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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 20 Mar 2014.

Apolipoprotein C-I

Apolipoprotein C-I, apoC-I, APOC1
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: apolipoprotein E, Apo, HDL, Apolipoprotein C-III, HAD
Papers on Apolipoprotein C-I
Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans.
New
Lange et al., Chapel Hill, United States. In Hum Genet, 19 Apr 2014
In the race-combined meta-analyses, 13 loci reached significance, including ten (CRP, TOMM40/APOE/APOC1, HNF1A, LEPR, GCKR, IL6R, IL1RN, NLRP3, HNF4A and BAZ1B/BCL7B) previously associated with CRP, and one (ARNTL) previously reported to be nominally associated with CRP.
Proteomic and genomic analyses suggest the association of Apolipoprotein C1 with abdominal aortic aneurysm.
New
Golledge et al., Townsville, Australia. In Proteomics Clin Appl, 03 Apr 2014
All 3 datasets suggested apolipoprotein C1 (ApoC1) as a marker for AAA; microarray data identified matrix metalloproteinase 9 (MMP9) as a second potential marker.
Proteome screening of pleural effusions identifies galectin 1 as a diagnostic biomarker and highlights several prognostic biomarkers for malignant mesothelioma.
New
Hjerpe et al., Stockholm, Sweden. In Mol Cell Proteomics, 31 Mar 2014
Seven candidates (aldo-keto reductase 1B10, apolipoprotein C-I, galectin 1, myosin-VIIb, superoxide dismutase 2, tenascin C, and thrombospondin 1) were validated by enzyme-linked immunosorbent assays in a larger group of patients with mesothelioma (n = 37) or metastatic carcinomas (n = 25) and in effusions from patients with benign, reactive conditions (n = 16).
Glycation of Apolipoprotein C1 Impairs Its CETP Inhibitory Property: Pathophysiological Relevance in Patients With Type 1 and Type 2 Diabetes.
New
Vergès et al., Dijon, France. In Diabetes Care, 26 Mar 2014
ApoC1 operates through its ability to modify the electrostatic charge at the lipoprotein surface.
Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly.
New
Pietschmann et al., Hannover, Germany. In J Virol, 28 Feb 2014
Thus, apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTTP), and apolipoprotein C1 (ApoC1), previously implicated in HCV assembly, are dispensable for production of infectious HCV.
Biochemical and functional characterization of charge-defined subfractions of high-density lipoprotein from normal adults.
New
Yang et al., Taiwan. In Anal Chem, Jan 2014
Sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis showed that apolipoprotein (apo) AI and apoAII were present in all 5 subfractions; apoCI was present only in H1, and apoCIII and apoE were most abundantly present in H4 and H5.
Association between APOC1 Polymorphism and Alzheimer's Disease: A Case-Control Study and Meta-Analysis.
New
Yang et al., Beijing, China. In Plos One, Dec 2013
BACKGROUND: Previous association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer's disease (AD) have shown conflicting results, and it is not clear if an APOC1 variant acts as a genetic risk factor in AD etiology across multiple populations.
Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets.
New
Olivecrona et al., Umeå, Sweden. In J Biol Chem, Dec 2013
We present evidence that either apoC-I or apoC-III, when bound to triglyceride-rich lipoproteins, prevent binding of LPL to the lipid/water interface.
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.
New
for the Alzheimer’s Disease Neuroimaging Initiative et al., Indianapolis, United States. In Brain Imaging Behav, Nov 2013
Several other genes (e.g., APOC1, FTO, GRIN2B, MAGI2, and TOMM40) were associated with multiple ADNI phenotypes, warranting further investigation on other data sets.
Expanding role of pharmacogenomics in the management of cardiovascular disorders.
Review
New
Pirmohamed et al., Liverpool, United Kingdom. In Am J Cardiovasc Drugs, Jun 2013
Response to statins has been associated with polymorphisms in the cholesterol ester transfer protein (CETP), apolipoprotein E (APOE), 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, calmin (CLMN) and apolipoprotein-CI (APOC1) genes.
Dyslipidemia in women with polycystic ovary syndrome.
Review
New
Choi et al., Seoul, South Korea. In Obstet Gynecol Sci, May 2013
Some studies have investigated apolipoprotein (Apo) A-I and ApoC-I levels in women with PCOS and levels of ApoA-I, which has cardio-protective effects, were significantly lower in women with PCOS than those of controls.
Constitutive inhibition of plasma CETP by apolipoprotein C1 is blunted in dyslipidemic patients with coronary artery disease.
GeneRIF
Lagrost et al., Bordeaux, France. In J Lipid Res, 2012
apoC1 as a CETP inhibitor no longer operates on cholesterol redistribution in high-risk patients with dyslipidemia
Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease.
GeneRIF
Zeng et al., Shanghai, China. In J Proteome Res, 2012
Apolipoprotein C-I was significantly increased in obese mice plasma.
Dyslipidemia in PCOS.
Review
Wild, Oklahoma City, United States. In Steroids, 2012
They have higher ApoCIII/ApoCII ratios and higher ApoCI even if they are not obese.
Apolipoprotein C-I binds more strongly to phospholipid/triolein/water than triolein/water interfaces: a possible model for inhibiting cholesterol ester transfer protein activity and triacylglycerol-rich lipoprotein uptake.
GeneRIF
Small et al., Boston, United States. In Biochemistry, 2012
The observed increase in apoC-I interface affinity due to higher degrees of apoC-I-palmitoyloleoylphosphatidylcholine/triolein/water interactions may explain how apoC-I can displace larger apolipoproteins, such as apoE, from lipoproteins.
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
GeneRIF
Lin et al., Chapel Hill, United States. In Plos Genet, 2011
our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains.
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
GeneRIF
Whitfield et al., Brisbane, Australia. In Bmc Med Genet, 2010
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
APOE and cholesterol homeostasis in Alzheimer's disease.
Review
Poirier et al., Montréal, Canada. In Trends Mol Med, 2010
These associations include the recognition of cholesterol transporters apolipoprotein E (APOE), APOC1 and APOJ as major genetic risk factors for common AD and observations associating risk factors for cardiovascular disease such as high midlife plasma cholesterol, diabetes, stroke, obesity and hypertension to dementia.
[Risk factors for Alzheimer's disease].
Review
Yamada et al., Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age.
Impact
GeneRIF
Macfarlane et al., Baltimore, United States. In Jama, 2005
Increased amounts of apolipoprotein C-I enriched HDL may have physiological significance and identify a novel group of low-birth-weight infants apparently distinct from traditionally classified small-for-gestational-age infants.
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