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Apolipoprotein A-II

Apolipoprotein A-II, apoA-II
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HDL, apolipoprotein A-I, Apo, HAD, apolipoprotein E
Papers on Apolipoprotein A-II
Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease.
Alzheimer’s Disease Neuroimaging Initiative et al., Basel, Switzerland. In Jama Neurol, Jan 2016
A combination of apolipoprotein A-II and cortisol levels in plasma and fibroblast growth factor 4, heart-type fatty acid binding protein, calcitonin, and tumor necrosis factor-related apoptosis-inducing ligand receptor 3 (TRAIL-R3) in CSF allowed for reliable prediction of disease status 3 years from the time of sample collection (80% classification accuracy, 88% sensitivity, and 70% specificity).
Identification and analysis of anti-HDL scFv-antibodies obtained from phage display based synthetic antibody library.
Lamminmäki et al., Turku, Finland. In Clin Biochem, Jan 2016
We found a variety of antibodies with different binding profiles, including apoA-I binding antibodies either in lipid-dependent or lipid-independent manner and binders against apoA-II.
Protein expression in dairy cows with and without subclinical hypocalcaemia.
Liu et al., Daqing, China. In N Z Vet J, Dec 2015
Expression of serum albumin, fibrinogen alpha chain, amyloid beta A4 proteins and neurosecretory protein VGF were increased, and expression of apolipoprotein A-II and serum amyloid A proteins were decreased in the subclinical hypocalcaemic cows compared with control cows.
Structural stability and functional remodeling of high-density lipoproteins.
Gursky, Boston, United States. In Febs Lett, Oct 2015
A mechanism for the conformational adaptation of the major HDL proteins, apoA-I and apoA-II, to the increasing lipid load is proposed.
Increased hepatic expression of miRNA-122 in patients infected with HCV genotype 3.
Pinho et al., São Paulo, Brazil. In Med Microbiol Immunol, Sep 2015
A positive correlation was observed between the blood and hepatic levels of miR-122 in patients infected with HCV genotype 1 (r = 0.302, p = 0.026); in these patients, an inverse correlation was observed between serum apolipoprotein A-II (ApoA-II) levels and the blood (r = -0.330; p = 0.014) and hepatic (r = -0.311; p = 0.020) levels of miR-122.
Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein.
Tozuka et al., Tokyo, Japan. In J Lipids, 2014
Myeloperoxidase (MPO) secreted by macrophages in atherosclerotic lesions generates tyrosyl radicals in apolipoprotein A-I (apoA-I) molecules, inducing the formation of apoA-I/apoA-II heterodimers through the tyrosine-tyrosine bond in HDL.
Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights.
Gursky et al., Boston, United States. In Adv Exp Med Biol, 2014
Misfolding of apoA-I, apoA-II, and serum amyloid A (SAA) causes systemic amyloidoses, apoE4 is a critical risk factor in Alzheimer's disease, and apolipoprotein misfolding is also implicated in cardiovascular disease.
High-density lipoprotein metabolism, composition, function, and deficiency.
Asztalos et al., Boston, United States. In Curr Opin Lipidol, 2014
SUMMARY: Recent data indicates that proteins other than apoA-I and apoA-II such as MPO and PON1 have important effects on HDL function.
Apolipoprotein A-II is a key regulatory factor of HDL metabolism as appears from studies with transgenic animals and clinical outcomes.
Chabert et al., Paris, France. In Biochimie, 2014
The structure and metabolism of HDL are linked to their major apolipoproteins (apo) A-I and A-II.
Apolipoprotein A-II-mediated conformational changes of apolipoprotein A-I in discoidal high density lipoproteins.
Silva et al., Cincinnati, United States. In J Biol Chem, 2012
Apolipoprotein A-II-mediated conformational changes of apolipoprotein A-I in discoidal high density lipoproteins.
Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity.
Garaulet et al., Boston, United States. In Int J Obes (lond), 2012
APOA2 m265 genotype may be associated with eating behaviours and dietary modulation of plasma ghrelin.
ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis.
Higuchi et al., Matsumoto, Japan. In J Lipid Res, 2011
ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis.
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Fu et al., Chengdu, China. In J Endocrinol Invest, 2011
ApoA-II played a dual function in the contents of HDL subclasses, and both small-sized HDL3b and HDL3a and large-sized HDL2b tended to increase with apoA-II concentration.
Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction.
Ordovas et al., Boston, United States. In Int J Obes (lond), 2011
a gene-diet interaction involving the APOA2 -265T>C SNP and saturated fat intake determines body weight in a Mediterranean and an Asian populations
Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function.
Nakayama et al., Chiba, Japan. In J Immunol, 2011
Exacerbated hepatitis is observed in ApoA-II-deficient mice, indicating that ApoA-II plays a suppressive role in concanavalin A-induced hepatitis under physiological conditions.
High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase.
Shaul et al., Dallas, United States. In Nat Med, 2001
In contrast, eNOS is not activated by purified forms of the major HDL apolipoproteins ApoA-I and ApoA-II or by low-density lipoprotein.
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23.
Peltonen et al., Helsinki, Finland. In Nat Genet, 1998
One marker, D1S104, adjacent to the apolipoprotein A-II (APOA2) gene on chromosome 1, revealed a lod score of Z = 3.50 assuming a dominant mode of inheritance.
Protein composition determines the anti-atherogenic properties of HDL in transgenic mice.
Rubin et al., Berkeley, United States. In Nature, 1993
High-density lipoprotein (HDL) contains two major proteins, apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II), comprising about 70% and 20% of the total HDL protein mass, respectively.
Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.
Lusis et al., Los Angeles, United States. In Science, 1993
The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II).
A multicenter comparison of lovastatin and cholestyramine therapy for severe primary hypercholesterolemia. The Lovastatin Study Group III.
In Jama, 1988
Cholestyramine resin treatment had no significant effect on very low-density lipoprotein cholesterol and apolipoprotein A-II levels and produced a median 11% increase in plasma triglyceride concentration; in contrast, administration of either 20 or 40 mg of lovastatin twice a day was associated with median reductions in very low-density lipoprotein cholesterol levels (-34% and -31%, respectively) and plasma triglyceride levels (-21% and -27%, respectively) and median increases in levels of apolipoprotein A-II (8% and 13%, respectively).
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