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Apolipoprotein B
apolipoprotein B, apoB, Apolipoprotein B-100, apoB-100
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
apolipoprotein B
antibodies
siRNA off-target effects can be reduced at concentrations that match their individual potency
Supplier
In Molecular Therapy. Nucleic Acids, 2010
... Membranes were then incubated with primary antibody for mouse apoB-100 or -48 (Meridian Life Science, Inc., Saco, ME) for ...
Adeno-Associated Virus Capsid Structure Drives CD4-Dependent CD8+ T Cell Response to Vector Encoded Proteins.
Supplier
In PLoS ONE, 2008
... ApoB transgenic mice ...
Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins
Supplier
In PLoS ONE, 2008
... the goat polyclonal IgG to human apolipoprotein A-II and the goat polyclonal IgG to human apolipoprotein B were from Abcam (Cambridge, UK) ...
Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice.
Supplier
In PLoS ONE, 2001
... Seven-week-old male C57Bl/6 and human apoB-transgenic mice (B6.SJL-Tg(APOB)1102Sgy-mice backcrossed to ...
A third-generation lentivirus vector with a conditional packaging system.
more suppliersSupplier
In PLoS Pathogens, 1997
... Antibodies were obtained from the following companies: Apolipoprotein B (Millipore); PLA2G4A (Abcam ...
Papers on
apolipoprotein B
Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia.
New
United States. In J Lipid Res, 08 Apr 2013
Mutations in microsomal triglyceride transfer protein (MTP) cause abetalipoproteinemia (ABL) characterized by the absence of plasma Apolipoprotein B (ApoB)-containing lipoproteins.
Proteomic characterization of the acute-phase response of yellow stingrays Urobatis jamaicensis after injection with a Vibrio anguillarum-ordalii bacterin.
New
Gambia. In Fish Shellfish Immunol, 04 Apr 2013
Seventy-six of 156 (48.7%) proteins were downregulated in the acute-phase response, including transferrin, apolipoprotein B, heparin cofactor 2, alpha2-macroglobulin, and various growth factors.
Management of familial hypercholesterolemia: a review of the recommendations from the national lipid association expert panel on familial hypercholesterolemia.
New
Iowa City, United States. In J Manag Care Pharm, 31 Mar 2013
Mipomersen is an oligonucleotide inhibitor of apolipoprotein B-100 synthesis (called an antisense inhibitor) indicated as an adjunct to lipid-lowering medications and diet to reduce LDL-C, apolipoprotein B, total cholesterol, and non-high density lipoprotein-cholesterol (non-HDL-C) levels in patients with homozygous FH (HoFH).
Effects of lifestyle on plasma levels of the IGF system and the antioxidants coenzyme Q10 and vitamin E in Kenyan rural and urban populations.
New
Nairobi, Kenya. In Growth Horm Igf Res, 26 Mar 2013
Plasma lipid levels such as cholesterol, triglycerides, LDL/HDL, ApoB/ApoA ratios as well as BMI and weight were significantly higher in the Nairobi population (P<0.0001).
Nox2 Modification of LDL Is Essential for Optimal Apolipoprotein B-mediated Control of agr Type III Staphylococcus aureus Quorum-sensing.
New
Albuquerque, United States. In Plos Pathog, 28 Feb 2013
We determined whether two host defense factors that inhibit AIP1-induced I signaling, Nox2 and apolipoprotein B (apoB), also contribute to innate control of AIP3-induced III signaling.
Acute central neuropeptide y administration increases food intake but does not affect hepatic very low-density lipoprotein (vldl) production in mice.
New
Leiden, Netherlands. In Plos One, Dec 2012
One week later, after a 4 h fast, the animals received an intravenous (i.v.) injection of TranS (100 µCi) followed by tyloxapol (500 mg/kg body weight; BW), enabling the study of hepatic VLDL-apoB and VLDL-TG production, respectively.
Meta-analysis of comparison of effectiveness of lowering apolipoprotein B versus low-density lipoprotein cholesterol and nonhigh-density lipoprotein cholesterol for cardiovascular risk reduction in randomized trials.
Review
New
Iowa City, United States. In Am J Cardiol, Dec 2012
This study evaluated the relation between apolipoprotein B (apoB) decrease and coronary heart disease, stroke, and cardiovascular disease risk.
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis.
New
Impact
Los Angeles, United States. In Cell Metab, Nov 2012
Hepatocyte-specific deletion of Ire1α reduces lipid partitioning into the ER lumen and impairs the assembly of triglyceride (TG)-rich VLDL but does not affect TG synthesis, de novo lipogenesis, or the synthesis or secretion of apolipoprotein B (apoB).
LOX-1: a multiligand receptor at the crossroads of response to danger signals.
Review
New
Suita, Japan. In Curr Opin Lipidol, Oct 2012
In a human cohort study, high concentration of apoB-containing LOX-1 ligands predicted the incidence of cardiovascular disease.
Electronegative low-density lipoprotein. A link between apolipoprotein B misfolding, lipoprotein aggregation and proteoglycan binding.
Review
New
Barcelona, Spain. In Curr Opin Lipidol, Oct 2012
RESULTS: Circular dichroism, Trp-fluorescence and two-dimensional nuclear magnetic resonance have shown that apolipoprotein B (apoB) in LDL(-) has an abnormal, misfolded conformation.
Recent advances targeting innate immunity-mediated therapies against HIV-1 infection.
Review
New
Kuala Lumpur, Malaysia. In Microbiol Immunol, Aug 2012
Recent research has highlighted the intrinsic roles of apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G, tripartite motif-containing protein 5, tetherin, sterile α-motif and histidine/aspartic acid domain-containing protein 1 in restricting HIV-1 replication.
Role of the gut in lipid homeostasis.
Review
New
Impact
Saint Louis, United States. In Physiol Rev, Jul 2012
We review the pathways and genetic regulation of chylomicron assembly, the role of dominant restriction points such as microsomal triglyceride transfer protein and apolipoprotein B, and the role of CD36, l-FABP, and other proteins in formation of the prechylomicron complex.
Lipid-related markers and cardiovascular disease prediction.
New
Impact
In Jama, Jul 2012
OBJECTIVE: To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction.
ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.
New
Impact
Israel. In Nat Med, Jun 2012
Using a genetic screen for vascular defects in zebrafish, we initially identified a mutation, stalactite (stl), in the gene encoding microsomal triglyceride transfer protein (mtp), which is involved in the biosynthesis of apolipoprotein B (ApoB)-containing lipoproteins.
Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis.
New
Impact
Amsterdam, Netherlands. In Jama, Apr 2012
BACKGROUND: The associations of low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and apolipoprotein B (apoB) levels with the risk of cardiovascular events among patients treated with statin therapy have not been reliably documented.
Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.
GeneRIF
Dijon, France. In Arterioscler Thromb Vasc Biol, 2011
Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.
The Apolipoprotein B/Apolipoprotein A 1 ratio in relation to metabolic syndrome and its components in a sample of the Tunisian population.
GeneRIF
Tunis, Tunisia. In Exp Mol Pathol, 2011
ApoB/ApoA 1 ratio is strongly associated with metabolic syndrome and its components, as well as with insulin resistance.
Immuno-electron cryo-microscopy imaging reveals a looped topology of apoB at the surface of human LDL.
GeneRIF
Boston, United States. In J Lipid Res, 2011
Image information revealed a looped topology of apoB on the LDL surface and demonstrated the active role of apoB in maintaining the shape of the LDL particle.
Familial hypobetalipoproteinemia in a hospital survey: genetics, metabolism and non-alcoholic fatty liver disease.
GeneRIF
Mexico City, Mexico. In Ann Hepatol, 2011
familial hypobetalipoproteineima without truncated apoB is a heterogeneous disease from a metabolic and a genetic perspective
A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression.
More papers using
apolipoprotein B
antibodies
GeneRIF
Wuhan, China. In Plos One, 2010
Data suggest that ApoE associated with ApoB-carrying lipoproteins has an upregulatory role on ABCA1 expression, and that induction of Sp1 phosphorylation is a mechanism by which ApoE upregulates ABCA1 expression.
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
Supplier
In PLoS ONE, 1996
... Heart Institute (University of Ottawa, Ontario, Canada), anti-apoB (clone 1609) monoclonal antibodies and peroxidase-conjugated goat anti-apoB antibodies were from Biodesign (Saco, ME, USA) ...
PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning
Supplier
In PLoS ONE, 1992
... ApoB-100 transgenic mice were produced in ...
