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Apolipoprotein B

apolipoprotein B, apoB, Apolipoprotein B-100, apoB-100
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HDL, HAD, AGE, CAN, ACID
Papers using apolipoprotein B antibodies
siRNA off-target effects can be reduced at concentrations that match their individual potency
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Harada-Shiba Mariko et al., In Molecular Therapy. Nucleic Acids, 2010
... Membranes were then incubated with primary antibody for mouse apoB-100 or -48 (Meridian Life Science, Inc., Saco, ME) for ...
Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins
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Reitsma Pieter H., In PLoS ONE, 2008
... the goat polyclonal IgG to human apolipoprotein A-II and the goat polyclonal IgG to human apolipoprotein B were from Abcam (Cambridge, UK) ...
Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice.
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Polidori Carlo, In PLoS ONE, 2001
... Seven-week-old male C57Bl/6 and human apoB-transgenic mice (B6.SJL-Tg(APOB)1102Sgy-mice backcrossed to ...
A third-generation lentivirus vector with a conditional packaging system.
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Lindenbach Brett D., In PLoS Pathogens, 1997
... Antibodies were obtained from the following companies: Apolipoprotein B (Millipore); PLA2G4A (Abcam ...
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Papers on apolipoprotein B
Acidification of the intimal fluid: the perfect storm for atherogenesis.
New
Kovanen et al., Finland. In J Lipid Res, 25 Dec 2014
In this review, we summarize our current understanding of the effects of acidic extracellular pH on three key players in atherogenesis: macrophages, apoB-containing lipoproteins, and HDL particles.
The distribution of Apolipoprotein E gene polymorphism and their influences in dyslipidemias in HIV-1 infections.
New
Sukasem et al., In Jpn J Infect Dis, 25 Dec 2014
However, level of the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-cholesterol) and apolipoprotein B (ApoB) were trend to be lower in patient carrying E2 allele but were higher in E4 carriers.
Hypermutation in human cancer genomes: footprints and mechanisms.
New
Impact
Gordenin et al., Durham, United States. In Nat Rev Cancer, 24 Dec 2014
This major expansion of cancer mutation data sets has provided unprecedented statistical power for the analysis of mutation spectra, which has confirmed several classical sources of mutation in cancer, highlighted new prominent mutation sources (such as apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) enzymes) and empowered the search for cancer drivers.
Refinement of Variant Selection for the LDL Cholesterol Genetic Risk Score in the Diagnosis of the Polygenic Form of Clinical Familial Hypercholesterolemia and Replication in Samples from 6 Countries.
New
Humphries et al., London, United Kingdom. In Clin Chem, 20 Dec 2014
Metaanalysis of the weighted 6-SNP score, on the basis of polymorphisms in CELSR2 (cadherin, EGF LAG 7-pass G-type receptor 2), APOB (apolipoprotein B), ABCG5/8 [ATP-binding cassette, sub-family G (WHITE), member 5/8], LDLR (low density lipoprotein receptor), and APOE (apolipoprotein E) loci, in the independent FH/M- cohorts showed a consistently higher score in comparison to the WHII population (P < 2.2 × 10(-16)).
Association of Plasma MiR-17-92 With Dyslipidemia in Patients With Coronary Artery Disease.
New
Ling et al., Guangzhou, China. In Medicine (baltimore), 30 Nov 2014
Moreover, these miRNAs were found widely related to the blood lipids in the patients with CAD, as miR-17 was positively correlated with total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B, while miR-92a was found positively related to high-density lipoprotein cholesterol (HDL-C) but negatively related to lipoprotein-a.
Peripheral arterial disease, type 2 diabetes and postprandial lipidaemia: Is there a link?
Review
New
Pérez-López et al., Málaga, Spain. In World J Diabetes, 15 Nov 2014
Additionally, the use of certain specific postprandial particle markers, such as apolipoprotein B-48, makes it easier and more simple to approach the postprandial phenomenon.
Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.
Review
New
Kastelein et al., Amsterdam, Netherlands. In J Am Coll Cardiol, Sep 2014
OBJECTIVES: The aim of this meta-analysis was to evaluate: 1) the interindividual variability of reductions in low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), or apolipoprotein B (apoB) levels achieved with statin therapy; 2) the proportion of patients not reaching guideline-recommended lipid levels on high-dose statin therapy; and 3) the association between very low levels of atherogenic lipoproteins achieved with statin therapy and cardiovascular disease risk.
A 52-week placebo-controlled trial of evolocumab in hyperlipidemia.
New
Impact
DESCARTES Investigators et al., Stellenbosch, South Africa. In N Engl J Med, Jun 2014
Evolocumab treatment also significantly reduced levels of apolipoprotein B, non-high-density lipoprotein cholesterol, lipoprotein(a), and triglycerides.
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Review
New
Impact
Mani et al., New Haven, United States. In Cell Metab, Mar 2014
Further investigation showed that LRP6(R611C) mutation triggers hepatic de novo lipogenesis, lipid and cholesterol biosynthesis, and apoB secretion by an Sp1-dependent activation of IGF1, AKT, and both mTORC1 and mTORC2.
[The clinical biochemistry of hypo-lipedemic therapy and mechanisms of action of statins: the fatty acids, statins and diabetes mellitus].
Review
New
Titov, In Klin Lab Diagn, Feb 2014
The statins, decreasing content of non-esterified cholesterol in monolayer, activate hydrolysis of triglycerides in lipoproteins of very low density, formation of lipoproteins of low density and their absorption by cells through apoB-100 receptors.
[The positional isomers of triglycerides in oils, fats and apoB-100 lipoproteins: palmitic and oleic modes of metabolism of fatty acids-substrates for energy acquiring].
Review
New
Titov V N et al., In Klin Lab Diagn, Jan 2014
Even total resemblance of content of fatty acids in triglycerides has both no standing for their functional unity nor even identity of their physical chemical characteristics.
Quantitative proteomic analysis of meningiomas for the identification of surrogate protein markers.
New
Srivastava et al., Mumbai, India. In Sci Rep, Dec 2013
Identified proteins like vimentin, alpha-2-macroglobulin, apolipoprotein B and A-I and antithrombin-III, which exhibited a sequential increase in different malignancy grades of meningiomas, could serve as potential predictive markers.
Lomitapide for the management of homozygous familial hypercholesterolemia.
Review
New
deGoma, Philadelphia, United States. In Rev Cardiovasc Med, Dec 2013
Lomitapide is an orally administered inhibitor of microsomal triglyceride transfer protein that is indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available for the reduction of LDL-C, total cholesterol, apolipoprotein B, and non-high-density lipoprotein cholesterol in adult patients with HoFH.
MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion.
New
Impact
Hussain et al., New York City, United States. In Nat Med, Jul 2013
We show that microRNA-30c (miR-30c) interacts with the 3' untranslated region of MTP mRNA and induces its degradation, leading to reductions in MTP activity and in apolipoprotein B (APOB) secretion.
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis.
Impact
Kaufman et al., Los Angeles, United States. In Cell Metab, 2012
Hepatocyte-specific deletion of Ire1α reduces lipid partitioning into the ER lumen and impairs the assembly of triglyceride (TG)-rich VLDL but does not affect TG synthesis, de novo lipogenesis, or the synthesis or secretion of apolipoprotein B (apoB).
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.
GeneRIF
Rader et al., Philadelphia, United States. In J Clin Invest, 2012
model in which increased hepatic sortilin binds intracellular APOB-containing particles in the Golgi apparatus as well as extracellular LDL at the plasma membrane and traffics them to the lysosome for degradation
Elevated ApoB serum levels strongly predict early cardiovascular events.
GeneRIF
de Faire et al., Stockholm, Sweden. In Heart, 2012
Data indicate that increased ApoB serum levels are important predictors of early cardiovascular events.
ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.
Impact
GeneRIF
Yaniv et al., Israel. In Nat Med, 2012
found that ApoB negatively regulates angiogenesis and that it is the ApoB protein particle
A prospective genetic marker of the visual-perception disorder Meares-Irlen syndrome.
GeneRIF
Watson et al., Armidale, Australia. In Percept Mot Skills, 2012
APOB 3' VNTR locus is a potential marker for susceptibility to Meares-Irlen syndrome and perhaps other related conditions
Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B.
GeneRIF
Vijai Prakash et al., Lucknow, India. In Indian J Biochem Biophys, 2002
Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B
More papers using apolipoprotein B antibodies
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
Supplier
Lindenbach Brett, In PLoS ONE, 1996
... Heart Institute (University of Ottawa, Ontario, Canada), anti-apoB (clone 1609) monoclonal antibodies and peroxidase-conjugated goat anti-apoB antibodies were from Biodesign (Saco, ME, USA) ...
PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning
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Skoulakis Efthimios M. C., In PLoS ONE, 1992
... ApoB-100 transgenic mice were produced in ...
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