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Apoptosis-associated tyrosine kinase

apoptosis-associated tyrosine kinase, AATYK, lmr1, AATK
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: LMTK2, HAD, TH2, ACID, CAN
Papers on apoptosis-associated tyrosine kinase
A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia.
New
Momeni et al., London, United Kingdom. In Neurobiol Aging, Oct 2015
Suggestive alleles at 17q25.3 identified a disease-associated haplotype causing decreased expression of -cis genes such as RFNG and AATK involved in neuronal genesis and differentiation and axon outgrowth, respectively.
Tumor vessel up-regulation of INSR revealed by single-cell expression analysis of the tyrosine kinome and phosphatome in human cancers.
New
Sjöblom et al., Uppsala, Sweden. In Am J Pathol, Jun 2015
Further, pan-cancer expression of AATK, PTPRK, and PTPRU and expression of PTPRS in a subset of tumors were observed.
Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion.
New
Regazzi et al., Lausanne, Switzerland. In Mol Endocrinol, May 2015
miR-338-3p is generated from an intron of the gene coding for apoptosis-associated tyrosine kinase (AATK).
Transcriptomic Analysis of mRNAs in Human Monocytic Cells Expressing the HIV-1 Nef Protein and Their Exosomes.
Jameel et al., New Delhi, India. In Biomed Res Int, 2014
These are AATK, SLC27A1, and CDKAL and are important in apoptosis and fatty acid transport.
The apoptosis associated tyrosine kinase gene is frequently hypermethylated in human cancer and is regulated by epigenetic mechanisms.
Dammann et al., Gießen, Germany. In Genes Cancer, 2014
Here we identified the apoptosis associated tyrosine kinase (AATK) as an epigenetically downregulated tumor related gene.
Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma.
Rubin et al., Cleveland, United States. In Lab Invest, 2014
Apoptosis-associated tyrosine kinase 1 (AATK1) was initially identified as a protein that was dramatically overexpressed during growth arrest and apoptosis of 32Dcl myeloblastic leukemia cells.
LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner.
GeneRIF
Hisanaga et al., Tokyo, Japan. In J Neurosci, 2012
Overexpression of the unphosphorylated mutant LMTK1-S34A dramatically promotes axonal outgrowth in cultured neurons.
Developmental regulation of microRNA expression in Schwann cells.
Svaren et al., Madison, United States. In Mol Cell Biol, 2012
In vivo chromatin immunoprecipitation (ChIP) of sciatic nerve cells revealed a Sox10 binding site upstream of an alternate promoter within the Aatk gene, which hosts miR-338.
A potential regulatory role for intronic microRNA-338-3p for its host gene encoding apoptosis-associated tyrosine kinase.
Aschrafi et al., Nijmegen, Netherlands. In Plos One, 2011
In the present study, we monitored the dynamic gene expression changes of the intronic miR-338-3p and miR-338-5p and their host gene Apoptosis-associated Tyrosine Kinase (AATK) during the maturation of rat hippocampal neurons.
Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice.
Oosterhout et al., Groningen, Netherlands. In Am J Respir Cell Mol Biol, 2011
The lmr RC strains are derived from C57BL/6 and BALB/c intercrosses and carry congenic loci on chromosome 17 (lmr1) and 9 (lmr2) in both backgrounds.
Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA.
Ceman et al., Champaign, United States. In Hum Mol Genet, 2010
The model G-quadruplex RNA sc1 required arginines 533 and 538 for normal association with FMRP, whereas AATYK mRNA did not.
Apoptosis-associated tyrosine kinase and neuronal cell death.
Skaper et al., Harlow, United Kingdom. In Neurochem Res, 2010
Apoptosis-associated tyrosine kinase (AATYK) is up-regulated by phosphorylation in cultured cerebellar granule neurons (CGN) undergoing apoptosis upon switch to low KCl-containing medium.
A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians.
Koizumi et al., In Environ Health Prev Med, 2010
Three genes, CARD14, Raptor, and AATK, were selected based on key words, namely, "inflammation", "apoptosis", "proliferation", and "vascular system", for further sequencing.
Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.
GeneRIF
Hisanaga et al., Hachiōji, Japan. In Plos One, 2009
results suggest a possibility that AATYK1A plays a role in early to recycling endosomes and its function is regulated by phosphorylation with Cdk5 or Src-family kinases
Effect of tobacco compounds on gene expression profiles in human epithelial cells.
Kim et al., Seoul, South Korea. In Environ Toxicol Pharmacol, 2009
By microarray, we found that apoptosis-related genes such as apoptosis-associated tyrosine kinase, interleukin 10 receptor beta, caspase 1 and DNA fragmentation factor beta subunit (40kDa) were down-regulated in TC-treated A549 cells.
Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family.
GeneRIF
Kamiguchi et al., Wako, Japan. In Neuroscience, 2007
This paper deals with the mouse ortholog.
Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation.
GeneRIF
Delpire et al., United States. In Am J Physiol Cell Physiol, 2007
AATYK1 indirectly inhibits the SPAK/WNK4 activation of the Na-K-2Cl cotransporter by scaffolding an inhibitory phosphatase in proximity to a stimulatory kinase.
Apoptosis-associated tyrosine kinase (AATYK) has differential Ca2+-dependent phosphorylation states in response to survival and apoptotic conditions in cerebellar granule cells.
GeneRIF
Furuichi et al., Wako, Japan. In J Biol Chem, 2005
phosphorylation states of AATYK are closely related to the high potassium-induced survival and low potassium-induced apoptosis of cerebellar granule cells
Horizontal transfer in the phytopathogenic fungal genus Leptosphaeria and host-range expansion.
Review
Morales et al., Saskatoon, Canada. In Trends Microbiol, 1995
All isolates examined of the phytopathogenic fungus Leptosphaeria maculans that are aggressive to Brassica napus and Brassica rapa have a repetitive element, LMR1.
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