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Apolipoprotein B

apolipoprotein B, apoB, Apolipoprotein B-100, apoB-100
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HDL, HAD, AGE, CAN, ACID
Papers using apolipoprotein B antibodies
siRNA off-target effects can be reduced at concentrations that match their individual potency
Harada-Shiba Mariko et al., In Molecular Therapy. Nucleic Acids, 2010
... Membranes were then incubated with primary antibody for mouse apoB-100 or -48 (Meridian Life Science, Inc., Saco, ME) for ...
Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins
Reitsma Pieter H., In PLoS ONE, 2008
... the goat polyclonal IgG to human apolipoprotein A-II and the goat polyclonal IgG to human apolipoprotein B were from Abcam (Cambridge, UK) ...
Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice.
Polidori Carlo, In PLoS ONE, 2001
... Seven-week-old male C57Bl/6 and human apoB-transgenic mice (B6.SJL-Tg(APOB)1102Sgy-mice backcrossed to ...
A third-generation lentivirus vector with a conditional packaging system.
Lindenbach Brett D., In PLoS Pathogens, 1997
... Antibodies were obtained from the following companies: Apolipoprotein B (Millipore); PLA2G4A (Abcam ...
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Papers on apolipoprotein B
Beer Is Less Harmful for the Liver than Plain Ethanol: Studies in Male Mice Using a Binge-Drinking Model.
Bergheim et al., Jena, Germany. In Alcohol Alcohol, 21 Jun 2015
Protein levels of apolipoprotein B were induced in livers of beer-fed mice only.
Low-Molecular-Weight Peptides from Salmon Protein Prevent Obesity-Linked Glucose Intolerance, Inflammation and Dyslipidemia in LDLR-/-/ApoB100/100 Mice.
Marette et al., Québec, Canada. In J Nutr, 20 Jun 2015
METHODS: ApoB(100) only, LDL receptor knockout male mice (LDLR(-/-)/ApoB(100/100)) were fed a high-fat and -sucrose (HFS) diet (25 g/kg sucrose).
Effects of phenotypic and genotypic factors on the lipid responses to niacin in chinese patients with dyslipidemia.
Tomlinson et al., Bhutan. In Medicine (baltimore), 31 May 2015
The DGAT2 rs3060 T>C polymorphism was associated with lower baseline LDL-C, apoB, high-density lipoprotein cholesterol (HDL-C), and apoAI in patients on statin therapy in the primary study.
Reassessing lipid metabolism and its potentialities in the prediction of cardiovascular risk.
Ferreira et al., São Paulo, Brazil. In Arch Endocrinol Metab, 30 Apr 2015
Some of bloodstream biomarkers related to lipid metabolism are modified LDL particles, apolipoprotein AI (apo AI), apolipoprotein B, lipoprotein (a) [Lp (a)], cholesteryl ester transfer protein (CETP), subtypes of LDL and HDL particles, and lipoprotein-associated phospholipase A2 (Lp-PLA2).
New drugs for treating dyslipidemia: beyond statins.
Choi et al., Seoul, South Korea. In Diabetes Metab J, 30 Apr 2015
The microsomal triglyceride transport protein (MTP) inhibitor and antisense oligonucleotide against apolipoprotein B (ApoB) reduce the ApoB containing lipoprotein by blocking the hepatic very low density lipoprotein synthesis pathway.
[New agents for hypercholesterolemia].
García Gómez et al., Barcelona, Spain. In Med Clin (barc), 24 Apr 2015
Agents inhibiting apolipoprotein B synthesis and microsomal transfer protein are also providing a new potential to decrease cholesterol in patients with severe hypercholesterolemia and in particular in homozygote familial hypercholesterolemia. Last, cholesteryl ester transfer protein inhibitors have shown powerful effects on c-HDL and c-LDL, although their efficacy in cardiovascular prevention and safety has not been demonstrated yet.
Association between familial hypercholesterolemia and prevalence of type 2 diabetes mellitus.
Hovingh et al., Amsterdam, Netherlands. In Jama, 10 Apr 2015
Low-density lipoprotein (LDL) receptor mutations were considered more severe than apolipoprotein B gene (APOB) mutations, and receptor-negative LDL receptor mutations were considered more severe than receptor-deficient mutations.
JCL Roundtable: Is inflammation a future target in preventing arteriosclerotic cardiovascular disease.
Ridker et al., Atlanta, United States. In J Clin Lipidol, Mar 2015
However, we have thought of this as a secondary phenomenon resulting from the causative insults of high concentrations of apolipoprotein B (apoB)-containing lipoproteins, toxins such as those from cigarette smoke, high blood pressure, and high blood glucose.
Hypermutation in human cancer genomes: footprints and mechanisms.
Gordenin et al., In Nat Rev Cancer, Dec 2014
This major expansion of cancer mutation data sets has provided unprecedented statistical power for the analysis of mutation spectra, which has confirmed several classical sources of mutation in cancer, highlighted new prominent mutation sources (such as apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) enzymes) and empowered the search for cancer drivers.
Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism.
Francis et al., Vancouver, Canada. In Front Cell Dev Biol, Dec 2014
Unregulated cellular uptake of apolipoprotein B-containing lipoproteins in the arterial intima leads to the formation of foam cells in atherosclerosis.
The genetics of familial hypercholesterolemia and emerging therapies.
Vogt, München, Germany. In Appl Clin Genet, Dec 2014
Mutations of the genes encoding for the LDL receptor, apolipoprotein B and proprotein convertase subtilisin/kexin type 9, are causes for this autosomal dominant inherited condition.
Biomarker identification and effect estimation on schizophrenia - a high dimensional data analysis.
Niebuhr et al., Silver Spring, United States. In Front Public Health, Dec 2014
In DGR analysis of serum specimens of US military service members with a diagnosis of schizophrenia from 1992 to 2005 and their controls, Alpha-1-Antitrypsin (AAT), Interleukin-6 receptor (IL-6r) and connective tissue growth factor were selected to identify schizophrenia for males; and AAT, Apolipoprotein B and Sortilin were selected for females.
A 52-week placebo-controlled trial of evolocumab in hyperlipidemia.
DESCARTES Investigators et al., Stellenbosch, South Africa. In N Engl J Med, Jun 2014
Evolocumab treatment also significantly reduced levels of apolipoprotein B, non-high-density lipoprotein cholesterol, lipoprotein(a), and triglycerides.
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Mani et al., New Haven, United States. In Cell Metab, Mar 2014
Further investigation showed that LRP6(R611C) mutation triggers hepatic de novo lipogenesis, lipid and cholesterol biosynthesis, and apoB secretion by an Sp1-dependent activation of IGF1, AKT, and both mTORC1 and mTORC2.
MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion.
Hussain et al., New York City, United States. In Nat Med, 2013
We show that microRNA-30c (miR-30c) interacts with the 3' untranslated region of MTP mRNA and induces its degradation, leading to reductions in MTP activity and in apolipoprotein B (APOB) secretion.
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.
Rader et al., Philadelphia, United States. In J Clin Invest, 2012
model in which increased hepatic sortilin binds intracellular APOB-containing particles in the Golgi apparatus as well as extracellular LDL at the plasma membrane and traffics them to the lysosome for degradation
Elevated ApoB serum levels strongly predict early cardiovascular events.
de Faire et al., Stockholm, Sweden. In Heart, 2012
Data indicate that increased ApoB serum levels are important predictors of early cardiovascular events.
ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.
Yaniv et al., Israel. In Nat Med, 2012
found that ApoB negatively regulates angiogenesis and that it is the ApoB protein particle
A prospective genetic marker of the visual-perception disorder Meares-Irlen syndrome.
Watson et al., Armidale, Australia. In Percept Mot Skills, 2012
APOB 3' VNTR locus is a potential marker for susceptibility to Meares-Irlen syndrome and perhaps other related conditions
Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B.
Vijai Prakash et al., Lucknow, India. In Indian J Biochem Biophys, 2002
Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B
More papers using apolipoprotein B antibodies
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
Lindenbach Brett, In PLoS ONE, 1996
... Heart Institute (University of Ottawa, Ontario, Canada), anti-apoB (clone 1609) monoclonal antibodies and peroxidase-conjugated goat anti-apoB antibodies were from Biodesign (Saco, ME, USA) ...
PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning
Skoulakis Efthimios M. C., In PLoS ONE, 1992
... ApoB-100 transgenic mice were produced in ...
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