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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Aug 2015.

Apolipoprotein Ea

apolipoprotein E
Top mentioned proteins: apolipoprotein E, AGE, HAD, CAN, V1a
Papers on apolipoprotein E
Scavenger Receptor Class B Type I Regulates Plasma Apolipoprotein E levels and Dietary Lipid Deposition to the Liver.
New
Kypreos et al., In Biochemistry, 27 Sep 2015
Analysis of apolipoprotein composition of plasma lipoproteins revealed a significant accumulation of apolipoprotein E (ApoE)-containing HDL and TG-rich lipoproteins in scarb1(-/-) mice that correlated with a reduced plasma LpL activity.
The genetic landscape of Alzheimer disease: clinical implications and perspectives.
New
Sleegers et al., Antwerp, Belgium. In Genet Med, 27 Sep 2015
It started from the discovery of fully penetrant mutations in Amyloid precursor protein, Presenilin 1, and Presenilin 2 as a cause of autosomal dominant AD, the identification of the ɛ4 allele of Apolipoprotein E as a strong genetic risk factor for both early-onset and late-onset AD, and evolved to the more recent detection of at least 21 additional genetic risk loci for the genetically complex form of AD emerging from genome-wide association studies and massive parallel resequencing efforts.
Apolipoprotein E-ε4 deficiency and cognitive function in hepatitis C virus-infected patients.
New
Weissenborn et al., Hannover, Germany. In J Viral Hepat, 26 Sep 2015
Previous studies have shown that the type 4 allele of the gene for apolipoprotein E (APOE) is strongly protective against HCV-induced damage in liver.
Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.
New
Koldamova et al., Pittsburgh, United States. In J Neurosci, 26 Sep 2015
UNASSIGNED: Bexarotene-activated retinoid X receptors (RXRs) ameliorate memory deficits in Alzheimer's disease mouse models, including mice expressing human apolipoprotein E (APOE) isoforms.
Estrogen receptor β in Alzheimer's disease: from mechanisms to therapeutics.
New
Chhibber et al., Lawrence, United States. In Ageing Res Rev, 22 Sep 2015
Future studies that explore the potential interactions between ERβ signaling and the genetic isoforms of human apolipoprotein E (APOE) in brain aging and development of AD-risk phenotype are critically needed.
Association between apolipoprotein E gene polymorphism and depression.
Review
New
Sun et al., Hefei, China. In J Clin Neurosci, 31 Aug 2015
We performed an updated meta-analysis to obtain a more precise estimation of the relationship between apolipoprotein E (ApoE) gene polymorphism and susceptibility to depression, as previous reports have been inconsistent.
Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.
New
Impact
Shi et al., Boston, United States. In Nat Med, 31 Jul 2015
Here, we show that absence of the IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice, nor does it affect IL18 cell surface binding to or signaling in endothelial cells.
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
New
Impact
Zetterberg et al., Maastricht, Netherlands. In Jama, Jun 2015
MAIN OUTCOMES AND MEASURES: Prevalence of amyloid pathology on positron emission tomography or in cerebrospinal fluid according to AD risk factors (age, apolipoprotein E [APOE] genotype, sex, and education) estimated by generalized estimating equations.
Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
New
Impact
Brooks et al., Maastricht, Netherlands. In Jama, Jun 2015
MAIN OUTCOMES AND MEASURES: Estimated prevalence of positive amyloid PET scans according to diagnosis, age, and apolipoprotein E (APOE) ε4 status, using the generalized estimating equations method.
Additional mechanisms conferring genetic susceptibility to Alzheimer's disease.
Review
New
Medina et al., Madrid, Spain. In Front Cell Neurosci, Dec 2014
Besides apolipoprotein E, that presents a strong association with the disease (OR∼4), the rest of these genes have moderate or low degrees of association, with OR ranging from 0.88 to 1.23.
The role of APOE-ɛ4 and beta amyloid in the differential rate of recovery from ECT: a review.
Review
New
Martins et al., Australia. In Transl Psychiatry, Dec 2014
A narrative review of the research literature on carriage of the apolipoprotein E ɛ4 allele (APOE-ɛ4) and the protein biomarker beta amyloid (Aβ) with ECT cognitive outcome was undertaken.
Role of apolipoprotein E in neurodegenerative diseases.
Review
New
Kim et al., South Korea. In Neuropsychiatr Dis Treat, Dec 2014
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system.
Cholesterol and metal ions in Alzheimer's disease.
Review
New
Impact
Lim et al., Ann Arbor, United States. In Chem Soc Rev, Nov 2014
For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-β (Aβ) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation.
Apolipoprotein E in Alzheimer's disease: an update.
Review
Impact
Hardy et al., Qingdao, China. In Annu Rev Neurosci, 2013
Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for LOAD.
Review
Lau et al., Rockville, United States. In Unknown Journal, 0001
OBJECTIVE: We assessed four pharmacogenetic tests: 1) cytochrome P450, subfamily IIC, polypeptide 9 (CYP2C9), 2) vitamin K epoxide reductase subunit protein 1 (VKORC1), 3) apolipoprotein E (Apo E), and 4) methylenetetrahydrofolate reductase (MTHFR) for their associations with patient’s response to therapy with warfarin (CYP2C9 and VKORC1), statins (Apo E), or antifolate chemotherapy (MTHFR).
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