gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Jul 2015.

Amyloid beta

APP, Abeta
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Presenilin-1, CAN, AGE, beta-secretase, V1a
Papers using APP antibodies
The anti-cholinesterase phenserine and its enantiomer Posiphen as 5′ untranslated region directed translation blockers of the Parkinson's alpha synuclein expression
Supplier
Greig Nigel H et al., In Journal of Neurology, Neurosurgery, and Psychiatry, 2011
... Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of ...
TrkB and protein kinase Mzeta regulate synaptic localization of PSD-95 in developing cortex
Supplier
Rivest Serge et al., In Frontiers in Cellular Neuroscience, 2010
... (B6.129S4-Ccr2tm1Ifc/J) and APP transgenic mice (APP ...
The projected effect of risk factor reduction on Alzheimer's disease prevalence.
Supplier
Ginsberg Stephen D., In PLoS ONE, 2010
... Rabbit polyclonal antibody against amyloid precursor protein (APP) was from Novus Biologicals (Littleton, CO) ...
Neurogenesis and Alzheimer's disease: At the crossroads.
Supplier
Gaetani Silvana, In PLoS ONE, 2008
... For all experiments, we used age-matched littermate female mice obtained from heterozygous APPSw,Ind x non-transgenic (WT) crossings ...
Beta-secretase-1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
Supplier
Gutierrez Antonia et al., In Acta Neuropathologica, 2008
... The generation and characterization of PS1/APP transgenic (tg) mice has been ...
more suppliers
Papers on APP
The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease.
New
Wang et al., Hangzhou, China. In Cell Mol Neurobiol, 29 Jul 2015
Aβ is the proteolytic product from its precursor amyloid precursor protein (APP) by β- and γ- secretase.
SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport.
New
Kins et al., Hamburg, Germany. In J Neurochem, 28 Jul 2015
UNASSIGNED: Processing of amyloid precursor protein (APP) into amyloid-β peptide (Aβ) is crucial for the development of Alzheimer's disease (AD).
Modulation of the neuronal network activity by P2X receptors and their involvement in neurological disorders.
Review
New
Fuentealba et al., Santiago, Chile. In Pharmacol Res, 26 Jul 2015
Growing evidence shows that P2XR play an important role in neuronal disorders and neurodegenerative diseases, like Parkinson's and Alzheimer's disease; this role involves changes on P2XR expression levels, activation of key pathways like GSK3β, APP processing, oxidative stress and inflammatory response.
C-terminal threonine reduces Aβ43 amyloidogenicity compared with Aβ42.
New
Wetzel et al., Pittsburgh, United States. In J Mol Biol, 26 Jul 2015
UNASSIGNED: Aβ43, a product of the proteolysis of the amyloid precursor protein APP, is related to Aβ42 by an additional Thr residue at the C-terminus.
Chronic hypoxia facilitates Alzheimer's disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b.
New
Le et al., Shanghai, China. In Alzheimers Dement, 26 Jul 2015
METHODS: The 3-month-old APP(swe)/PS1(dE9) mice were exposed to hypoxic environment 6 hour/day for 30 days, followed by learning and memory tests and biochemical and neuropathology measurement at the age of 4, 6, and 9 months.
Inhibition of amyloid-β plaque formation by α-synuclein.
New
Impact
Meyer-Luehmann et al., München, Germany. In Nat Med, 22 Jul 2015
Here we performed intracerebral injections of α-syn-containing preparations into amyloid precursor protein (APP) transgenic mice (expressing APP695(KM670/671NL) and PSEN1(L166P) under the control of the neuron-specific Thy-1 promoter; referred to here as 'APPPS1').
In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs.
Review
New
Croubels et al., Merelbeke, Belgium. In Vet Immunol Immunopathol, 07 Jul 2015
To investigate the influence of these drugs on the clinical response, production of pro-inflammatory cytokines, acute phase proteins (APP) and the course of the febrile response in pigs, in vivo LPS inflammation models can be applied.
Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.
New
Impact
Goldstein et al., San Diego, United States. In Cell Stem Cell, May 2015
We found that human neurons carrying SORL1 variants associated with an increased SAD risk show a reduced response to treatment with BDNF, at the level of both SORL1 expression and APP processing.
Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion.
New
Impact
Pichler et al., Tübingen, Germany. In Nat Med, Dec 2014
We present longitudinal in vivo data on the dynamics of β-amyloid deposition and the decline of rCBF in two different amyloid precursor protein (APP) transgenic mouse models of AD.
Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and A β Accumulation.
Review
New
Šimić et al., Zagreb, Croatia. In Oxid Med Cell Longev, Dec 2014
Enhanced levels of ceramides directly increase Aβ through stabilization of β-secretase, the key enzyme in the amyloidogenic processing of Aβ precursor protein (APP).
Transmembrane Amyloid-Related Proteins in CSF as Potential Biomarkers for Alzheimer's Disease.
Review
New
Sáez-Valero et al., San Juan de Alicante, Spain. In Front Neurol, Dec 2014
In the continuing search for new cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD), reasonable candidates are the secretase enzymes involved in the processing of the amyloid precursor protein (APP), as well as the large proteolytic cleavage fragments sAPPα and sAPPβ.
The Maze of APP Processing in Alzheimer's Disease: Where Did We Go Wrong in Reasoning?
Review
New
Chen, United States. In Front Cell Neurosci, Dec 2014
Why has Alzheimer's disease (AD) remained a conundrum today?
The Amyloid Precursor Protein Controls PIKfyve Function.
New
Wassmer et al., Birmingham, United Kingdom. In Plos One, Dec 2014
UNASSIGNED: While the Amyloid Precursor Protein (APP) plays a central role in Alzheimer's disease, its cellular function still remains largely unclear.
Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.
New
Impact
Tavazoie et al., New York City, United States. In Nature, Oct 2014
Endogenous TARBP2 promotes metastatic cell invasion and colonization by destabilizing amyloid precursor protein (APP) and ZNF395 transcripts, two genes previously associated with Alzheimer's and Huntington's disease, respectively.
The ongoing search for small molecules to study metal-associated amyloid-β species in Alzheimer's disease.
New
Impact
Lim et al., Ann Arbor, United States. In Acc Chem Res, Sep 2014
Amyloid-β (Aβ), generated from proteolytic processing of the amyloid precursor protein (APP), and its aggregated forms, particularly oligomers, are suggested as key pathological features in AD-affected brains.
Structural origin of polymorphism of Alzheimer's amyloid β-fibrils.
GeneRIF
Guo et al., Los Angeles, United States. In Biochem J, 2012
propose that the strength of inter-strand side-chain interactions determines the degree of beta-sheet twist, which then leads to the different association patterns between different cross beta-units and thus distinct fibril morphologies
Down's syndrome and Alzheimer's disease: towards secondary prevention.
Impact
GeneRIF
Manji et al., Trenton, United States. In Nat Rev Drug Discov, 2012
[review] Based on the apparent common pathogenic role of amyloid precursor protein in both Down's syndrome and Alzheimer's disease (AD), the idea that the dementia associated with Down's syndrome is in fact AD is supported on many levels.
Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.
GeneRIF
Boehning et al., Galveston, United States. In Proc Natl Acad Sci U S A, 2012
These results reveal the mechanistic basis by which ubiquilin-1 regulates APP maturation.
Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment.
GeneRIF
Fändrich et al., Halle, Germany. In Proc Natl Acad Sci U S A, 2012
Molecular basis of beta-amyloid oligomer recognition with a conformational antibody fragment.
Neurologic and motor dysfunctions in APP transgenic mice.
Review
GeneRIF
Strazielle et al., Mont-Saint-Aignan, France. In Rev Neurosci, 2011
In APP transgenic mice models showed Neurologic and motor dysfunctions.
More papers using APP antibodies
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
Supplier
da Cruz e Silva Odete AB et al., In Molecular Neurodegeneration, 2007
... Primary monoclonal antibodies used were 22C11 (Chemicon) against the APP ectodomain, JL-8 (BD Biosciences) for detection of the ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
Supplier
Liu Jian-xun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... = 10), controlled for age (5 months, range 4–6), were separated into 4 groups: APP/PS1+tap water (transgenic group), ...
Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells
Supplier
Jutila Mark A. et al., In Genes and immunity, 2006
... For transcript stabilization studies, cells in X-VIVO were treated with APP (Apple PolyR, Littleton, CO, USA) at 54μg/mL, recombinant human TNFα (PeproTech, Rocky Hill, NJ, USA) at 50ng/mL, recombinant bovine TNFα (Thermo Scientific, Waltham, MA), PC1 (Phytolab, ...
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD
Supplier
Suzuki Toshiharu et al., In Molecular Neurodegeneration, 2005
... The APP-ibl transgenic mouse was generated ...
Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice
Supplier
Shen Yong et al., In The Journal of Cell Biology, 2004
... Generation of APP transgenic AD mice with deletion ...
Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent
Supplier
Li Feng et al., In Molecular therapy. Nucleic acids, 2003
... polyvinylidene fluoride membranes were incubated with antibody (BACE1 polyclonal antibody (1:1,000): AB5940; Millipore (Billerica, MA); APP monoclonal antibody (1:2,000): catalog number 1565-1; Epitomics (Burlingame, CA); β-actin monoclonal ...
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
Supplier
Morgan Dave et al., In Journal of Neuroinflammation, 2002
... For the 5-month treatment study, 13 APP-transgenic mice, aged 23 months, ...
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Supplier
Grutzendler Jaime et al., In Scientific Reports, 2002
... Imaging Abeta plaques in living transgenic mice with multiphoton microscopy ...
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
Supplier
Chang N-S et al., In Cell Death & Disease, 1999
... Antibody against phospho-APP at Thr668 was from Cell Signaling Technology (Danvers, MA, USA) ...
Sunday Driver links axonal transport to damage signaling
Supplier
Goldstein Lawrence S.B. et al., In The Journal of Cell Biology, 1998
... Brady, University of Illinois, Chicago, IL), anti-DIC and anti-APP (Chemicon), anti-syntaxin13 (Synaptic Systems GmbH), anti-myelin basic protein ...
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
Supplier
Liebman Susan W. et al., In Disease Models & Mechanisms, 1998
... Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice ...
Coordinated transport of phosphorylated amyloid-β precursor protein and c-Jun NH2-terminal kinase–interacting protein-1
Supplier
Muresan Virgil et al., In The Journal of Cell Biology, 1998
... 22C11; CHEMICON International, Inc.); mouse anti–human amyloid-β protein (clones 4G8 and 6E10; Signet Laboratories); rabbit anti-APP (raised against a polypeptide from the cytoplasmic domain of APP; Cell Signaling Technology); mouse anti–human APP ...
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
Supplier
Finkelstein David I., In PLoS ONE, 1996
... The APP mice were heterozygous transgenic mice (C57B6/SJL, I.D ...
share on facebooktweetadd +1mail to friends