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proteins. Page last changed on 14 Mar 2013.
Apolipoprotein C-I
Apolipoprotein C-I, apoC-I, APOC1
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
Apolipoprotein C-I
The identification of apolipoprotein C-I in rare minnow (Gobiocypris rarus) and its expression following cadmium exposure.
New
Wuhan, China. In Environ Toxicol Pharmacol, 11 Mar 2013
Differential expression sequence tags (ESTs) were screened and an EST similar to Hemibarbus mylodon apolipoprotein C-I (ApoC-I) was identified.
Human HDL Containing a Novel ApoC-I Isoform Induces Smooth Muscle Cell Apoptosis.
New
Temple, United States. In Cardiovasc Res, 25 Feb 2013
We observed that apoptotic HDL was 1) predominately associated with the HDL2 subclass; 2) almost exclusively found in individuals with a higher apoC-I serum level and a novel, higher molecular weight isoform of apoC-I; and 3) more common in adults with CHD, the majority of whom had high (> 60 mg/dL) HDL-C levels.
Genome-wide linkage analysis for human longevity: Genetics of Healthy Ageing Study.
New
Leiden, Netherlands. In Aging Cell, 03 Feb 2013
Using a fixed effect meta-analysis approach, rs4420638 at the TOMM40/APOE/APOC1 gene locus showed significant association with longevity (p-value=9.6 x 10(-8) ).
Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.
New
Philadelphia, United States. In Hum Mol Genet, Feb 2013
At an array-wide significance (P < 2.40E-06), we identify novel BMI associations in loci translocase of outer mitochondrial membrane 40 homolog (yeast) - apolipoprotein E - apolipoprotein C-I (TOMM40-APOE-APOC1) (rs2075650, P = 2.95E-10), sterol regulatory element binding transcription factor 2 (SREBF2, rs5996074, P = 9.43E-07) and neurotrophic tyrosine kinase, receptor, type 2 [NTRK2, a brain-derived neurotrophic factor (BDNF) receptor gene, rs1211166, P = 1.04E-06] in the Phase IV meta-analysis.
Interrelationships between the concentration and size of the largest high-density lipoprotein subfraction and apolipoprotein C-I in infants at birth and follow-up at 2-3 months of age and their parents.
New
Baltimore, United States. In J Clin Lipidol, Jan 2013
At birth and at FU, apoC-I was strongly related with H5C but not TG.
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
New
Boston, United States. In Circ Cardiovasc Genet, Dec 2012
In addition, genome-wide associations (P<5 × 10(-8)) were identified and replicated for baseline Lp-PLA(2) mass at CETP and for Lp-PLA(2) activity at the APOC1-APOE and PLA2G7 loci.
Oxidized ApoC1 on MALDI-TOF and Glycated-ApoA1 Band on Gradient Gel as Potential Diagnostic Tools for Atherosclerotic Vascular Disease.
New
Taiwan. In Clin Chim Acta, Nov 2012
RESULTS: Oxidation of ApoC1 was detected specifically in ASVD samples by MALDI-TOF.
Dyslipidemia in PCOS.
Review
New
Oklahoma City, United States. In Steroids, Apr 2012
They have higher ApoCIII/ApoCII ratios and higher ApoCI even if they are not obese.
Ovarian cyst fluid is a rich proteome resource for detection of new tumor biomarkers.
Göteborg, Sweden. In Clin Proteomics, 2011
Seventeen peaks had receiver operating curve and area under the curve values >0.70; the majority of these represented peaks for apolipoproteins C-III and C-I (ApoC-I), transthyretin (TTR), serum amyloid A4 (SAA4), and protein C inhibitor (PCI).
Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate.
Birmingham, United States. In Plos One, 2011
Suggestive associations with fenofibrate response were observed for markers in or near PDE3A, MOSC1, FLJ36070, CETP, the APOE-APOC1-APOC4-APOC2, and CILP2.
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
GeneRIF
Chapel Hill, United States. In Plos Genet, 2011
our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains.
Genetic influences on Alzheimer's disease: evidence of interactions between the genes APOE, APOC1 and ACE in a sample population from the South of Brazil.
GeneRIF
Novo Hamburgo, Brazil. In Neurochem Res, 2011
Results describe the association of ACE and APOC1 gene polymorphisms with susceptibility to Alzheimer's disease and dementia in general, both alone and combined with the APOE gene.
Isoforms of apolipoprotein C-I associated with individuals with coronary artery disease.
GeneRIF
College Station, United States. In Biochem Biophys Res Commun, 2011
New isoforms of apoC-I, were detected in the cohort of individuals with coronary artery disease using mass spectrometry while the expected apoC-I isoforms were absent.
Serum apolipoproteins C-I and C-III are reduced in stomach cancer patients: results from MALDI-based peptidome and immuno-based clinical assays.
GeneRIF
Beersheba, Israel. In Plos One, 2010
Serum levels of apoC-I and apoC-III combined with other clinical parameters can serve as a basis for the formulation of a diagnostic score for stomach cancer patients
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
GeneRIF
Brisbane, Australia. In Bmc Med Genet, 2010
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
APOE and cholesterol homeostasis in Alzheimer's disease.
Review
Montréal, Canada. In Trends Mol Med, 2010
These associations include the recognition of cholesterol transporters apolipoprotein E (APOE), APOC1 and APOJ as major genetic risk factors for common AD and observations associating risk factors for cardiovascular disease such as high midlife plasma cholesterol, diabetes, stroke, obesity and hypertension to dementia.
[Risk factors for Alzheimer's disease].
Review
Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
The use of network analyses for elucidating mechanisms in cardiovascular disease.
Review
Uji, Japan. In Mol Biosyst, 2010
In particular, the APOC1 gene was 2.1-fold down-regulated in plaques in women relative to men and was selected for further analysis based upon a purported role in cardiovascular disease.
Proinflammatory status, genetics and atherosclerosis.
Review
Praha, Czech Republic. In Physiol Res, 2008
The participation of genes related to lipoprotein metabolism (genes for apolipoprotein CI and apolipoprotein E) influence hsCRP concentrations.
A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age.
Impact
GeneRIF
Baltimore, United States. In Jama, 2005
Increased amounts of apolipoprotein C-I enriched HDL may have physiological significance and identify a novel group of low-birth-weight infants apparently distinct from traditionally classified small-for-gestational-age infants.
