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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Apolipoprotein Ea

apolipoprotein E
Top mentioned proteins: apolipoprotein E, AGE, HAD, CAN, V1a
Papers on apolipoprotein E
Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk.
New
De Keulenaer et al., Antwerp, Belgium. In Am J Physiol Endocrinol Metab, Feb 2016
We tested this hypothesis in a hypercholesterolemic apolipoprotein E-deficient (ApoE-/-) type 1 diabetes mouse model, prone to the development of cardiomyopathy, atherosclerosis and nephropathy, and compared the effects of NRG-1 with insulin.
Notch1 Inhibition Reduces Low Shear Stress-Induced Plaque Formation.
New
Zhang et al., Jinan, China. In Int J Biochem Cell Biol, Feb 2016
Apolipoprotein E-deficient (ApoE(-/-)) mice were fed with high fat diet and administered intraperitoneally with DAPT (a γ-secretase inhibitor).
Genetics of psychosis of Alzheimer disease.
Review
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Sweet et al., Pittsburgh, United States. In Am J Med Genet B Neuropsychiatr Genet, Feb 2016
Association studies examining apolipoprotein E gene, the best established genetic risk factor for late-onset AD, did not find any significant association of this gene with AD+P.
Statins for the prevention of dementia.
Review
New
Passmore et al., Antrim, United Kingdom. In Cochrane Database Syst Rev, Feb 2016
OBJECTIVES: To evaluate the efficacy and safety of statins for the prevention of dementia in people at risk of dementia due to their age and to determine whether the efficacy and safety of statins for this purpose depends on cholesterol level, apolipoprotein E (ApoE) genotype or cognitive level.
Genetic risk factors for spontaneous intracerebral haemorrhage.
Review
New
Prestigiacomo et al., United States. In Nat Rev Neurol, Jan 2016
Two variants of the gene encoding apolipoprotein E (APOE) - which also contributes to the pathogenesis of cerebral amyloid angiopathy - are the most likely candidates for variants that increase the risk of ICH.
The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.
New
Tzourio et al., Bordeaux, France. In Neurobiol Aging, Jan 2016
UNASSIGNED: The apolipoprotein E ε4 allele (APOE4) is an established risk factor for dementia; however, conflicting findings have been reported as to whether this phenotype confers a heightened risk for late onset depression (LOD) independent of dementia.
Obesity and sex interact in the regulation of Alzheimer's disease.
Review
New
Pike et al., Los Angeles, United States. In Neurosci Biobehav Rev, Jan 2016
Inflammation and the E4 allele of apolipoprotein E have been identified as independent risk factors for AD and both interact with obesity and sex steroid hormones.
Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition.
New
Impact
Lai et al., Kunming, China. In Immunity, Jan 2016
Mouse model studies indicated that Cramp-mtDNA complex aggravated atherosclerotic lesion formation in apolipoprotein E-deficient mice and antibody treatment against the complex alleviated the lesion.
Cognitive Function in Patients With Colorectal Cancer Who Do and Do Not Receive Chemotherapy: A Prospective, Longitudinal, Controlled Study.
New
Impact
Tannock et al., Sydney, Australia. In J Clin Oncol, Jan 2016
Blood tests included cytokines, clotting factors, apolipoprotein E genotype, and sex hormones.
Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice.
New
Zhang et al., Jinan, China. In Cell Death Dis, Dec 2015
Importantly, Pdcd4 deficiency in mice significantly upregulated macrophage autophagy in local plaques along with attenuated lipid accumulation and atherosclerotic lesions in high-fat-fed Apolipoprotein E knockout mice.
Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.
New
Impact
Shi et al., Boston, United States. In Nat Med, Jul 2015
Here, we show that absence of the IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice, nor does it affect IL18 cell surface binding to or signaling in endothelial cells.
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
New
Impact
Zetterberg et al., Maastricht, Netherlands. In Jama, Jun 2015
MAIN OUTCOMES AND MEASURES: Prevalence of amyloid pathology on positron emission tomography or in cerebrospinal fluid according to AD risk factors (age, apolipoprotein E [APOE] genotype, sex, and education) estimated by generalized estimating equations.
Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
New
Impact
Brooks et al., Maastricht, Netherlands. In Jama, Jun 2015
MAIN OUTCOMES AND MEASURES: Estimated prevalence of positive amyloid PET scans according to diagnosis, age, and apolipoprotein E (APOE) ε4 status, using the generalized estimating equations method.
Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population.
Zhang et al., China. In Genet Mol Res, 2014
This case-control study examined the genotypes of apolipoprotein E (APOE e4) and BMAL1 rs2278749 T/C using restriction fragment length polymorphism and the TaqMan assay, respectively.
A systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for Alzheimer's disease.
Review
Rani et al., Coimbatore, India. In Sage Open Med, 2014
CONCLUSION: This analysis pinpoints that plasma Aβ42 and tau could not serve as reliable markers independently for diagnosis of Alzheimer's disease and a cohort study with age, sex and apolipoprotein E correction is warranted for their possible use as Alzheimer's disease markers.
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