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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Apolipoprotein L, 1

apolipoprotein L-I, apoL-I, apoL, APOL1, apolipoprotein L1
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, MHA, HDL
Papers on apolipoprotein L-I
Analytical Validation of a Personalized Medicine APOL1 Genotyping Assay for Nondiabetic Chronic Kidney Disease Risk Assessment.
New
Scott et al., New York City, United States. In J Mol Diagn, Feb 2016
Notably, two APOL1 alleles, termed G1 [c.(1072A>G; 1200T>G)] and G2 (c.1212_1217del6), are strongly associated with higher rates of nondiabetic CKD and an increased risk for hypertensive end-stage renal disease.
Hypertension-attributed nephropathy: what's in a name?
Review
New
Cohen et al., Winston-Salem, United States. In Nat Rev Nephrol, Jan 2016
Although nephropathies that are associated with variants in the apolipoprotein L1 gene (APOL1) often cause secondarily elevated blood pressure, they belong to the spectrum of focal segmental glomerulosclerosis and are not initiated by systemic hypertension.
Determining the effects and challenges of incorporating genetic testing into primary care management of hypertensive patients with African ancestry.
New
Bottinger et al., New York City, United States. In Contemp Clin Trials, Jan 2016
Two variants in the APOL1 gene are now thought to account for much of the racial disparity associated with hypertensive kidney failure in Blacks.
APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.
New
Pollak et al., Boston, United States. In Proc Natl Acad Sci U S A, Jan 2016
UNASSIGNED: Two specific genetic variants of the apolipoprotein L1 (APOL1) gene are responsible for the high rate of kidney disease in people of recent African ancestry.
Association of APOL1 Genotype with Renal Histology among Black HIV-Positive Patients Undergoing Kidney Biopsy.
New
Fine et al., Haifa, Israel. In Clin J Am Soc Nephrol, Jan 2016
BACKGROUND AND OBJECTIVES: Prior studies have shown that the APOL1 risk alleles are associated with a greater risk of HIV-associated nephropathy and FSGS among blacks who are HIV positive.
KIDNEY DISEASE GENETICS AND THE IMPORTANCE OF DIVERSITY IN PRECISION MEDICINE.
New
Crawford et al., Cleveland, United States. In Pac Symp Biocomput, Dec 2015
Common genetic variants in the myosin, heavy chain 9, non-muscle (MYH9) gene were initially identified as associated with non-diabetic end-stage renal disease in African Americans, and it is now understood that these variants are in strong linkage disequilibrium with likely causal variants in neighboring APOL1.
African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era.
Review
New
Naicker et al., Johannesburg, South Africa. In World J Nephrol, Jun 2015
The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1 risk haplotype in individuals of African ancestry.
APOL1 Kidney Disease Risk Variants: An Evolving Landscape.
Review
New
Kopp et al., Bethesda, United States. In Semin Nephrol, May 2015
Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of chronic and end-stage kidney disease, which results in a significant global health disparity for persons of African ancestry.
Opportunities and Challenges of Genotyping Patients With Nephrotic Syndrome in the Genomic Era.
Review
New
Pollak et al., Boston, United States. In Semin Nephrol, May 2015
Here, we summarize our understanding of NS-associated genetic factors, namely rare causal mutations or common risk alleles in apolipoprotein L1.
Apolipoprotein L1 (APOL1) Variants (Vs) a possible link between Heroin-associated Nephropathy (HAN) and HIV-associated Nephropathy (HIVAN).
Review
Singhal et al., Long Beach, United States. In Front Microbiol, 2014
Recent studies in AAs have identified APOL1 variants (Vs) as a major risk factor for the development and progression of non-diabetic kidney diseases including idiopathic FSGS and hypertension-attributed nephrosclerosis.
APOL1 risk variants, race, and progression of chronic kidney disease.
Impact
CRIC Study Investigators et al., Aş Şanamayn, Syria. In N Engl J Med, 2014
METHODS: In two studies, we examined the effects of variants in the gene encoding apolipoprotein L1 (APOL1) on the progression of chronic kidney disease.
Mechanism of Trypanosoma brucei gambiense resistance to human serum.
Impact
Pays et al., Brussels, Belgium. In Nature, 2013
Human immunity to some African trypanosomes is due to two serum complexes designated trypanolytic factors (TLF-1 and -2), which both contain haptoglobin-related protein (HPR) and apolipoprotein LI (APOL1).
Association study of apolipoprotein L-I Lys166Glu and Ile244Met gene variants with obesity in Chinese subjects.
GeneRIF
Bai et al., Chengdu, China. In Genet Test Mol Biomarkers, 2012
The current study has provided evidence that genetic variations of polymorphic sites in apoL-I gene might affect plasma TG variability in nonobese Chinese subjects, but are not associated with obesity in the population.
Human apolipoprotein L1 (ApoL1) in cancer and chronic kidney disease.
Review
GeneRIF
Ray et al., Albuquerque, United States. In Febs Lett, 2012
discussion of role of ApoL1 in renal cell carcinoma and chronic kidney disease: Intracellularly, elevated ApoL1 can induce autophagy and autophagy-associated cell death, which may be critical in maintenance of cellular homeostasis in kidney. [REVIEW]
APOL1 allelic variants are associated with lower age of dialysis initiation and thereby increased dialysis vintage in African and Hispanic Americans with non-diabetic end-stage kidney disease.
GeneRIF
Wasser et al., Haifa, Israel. In Nephrol Dial Transplant, 2012
APOL1 allelic variants are associated with lower age of dialysis initiation and thereby increased dialysis vintage in African and Hispanic Americans with non-diabetic end-stage kidney disease.
Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy.
GeneRIF
Family Investigation of Nephropathy and Diabetes (FIND) Research Group et al., Winston-Salem, United States. In Am J Kidney Dis, 2012
A genome-wide association study provides additional and independent evidence that APOL1 variants contribute to nondiabetic nephropathy in African Americans.
APOL1 risk variants predict histopathology and progression to ESRD in HIV-related kidney disease.
GeneRIF
Skorecki et al., Baltimore, United States. In J Am Soc Nephrol, 2012
an association between APOL1 variants and renal outcomes in non-HIVAN kidney disease, suggesting a possible use for APOL1 genotyping to help guide the care of HIV-infected patients.
Association of trypanolytic ApoL1 variants with kidney disease in African Americans.
Impact
GeneRIF
Pollak et al., Boston, United States. In Science, 2010
in African Americans, focal segmental glomerulosclerosis and hypertension-attributed end-stage kidney disease are associated with 2 independent sequence variants in APOL1 gene; only kidney disease-associated ApoL1 variants lysed Trypanosoma rhodesiense
A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans.
Impact
Pays et al., Brussels, Belgium. In Science, 2008
The protozoan parasite Trypanosoma brucei is lysed by apolipoprotein L-I, a component of human high-density lipoprotein (HDL) particles that are also characterized by the presence of haptoglobin-related protein.
Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I.
Impact
Pays et al., Brussels, Belgium. In N Engl J Med, 2007
Humans have innate immunity against Trypanosoma brucei brucei that is known to involve apolipoprotein L-I (APOL1).
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