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Apolipoprotein C-I

Apolipoprotein C-I, apoC-I, APOC1
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: apolipoprotein E, Apo, HDL, Apolipoprotein C-III, HAD
Papers on Apolipoprotein C-I
BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development.
Gui et al., Wuhan, China. In Gene, 28 Nov 2014
Here we have shown that apolipoprotein C1 (apoc1) gene is highly expressed in the yolk syncytial layer, a structure implicated in embryonic and larval nutrition.
Changes in total and central fat mass after a hypocaloric diet associate with changes of apoC-I in postmenopausal obese women.
Faraj et al., Montréal, Canada. In J Clin Lipidol, Sep 2014
BACKGROUND: We previously reported the secretion of apolipoprotein apoC-I, apoC-II, apoC-III, and apoE from adipose tissue in postmenopausal obese women, suggesting their potential regulation by energy balance in humans.
Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes.
Puppione, Los Angeles, United States. In Comp Biochem Physiol Part D Genomics Proteomics, Sep 2014
Previous studies have demonstrated that the apoC-I gene and its pseudogene on human chromosome 19 are flanked by a duplicate set of enhancers.
Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study.
Kooperberg et al., In Circ Cardiovasc Genet, Aug 2014
With Association-analysis-based-on-subsets, we identify 27 single nucleotide polymorphisms in 1 glucose and 4 lipids loci (TCF7L2, LPL, APOA5, CETP, and APOC1/APOE/TOMM40) significantly associated with MetS components overall, all P<2.5e-7, the Bonferroni adjusted P value.
Physiological regulation of lipoprotein lipase.
Kersten, Wageningen, Netherlands. In Biochim Biophys Acta, Jul 2014
These proteins can be divided into two main groups: the liver-derived apolipoproteins APOC1, APOC2, APOC3, APOA5, and APOE, and the angiopoietin-like proteins ANGPTL3, ANGPTL4 and ANGPTL8, which have a broader expression profile.
Multiplexed MRM with Internal Standards for Cerebrospinal Fluid Candidate Protein Biomarker Quantitation.
Borchers et al., In J Proteome Res, Jul 2014
These proteins are of high-to-low abundance with determined concentrations from 118 µg/mL (serum albumin) to 550 pg/mL (apolipoprotein C-I).
APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease.
Yang et al., Beijing, China. In Neural Regen Res, Apr 2014
Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease.
Novel serum protein biomarker panel revealed by mass spectrometry and its prognostic value in breast cancer.
Baxter et al., In Breast Cancer Res, Dec 2013
By matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS, immunoprecipitation and western blotting the proteins were identified as a fragment of apolipoprotein H (ApoH), ApoCI, complement C3a, transthyretin, and ApoAI.
Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans.
Cha et al., Taejŏn, South Korea. In Bmc Complement Altern Med, Dec 2013
By analyzing TE and non-TE type (each 2,664 subjects) populations classified on the basis of Sasang constitutional medicine, we found that the minor allele effects of three variants enriched in TE type had a harmful influence on lipid risk (near apolipoprotein A-V (APOA5)-APOA4-APOC3-APOA1 on increased triglyceride: p = 8.90 × 10(-11), in APOE-APOC1-APOC4 on increased low-density lipoprotein cholesterol: p = 1.63 × 10(-5), and near endothelial lipase gene on decreased high-density lipoprotein cholesterol: p = 4.28 × 10(-3)), whereas those of three variants (near angiopoietin-like 3 gene, APOA5-APOA4-APOC3-APOA1, and near lipoprotein lipase gene on triglyceride and high-density lipoprotein cholesterol) associated in non-TE type had neutral influences because of a compensating effect.
Identification of apolipoprotein C-I as a potential Wilms' tumor marker after excluding inflammatory factors.
Wang et al., Zhengzhou, China. In Int J Mol Sci, Dec 2013
Purification and identification of the target protein using high-pressure liquid chromatography (HPLC) and two-dimensional liquid chromatography-linearion trap mass spectrometry(2D-LC-LTQ-MS) mass spectrometry, respectively, revealed that it was apolipoprotein C-I (APO C-I).
Expanding role of pharmacogenomics in the management of cardiovascular disorders.
Pirmohamed et al., Liverpool, United Kingdom. In Am J Cardiovasc Drugs, Jun 2013
Response to statins has been associated with polymorphisms in the cholesterol ester transfer protein (CETP), apolipoprotein E (APOE), 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, calmin (CLMN) and apolipoprotein-CI (APOC1) genes.
Dyslipidemia in women with polycystic ovary syndrome.
Choi et al., Seoul, South Korea. In Obstet Gynecol Sci, May 2013
Some studies have investigated apolipoprotein (Apo) A-I and ApoC-I levels in women with PCOS and levels of ApoA-I, which has cardio-protective effects, were significantly lower in women with PCOS than those of controls.
Constitutive inhibition of plasma CETP by apolipoprotein C1 is blunted in dyslipidemic patients with coronary artery disease.
Lagrost et al., Bordeaux, France. In J Lipid Res, 2012
apoC1 as a CETP inhibitor no longer operates on cholesterol redistribution in high-risk patients with dyslipidemia
Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease.
Zeng et al., Shanghai, China. In J Proteome Res, 2012
Apolipoprotein C-I was significantly increased in obese mice plasma.
Dyslipidemia in PCOS.
Wild, Oklahoma City, United States. In Steroids, 2012
They have higher ApoCIII/ApoCII ratios and higher ApoCI even if they are not obese.
Apolipoprotein C-I binds more strongly to phospholipid/triolein/water than triolein/water interfaces: a possible model for inhibiting cholesterol ester transfer protein activity and triacylglycerol-rich lipoprotein uptake.
Small et al., Boston, United States. In Biochemistry, 2012
The observed increase in apoC-I interface affinity due to higher degrees of apoC-I-palmitoyloleoylphosphatidylcholine/triolein/water interactions may explain how apoC-I can displace larger apolipoproteins, such as apoE, from lipoproteins.
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
Lin et al., Chapel Hill, United States. In Plos Genet, 2011
our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains.
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
Whitfield et al., Brisbane, Australia. In Bmc Med Genet, 2010
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
APOE and cholesterol homeostasis in Alzheimer's disease.
Poirier et al., Montréal, Canada. In Trends Mol Med, 2010
These associations include the recognition of cholesterol transporters apolipoprotein E (APOE), APOC1 and APOJ as major genetic risk factors for common AD and observations associating risk factors for cardiovascular disease such as high midlife plasma cholesterol, diabetes, stroke, obesity and hypertension to dementia.
A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age.
Macfarlane et al., Baltimore, United States. In Jama, 2005
Increased amounts of apolipoprotein C-I enriched HDL may have physiological significance and identify a novel group of low-birth-weight infants apparently distinct from traditionally classified small-for-gestational-age infants.
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