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Apolipoprotein B

apolipoprotein B, apoB, Apolipoprotein B-100, apoB-100
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HDL, HAD, AGE, ACID, CAN
Papers using apolipoprotein B antibodies
siRNA off-target effects can be reduced at concentrations that match their individual potency
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Harada-Shiba Mariko et al., In Molecular Therapy. Nucleic Acids, 2010
... Membranes were then incubated with primary antibody for mouse apoB-100 or -48 (Meridian Life Science, Inc., Saco, ME) for ...
Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins
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Reitsma Pieter H., In PLoS ONE, 2008
... the goat polyclonal IgG to human apolipoprotein A-II and the goat polyclonal IgG to human apolipoprotein B were from Abcam (Cambridge, UK) ...
Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice.
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Polidori Carlo, In PLoS ONE, 2001
... Seven-week-old male C57Bl/6 and human apoB-transgenic mice (B6.SJL-Tg(APOB)1102Sgy-mice backcrossed to ...
A third-generation lentivirus vector with a conditional packaging system.
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Lindenbach Brett D., In PLoS Pathogens, 1997
... Antibodies were obtained from the following companies: Apolipoprotein B (Millipore); PLA2G4A (Abcam ...
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Papers on apolipoprotein B
Serum Apolipoprotein A-I and Large HDL Particles are Positively Correlated with FEV1 in Atopic Asthma.
New
Levine et al., Bethesda, United States. In Am J Respir Crit Care Med, 18 Mar 2015
Serum levels of HDL cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) were positively correlated with FEV1 in atopic asthmatics, whereas a negative correlation existed between FEV1 and serum levels of triglycerides (TG), LDL cholesterol (LDL-C), apolipoprotein B (apoB) and the apoB/apoA-I ratio.
Recent developments in genome and exome-wide analyses of plasma lipids.
New
Rich et al., Charlottesville, United States. In Curr Opin Lipidol, 16 Mar 2015
Exome sequencing promises to identify genes with protein-coding variants with a large impact on lipids, as shown for LDL-cholesterol levels associated with novel (PNPLA5) and known (LDLR, PCSK9, APOB) genes.
Comparative effects of high-dose atorvastatin versus moderate-dose rosuvastatin on lipid parameters, oxidized-LDL and inflammatory markers in ST elevation myocardial infarction.
New
Taner et al., Denizli, Turkey. In Atherosclerosis, 07 Mar 2015
The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), LDL-C, apolipoprotein B and apolipoprotein A were compared between groups after 4-week therapy.
Genetic therapies to lower cholesterol.
Review
New
Khoo, London, United Kingdom. In Vascul Pharmacol, Jan 2015
Other strategies involve knocking down the expression of Apolipoprotein B100 (APOB100) and the protease PCSK9 which designates LDLR for degradation.
The genetics of familial hypercholesterolemia and emerging therapies.
Review
New
Vogt, München, Germany. In Appl Clin Genet, Dec 2014
Mutations of the genes encoding for the LDL receptor, apolipoprotein B and proprotein convertase subtilisin/kexin type 9, are causes for this autosomal dominant inherited condition.
Hypermutation in human cancer genomes: footprints and mechanisms.
Review
New
Impact
Gordenin et al., In Nat Rev Cancer, Dec 2014
This major expansion of cancer mutation data sets has provided unprecedented statistical power for the analysis of mutation spectra, which has confirmed several classical sources of mutation in cancer, highlighted new prominent mutation sources (such as apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) enzymes) and empowered the search for cancer drivers.
Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism.
Review
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Francis et al., Vancouver, Canada. In Front Cell Dev Biol, Dec 2014
Unregulated cellular uptake of apolipoprotein B-containing lipoproteins in the arterial intima leads to the formation of foam cells in atherosclerosis.
LOX-1 in atherosclerotic disease.
Review
New
Okamura et al., Matsumoto, Japan. In Clin Chim Acta, Dec 2014
We hypothesized that LOX-1 is a candidate risk factor beyond LDL cholesterol (LDLC) and developed a novel assay to quantify LOX-1 ligand containing apoB (LAB).
[Homozygous familial hypercholesterolemia].
New
Kayikçioğlu, In Turk Kardiyol Dern Ars, Oct 2014
As both agents are targeted against ApoB, they are expected to be effective even in receptor negative homozygous AH patients.
[Heterozygous familial hypercholesterolemia].
New
Güleç et al., In Turk Kardiyol Dern Ars, Oct 2014
New classes of drugs for the treatment of hypercholesterolemia include microsomal triglyceride transfer protein inhibitors, apolipoprotein B synthesis inhibitors, and pro-protein convertase subtilisin/kexin 9 inhibitors.
[Familial hypercholesterolemia: epidemiology, genetics, diagnosis, and screening].
New
Sansoy et al., In Turk Kardiyol Dern Ars, Oct 2014
Other rare causes are the mutations of genes encoding apolipoprotein B (Apo B), pro-protein convertase subtilisin/ kexin type 9 (PCSK9) and LDL adaptor protein 1 (LDLRAP 1).
A 52-week placebo-controlled trial of evolocumab in hyperlipidemia.
New
Impact
DESCARTES Investigators et al., Stellenbosch, South Africa. In N Engl J Med, Jun 2014
Evolocumab treatment also significantly reduced levels of apolipoprotein B, non-high-density lipoprotein cholesterol, lipoprotein(a), and triglycerides.
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Review
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Impact
Mani et al., New Haven, United States. In Cell Metab, Mar 2014
Further investigation showed that LRP6(R611C) mutation triggers hepatic de novo lipogenesis, lipid and cholesterol biosynthesis, and apoB secretion by an Sp1-dependent activation of IGF1, AKT, and both mTORC1 and mTORC2.
MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion.
Impact
Hussain et al., New York City, United States. In Nat Med, 2013
We show that microRNA-30c (miR-30c) interacts with the 3' untranslated region of MTP mRNA and induces its degradation, leading to reductions in MTP activity and in apolipoprotein B (APOB) secretion.
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis.
Impact
Kaufman et al., Los Angeles, United States. In Cell Metab, 2012
Hepatocyte-specific deletion of Ire1α reduces lipid partitioning into the ER lumen and impairs the assembly of triglyceride (TG)-rich VLDL but does not affect TG synthesis, de novo lipogenesis, or the synthesis or secretion of apolipoprotein B (apoB).
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.
GeneRIF
Rader et al., Philadelphia, United States. In J Clin Invest, 2012
model in which increased hepatic sortilin binds intracellular APOB-containing particles in the Golgi apparatus as well as extracellular LDL at the plasma membrane and traffics them to the lysosome for degradation
Elevated ApoB serum levels strongly predict early cardiovascular events.
GeneRIF
de Faire et al., Stockholm, Sweden. In Heart, 2012
Data indicate that increased ApoB serum levels are important predictors of early cardiovascular events.
ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.
Impact
GeneRIF
Yaniv et al., Israel. In Nat Med, 2012
found that ApoB negatively regulates angiogenesis and that it is the ApoB protein particle
A prospective genetic marker of the visual-perception disorder Meares-Irlen syndrome.
GeneRIF
Watson et al., Armidale, Australia. In Percept Mot Skills, 2012
APOB 3' VNTR locus is a potential marker for susceptibility to Meares-Irlen syndrome and perhaps other related conditions
Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B.
GeneRIF
Vijai Prakash et al., Lucknow, India. In Indian J Biochem Biophys, 2002
Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B
More papers using apolipoprotein B antibodies
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
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Lindenbach Brett, In PLoS ONE, 1996
... Heart Institute (University of Ottawa, Ontario, Canada), anti-apoB (clone 1609) monoclonal antibodies and peroxidase-conjugated goat anti-apoB antibodies were from Biodesign (Saco, ME, USA) ...
PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning
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Skoulakis Efthimios M. C., In PLoS ONE, 1992
... ApoB-100 transgenic mice were produced in ...
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