Childhood adiposity: being male is a potential cardiovascular risk factor.
Coimbra, Portugal. In Eur J Pediatr, 31 Aug 2015
After adjusting for age, waist circumference in boys, compared to girls, correlated more strongly and directly to systolic (r = 0.538; p < 0.001) and diastolic blood pressure (ρ = 0.401; p < 0.01), ApoB/ApoA ratio (ρ = 0.515; p < 0.01), high-density lipoprotein cholesterol (r = -0.441; p < 0.001), low-density lipoprotein cholesterol (ρ = 0.280; p < 0.01), triglycerides (ρ = 0.420; p < 0.001), homeostasis model assessment-insulin resistance (ρ = 0.463; p < 0.001), and the left ventricular mass index (ρ = 0.286; p < 0.01).
Circulating miR-33a and miR-33b are up-regulated in familial hypercholesterolemia in paediatric age.
Roma, Italy. In Clin Sci (lond), 30 Aug 2015
We found that miR-33a and miR-33b were significantly up-regulated in the plasma of 28 hypercholesterolemic children compared to 25 healthy subjects (4.49+ 0.27 fold increase; P-value <0.001; 3.21+ 0.39 fold increase; P-value <0.05 respectively), and for both miRNAs a positive correlation with total cholesterol, low density lipoprotein cholesterol (LDL), LDL/ high-density lipoprotein cholesterol ratio, Apolipoprotein B, C Reactive Protein (CRP) and glycaemia was found.
Management of patients with familial hypercholesterolaemia.
Zagreb, Croatia. In Nat Rev Cardiol, 16 Jul 2015
Mipomersen, an inhibitor of apolipoprotein B-100 synthesis, and lomitapide, a microsomal triglyceride transfer protein inhibitor, reduce LDL-C levels further when added to high-intensity statin treatment in homozygous FH, but both have important adverse effects, such as increasing liver fat content.
New drugs for treating dyslipidemia: beyond statins.
Seoul, South Korea. In Diabetes Metab J, Apr 2015
The microsomal triglyceride transport protein (MTP) inhibitor and antisense oligonucleotide against apolipoprotein B (ApoB) reduce the ApoB containing lipoprotein by blocking the hepatic very low density lipoprotein synthesis pathway.
Hypermutation in human cancer genomes: footprints and mechanisms.
In Nat Rev Cancer, Dec 2014
This major expansion of cancer mutation data sets has provided unprecedented statistical power for the analysis of mutation spectra, which has confirmed several classical sources of mutation in cancer, highlighted new prominent mutation sources (such as apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) enzymes) and empowered the search for cancer drivers.
APOBEC3 Interference during Replication of Viral Genomes.
More papers using
Liège, Belgium. In Viruses, Dec 2014
In particular, single-strand DNA editing by Apolipoprotein B Editing Catalytic subunits proteins 3 (APOBEC3s) is a well-conserved mechanism of mammalian innate immunity that mutates and inactivates viral genomes.