gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Apolipoprotein A-IV

apolipoprotein A-IV, apoA-IV, APOA4
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Apo, HDL, apolipoprotein A-I, apolipoprotein E, HAD
Papers on apolipoprotein A-IV
Recognition of purified beta 1,3/1,6 glucan and molecular signalling in the intestine of Atlantic salmon.
New
Elvebo et al., Bodø, Norway. In Dev Comp Immunol, Mar 2016
Among the altered proteins, the Apoa4 (involved in carbohydrate and lipid metabolism); Tagln, Actb (uptake of β-glucan); Psma2 (associated with substrate recognition); and Ckt (energy metabolism-related) were the overexpressed ones.
ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.
New
Fan et al., Japan. In Atherosclerosis, Jan 2016
Interestingly, increased remnant lipoproteins in apoE KO rabbits were predominated by apoB-48 and rich in both apoA-I and apoA-IV contents.
Multiple Susceptibility Loci at Chromosome 11q23.3 are Associated with Plasma Triglyceride in East Asians.
New
Sung et al., Seoul, South Korea. In J Lipid Res, Jan 2016
ApoA5 [rs651821; rs2075291]; ZNF259 [rs964184; rs603446]; BUD13 [rs11216126]; Apoa4 [rs7396851]; SIK3 [rs12292858]; PCSK7 [rs199890178]; PAFAH1B2 [rs12420127] and SIDT2 [rs2269399].
Apolipoprotein A-IV: a protein intimately involved in metabolism.
Review
New
Tso et al., Cincinnati, United States. In J Lipid Res, Aug 2015
The purpose of this review is to summarize our current understanding of the physiological roles of apoA-IV in metabolism, and to underscore the potential for apoA-IV to be a focus for new therapies aimed at the treatment of diabetes and obesity-related disorders.
Different vitamin D receptor agonists exhibit differential effects on endothelial function and aortic gene expression in 5/6 nephrectomized rats.
Review
New
Chen et al., Chicago, United States. In J Steroid Biochem Mol Biol, Apr 2015
Real-time RT-PCR analysis confirmed that selected genes such as Abra, Apoa4, Fabp2, Hsd17b2, and Hspa1b affected by uremia were normalized by the vitamin D analogs with alfacalcidol exhibiting less of an effect.
ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety.
Review
New
Tso et al., Cincinnati, United States. In Am J Physiol Gastrointest Liver Physiol, Apr 2015
Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into intestinal lymph in response to fat absorption.
Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line.
Tso et al., Xi'an, China. In Plos One, 2014
We have previously shown that the nuclear receptor, NR1D1, is a cofactor in ApoA-IV-mediated downregulation of gluconeogenesis.
Decreased expression of the APOA1-APOC3-APOA4 gene cluster is associated with risk of Alzheimer's disease.
Gao et al., Shenyang, China. In Drug Des Devel Ther, 2014
The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11.
HDL biogenesis, remodeling, and catabolism.
Review
Chroni et al., Boston, United States. In Handb Exp Pharmacol, 2014
Similarly to apoA-I, apolipoprotein E and apolipoprotein A-IV were shown to form discrete HDL particles containing these apolipoproteins which may have important but still unexplored functions.
Enterocyte-afferent nerve interactions in dietary fat sensing.
Review
Langhans et al., Zürich, Switzerland. In Diabetes Obes Metab, 2014
Further dietary fat sensing mechanisms that are related to enterocyte fat handling and metabolism involve the release of several possible chemical mediators such as fatty acid ethanolamides or apolipoprotein A-IV.
Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion.
GeneRIF
Tso et al., Cincinnati, United States. In Proc Natl Acad Sci U S A, 2012
results suggest that apoA-IV may provide a therapeutic target for the regulation of glucose-stimulated insulin secretion and treatment of diabetes
Apolipoprotein A-IV regulates chylomicron metabolism-mechanism and function.
GeneRIF
Tso et al., Cincinnati, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
These data suggest that Apoa4 has a previously unknown role in mediating the metabolism of chylomicrons, and therefore may be important in regulating plasma lipid metabolism.
Analysis of genes regulated by the transcription factor LUMAN identifies ApoA4 as a target gene in dendritic cells.
GeneRIF
Adema et al., Nijmegen, Netherlands. In Mol Immunol, 2012
Data show that ApoA4 is a true target gene of LUMAN in bone marrow-derived DCs (BMDCs).
Impact of murine intestinal apolipoprotein A-IV expression on regional lipid absorption, gene expression, and growth.
GeneRIF
Weinberg et al., Winston-Salem, United States. In J Lipid Res, 2011
apoA-IV may play a unique role in integrating feeding behavior, intestinal lipid absorption, and energy storage
Association of a DNA polymorphism of the apolipoprotein AI-CIII-AIV gene cluster with myocardial infarction in a Tunisian population.
GeneRIF
Kaabachi et al., Tunis, Tunisia. In Eur J Intern Med, 2011
the ApoAI-CIII-AIV SacI polymorphism was associated with MI in Tunisian patients.
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism.
Impact
Lee et al., Boston, United States. In Nat Med, 2011
CREB-H-deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance catalyzed by lipoprotein lipase (Lpl), partly due to defective expression of the Lpl coactivators Apoc2, Apoa4 and Apoa5 (encoding apolipoproteins C2, A4 and A5, respectively) and concurrent augmentation of the Lpl inhibitor Apoc3.
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
Impact
Abecasis et al., Ann Arbor, United States. In Nat Genet, 2008
Overall, we identify strongly associated variants in eleven loci previously implicated in lipid metabolism (ABCA1, the APOA5-APOA4-APOC3-APOA1 and APOE-APOC clusters, APOB, CETP, GCKR, LDLR, LPL, LIPC, LIPG and PCSK9) and also in several newly identified loci (near MVK-MMAB and GALNT2, with variants primarily associated with high-density lipoprotein (HDL) cholesterol; near SORT1, with variants primarily associated with low-density lipoprotein (LDL) cholesterol; near TRIB1, MLXIPL and ANGPTL3, with variants primarily associated with triglycerides; and a locus encompassing several genes near NCAN, with variants strongly associated with both triglycerides and LDL cholesterol).
Protection against atherogenesis in mice mediated by human apolipoprotein A-IV.
Impact
Denèfle et al., Vitry-sur-Seine, France. In Science, 1996
Human apolipoprotein A-IV (apoA-IV) was expressed in the liver of C57BL/6 mice and mice deficient in apoE, both of which are prone to atherosclerosis, to investigate whether apoA-IV protects against this disease.
Attenuated hypercholesterolemic response to a high-cholesterol diet in subjects heterozygous for the apolipoprotein A-IV-2 allele.
Impact
Weinberg et al., Winston-Salem, United States. In N Engl J Med, 1994
BACKGROUND: Previous studies have suggested that the variant apolipoprotein (apo) allele apo A-IV-2 may influence the response of the plasma cholesterol concentration to dietary cholesterol.
Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis. Effect of chenodeoxycholic acid.
Impact
Shefer et al., In N Engl J Med, 1987
Apolipoprotein AIV and apolipoprotein E concentrations were comparable to those in controls, and apolipoprotein AII was considerably decreased.
share on facebooktweetadd +1mail to friends