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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Nov 2014.

Apolipoprotein Ea

apolipoprotein E
Top mentioned proteins: apolipoprotein E, AGE, HAD, CAN, V1a
Papers on apolipoprotein E
Endogenous female sex hormones delay the development of renal dysfunction in apolipoprotein E-deficient mice.
New
Gava et al., In Lipids Health Dis, 25 Dec 2014
METHODS: Apolipoprotein E-deficient (ApoE) and C57 control female mice underwent an ovariectomy (OVX) or sham surgery and after 2 months, creatinine clearance, uremia and proteinuria were determined.
The distribution of Apolipoprotein E gene polymorphism and their influences in dyslipidemias in HIV-1 infections.
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Sukasem et al., In Jpn J Infect Dis, 25 Dec 2014
UNLABELLED: The purpose of this study was to investigate the frequency of ApoE (Apolipoprotein E) polymorphisms and their influence on antiretroviral therapy (ART) induced lipodystrophy/dyslipidemia in HIV-infected Thai patients.
Gal-geun-dang-gwi-tang improves diabetic vascular complication in apolipoprotein E KO mice fed a western diet.
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Lee et al., In Bmc Complement Altern Med, 22 Dec 2014
This study aimed to evaluate the effects of GGDGT in a diabetic atherosclerosis model using apolipoprotein E knockout (ApoE-/-) mice fed a Western diet.
Linking Genes to Neurological Clinical Practice: The Genomic Basis for Neurorehabilitation.
New
Kleim et al., Flint, United States. In J Neurol Phys Ther, 20 Dec 2014
Furthermore, such plasticity may be influenced in part by the presence of polymorphisms in several genes known to orchestrate neural plasticity including brain-derived neurotrophic factor (BDNF) and Apolipoprotein E. (APOE).
Refinement of Variant Selection for the LDL Cholesterol Genetic Risk Score in the Diagnosis of the Polygenic Form of Clinical Familial Hypercholesterolemia and Replication in Samples from 6 Countries.
New
Humphries et al., London, United Kingdom. In Clin Chem, 20 Dec 2014
Metaanalysis of the weighted 6-SNP score, on the basis of polymorphisms in CELSR2 (cadherin, EGF LAG 7-pass G-type receptor 2), APOB (apolipoprotein B), ABCG5/8 [ATP-binding cassette, sub-family G (WHITE), member 5/8], LDLR (low density lipoprotein receptor), and APOE (apolipoprotein E) loci, in the independent FH/M- cohorts showed a consistently higher score in comparison to the WHII population (P < 2.2 × 10(-16)).
Cholesterol and metal ions in Alzheimer's disease.
New
Impact
Lim et al., Ann Arbor, United States. In Chem Soc Rev, 07 Nov 2014
For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-β (Aβ) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation.
Post-Traumatic Brain Injury: Genetic Susceptibility to Outcome.
Review
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Bendena et al., Toronto, Canada. In Neuroscientist, Aug 2014
To provide health care workers with the basic information for clinical management we summarize and compare the data on post-TBI outcome with regard to the impact of genetic variation: apolipoprotein E (APOE), brain-derived neurotrophic factor (BDNF), calcium channel, voltage dependent P/Q type, catechol-O-methyltransferase (COMT), dopamine receptor D2 and ankyrin repeat and kinase domain containing 1 (DRD2 and ANKK1), interleukin-1 (IL-1), interleukin-6 (IL-6), kidney and brain expressed protein (KIBRA), neurofilament, heavy polypeptide (NEFH), endothelial nitric oxide synthase 3 (NOS3), poly (ADP-ribose) polymerase-1 (PARP-1), protein phosphatase 3, catalytic subunit, gamma isozyme (PPP3CC), the serotonin transporter (5-HTT) gene solute carrier family 6 member (SLC6A4) and tumor protein 53 (TP53).
[Role of apolipoprotein E in the molecular pathomechanism of Alzheimer disease].
Review
New
Michikawa, In Nihon Shinkei Seishin Yakurigaku Zasshi, Feb 2014
Apolipoprotein E (Apo-E) is a major cholesterol carrier regulating lipid transport and injury repair in the brain.
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
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Impact
Bapineuzumab 301 and 302 Clinical Trial Investigators et al., Jarash, Jordan. In N Engl J Med, Feb 2014
METHODS: We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate Alzheimer's disease--one involving 1121 carriers of the apolipoprotein E (APOE) ε4 allele and the other involving 1331 noncarriers.
Apolipoprotein E in Alzheimer's disease: an update.
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Impact
Hardy et al., Qingdao, China. In Annu Rev Neurosci, Dec 2013
Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for LOAD.
Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus.
Review
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Itzhaki, Manchester, United Kingdom. In Front Aging Neurosci, Dec 2013
Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer's disease (AD).
The potential applications of Apolipoprotein E in personalized medicine.
Review
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Gaudet et al., Montréal, Canada. In Front Aging Neurosci, Dec 2013
Personalized medicine uses various individual characteristics to guide medical decisions.
[Clinical and prognostic significance of genetic markers in craniocerebral injury (Part III)].
Review
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Potapov et al., In Vopr Neirokhir, Dec 2013
The first part of the review by Potapov et al. (201 0) [2] was devoted to the role of apolipoprotein E (apoE) gene polymorphism in CCI, the second one [3]- to the role of inflammation and immune response genes in the course and outcome of CCI.
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
New
Impact
Amouyel et al., In Nat Genet, Dec 2013
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease.
New
Impact
Abeliovich et al., New York City, United States. In Nature, Sep 2013
Late-onset Alzheimer's disease (LOAD) risk is strongly influenced by genetic factors such as the presence of the apolipoprotein E ε4 allele (referred to here as APOE4), as well as non-genetic determinants including ageing.
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