Human HDL Containing a Novel ApoC-I Isoform Induces Smooth Muscle Cell Apoptosis.
Temple, United States. In Cardiovasc Res, 25 Feb 2013
We observed that apoptotic HDL was 1) predominately associated with the HDL2 subclass; 2) almost exclusively found in individuals with a higher apoC-I serum level and a novel, higher molecular weight isoform of apoC-I; and 3) more common in adults with CHD, the majority of whom had high (> 60 mg/dL) HDL-C levels.
Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.
Philadelphia, United States. In Hum Mol Genet, Feb 2013
At an array-wide significance (P < 2.40E-06), we identify novel BMI associations in loci translocase of outer mitochondrial membrane 40 homolog (yeast) - apolipoprotein E - apolipoprotein C-I (TOMM40-APOE-APOC1) (rs2075650, P = 2.95E-10), sterol regulatory element binding transcription factor 2 (SREBF2, rs5996074, P = 9.43E-07) and neurotrophic tyrosine kinase, receptor, type 2 [NTRK2, a brain-derived neurotrophic factor (BDNF) receptor gene, rs1211166, P = 1.04E-06] in the Phase IV meta-analysis.
Dyslipidemia in PCOS.
Oklahoma City, United States. In Steroids, Apr 2012
They have higher ApoCIII/ApoCII ratios and higher ApoCI even if they are not obese.
APOE and cholesterol homeostasis in Alzheimer's disease.
Montréal, Canada. In Trends Mol Med, 2010
These associations include the recognition of cholesterol transporters apolipoprotein E (APOE), APOC1 and APOJ as major genetic risk factors for common AD and observations associating risk factors for cardiovascular disease such as high midlife plasma cholesterol, diabetes, stroke, obesity and hypertension to dementia.
[Risk factors for Alzheimer's disease].
Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.