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Apolipoprotein C-I

Apolipoprotein C-I, apoC-I, APOC1
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: apolipoprotein E, Apo, Apolipoprotein C-III, HDL, HAD
Papers on Apolipoprotein C-I
Effects of a Terrified-Sound Stress on Serum Proteomic Profiling in Mice.
Huang et al., Xi'an, China. In J Mol Neurosci, 31 Oct 2015
These were sequence identified as peptide regions of dimethylaniline monooxygenase, myosin-9, uncharacterized protein in Rattus norvegicus, apolipoprotein C-I, and plasma serine protease inhibitor (Serpina 5).
Host Protein Biomarkers Identify Active Tuberculosis in HIV Uninfected and Co-infected Individuals.
Paramithiotis et al., United States. In Ebiomedicine, Sep 2015
Biomarker panels whose composition differed according to HIV status, and consisted of 8 host proteins in HIV(-) individuals (CD14, SEPP1, SELL, TNXB, LUM, PEPD, QSOX1, COMP, APOC1), or 10 host proteins in HIV(+) individuals (CD14, SEPP1, PGLYRP2, PFN1, VASN, CPN2, TAGLN2, IGFBP6), respectively, distinguished TB from ORD with excellent accuracy (AUC = 0.96 for HIV(-) TB, 0.95 for HIV(+) TB).
Sitagliptin Results in a Decrease of Truncated Apolipoprotein C1.
Seaquist et al., Minneapolis, United States. In Diabetes Ther, Sep 2015
UNLABELLED: Apolipoprotein C1 (ApoC1) is a component of multiple lipoproteins where it performs a variety of roles in lipid metabolism and transport.
Rare Coding Variation and Risk of Intracerebral Hemorrhage.
Rosand et al., Boston, United States. In Stroke, Aug 2015
Three common variants on chromosome 19q13 at an established susceptibility locus, encompassing TOMM40, APOE, and APOC1, met genome-wide significance (P<5e-08).
The potential of cholesteryl ester transfer protein as a therapeutic target.
Lagrost et al., Dijon, France. In Expert Opin Ther Targets, Aug 2015
Specific attention is given to physiological modulation of endogenous CETP activity by the apoC1 inhibitor.
Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort.
Shen et al., Harbin, China. In Biomed Res Int, Dec 2014
The GWAS analysis revealed significant hits within or proximal to APOE, APOC1, and TOMM40 genes, which were previously implicated in AD.
Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights.
Gursky et al., Boston, United States. In Adv Exp Med Biol, Dec 2014
Surprisingly, the rank order of the amino acid sequence propensity to form amyloid (apoB>apoA-II>apoC-II≥apoA-I, apoC-III, SAA, apoC-I>apoA-IV, apoA-V, apoE) does not correlate with the proteins' involvement in amyloidosis.
Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses.
Pietschmann et al., Hannover, Germany. In Plos One, Dec 2014
Since apolipoproteins complementing HCV virus production share amphipathic alpha helices as common structural features we altered the two alpha helices of ApoC1.
Physiological regulation of lipoprotein lipase.
Kersten, Wageningen, Netherlands. In Biochim Biophys Acta, Jul 2014
These proteins can be divided into two main groups: the liver-derived apolipoproteins APOC1, APOC2, APOC3, APOA5, and APOE, and the angiopoietin-like proteins ANGPTL3, ANGPTL4 and ANGPTL8, which have a broader expression profile.
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.
Alzheimer’s Disease Neuroimaging Initiative et al., Indianapolis, United States. In Brain Imaging Behav, Jun 2014
Several other genes (e.g., APOC1, FTO, GRIN2B, MAGI2, and TOMM40) were associated with multiple ADNI phenotypes, warranting further investigation on other data sets.
Expanding role of pharmacogenomics in the management of cardiovascular disorders.
Pirmohamed et al., Liverpool, United Kingdom. In Am J Cardiovasc Drugs, 2013
Response to statins has been associated with polymorphisms in the cholesterol ester transfer protein (CETP), apolipoprotein E (APOE), 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, calmin (CLMN) and apolipoprotein-CI (APOC1) genes.
Dyslipidemia in women with polycystic ovary syndrome.
Choi et al., Seoul, South Korea. In Obstet Gynecol Sci, 2013
Some studies have investigated apolipoprotein (Apo) A-I and ApoC-I levels in women with PCOS and levels of ApoA-I, which has cardio-protective effects, were significantly lower in women with PCOS than those of controls.
PP032. Apolipoprotein profiling in umbilical cord blood of intrauterine growth restricted (IUGR) neonates.
Rath et al., In Pregnancy Hypertens, 2013
ApoC1 (p<0.0001), and ApoE (p=0.0001)
Constitutive inhibition of plasma CETP by apolipoprotein C1 is blunted in dyslipidemic patients with coronary artery disease.
Lagrost et al., Bordeaux, France. In J Lipid Res, 2012
apoC1 as a CETP inhibitor no longer operates on cholesterol redistribution in high-risk patients with dyslipidemia
Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease.
Zeng et al., Shanghai, China. In J Proteome Res, 2012
Apolipoprotein C-I was significantly increased in obese mice plasma.
Dyslipidemia in PCOS.
Wild, Oklahoma City, United States. In Steroids, 2012
They have higher ApoCIII/ApoCII ratios and higher ApoCI even if they are not obese.
Apolipoprotein C-I binds more strongly to phospholipid/triolein/water than triolein/water interfaces: a possible model for inhibiting cholesterol ester transfer protein activity and triacylglycerol-rich lipoprotein uptake.
Small et al., Boston, United States. In Biochemistry, 2012
The observed increase in apoC-I interface affinity due to higher degrees of apoC-I-palmitoyloleoylphosphatidylcholine/triolein/water interactions may explain how apoC-I can displace larger apolipoproteins, such as apoE, from lipoproteins.
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
Lin et al., Chapel Hill, United States. In Plos Genet, 2011
our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains.
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
Whitfield et al., Brisbane, Australia. In Bmc Med Genet, 2010
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age.
Macfarlane et al., Baltimore, United States. In Jama, 2005
Increased amounts of apolipoprotein C-I enriched HDL may have physiological significance and identify a novel group of low-birth-weight infants apparently distinct from traditionally classified small-for-gestational-age infants.
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