Novus Biologicals (Littleton, CO) ...
Neurogenesis and Alzheimer's disease: At the crossroads.
Gaetani Silvana, In PLoS ONE, 2008
... For all experiments, we used age-matched littermate female mice obtained from heterozygous APPSw,Ind x non-transgenic (WT) crossings ...
Beta-secretase-1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
Gutierrez Antonia et al., In Acta Neuropathologica, 2008
... The generation and characterization of PS1/APP transgenic (tg) mice has been ...
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Papers on APP
Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.
Hasegawa et al., Tokyo, Japan. In Acta Neuropathol, 14 May 2015
In this study, we investigated whether expression of amyloid precursor protein (APP) influences extracellular seed-dependent intracellular tau accumulation in cultured cells.
A strategy focused on MAPT, APP, NCSTN and BACE1 to build blood classifiers for Alzheimer's disease.
Emiliano Aranda-Abreu et al., Jalapa Enríquez, Mexico. In J Theor Biol, 08 May 2015
We focused on MAPT, APP, NCSTN and BACE1 as the basis to build and compare blood classifiers for AD.
CyToStruct: Augmenting the Network Visualization of Cytoscape with the Power of Molecular Viewers.
Kolodny et al., United States. In Structure, 03 May 2015
CyToStruct is available at and in the Cytoscape App Store.
Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer's Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells.
Goldstein et al., San Diego, United States. In Cell Stem Cell, 02 May 2015
We found that human neurons carrying SORL1 variants associated with an increased SAD risk show a reduced response to treatment with BDNF, at the level of both SORL1 expression and APP processing.
Structural insight into the mechanism of amyloid precursor protein recognition by β-secretase 1: A molecular dynamics study.
Basu et al., Calcutta, India. In Biophys Chem, 25 Apr 2015
UNASSIGNED: β-secretase 1 (BACE1) initiates the proteolysis of amyloid precursor protein (APP) to generate Aβ, aggregation of which has been considered to be the main histopathological feature of Alzheimer's Disease.
Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways.
St George-Hyslop et al., Toronto, Canada. In Mol Cell Neurosci, 04 Apr 2015
Thus missense, splice site or duplication mutants in the presenilin 1 (PS1), presenilin 2 (PS2) or the amyloid precursor protein (APP) genes, which alter the levels or shift the balance of Aβ produced, are associated with rare, highly penetrant autosomal dominant forms of Familial Alzheimer's Disease (FAD).
Cellular functions of the amyloid precursor protein from development to dementia.
Goldstein et al., San Diego, United States. In Dev Cell, 23 Mar 2015
Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD).
Extracellular vesicles - their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases.
Hill et al., Melbourne, Australia. In Semin Cell Dev Biol, 19 Mar 2015
Exosomes are also involved in processing the amyloid precursor protein (APP), which is associated with Alzheimer's disease (AD).
Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion.
Pichler et al., Tübingen, Germany. In Nat Med, Dec 2014
We present longitudinal in vivo data on the dynamics of β-amyloid deposition and the decline of rCBF in two different amyloid precursor protein (APP) transgenic mouse models of AD.
Role of P2X7 and P2Y2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation "in vivo" by P2X7 receptor.
Gualix et al., Madrid, Spain. In Comput Struct Biotechnol J, Dec 2014
Amyloid precursor protein (APP) is expressed in a large variety of neural and non-neural cells.
Mechanism of protein phosphatase-2Aregulating phosphorylation of amyloid precursor proteosome and Aβ generation.
Dong et al., In Bratisl Lek Listy, Dec 2014
OBJECTIVE: To discuss whether PP-2A influences the phosphorylation level at APP threonine 668 locus thus regulating Aβ secretion.
Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.
Tavazoie et al., New York City, United States. In Nature, Oct 2014
Endogenous TARBP2 promotes metastatic cell invasion and colonization by destabilizing amyloid precursor protein (APP) and ZNF395 transcripts, two genes previously associated with Alzheimer's and Huntington's disease, respectively.
The ongoing search for small molecules to study metal-associated amyloid-β species in Alzheimer's disease.
Lim et al., Ann Arbor, United States. In Acc Chem Res, Sep 2014
Amyloid-β (Aβ), generated from proteolytic processing of the amyloid precursor protein (APP), and its aggregated forms, particularly oligomers, are suggested as key pathological features in AD-affected brains.
Three-dimensional structure of human γ-secretase.
Shi et al., Beijing, China. In Nature, Sep 2014
Aberrant cleavage of the amyloid precursor protein (APP) results in aggregation of amyloid-β, which accumulates in the brain and consequently causes Alzheimer's disease.
Complex regulation of γ-secretase: from obligatory to modulatory subunits.
Li et al., New York City, United States. In Front Aging Neurosci, 2013
γ-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein (APP), catalyzing the formation of amyloid beta (Aβ) peptides that form amyloid plaques, which contribute to Alzheimer's disease (AD) pathogenesis.
Structural origin of polymorphism of Alzheimer's amyloid β-fibrils.
Guo et al., Los Angeles, United States. In Biochem J, 2012
propose that the strength of inter-strand side-chain interactions determines the degree of beta-sheet twist, which then leads to the different association patterns between different cross beta-units and thus distinct fibril morphologies
Down's syndrome and Alzheimer's disease: towards secondary prevention.
Manji et al., Trenton, United States. In Nat Rev Drug Discov, 2012
[review] Based on the apparent common pathogenic role of amyloid precursor protein in both Down's syndrome and Alzheimer's disease (AD), the idea that the dementia associated with Down's syndrome is in fact AD is supported on many levels.
Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.
Boehning et al., Galveston, United States. In Proc Natl Acad Sci U S A, 2012
These results reveal the mechanistic basis by which ubiquilin-1 regulates APP maturation.
Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment.
Fändrich et al., Halle, Germany. In Proc Natl Acad Sci U S A, 2012
Molecular basis of beta-amyloid oligomer recognition with a conformational antibody fragment.
Neurologic and motor dysfunctions in APP transgenic mice.
Strazielle et al., Mont-Saint-Aignan, France. In Rev Neurosci, 2011
In APP transgenic mice models showed Neurologic and motor dysfunctions.
More papers using APP antibodies
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
da Cruz e Silva Odete AB et al., In Molecular Neurodegeneration, 2007
... Primary monoclonal antibodies used were 22C11 (Chemicon) against the APP ectodomain, JL-8 (BD Biosciences) for detection of the ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
Liu Jian-xun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... = 10), controlled for age (5 months, range 4–6), were separated into 4 groups: APP/PS1+tap water (transgenic group), ...
Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells
Jutila Mark A. et al., In Genes and immunity, 2006
... For transcript stabilization studies, cells in X-VIVO were treated with APP (Apple PolyR, Littleton, CO, USA) at 54μg/mL, recombinant human TNFα (PeproTech, Rocky Hill, NJ, USA) at 50ng/mL, recombinant bovine TNFα (Thermo Scientific, Waltham, MA), PC1 (Phytolab, ...
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD
Suzuki Toshiharu et al., In Molecular Neurodegeneration, 2005
... The APP-ibl transgenic mouse was generated ...
Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice
Shen Yong et al., In The Journal of Cell Biology, 2004
... Generation of APP transgenic AD mice with deletion ...
Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent
Li Feng et al., In Molecular therapy. Nucleic acids, 2003
... polyvinylidene fluoride membranes were incubated with antibody (BACE1 polyclonal antibody (1:1,000): AB5940; Millipore (Billerica, MA); APP monoclonal antibody (1:2,000): catalog number 1565-1; Epitomics (Burlingame, CA); β-actin monoclonal ...
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
Morgan Dave et al., In Journal of Neuroinflammation, 2002
... For the 5-month treatment study, 13 APP-transgenic mice, aged 23 months, ...
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Grutzendler Jaime et al., In Scientific Reports, 2002
... Imaging Abeta plaques in living transgenic mice with multiphoton microscopy ...
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
Chang N-S et al., In Cell Death & Disease, 1999
... Antibody against phospho-APP at Thr668 was from Cell Signaling Technology (Danvers, MA, USA) ...
Sunday Driver links axonal transport to damage signaling
Goldstein Lawrence S.B. et al., In The Journal of Cell Biology, 1998
... Brady, University of Illinois, Chicago, IL), anti-DIC and anti-APP (Chemicon), anti-syntaxin13 (Synaptic Systems GmbH), anti-myelin basic protein ...
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
Liebman Susan W. et al., In Disease Models & Mechanisms, 1998
... Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice ...
Coordinated transport of phosphorylated amyloid-β precursor protein and c-Jun NH2-terminal kinase–interacting protein-1
Muresan Virgil et al., In The Journal of Cell Biology, 1998
... 22C11; CHEMICON International, Inc.); mouse anti–human amyloid-β protein (clones 4G8 and 6E10; Signet Laboratories); rabbit anti-APP (raised against a polypeptide from the cytoplasmic domain of APP; Cell Signaling Technology); mouse anti–human APP ...
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
Finkelstein David I., In PLoS ONE, 1996
... The APP mice were heterozygous transgenic mice (C57B6/SJL, I.D ...
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