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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Apolipoprotein A-II

Apolipoprotein A-II, apoA-II
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HDL, apolipoprotein A-I, Apo, HAD, apolipoprotein E
Papers on Apolipoprotein A-II
C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice.
New
Higuchi et al., Matsumoto, Japan. In Proc Natl Acad Sci U S A, 24 Mar 2015
Mouse strains carrying type C apoA-II (APOA2C) protein exhibit a high incidence of severe systemic amyloidosis.
Remarkable quantitative and qualitative differences in HDL after niacin or fenofibrate therapy in type 2 diabetic patients.
New
Blanco-Vaca et al., Reus, Spain. In Atherosclerosis, 28 Feb 2015
ERN/LRP increased apoA-I but not apoA-II, whereas FFB produced the opposite effect.
Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart.
New
Higuchi et al., Matsumoto, Japan. In Lab Invest, Jan 2015
UNASSIGNED: Mouse senile amyloidosis is a disorder in which apolipoprotein A-II deposits extracellularly in many organs as amyloid fibrils (AApoAII).
Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome.
New
Kontush et al., São Paulo, Brazil. In J Lipid Res, Dec 2014
HDL subpopulations from both homozygotes and heterozygotes displayed altered chemical composition, with depletion in apoA-I, GP, and cholesteryl ester; enrichment in apoA-II, free cholesterol, and TG; and altered phosphosphingolipidome.
Evaluating the association of APOA2 polymorphism with insulin resistance in adolescents.
New
Abdel-Hamid et al., Egypt. In Meta Gene, Dec 2014
BACKGROUND: 265T>C SNP in the APOA-II gene promoter may be associated with obesity risk and insulin resistance (IR).
High-density lipoprotein metabolism, composition, function, and deficiency.
Review
New
Asztalos et al., Boston, United States. In Curr Opin Lipidol, Jun 2014
SUMMARY: Recent data indicates that proteins other than apoA-I and apoA-II such as MPO and PON1 have important effects on HDL function.
Apolipoprotein A-II is a key regulatory factor of HDL metabolism as appears from studies with transgenic animals and clinical outcomes.
Review
Chabert et al., Paris, France. In Biochimie, 2014
The structure and metabolism of HDL are linked to their major apolipoproteins (apo) A-I and A-II.
Apolipoprotein A-II: evaluating its significance in dyslipidaemia, insulin resistance, and atherosclerosis.
Review
Watts et al., Perth, Australia. In Ann Med, 2012
ApoA-II, a constituent apolipoprotein of certain HDL particles, plays an important role in the regulation of cholesterol efflux, HDL remodelling, and cholesteryl ester uptake via its interactions with lipid transfer proteins, lipases, and cellular HDL receptors.
Apolipoprotein A-II-mediated conformational changes of apolipoprotein A-I in discoidal high density lipoproteins.
GeneRIF
Silva et al., Cincinnati, United States. In J Biol Chem, 2012
Apolipoprotein A-II-mediated conformational changes of apolipoprotein A-I in discoidal high density lipoproteins.
Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity.
GeneRIF
Garaulet et al., Boston, United States. In Int J Obes (lond), 2012
APOA2 m265 genotype may be associated with eating behaviours and dietary modulation of plasma ghrelin.
ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis.
GeneRIF
Higuchi et al., Matsumoto, Japan. In J Lipid Res, 2011
ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis.
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Review
Fu et al., Chengdu, China. In J Endocrinol Invest, 2011
ApoA-II played a dual function in the contents of HDL subclasses, and both small-sized HDL3b and HDL3a and large-sized HDL2b tended to increase with apoA-II concentration.
Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction.
GeneRIF
Ordovas et al., Boston, United States. In Int J Obes (lond), 2011
a gene-diet interaction involving the APOA2 -265T>C SNP and saturated fat intake determines body weight in a Mediterranean and an Asian populations
Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function.
GeneRIF
Nakayama et al., Chiba, Japan. In J Immunol, 2011
Exacerbated hepatitis is observed in ApoA-II-deficient mice, indicating that ApoA-II plays a suppressive role in concanavalin A-induced hepatitis under physiological conditions.
Apolipoproteins and amyloid fibril formation in atherosclerosis.
Review
Howlett et al., Melbourne, Australia. In Protein Cell, 2011
A number of plasma apolipoproteins, including apolipoprotein (apo) A-I, apoA-II, apoC-II and apoE are implicated in amyloid formation or influence amyloid formation by other proteins.
High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase.
Impact
Shaul et al., Dallas, United States. In Nat Med, 2001
In contrast, eNOS is not activated by purified forms of the major HDL apolipoproteins ApoA-I and ApoA-II or by low-density lipoprotein.
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23.
Impact
Peltonen et al., Helsinki, Finland. In Nat Genet, 1998
One marker, D1S104, adjacent to the apolipoprotein A-II (APOA2) gene on chromosome 1, revealed a lod score of Z = 3.50 assuming a dominant mode of inheritance.
Protein composition determines the anti-atherogenic properties of HDL in transgenic mice.
Impact
Rubin et al., Berkeley, United States. In Nature, 1993
High-density lipoprotein (HDL) contains two major proteins, apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II), comprising about 70% and 20% of the total HDL protein mass, respectively.
Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.
Impact
Lusis et al., Los Angeles, United States. In Science, 1993
The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II).
A multicenter comparison of lovastatin and cholestyramine therapy for severe primary hypercholesterolemia. The Lovastatin Study Group III.
Impact
In Jama, 1988
Cholestyramine resin treatment had no significant effect on very low-density lipoprotein cholesterol and apolipoprotein A-II levels and produced a median 11% increase in plasma triglyceride concentration; in contrast, administration of either 20 or 40 mg of lovastatin twice a day was associated with median reductions in very low-density lipoprotein cholesterol levels (-34% and -31%, respectively) and plasma triglyceride levels (-21% and -27%, respectively) and median increases in levels of apolipoprotein A-II (8% and 13%, respectively).
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