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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Sep 2015.

Apolipoprotein B

apolipoprotein B, apoB, Apolipoprotein B-100, apoB-100
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HDL, HAD, AGE, ACID, CAN
Papers using apolipoprotein B antibodies
siRNA off-target effects can be reduced at concentrations that match their individual potency
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Harada-Shiba Mariko et al., In Molecular Therapy. Nucleic Acids, 2010
... Membranes were then incubated with primary antibody for mouse apoB-100 or -48 (Meridian Life Science, Inc., Saco, ME) for ...
Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins
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Reitsma Pieter H., In PLoS ONE, 2008
... the goat polyclonal IgG to human apolipoprotein A-II and the goat polyclonal IgG to human apolipoprotein B were from Abcam (Cambridge, UK) ...
Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice.
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Polidori Carlo, In PLoS ONE, 2001
... Seven-week-old male C57Bl/6 and human apoB-transgenic mice (B6.SJL-Tg(APOB)1102Sgy-mice backcrossed to ...
A third-generation lentivirus vector with a conditional packaging system.
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Lindenbach Brett D., In PLoS Pathogens, 1997
... Antibodies were obtained from the following companies: Apolipoprotein B (Millipore); PLA2G4A (Abcam ...
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Papers on apolipoprotein B
HDL Cholesterol Efflux Predicts Graft Failure in Renal Transplant Recipients.
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Tietge et al., Groningen, Netherlands. In J Am Soc Nephrol, 28 Sep 2015
Cholesterol efflux capacity at baseline was quantified using incubation of human macrophage foam cells with apolipoprotein B-depleted plasma.
Vitamin D reduces LPS-induced cytokine release in omental adipose tissue of women but not men.
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Gagnon et al., Québec, Canada. In Steroids, 27 Sep 2015
OBJECTIVES: To evaluate the effects of vitamin D (25(OH)D3 and 1,25(OH)2D3) on the secretion of inflammatory cytokines (TNF-α and IL-6) in omental (OM) and SC human AT and to explore factors that could correlate with the individual response to vitamin D including age, smoking status, BMI, comorbidities, medication, HbA1c, apolipoprotein B, serum 25-hydroxyvitamin D and high sensitivity C-reactive protein.
Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study.
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Impact
Witztum et al., San Diego, United States. In Lancet, 22 Aug 2015
Similar reductions were observed in the amount of oxidized phospholipids associated with apolipoprotein B-100 and apolipoprotein(a).
PCSK9 and triglyceride-rich lipoprotein metabolism.
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Ooi et al., Ottawa, Canada. In J Biomed Res, 20 Aug 2015
A link between PCSK9 and TRL has been suggested through the demonstration of (1) a correlation between plasma PCSK9 and triglyceride (TG) levels in health and disease, (2) a correlation between plasma PCSK9 and markers of carbohydrate metabolism, which is closely related to TG metabolism, (3) an effect of TG-lowering fibrate therapy on plasma PCSK9 levels, (4) an effect of PCSK9 on postprandial lipemia, (5) an effect of PCSK9 on adipose tissue biology, (6) an effect of PCSK9 on apolipoprotein B production from the liver and intestines, (7) an effect of PCSK9 on receptors other than low density lipoprotein receptor (LDLR) that are involved in TRL metabolism, and (8) an effect of anti-PCSK9 therapy on serum TG levels.
Management of patients with familial hypercholesterolaemia.
Review
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Reiner, Zagreb, Croatia. In Nat Rev Cardiol, Jul 2015
Mipomersen, an inhibitor of apolipoprotein B-100 synthesis, and lomitapide, a microsomal triglyceride transfer protein inhibitor, reduce LDL-C levels further when added to high-intensity statin treatment in homozygous FH, but both have important adverse effects, such as increasing liver fat content.
Effect of dietary Fatty acids on human lipoprotein metabolism: a comprehensive update.
Review
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Barrett et al., Perth, Australia. In Nutrients, Jun 2015
n-3 PUFA also decreased TRL-apoB-48 concentration by decreasing TRL-apoB-48 secretion.
APOBEC3 Interference during Replication of Viral Genomes.
Review
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Gillet et al., Liège, Belgium. In Viruses, Jun 2015
In particular, single-strand DNA editing by Apolipoprotein B Editing Catalytic subunits proteins 3 (APOBEC3s) is a well-conserved mechanism of mammalian innate immunity that mutates and inactivates viral genomes.
New drugs for treating dyslipidemia: beyond statins.
Review
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Choi et al., Seoul, South Korea. In Diabetes Metab J, Apr 2015
The microsomal triglyceride transport protein (MTP) inhibitor and antisense oligonucleotide against apolipoprotein B (ApoB) reduce the ApoB containing lipoprotein by blocking the hepatic very low density lipoprotein synthesis pathway.
Association between familial hypercholesterolemia and prevalence of type 2 diabetes mellitus.
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Impact
Hovingh et al., Amsterdam, Netherlands. In Jama, Apr 2015
Low-density lipoprotein (LDL) receptor mutations were considered more severe than apolipoprotein B gene (APOB) mutations, and receptor-negative LDL receptor mutations were considered more severe than receptor-deficient mutations.
JCL Roundtable: is inflammation a future target in preventing arteriosclerotic cardiovascular disease.
Review
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Ridker et al., Atlanta, United States. In J Clin Lipidol, Mar 2015
However, we have thought of this as a secondary phenomenon resulting from the causative insults of high concentrations of apolipoprotein B (apoB)-containing lipoproteins, toxins such as those from cigarette smoke, high blood pressure, and high blood glucose.
A Subregion of Reelin Suppresses Lipoprotein-Induced Cholesterol Accumulation in Macrophages.
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Yang et al., Nashville, United States. In Plos One, Dec 2014
Further, the cholesterol accumulation induced by apoB-containing, apoE-free lipoproteins was significantly less in macrophages incubated with R5-6- or R5-6C-conditioned medium than in those incubated with control conditioned medium.
Hypermutation in human cancer genomes: footprints and mechanisms.
Review
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Impact
Gordenin et al., In Nat Rev Cancer, Dec 2014
This major expansion of cancer mutation data sets has provided unprecedented statistical power for the analysis of mutation spectra, which has confirmed several classical sources of mutation in cancer, highlighted new prominent mutation sources (such as apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) enzymes) and empowered the search for cancer drivers.
Association of Apolipoprotein B and Adiponectin Receptor 1 Genes with Carcass, Bone Integrity and Performance Traits in a Paternal Broiler Line.
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Munari et al., Jaboticabal, Brazil. In Plos One, Dec 2014
UNASSIGNED: Apolipoprotein B (APOB) and Adiponectin Receptor 1 (ADIPOR1) are related to the regulation of feed intake, fat metabolism and protein deposition and are candidate genes for genomic studies in birds.
A 52-week placebo-controlled trial of evolocumab in hyperlipidemia.
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Impact
DESCARTES Investigators et al., Stellenbosch, South Africa. In N Engl J Med, Jun 2014
Evolocumab treatment also significantly reduced levels of apolipoprotein B, non-high-density lipoprotein cholesterol, lipoprotein(a), and triglycerides.
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Review
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Impact
Mani et al., New Haven, United States. In Cell Metab, Mar 2014
Further investigation showed that LRP6(R611C) mutation triggers hepatic de novo lipogenesis, lipid and cholesterol biosynthesis, and apoB secretion by an Sp1-dependent activation of IGF1, AKT, and both mTORC1 and mTORC2.
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.
GeneRIF
Rader et al., Philadelphia, United States. In J Clin Invest, 2012
model in which increased hepatic sortilin binds intracellular APOB-containing particles in the Golgi apparatus as well as extracellular LDL at the plasma membrane and traffics them to the lysosome for degradation
Elevated ApoB serum levels strongly predict early cardiovascular events.
GeneRIF
de Faire et al., Stockholm, Sweden. In Heart, 2012
Data indicate that increased ApoB serum levels are important predictors of early cardiovascular events.
ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.
Impact
GeneRIF
Yaniv et al., Israel. In Nat Med, 2012
found that ApoB negatively regulates angiogenesis and that it is the ApoB protein particle
A prospective genetic marker of the visual-perception disorder Meares-Irlen syndrome.
GeneRIF
Watson et al., Armidale, Australia. In Percept Mot Skills, 2012
APOB 3' VNTR locus is a potential marker for susceptibility to Meares-Irlen syndrome and perhaps other related conditions
Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B.
GeneRIF
Vijai Prakash et al., Lucknow, India. In Indian J Biochem Biophys, 2002
Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B
More papers using apolipoprotein B antibodies
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
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Lindenbach Brett, In PLoS ONE, 1996
... Heart Institute (University of Ottawa, Ontario, Canada), anti-apoB (clone 1609) monoclonal antibodies and peroxidase-conjugated goat anti-apoB antibodies were from Biodesign (Saco, ME, USA) ...
PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning
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Skoulakis Efthimios M. C., In PLoS ONE, 1992
... ApoB-100 transgenic mice were produced in ...
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