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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Apolipoprotein Ea

apolipoprotein E
Top mentioned proteins: apolipoprotein E, AGE, HAD, CAN, V1a
Papers on apolipoprotein E
Brain metabolite clearance: impact on Alzheimer's disease.
New
Inestrosa et al., Arica, Chile. In Metab Brain Dis, 30 Sep 2014
Moreover, these authors demonstrated that bexarotene, a retinoid X receptor (RXR) agonist, exerts major effects on Aβ levels, mainly through increased apolipoprotein E (ApoE) expression.
Coenzyme Q10 Promotes Macrophage Cholesterol Efflux by Regulation of the Activator Protein-1/miR-378/ATP-Binding Cassette Transporter G1-Signaling Pathway.
New
Ling et al., Guangzhou, China. In Arterioscler Thromb Vasc Biol, 30 Sep 2014
Subsequently, the axis of activator protein-1/miR-378/ATP-binding cassette transporter G1 cholesterol efflux was confirmed in peritoneal macrophages isolated from CoQ10-treated apolipoprotein E-deficient mice.
Increased sensitivity of Apolipoprotein E knockout mice to swainsonine dependent immunomodulation.
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Patel et al., Birmingham, United States. In Immunobiology, Jul 2014
The mechanisms that mediate accelerated atherosclerosis in autoimmune diseases remain unclear.
Long-term cognitive correlates of traumatic brain injury across adulthood and interactions with APOE genotype, sex, and age cohorts.
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Anstey et al., Australia. In J Int Neuropsychol Soc, Apr 2014
We examined a range of traumatic brain injury (TBI) variables (TBI history, severity, frequency, and age of injury) as predictors of cognitive outcome over 8 years in an adult population, and interactions with apolipoprotein E (APOE) genotype, sex, and age cohorts.
ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?
Review
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Bu et al., Jacksonville, United States. In Neuron, Mar 2014
Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD).
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
New
Impact
Bapineuzumab 301 and 302 Clinical Trial Investigators et al., Jarash, Jordan. In N Engl J Med, Feb 2014
METHODS: We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate Alzheimer's disease--one involving 1121 carriers of the apolipoprotein E (APOE) ε4 allele and the other involving 1331 noncarriers.
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
New
Impact
Amouyel et al., In Nat Genet, Dec 2013
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease.
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Rebeck et al., Washington, D.C., United States. In Plos One, Dec 2013
Under normal conditions, brain apolipoprotein E (apoE) is secreted and lipidated by astrocytes, then taken up by neurons via receptor mediated endocytosis.
Mouse models of plaque rupture.
Review
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Egashira et al., Fukuoka, Japan. In Curr Opin Lipidol, Oct 2013
Atherosclerotic plaques in the brachiocephalic arteries of apolipoprotein E (ApoE)-deficient mice fed a high-fat diet demonstrate several key histological features of ruptured human plaques.
Sortilin, a novel APOE receptor implicated in Alzheimer disease.
Review
New
Carlo, Berlin, Germany. In Prion, Sep 2013
In the brain, apolipoprotein E (APOE) delivers cholesterol-rich lipoproteins to neurons to support synaptogenesis and maintenance of synaptic connections.
Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease.
New
Impact
Abeliovich et al., New York City, United States. In Nature, Sep 2013
Late-onset Alzheimer's disease (LOAD) risk is strongly influenced by genetic factors such as the presence of the apolipoprotein E ε4 allele (referred to here as APOE4), as well as non-genetic determinants including ageing.
Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis.
New
Impact
Cao et al., Jinan, China. In Cell Metab, Aug 2013
In two genetic mouse knockout models (apolipoprotein E(-/-) [ApoE(-/-)] and LDL receptor(-/-) [Ldlr(-/-)] mice), persistent cold exposure stimulated atherosclerotic plaque growth by increasing lipid deposition.
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
New
Impact
Alzheimer Disease Genetics Consortium et al., New York City, United States. In Jama, May 2013
IMPORTANCE: Genetic variants associated with susceptibility to late-onset Alzheimer disease are known for individuals of European ancestry, but whether the same or different variants account for the genetic risk of Alzheimer disease in African American individuals is unknown.
Salusins: potential use as a biomarker for atherosclerotic cardiovascular diseases.
Review
Watanabe et al., Hachiōji, Japan. In Int J Hypertens, 2012
Chronic salusin- β infusion into apolipoprotein E-deficient mice enhances atherosclerotic lesions; salusin- α infusion reduces lesions.
What causes alzheimer's disease?
Review
Armstrong, Birmingham, United Kingdom. In Folia Neuropathol, 2012
These include: (1) exacerbation of aging, (2) degeneration of anatomical pathways, including the cholinergic and cortico-cortical pathways, (3) an environmental factor such as exposure to aluminium, head injury, or malnutrition, (4) genetic factors including mutations of amyloid precursor protein (APP) and presenilin (PSEN) genes and allelic variation in apolipoprotein E (Apo E), (5) mitochondrial dysfunction, (6) a compromised blood brain barrier, (7) immune system dysfunction, and (8) infectious agents.
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