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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Oct 2014.

Amyloid beta

APP, Abeta
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Presenilin-1, CAN, AGE, beta-secretase, V1a
Papers using APP antibodies
The anti-cholinesterase phenserine and its enantiomer Posiphen as 5′ untranslated region directed translation blockers of the Parkinson's alpha synuclein expression
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Greig Nigel H et al., In Journal of Neurology, Neurosurgery, and Psychiatry, 2011
... Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of ...
TrkB and protein kinase Mzeta regulate synaptic localization of PSD-95 in developing cortex
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Rivest Serge et al., In Frontiers in Cellular Neuroscience, 2010
... (B6.129S4-Ccr2tm1Ifc/J) and APP transgenic mice (APP ...
The projected effect of risk factor reduction on Alzheimer's disease prevalence.
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Ginsberg Stephen D., In PLoS ONE, 2010
... Rabbit polyclonal antibody against amyloid precursor protein (APP) was from Novus Biologicals (Littleton, CO) ...
Neurogenesis and Alzheimer's disease: At the crossroads.
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Gaetani Silvana, In PLoS ONE, 2008
... For all experiments, we used age-matched littermate female mice obtained from heterozygous APPSw,Ind x non-transgenic (WT) crossings ...
Beta-secretase-1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
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Gutierrez Antonia et al., In Acta Neuropathologica, 2008
... The generation and characterization of PS1/APP transgenic (tg) mice has been ...
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Papers on APP
Synthetic Antibody Fragment Targeting Nicastrin Affects Assembly and Trafficking of γ-Secretase.
New
Sisodia et al., Chicago, United States. In J Biol Chem, 28 Nov 2014
UNLABELLED: The γ-secretase complex, composed of presenilin (PS), nicastrin (NCT), anterior pharynx-defective 1 (APH-1) and presenilin enhancer 2 (PEN-2), is assembled in a highly regulated manner, and catalyzes the intramembranous proteolysis of many type I membrane proteins, including Notch and amyloid precursor protein (APP).
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.
New
Vocadlo et al., In Mol Neurodegener, 26 Nov 2014
RESULTS: We treated double transgenic TAPP mice, which express both mutant human tau and amyloid precursor protein (APP), with a highly selective orally bioavailable inhibitor of the enzyme responsible for removing O-GlcNAc (OGA) to increase O-GlcNAc in the brain.
Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin.
New
Fellgiebel et al., Rostock, Germany. In Neurology, 24 Nov 2014
OBJECTIVE: We investigated induction of α-secretase A disintegrin and metalloprotease 10 (ADAM10) by the synthetic retinoid acitretin (Neotigason; Actavis, München-Riem, Germany) in patients with mild to moderate Alzheimer disease (AD) via measurement of CSF content of α-secretase-derived amyloid precursor protein (APPs-α).
Clinical workout for the early detection of cognitive decline and dementia.
Review
New
Tsolaki, Thessaloníki, Greece. In Eur J Clin Nutr, 01 Nov 2014
Diagnosis of cognitive decline is mostly clinical (clinical criteria), but there are multiple biomarkers that could help us mostly in research programs such as short or long, paper and pencil or computerized neuropsychological batteries for cognition, activities of daily living and behavior, electroencephalograph, event-related potentials, and imaging-structural magnetic resonance imaging (MRI) and functional (fMRI, Pittsburgh bound positron emission tomography, FDG-PET, single photon emission computerized tomography and imaging of tau pathology)-cerebrospinal fluid proteins (Abeta, tau and phospho-tau in AD and α-synuclein (αSyn) for PD).
Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.
New
Impact
Tavazoie et al., New York City, United States. In Nature, 11 Oct 2014
Endogenous TARBP2 promotes metastatic cell invasion and colonization by destabilizing amyloid precursor protein (APP) and ZNF395 transcripts, two genes previously associated with Alzheimer's and Huntington's disease, respectively.
The ongoing search for small molecules to study metal-associated amyloid-β species in Alzheimer's disease.
New
Impact
Lim et al., Ann Arbor, United States. In Acc Chem Res, 19 Sep 2014
Amyloid-β (Aβ), generated from proteolytic processing of the amyloid precursor protein (APP), and its aggregated forms, particularly oligomers, are suggested as key pathological features in AD-affected brains.
Three-dimensional structure of human γ-secretase.
New
Impact
Shi et al., Beijing, China. In Nature, 14 Sep 2014
Aberrant cleavage of the amyloid precursor protein (APP) results in aggregation of amyloid-β, which accumulates in the brain and consequently causes Alzheimer's disease.
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.
New
Impact
Goate et al., Saint Louis, United States. In Nature, Feb 2014
Overexpression of PLD3 leads to a significant decrease in intracellular amyloid-β precursor protein (APP) and extracellular Aβ42 and Aβ40 (the 42- and 40-residue isoforms of the amyloid-β peptide), and knockdown of PLD3 leads to a significant increase in extracellular Aβ42 and Aβ40.
Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.
Review
New
Li et al., New York City, United States. In Front Genet, Dec 2013
It is a progressive neurodegenerative disorder, characterized by the prevalence of extracellular Aβ plaques and intracellular neurofibrillary tangles, derived from the proteolysis of the amyloid precursor protein (APP) and the hyperphosphorylation of microtubule-associated protein tau, respectively.
Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus.
Review
New
Itzhaki, Manchester, United Kingdom. In Front Aging Neurosci, Dec 2013
Other relevant, harmful effects of infection include the following: dynamic interactions between HSV1 and amyloid precursor protein (APP), which would affect both viral and APP transport; induction of toll-like receptors (TLRs) in HSV1-infected astrocyte cultures, which has been linked to the likely effects of reactivation of the virus in brain.
β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease.
Review
New
Claassen et al., Nijmegen, Netherlands. In Front Aging Neurosci, Dec 2013
Much of AD research has investigated the amyloid cascade hypothesis, which postulates that AD is caused by changes in amyloid beta (Aβ) stability and aggregation.
Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.
Review
New
Turner et al., Leeds, United Kingdom. In Front Aging Neurosci, Dec 2013
It is now evident that Aβ levels in the brain are manipulable due to a dynamic equilibrium between its production from the amyloid precursor protein (APP) and removal by amyloid clearance proteins.
Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity.
New
Ran et al., San Diego, United States. In Plos One, Dec 2013
Altered production of β-amyloid (Aβ) from the amyloid precursor protein (APP) is closely associated with Alzheimer's disease (AD).
Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches.
New
Glucksman et al., North Chicago, United States. In Front Aging Neurosci, Dec 2013
A key component of the amyloid burden of AD comes from accumulation of the amyloid-beta (Aβ) peptide which comes from processing of the amyloid precursor protein (APP) by enzymes termed secretases, leading to production of these toxic Aβ peptides of 40-42 amino acids.
PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
New
Impact
Schneider et al., Paris, France. In Nat Med, Sep 2013
α-secretase-mediated cleavage of amyloid precursor protein (APP) precludes formation of neurotoxic amyloid-β (Aβ) peptides, and α-cleavage of cellular prion protein (PrP(C)) prevents its conversion into misfolded, pathogenic prions (PrP(Sc)).
Structural origin of polymorphism of Alzheimer's amyloid β-fibrils.
GeneRIF
Guo et al., Los Angeles, United States. In Biochem J, 2012
propose that the strength of inter-strand side-chain interactions determines the degree of beta-sheet twist, which then leads to the different association patterns between different cross beta-units and thus distinct fibril morphologies
Down's syndrome and Alzheimer's disease: towards secondary prevention.
Impact
GeneRIF
Manji et al., Trenton, United States. In Nat Rev Drug Discov, 2012
[review] Based on the apparent common pathogenic role of amyloid precursor protein in both Down's syndrome and Alzheimer's disease (AD), the idea that the dementia associated with Down's syndrome is in fact AD is supported on many levels.
Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.
GeneRIF
Boehning et al., Galveston, United States. In Proc Natl Acad Sci U S A, 2012
These results reveal the mechanistic basis by which ubiquilin-1 regulates APP maturation.
Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment.
GeneRIF
Fändrich et al., Halle, Germany. In Proc Natl Acad Sci U S A, 2012
Molecular basis of beta-amyloid oligomer recognition with a conformational antibody fragment.
Neurologic and motor dysfunctions in APP transgenic mice.
Review
GeneRIF
Strazielle et al., Mont-Saint-Aignan, France. In Rev Neurosci, 2011
In APP transgenic mice models showed Neurologic and motor dysfunctions.
More papers using APP antibodies
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
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da Cruz e Silva Odete AB et al., In Molecular Neurodegeneration, 2007
... Primary monoclonal antibodies used were 22C11 (Chemicon) against the APP ectodomain, JL-8 (BD Biosciences) for detection of the ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
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Liu Jian-xun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... = 10), controlled for age (5 months, range 4–6), were separated into 4 groups: APP/PS1+tap water (transgenic group), ...
Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells
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Jutila Mark A. et al., In Genes and immunity, 2006
... For transcript stabilization studies, cells in X-VIVO were treated with APP (Apple PolyR, Littleton, CO, USA) at 54μg/mL, recombinant human TNFα (PeproTech, Rocky Hill, NJ, USA) at 50ng/mL, recombinant bovine TNFα (Thermo Scientific, Waltham, MA), PC1 (Phytolab, ...
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD
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Suzuki Toshiharu et al., In Molecular Neurodegeneration, 2005
... The APP-ibl transgenic mouse was generated ...
Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice
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Shen Yong et al., In The Journal of Cell Biology, 2004
... Generation of APP transgenic AD mice with deletion ...
Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent
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Li Feng et al., In Molecular therapy. Nucleic acids, 2003
... polyvinylidene fluoride membranes were incubated with antibody (BACE1 polyclonal antibody (1:1,000): AB5940; Millipore (Billerica, MA); APP monoclonal antibody (1:2,000): catalog number 1565-1; Epitomics (Burlingame, CA); β-actin monoclonal ...
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
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Morgan Dave et al., In Journal of Neuroinflammation, 2002
... For the 5-month treatment study, 13 APP-transgenic mice, aged 23 months, ...
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
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Grutzendler Jaime et al., In Scientific Reports, 2002
... Imaging Abeta plaques in living transgenic mice with multiphoton microscopy ...
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
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Chang N-S et al., In Cell Death & Disease, 1999
... Antibody against phospho-APP at Thr668 was from Cell Signaling Technology (Danvers, MA, USA) ...
Sunday Driver links axonal transport to damage signaling
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Goldstein Lawrence S.B. et al., In The Journal of Cell Biology, 1998
... Brady, University of Illinois, Chicago, IL), anti-DIC and anti-APP (Chemicon), anti-syntaxin13 (Synaptic Systems GmbH), anti-myelin basic protein ...
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
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Liebman Susan W. et al., In Disease Models & Mechanisms, 1998
... Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice ...
Coordinated transport of phosphorylated amyloid-β precursor protein and c-Jun NH2-terminal kinase–interacting protein-1
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Muresan Virgil et al., In The Journal of Cell Biology, 1998
... 22C11; CHEMICON International, Inc.); mouse anti–human amyloid-β protein (clones 4G8 and 6E10; Signet Laboratories); rabbit anti-APP (raised against a polypeptide from the cytoplasmic domain of APP; Cell Signaling Technology); mouse anti–human APP ...
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
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Finkelstein David I., In PLoS ONE, 1996
... The APP mice were heterozygous transgenic mice (C57B6/SJL, I.D ...
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