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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Jul 2015.

Apolipoprotein Ea

apolipoprotein E
Top mentioned proteins: apolipoprotein E, AGE, HAD, CAN, V1a
Papers on apolipoprotein E
Systems Biology Research into Cardiovascular Disease: Contributions of Lipidomics-based Approaches to Biomarker Discovery.
New
Hoeng et al., Neuchâtel, Switzerland. In Curr Drug Discov Technol, 02 Aug 2015
Additionally, at the vascular tissue level, lipids from different classes are enriched in human plaques of coronary arteries and in the aortas of apolipoprotein E-deficient mice exposed to cigarette smoke, highlighting a set of lipid biomarkers for translational research.
Family member deaths across adulthood predict Alzheimer's disease risk: The Cache County Study.
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Smith et al., Logan, United States. In Int J Geriatr Psychiatry, 01 Aug 2015
Cox regression modeled survival time from baseline interview to AD onset, as a function of family deaths during childhood or adulthood, among different age groups, along with gender and presence of ε4 allele at apolipoprotein E (APOE) polymorphic genetic locus.
Review: Apolipoprotein E (Apo E) gene polymorphism and coronary heart disease in Asian populations.
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Iqbal et al., Karāchi, Pakistan. In Pak J Pharm Sci, 31 Jul 2015
UNASSIGNED: Apolipoprotein E (Apo E) is a basic component of very low-density lipoprotein (VLDL) and high-density lipoprotein (HDL).
7keto-stigmasterol and 7keto-cholesterol induce differential proteome changes to intestinal epitelial (Caco-2) cells.
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Cilla et al., Valencia, Spain. In Food Chem Toxicol, 30 Jul 2015
Remarkable differences between proteome patterns in cell cultures exposed to 7keto-cholesterol and 7keto-stigmasterol affect macrophage migration inhibitory factor, apolipoprotein E, Bcl-2-associated transcription factor and cellular retinoic acid-binding protein.
Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.
New
Impact
Shi et al., Boston, United States. In Nat Med, 22 Jul 2015
Here, we show that absence of the IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice, nor does it affect IL18 cell surface binding to or signaling in endothelial cells.
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
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Impact
Zetterberg et al., Maastricht, Netherlands. In Jama, 19 Jun 2015
MAIN OUTCOMES AND MEASURES: Prevalence of amyloid pathology on positron emission tomography or in cerebrospinal fluid according to AD risk factors (age, apolipoprotein E [APOE] genotype, sex, and education) estimated by generalized estimating equations.
Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
New
Impact
Brooks et al., Maastricht, Netherlands. In Jama, 19 Jun 2015
MAIN OUTCOMES AND MEASURES: Estimated prevalence of positive amyloid PET scans according to diagnosis, age, and apolipoprotein E (APOE) ε4 status, using the generalized estimating equations method.
Association between apolipoprotein E gene polymorphism and depression.
Review
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Sun et al., Hefei, China. In J Clin Neurosci, 12 Jun 2015
UNASSIGNED: We performed an updated meta-analysis to obtain a more precise estimation of the relationship between apolipoprotein E (ApoE) gene polymorphism and susceptibility to depression, as previous reports have been inconsistent.
No association between the ApoE ε2 and ε4 alleles and the risk of obstructive sleep apnea: A systematic review and meta-analysis.
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Yin et al., Shanghai, China. In Biomed Rep, May 2015
UNASSIGNED: Apolipoprotein E (ApoE) gene ε2 and ε4 alleles have been reported to be associated with the risk of obstructive sleep apnea (OSA); however, the results are controversial.
Additional mechanisms conferring genetic susceptibility to Alzheimer's disease.
Review
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Medina et al., Madrid, Spain. In Front Cell Neurosci, Dec 2014
Besides apolipoprotein E, that presents a strong association with the disease (OR∼4), the rest of these genes have moderate or low degrees of association, with OR ranging from 0.88 to 1.23.
The role of APOE-ɛ4 and beta amyloid in the differential rate of recovery from ECT: a review.
Review
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Martins et al., Australia. In Transl Psychiatry, Dec 2014
A narrative review of the research literature on carriage of the apolipoprotein E ɛ4 allele (APOE-ɛ4) and the protein biomarker beta amyloid (Aβ) with ECT cognitive outcome was undertaken.
Link between type 2 diabetes and Alzheimer's disease: from epidemiology to mechanism and treatment.
Review
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Leng et al., Dalian, China. In Clin Interv Aging, Dec 2014
It is worth mentioning that the therapeutic effects of these drugs are influenced by the apolipoprotein E (APOE)-ε4 genotype.
Cholesterol and metal ions in Alzheimer's disease.
Review
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Impact
Lim et al., Ann Arbor, United States. In Chem Soc Rev, Nov 2014
For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-β (Aβ) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation.
Apolipoprotein E in Alzheimer's disease: an update.
Review
Impact
Hardy et al., Qingdao, China. In Annu Rev Neurosci, 2013
Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for LOAD.
Review
Lau et al., Rockville, United States. In Unknown Journal, 0001
OBJECTIVE: We assessed four pharmacogenetic tests: 1) cytochrome P450, subfamily IIC, polypeptide 9 (CYP2C9), 2) vitamin K epoxide reductase subunit protein 1 (VKORC1), 3) apolipoprotein E (Apo E), and 4) methylenetetrahydrofolate reductase (MTHFR) for their associations with patient’s response to therapy with warfarin (CYP2C9 and VKORC1), statins (Apo E), or antifolate chemotherapy (MTHFR).
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