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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Jun 2015.

Apolipoprotein C-I

Apolipoprotein C-I, apoC-I, APOC1
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: apolipoprotein E, Apo, Apolipoprotein C-III, HDL, HAD
Papers on Apolipoprotein C-I
Rare Coding Variation and Risk of Intracerebral Hemorrhage.
New
Rosand et al., Boston, United States. In Stroke, 25 Jul 2015
Three common variants on chromosome 19q13 at an established susceptibility locus, encompassing TOMM40, APOE, and APOC1, met genome-wide significance (P<5e-08).
Development of multiplex mass spectrometric immunoassay for detection and quantification of apolipoproteins C-I, C-II, C-III and their proteoforms.
New
Nedelkov et al., Tempe, United States. In Methods, 15 Jul 2015
Described here is the development of a multiplex mass spectrometric immunoassay (MSIA) for quantification of apolipoprotein C-I (apoC-I), apolipoprotein C-II (apoC-II), apolipoprotein C-III (apoC-III) and their proteoforms.
A pressure-dependent model for the regulation of lipoprotein lipase by apolipoprotein C-II.
New
Small et al., Boston, United States. In J Biol Chem, 29 Jun 2015
UNASSIGNED: Apolipoprotein C-II (apoC-II) is the co-factor for lipoprotein lipase (LPL) at the surface of triacylglycerol-rich lipoproteins.
BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development.
New
Gui et al., Wuhan, China. In Gene, Feb 2015
Here we have shown that apolipoprotein C1 (apoc1) gene is highly expressed in the yolk syncytial layer, a structure implicated in embryonic and larval nutrition.
Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein.
New
Dehghan et al., Rotterdam, Netherlands. In Plos One, Dec 2014
Additional analyses showed that 6 regions (APOC1, HNF1A, IL6R, PPP1R3B, HNF4A and IL1F10) appeared to have a pleiotropic effect on CRP independent of the effects on the cardiometabolic phenotypes.
Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles.
New
Matsuura et al., Ōsaka, Japan. In Plos Pathog, Dec 2014
cDNA microarray analyses revealed that ApoB and ApoE are dominantly expressed in Huh7 cells, in contrast to the high level expression of all of the exchangeable apolipoproteins, including ApoA1, ApoA2, ApoC1, ApoC2 and ApoC3 in human liver tissues.
Changes in total and central fat mass after a hypocaloric diet associate with changes of apoC-I in postmenopausal obese women.
New
Faraj et al., Montréal, Canada. In J Clin Lipidol, Sep 2014
BACKGROUND: We previously reported the secretion of apolipoprotein apoC-I, apoC-II, apoC-III, and apoE from adipose tissue in postmenopausal obese women, suggesting their potential regulation by energy balance in humans.
Physiological regulation of lipoprotein lipase.
Review
New
Kersten, Wageningen, Netherlands. In Biochim Biophys Acta, Jul 2014
These proteins can be divided into two main groups: the liver-derived apolipoproteins APOC1, APOC2, APOC3, APOA5, and APOE, and the angiopoietin-like proteins ANGPTL3, ANGPTL4 and ANGPTL8, which have a broader expression profile.
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.
Review
New
Alzheimer’s Disease Neuroimaging Initiative et al., Indianapolis, United States. In Brain Imaging Behav, Jun 2014
Several other genes (e.g., APOC1, FTO, GRIN2B, MAGI2, and TOMM40) were associated with multiple ADNI phenotypes, warranting further investigation on other data sets.
Identifying genetic interactions associated with late-onset Alzheimer's disease.
Visweswaran et al., Pittsburgh, United States. In Biodata Min, 2013
Four genes were common to both datasets: APOE and APOC1, which have well established associations with LOAD, and CAMK1D and FBXL13, not previously linked to LOAD but having evidence of involvement in LOAD.
Expanding role of pharmacogenomics in the management of cardiovascular disorders.
Review
Pirmohamed et al., Liverpool, United Kingdom. In Am J Cardiovasc Drugs, 2013
Response to statins has been associated with polymorphisms in the cholesterol ester transfer protein (CETP), apolipoprotein E (APOE), 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, calmin (CLMN) and apolipoprotein-CI (APOC1) genes.
Dyslipidemia in women with polycystic ovary syndrome.
Review
Choi et al., Seoul, South Korea. In Obstet Gynecol Sci, 2013
Some studies have investigated apolipoprotein (Apo) A-I and ApoC-I levels in women with PCOS and levels of ApoA-I, which has cardio-protective effects, were significantly lower in women with PCOS than those of controls.
PP032. Apolipoprotein profiling in umbilical cord blood of intrauterine growth restricted (IUGR) neonates.
Rath et al., In Pregnancy Hypertens, 2013
ApoC1 (p<0.0001), and ApoE (p=0.0001)
Constitutive inhibition of plasma CETP by apolipoprotein C1 is blunted in dyslipidemic patients with coronary artery disease.
GeneRIF
Lagrost et al., Bordeaux, France. In J Lipid Res, 2012
apoC1 as a CETP inhibitor no longer operates on cholesterol redistribution in high-risk patients with dyslipidemia
Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease.
GeneRIF
Zeng et al., Shanghai, China. In J Proteome Res, 2012
Apolipoprotein C-I was significantly increased in obese mice plasma.
Dyslipidemia in PCOS.
Review
Wild, Oklahoma City, United States. In Steroids, 2012
They have higher ApoCIII/ApoCII ratios and higher ApoCI even if they are not obese.
Apolipoprotein C-I binds more strongly to phospholipid/triolein/water than triolein/water interfaces: a possible model for inhibiting cholesterol ester transfer protein activity and triacylglycerol-rich lipoprotein uptake.
GeneRIF
Small et al., Boston, United States. In Biochemistry, 2012
The observed increase in apoC-I interface affinity due to higher degrees of apoC-I-palmitoyloleoylphosphatidylcholine/triolein/water interactions may explain how apoC-I can displace larger apolipoproteins, such as apoE, from lipoproteins.
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
GeneRIF
Lin et al., Chapel Hill, United States. In Plos Genet, 2011
our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains.
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
GeneRIF
Whitfield et al., Brisbane, Australia. In Bmc Med Genet, 2010
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age.
Impact
GeneRIF
Macfarlane et al., Baltimore, United States. In Jama, 2005
Increased amounts of apolipoprotein C-I enriched HDL may have physiological significance and identify a novel group of low-birth-weight infants apparently distinct from traditionally classified small-for-gestational-age infants.
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