Hypertension-attributed nephropathy: what's in a name?
Winston-Salem, United States. In Nat Rev Nephrol, Jan 2016
Although nephropathies that are associated with variants in the apolipoprotein L1 gene (APOL1) often cause secondarily elevated blood pressure, they belong to the spectrum of focal segmental glomerulosclerosis and are not initiated by systemic hypertension.
KIDNEY DISEASE GENETICS AND THE IMPORTANCE OF DIVERSITY IN PRECISION MEDICINE.
Cleveland, United States. In Pac Symp Biocomput, Dec 2015
Common genetic variants in the myosin, heavy chain 9, non-muscle (MYH9) gene were initially identified as associated with non-diabetic end-stage renal disease in African Americans, and it is now understood that these variants are in strong linkage disequilibrium with likely causal variants in neighboring APOL1.
APOL1 Kidney Disease Risk Variants: An Evolving Landscape.
Bethesda, United States. In Semin Nephrol, May 2015
Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of chronic and end-stage kidney disease, which results in a significant global health disparity for persons of African ancestry.
Human apolipoprotein L1 (ApoL1) in cancer and chronic kidney disease.
Albuquerque, United States. In Febs Lett, 2012
discussion of role of ApoL1 in renal cell carcinoma and chronic kidney disease: Intracellularly, elevated ApoL1 can induce autophagy and autophagy-associated cell death, which may be critical in maintenance of cellular homeostasis in kidney. [REVIEW]