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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Oct 2014.

Apolipoprotein Ea

apolipoprotein E
Top mentioned proteins: apolipoprotein E, AGE, HAD, CAN, V1a
Papers on apolipoprotein E
Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice.
New
Calon et al., Québec, Canada. In J Cereb Blood Flow Metab, 22 Nov 2014
UNLABELLED: Human apolipoprotein E (APOE) exists in three isoforms ɛ2, ɛ3, and ɛ4, of which APOE4 is the main genetic risk factor of Alzheimer's disease (AD).
Opposite Neural Trajectories of Apolipoprotein E ϵ4 and ϵ2 Alleles with Aging Associated with Different Risks of Alzheimer's Disease.
New
Zhang et al., Milwaukee, United States. In Cereb Cortex, 21 Nov 2014
UNLABELLED: The apolipoprotein E (APOE) ϵ4 allele is a confirmed genetic risk factor and the APOE ϵ2 allele is a protective factor related to late-onset Alzheimer's disease (AD).
Cholesterol and metal ions in Alzheimer's disease.
New
Impact
Lim et al., Ann Arbor, United States. In Chem Soc Rev, 07 Nov 2014
For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-β (Aβ) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation.
[Hyperlipidemia inhibited inflammatory response to Porphyromonas gingivalis in apolipoprotein E knockout mice].
New
Yan et al., Fuzhou, China. In Shanghai Kou Qiang Yi Xue, Aug 2014
gingivalis) in apolipoprotein E knock out(ApoE-/-) mice.
[Role of apolipoprotein E in the molecular pathomechanism of Alzheimer disease].
Review
New
Michikawa, In Nihon Shinkei Seishin Yakurigaku Zasshi, Feb 2014
Apolipoprotein E (Apo-E) is a major cholesterol carrier regulating lipid transport and injury repair in the brain.
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
New
Impact
Bapineuzumab 301 and 302 Clinical Trial Investigators et al., Jarash, Jordan. In N Engl J Med, Feb 2014
METHODS: We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate Alzheimer's disease--one involving 1121 carriers of the apolipoprotein E (APOE) ε4 allele and the other involving 1331 noncarriers.
Apolipoprotein E in Alzheimer's disease: an update.
New
Impact
Hardy et al., Qingdao, China. In Annu Rev Neurosci, Dec 2013
Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for LOAD.
[Clinical and prognostic significance of genetic markers in craniocerebral injury (Part III)].
Review
New
Potapov et al., In Vopr Neirokhir, Dec 2013
The first part of the review by Potapov et al. (201 0) [2] was devoted to the role of apolipoprotein E (apoE) gene polymorphism in CCI, the second one [3]- to the role of inflammation and immune response genes in the course and outcome of CCI.
Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus.
Review
New
Itzhaki, Manchester, United Kingdom. In Front Aging Neurosci, Dec 2013
Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer's disease (AD).
The potential applications of Apolipoprotein E in personalized medicine.
Review
New
Gaudet et al., Montréal, Canada. In Front Aging Neurosci, Dec 2013
Personalized medicine uses various individual characteristics to guide medical decisions.
Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease?
Review
New
Plourde et al., Sherbrooke, Canada. In Nutrients, Dec 2013
UNLABELLED: Apolipoprotein E (ApoE) is a protein playing a pivotal role in lipid homeostasis since it regulates cholesterol, triglyceride and phospholipid metabolism in the blood and the brain.
Fyn Tyrosine Kinase Increases Apolipoprotein E Receptor 2 Levels and Phosphorylation.
New
Rebeck et al., Tampa, United States. In Plos One, Dec 2013
UNLABELLED: Apolipoprotein E Receptor 2 (ApoER2) and the tyrosine kinase Fyn are both members of the Reelin pathway, a signaling pathway essential for the laminar formation of the cortex during development and proper dendritic spine density and long-term potential (LTP) in the adult brain.
Two Alzheimer's disease risk genes increase entorhinal cortex volume in young adults.
New
Green et al., Washington, D.C., United States. In Front Hum Neurosci, Dec 2013
Apolipoprotein E (APOE) is the strongest known genetic risk factor for AD, and a related gene, apolipoprotein J (APOJ), also affects disease risk.
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
New
Impact
Amouyel et al., In Nat Genet, Dec 2013
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease.
New
Impact
Abeliovich et al., New York City, United States. In Nature, Sep 2013
Late-onset Alzheimer's disease (LOAD) risk is strongly influenced by genetic factors such as the presence of the apolipoprotein E ε4 allele (referred to here as APOE4), as well as non-genetic determinants including ageing.
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