gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Apolipoprotein Ea

apolipoprotein E
Top mentioned proteins: apolipoprotein E, AGE, HAD, CAN, V1a
Papers on apolipoprotein E
CCL22/Macrophage-derived Chemokine Expression in Apolipoprotein E-deficient Mice and Effects of Histamine in the Setting of Atherosclerosis.
New
Sasaguri et al., In J Atheroscler Thromb, 10 Jan 2015
In this study, we investigated the effects of CCL22 and the role of histamine in mouse monocytes with respect to atherosclerosis.Methods and Results: The expression of CCL22 was investigated in apolipoprotein E (apoE)-deficient mice.
Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population.
New
Arai et al., Tokyo, Japan. In Int J Geriatr Psychiatry, 09 Jan 2015
METHODS: The aim of this case-control study (398 cases and 149 controls) was to investigate whether Val158Met polymorphism influences the onset of AD stratified according to alcohol consumption and apolipoprotein E (APOE) status.
Activation of an Innate Immune Receptor, Nod1, Accelerates Atherogenesis in Apoe-/- Mice.
New
Hara et al., Fukuoka, Japan. In J Immunol, 08 Jan 2015
To investigate a potential role of NOD1 in atherogenesis, we orally administered FK565 to apolipoprotein E knockout (Apoe(-/-)) mice for 4 wk intermittently and performed quantification of atherosclerotic lesions in aortic roots and aortas, immunohistochemical analyses, and microarray-based gene expression profiling of aortic roots.
The genetic variants underlying breast cancer treatment-induced chronic and late toxicities: A systematic review.
Review
New
Chan et al., Singapore, Singapore. In Cancer Treat Rev, 31 Dec 2014
Two studies found a positive association between cognitive impairment and the Val allele of the COMT gene and the ε4 allele of the apolipoprotein E gene.
Periodontal disease associates with higher brain amyloid load in normal elderly.
New
de Leon et al., New York City, United States. In Neurobiol Aging, 05 Dec 2014
Linear regression models (adjusted for age, apolipoprotein E, and smoking) were used to test the hypothesis that periodontal disease assessed by clinical attachment loss was associated with brain Aβ load using (11)C-Pittsburgh compound B (PIB) positron emission tomography imaging.
Apolipoprotein E in Synaptic Plasticity and Alzheimer's Disease: Potential Cellular and Molecular Mechanisms.
Review
New
Kim et al., Jacksonville, United States. In Mol Cells, 30 Nov 2014
Among the established genetic risk factors for AD, the 4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor.
Cholesterol and metal ions in Alzheimer's disease.
New
Impact
Lim et al., Ann Arbor, United States. In Chem Soc Rev, 07 Nov 2014
For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-β (Aβ) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation.
Apolipoprotein E: Structure and Function in Lipid Metabolism, Neurobiology, and Alzheimer's Diseases.
Review
New
Mahley et al., San Francisco, United States. In Neurobiol Dis, Sep 2014
UNLABELLED: Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases.
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
New
Impact
Bapineuzumab 301 and 302 Clinical Trial Investigators et al., Jarash, Jordan. In N Engl J Med, Feb 2014
METHODS: We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate Alzheimer's disease--one involving 1121 carriers of the apolipoprotein E (APOE) ε4 allele and the other involving 1331 noncarriers.
Association between cell-bound blood amyloid-β(1-40) levels and hippocampus volume.
New
Sarasa et al., Barcelona, Spain. In Alzheimers Res Ther, Dec 2013
Pearson correlation analyses adjusted for the covariates age, sex, apolipoprotein E (ApoE), education and creatinine levels showed neuroimaging ROIs were associated with Aβ levels.
Apolipoprotein E in Alzheimer's disease: an update.
New
Impact
Hardy et al., Qingdao, China. In Annu Rev Neurosci, Dec 2013
Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for LOAD.
[Clinical and prognostic significance of genetic markers in craniocerebral injury (Part III)].
Review
New
Potapov et al., In Vopr Neirokhir, Dec 2013
The first part of the review by Potapov et al. (201 0) [2] was devoted to the role of apolipoprotein E (apoE) gene polymorphism in CCI, the second one [3]- to the role of inflammation and immune response genes in the course and outcome of CCI.
Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus.
Review
New
Itzhaki, Manchester, United Kingdom. In Front Aging Neurosci, Dec 2013
Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer's disease (AD).
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
New
Impact
Amouyel et al., In Nat Genet, Dec 2013
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease.
New
Impact
Abeliovich et al., New York City, United States. In Nature, Sep 2013
Late-onset Alzheimer's disease (LOAD) risk is strongly influenced by genetic factors such as the presence of the apolipoprotein E ε4 allele (referred to here as APOE4), as well as non-genetic determinants including ageing.
share on facebooktweetadd +1mail to friends