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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Apolipoprotein C-I

Apolipoprotein C-I, apoC-I, APOC1
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: apolipoprotein E, Apo, Apolipoprotein C-III, HDL, HAD
Papers on Apolipoprotein C-I
The use of matrix coating assisted by an electric field (MCAEF) to enhance mass spectrometric imaging of human prostate cancer biomarkers.
New
Borchers et al., Victoria, Canada. In J Mass Spectrom, 31 Jan 2016
Among these 17 species, the distributions of apolipoprotein C-I, S100-A6, and S100-A8 were verified by immunohistological staining.
Lactobacillus plantarum NCIMB8826 ameliorates inflammation of colon and skin in human APOC1 transgenic mice.
New
Nagelkerken et al., Leiden, Netherlands. In Benef Microbes, 21 Jan 2016
Hyperlipidemic human APOC1(+/+) transgenic mice display many features of human atopic dermatitis, such as scaling, lichenification, excoriations, and pruritus, along with a disturbed skin barrier function.
Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals.
New
Jiang et al., Harbin, China. In Oncotarget, 15 Jan 2016
After prioritizing these candidate genes, we found seven AD related genes: APOE, APOC1, TNFRSF1A, LRP1B, CDH1, TG and CASP7.
Targeted Proteomics Identifies PON1 and Apolipoprotein Cs as Potential Risk Factors for Hypoalphalipoproteinemia in Diabetic Subjects Treated with Fenofibrate and Rosiglitazone.
New
Heinecke et al., Washington, D.C., United States. In Mol Cell Proteomics, 14 Jan 2016
This approach demonstrated marked increases in the relative concentrations of paraoxonase/arylesterase 1 (PON1), apolipoprotein C-II (APOC2), apolipoprotein C-I, and apolipoprotein H in the HDL of subjects who developed hypoalphalipoproteinemia.
Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population.
New
Cai et al., Haikou, China. In J Hum Genet, 10 Jan 2016
UNASSIGNED: Apolipoprotein E (APOE), translocase of outer mitochondrial membrane 40 homolog (TOMM40) and apolipoprotein C-I (APOC1) may extend lifespan by marked delay or escape from age-related diseases.
Combined Genome-Wide CSF Aβ-42's Associations and Simple Network Properties Highlight New Risk Factors for Alzheimer's Disease.
New
Alzheimer’s Disease Neuroimaging Initiative et al., Recife, Brazil. In J Mol Neurosci, 17 Dec 2015
Both methods' results showed two identical significant SNPs associated with the A β-42 levels in CSF (rs2075650 at intron region TOMM40 with p-value ≥ 1 × 10-16 and rs439401 in the intergenic region of LOC100129500 and APOC1 with p-value ≥ 1 × 10-9) and highlighted APOC1 and TOMM40, which are well-known genes previously associated with AD.
Effects of a Terrified-Sound Stress on Serum Proteomic Profiling in Mice.
New
Huang et al., Xi'an, China. In J Mol Neurosci, Oct 2015
These were sequence identified as peptide regions of dimethylaniline monooxygenase, myosin-9, uncharacterized protein in Rattus norvegicus, apolipoprotein C-I, and plasma serine protease inhibitor (Serpina 5).
Sitagliptin Results in a Decrease of Truncated Apolipoprotein C1.
New
Seaquist et al., Minneapolis, United States. In Diabetes Ther, Sep 2015
UNLABELLED: Apolipoprotein C1 (ApoC1) is a component of multiple lipoproteins where it performs a variety of roles in lipid metabolism and transport.
Host Protein Biomarkers Identify Active Tuberculosis in HIV Uninfected and Co-infected Individuals.
New
Paramithiotis et al., United States. In Ebiomedicine, Sep 2015
Biomarker panels whose composition differed according to HIV status, and consisted of 8 host proteins in HIV(-) individuals (CD14, SEPP1, SELL, TNXB, LUM, PEPD, QSOX1, COMP, APOC1), or 10 host proteins in HIV(+) individuals (CD14, SEPP1, PGLYRP2, PFN1, VASN, CPN2, TAGLN2, IGFBP6), respectively, distinguished TB from ORD with excellent accuracy (AUC = 0.96 for HIV(-) TB, 0.95 for HIV(+) TB).
The potential of cholesteryl ester transfer protein as a therapeutic target.
New
Lagrost et al., Dijon, France. In Expert Opin Ther Targets, Aug 2015
Specific attention is given to physiological modulation of endogenous CETP activity by the apoC1 inhibitor.
Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights.
Gursky et al., Boston, United States. In Adv Exp Med Biol, 2014
Surprisingly, the rank order of the amino acid sequence propensity to form amyloid (apoB>apoA-II>apoC-II≥apoA-I, apoC-III, SAA, apoC-I>apoA-IV, apoA-V, apoE) does not correlate with the proteins' involvement in amyloidosis.
Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort.
Shen et al., Harbin, China. In Biomed Res Int, 2014
The GWAS analysis revealed significant hits within or proximal to APOE, APOC1, and TOMM40 genes, which were previously implicated in AD.
Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses.
Pietschmann et al., Hannover, Germany. In Plos One, 2014
Since apolipoproteins complementing HCV virus production share amphipathic alpha helices as common structural features we altered the two alpha helices of ApoC1.
Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for lung cancer: A marker phase I trial.
Kao et al., Taipei, Taiwan. In Thorac Cancer, 2014
METHODS: Candidate inflammation-associated genes, apolipoprotein C-1 (APOC1), MMP1, KMO)1, CXCL5, CXCL)7, IL-1α, IL-1β, TNF-α and IL-6 were verified by real-time quantitative polymerase chain reaction.
Constitutive inhibition of plasma CETP by apolipoprotein C1 is blunted in dyslipidemic patients with coronary artery disease.
GeneRIF
Lagrost et al., Bordeaux, France. In J Lipid Res, 2012
apoC1 as a CETP inhibitor no longer operates on cholesterol redistribution in high-risk patients with dyslipidemia
Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease.
GeneRIF
Zeng et al., Shanghai, China. In J Proteome Res, 2012
Apolipoprotein C-I was significantly increased in obese mice plasma.
Apolipoprotein C-I binds more strongly to phospholipid/triolein/water than triolein/water interfaces: a possible model for inhibiting cholesterol ester transfer protein activity and triacylglycerol-rich lipoprotein uptake.
GeneRIF
Small et al., Boston, United States. In Biochemistry, 2012
The observed increase in apoC-I interface affinity due to higher degrees of apoC-I-palmitoyloleoylphosphatidylcholine/triolein/water interactions may explain how apoC-I can displace larger apolipoproteins, such as apoE, from lipoproteins.
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
GeneRIF
Lin et al., Chapel Hill, United States. In Plos Genet, 2011
our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains.
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
GeneRIF
Whitfield et al., Brisbane, Australia. In Bmc Med Genet, 2010
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age.
Impact
GeneRIF
Macfarlane et al., Baltimore, United States. In Jama, 2005
Increased amounts of apolipoprotein C-I enriched HDL may have physiological significance and identify a novel group of low-birth-weight infants apparently distinct from traditionally classified small-for-gestational-age infants.
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