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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Aug 2015.

Apolipoprotein Ea

apolipoprotein E
Top mentioned proteins: apolipoprotein E, AGE, HAD, CAN, V1a
Papers on apolipoprotein E
Apolipoprotein E-ε4 deficiency and cognitive function in hepatitis C virus-infected patients.
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Weissenborn et al., Hannover, Germany. In J Viral Hepat, 26 Sep 2015
Previous studies have shown that the type 4 allele of the gene for apolipoprotein E (APOE) is strongly protective against HCV-induced damage in liver.
Preparation, characterization and in vitro-targeted delivery of novel Apolipoprotein E-based nanoparticles to C6 glioma with controlled size and loading efficiency.
New
Kazemi et al., Tehrān, Iran. In J Drug Target, 25 Sep 2015
UNASSIGNED: Apolipoprotein E (APOE) with its extraordinary features is readily assembled with hydrophobic compounds via its compact hydrophobic units (CHUs).
Cortisol, HDL-c, VLDL-c, and APOE Polymorphisms as Laboratorial Parameters Associated to Cognitive Impairment No Dementia (CIND) and Dementia.
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Gomes et al., Belo Horizonte, Brazil. In J Clin Lab Anal, 24 Sep 2015
The aim of this case-control study was to evaluate the laboratorial parameters lipid profile, cortisol, and apolipoprotein E (APOE) gene genotype, comparing cognitively healthy controls and subjects with cognitive impairment no dementia (CIND) and dementia in a group of elderly people.
Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences.
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CitAD Research Group et al., Baltimore, United States. In J Geriatr Psychiatry Neurol, 23 Sep 2015
Six functional genetic variants were studied in the following genes: serotonin receptor 2A (HTR2A-T102C), serotonin receptor 2C (HTR2C-Cys23Ser), serotonin transporter (5HTT-LPR), brain-derived neurotropic factor (BDNF-Val66Met), apolipoprotein E (ε2, ε3, ε4 variants), and cytochrome P450 (CYP2C19).
Estrogen receptor β in Alzheimer's disease: from mechanisms to therapeutics.
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Chhibber et al., Lawrence, United States. In Ageing Res Rev, 22 Sep 2015
Future studies that explore the potential interactions between ERβ signaling and the genetic isoforms of human apolipoprotein E (APOE) in brain aging and development of AD-risk phenotype are critically needed.
Association between apolipoprotein E gene polymorphism and depression.
Review
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Sun et al., Hefei, China. In J Clin Neurosci, 31 Aug 2015
We performed an updated meta-analysis to obtain a more precise estimation of the relationship between apolipoprotein E (ApoE) gene polymorphism and susceptibility to depression, as previous reports have been inconsistent.
Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.
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Impact
Shi et al., Boston, United States. In Nat Med, 31 Jul 2015
Here, we show that absence of the IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice, nor does it affect IL18 cell surface binding to or signaling in endothelial cells.
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
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Impact
Zetterberg et al., Maastricht, Netherlands. In Jama, Jun 2015
MAIN OUTCOMES AND MEASURES: Prevalence of amyloid pathology on positron emission tomography or in cerebrospinal fluid according to AD risk factors (age, apolipoprotein E [APOE] genotype, sex, and education) estimated by generalized estimating equations.
Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
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Impact
Brooks et al., Maastricht, Netherlands. In Jama, Jun 2015
MAIN OUTCOMES AND MEASURES: Estimated prevalence of positive amyloid PET scans according to diagnosis, age, and apolipoprotein E (APOE) ε4 status, using the generalized estimating equations method.
Additional mechanisms conferring genetic susceptibility to Alzheimer's disease.
Review
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Medina et al., Madrid, Spain. In Front Cell Neurosci, Dec 2014
Besides apolipoprotein E, that presents a strong association with the disease (OR∼4), the rest of these genes have moderate or low degrees of association, with OR ranging from 0.88 to 1.23.
The role of APOE-ɛ4 and beta amyloid in the differential rate of recovery from ECT: a review.
Review
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Martins et al., Australia. In Transl Psychiatry, Dec 2014
A narrative review of the research literature on carriage of the apolipoprotein E ɛ4 allele (APOE-ɛ4) and the protein biomarker beta amyloid (Aβ) with ECT cognitive outcome was undertaken.
Role of apolipoprotein E in neurodegenerative diseases.
Review
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Kim et al., South Korea. In Neuropsychiatr Dis Treat, Dec 2014
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system.
Cholesterol and metal ions in Alzheimer's disease.
Review
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Impact
Lim et al., Ann Arbor, United States. In Chem Soc Rev, Nov 2014
For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-β (Aβ) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation.
Apolipoprotein E in Alzheimer's disease: an update.
Review
Impact
Hardy et al., Qingdao, China. In Annu Rev Neurosci, 2013
Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for LOAD.
Review
Lau et al., Rockville, United States. In Unknown Journal, 0001
OBJECTIVE: We assessed four pharmacogenetic tests: 1) cytochrome P450, subfamily IIC, polypeptide 9 (CYP2C9), 2) vitamin K epoxide reductase subunit protein 1 (VKORC1), 3) apolipoprotein E (Apo E), and 4) methylenetetrahydrofolate reductase (MTHFR) for their associations with patient’s response to therapy with warfarin (CYP2C9 and VKORC1), statins (Apo E), or antifolate chemotherapy (MTHFR).
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