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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Apoptosis inducing factor

Apoptosis Inducing Factor, DmAIF
Top mentioned proteins: PrP, caspase-3, Bax, bcl-2, V1a
Papers on Apoptosis Inducing Factor
Central and peripheral defects in motor units of the diaphragm of spinal muscular atrophy mice.
New
Schümperli et al., Bern, Switzerland. In Mol Cell Neurosci, Jan 2016
These are apoptosis inducing factor 1 (AIFM1), a mitochondrial flavoprotein that initiates apoptosis in a caspase-independent pathway, and four and a half Lim domain protein 1 (FHL1), a regulator of skeletal muscle mass that has been implicated in several myopathies.
Obesity and hyperglycemia lead to impaired post-ischemic recovery after permanent ischemia in mice.
New
Shah et al., Toledo, United States. In Obesity (silver Spring), Jan 2016
Translocation of apoptosis inducing factor (AIF) to the nucleus was observed in both the O/H and control groups, but O/H mice showed a higher expression of AIF in the nucleus.
Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.
New
St Clair et al., Lexington, United States. In Free Radic Biol Med, Jan 2016
Here, we demonstrate that 4-hydroxy-2-nonenal (HNE) activates the translocation of the mitochondrial apoptosis inducing factor (AIFm2) and facilitates apoptosis in heart tissue of mice and humans.
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
New
Zhen et al., Dalian, China. In Chem Biol Interact, Jan 2016
Western blot assay showed that endonuclease G and apoptosis inducing factor might be relative to the apoptosis.
Activation of mitochondrial calpain and increased cardiac injury: Beyond AIF release.
New
Chen et al., Virginia, South Africa. In Am J Physiol Heart Circ Physiol, Jan 2016
Activation of mit-CPN1 within the intermembrane space increases cardiac injury by releasing apoptosis inducing factor (AIF) from mitochondria during ischemia-reperfusion (IR).
Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer.
New
Wu et al., Hong Kong, Hong Kong. In Phytomedicine, Dec 2015
The apoptosis induced by DHTS was suppressed by knockdown of apoptosis inducing factor (AIF), inhibition of caspase-3/9 but was increased after knockdown of caspase-2.
Heart mitochondria and calpain 1: Location, function, and targets.
Review
New
Lesnefsky et al., Richmond, United States. In Biochim Biophys Acta, Nov 2015
Activation of the mit-CPN1 within intermembrane space cleaves apoptosis inducing factor (AIF), whereas the activated mit-CPN1 within matrix cleaves complex I subunits and metabolic enzymes.
Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats.
New
Kim et al., Ch'unch'ŏn, South Korea. In Neuroscience, Nov 2015
In the molecular layer of the dentate gyrus, PDI-positive astrocytes showed TUNEL signal, nuclear apoptosis inducing factor translocation and pPERK/peIF2A/CHOP immunoreactivities.
Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes.
New
Hersey et al., Sydney, Australia. In Oncotarget, Oct 2015
The latter was caspase independent and mediated by the release of apoptosis inducing factor (AIFM1) from mitochondria.
Calcium and mitochondria in the regulation of cell death.
Review
New
Zhivotovsky et al., Stockholm, Sweden. In Biochem Biophys Res Commun, May 2015
Subsequent characterization of the signaling pathways in apoptosis revealed that Ca(2+)/calpain was critically involved in the processing of the mitochondrially localized, Apoptosis Inducing Factor.
Modulation of the PI3K/Akt Pathway and Bcl-2 Family Proteins Involved in Chicken's Tubular Apoptosis Induced by Nickel Chloride (NiCl₂).
Deng et al., China. In Int J Mol Sci, 2014
We found that dietary NiCl₂ in excess of 300 mg/kg resulted in a significant increase in apoptosis, which was associated with decrease in MMP, and increase in apoptosis inducing factor (AIF) and endonuclease G (EndoG) protein and mRNA expression.
Poly (ADP-ribose) in the pathogenesis of Parkinson's disease.
Review
Shin et al., Baltimore, United States. In Bmb Rep, 2014
Parthanatos is a programmed necrotic cell death, characterized by PARP1 activation, apoptosis inducing factor (AIF) nuclear translocation, and large scale DNA fragmentation.
Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats.
Review
Adhihetty et al., Gainesville, United States. In Biogerontology, 2013
However, relative mitochondrial content was not reduced with age and this was consistent with the lack of change in the mitochondrial biogenesis regulator protein, peroxisome proliferator-activated receptor gamma coactivator 1-alpha and its downstream targets nuclear respiratory factor-1 and mitochondrial transcription factor A. No effect was observed in the pro- or anti-apoptotic proteins, Bax and Bcl-2, respectively, but age increased apoptosis inducing factor levels.
Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.
Review
Boothman et al., Dallas, United States. In Crit Rev Eukaryot Gene Expr, 2013
The hyperactivation of PARP has also been shown to result in a specific programmed cell death pathway involving NAD+/ATP depletion, mu-calpain activation, loss of mitochondrial membrane potential, and the release of apoptosis inducing factor.
The molecular archaeology of a mitochondrial death effector: AIF in Drosophila.
GeneRIF
Penninger et al., Vienna, Austria. In Cell Death Differ, 2008
Drosophila Apoptosis-inducing factor (AIF) is a mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function.
Heat-shock protein 70 antagonizes apoptosis-inducing factor.
Impact
Kroemer et al., Villejuif, France. In Nat Cell Biol, 2001
We investigated the effect of Hsp70 on apoptosis mediated by the caspase-independent death effector apoptosis inducing factor (AIF), which is a mitochondrial intermembrane flavoprotein [3,4].
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