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Apolipoprotein A-II

Apolipoprotein A-II, apoA-II
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HDL, apolipoprotein A-I, Apo, HAD, apolipoprotein E
Papers on Apolipoprotein A-II
Frequencies and Geographic Distributions of Genetic Mutations in Transthyretin- and Non-Transthyretin-Related Familial Amyloidosis.
New
Gertz et al., Rochester, United States. In Clin Genet, 11 Oct 2014
Non-ATTR mutations included gelsolin (n = 3), apolipoprotein A-I (n = 6), apolipoprotein A-II (n = 1), fibrinogen A-α (n = 9), and lysozyme (n = 1).
Effects of alcohol and polyphenols from beer on atherosclerotic biomarkers in high cardiovascular risk men: A randomized feeding trial.
New
Estruch et al., Barcelona, Spain. In Nutr Metab Cardiovasc Dis, 02 Sep 2014
Moderate alcohol consumption increased serum HDL-cholesterol (∼5%), ApoA-I (∼6%), ApoA-II (∼7%) and adiponectin (∼7%), and decreased serum fibrinogen (∼8%), and interleukin (IL)-5 (∼14%) concentrations, whereas the non-alcoholic fraction of beer (mainly polyphenols) increased the receptor antagonist of IL-1 (∼24%), and decreased lymphocyte expression of lymphocyte function-associated antigen-1 (∼11%), lymphocyte and monocyte expression of Sialil-Lewis X (∼16%) and monocyte expression of CCR2 (∼31%), and tumor necrosis factor (TNF)-β (∼14%) and IL-15 (∼22%) plasma concentrations.
Acquired lcat deficiency as a major factor in lowering plasma hdl levels in chronic kidney disease.
New
Franceschini et al., Milano, Italy. In J Intern Med, Aug 2014
RESULTS: CKD was found to be associated with highly significant reductions in plasma HDL-C, unesterified cholesterol, apolipoprotein (apo)A-I, apoA-II and LpA-I:A-II levels in both CKD cohorts (with and without HD treatment).
Apolipoprotein A-II is a key regulatory factor of HDL metabolism as appears from studies with transgenic animals and clinical outcomes.
Review
New
Chabert et al., Paris, France. In Biochimie, Jan 2014
The structure and metabolism of HDL are linked to their major apolipoproteins (apo) A-I and A-II.
Apolipoprotein A-II: evaluating its significance in dyslipidaemia, insulin resistance, and atherosclerosis.
Review
Watts et al., Perth, Australia. In Ann Med, 2012
ApoA-II, a constituent apolipoprotein of certain HDL particles, plays an important role in the regulation of cholesterol efflux, HDL remodelling, and cholesteryl ester uptake via its interactions with lipid transfer proteins, lipases, and cellular HDL receptors.
Apolipoprotein A-II-mediated conformational changes of apolipoprotein A-I in discoidal high density lipoproteins.
GeneRIF
Silva et al., Cincinnati, United States. In J Biol Chem, 2012
Apolipoprotein A-II-mediated conformational changes of apolipoprotein A-I in discoidal high density lipoproteins.
Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity.
GeneRIF
Garaulet et al., Boston, United States. In Int J Obes (lond), 2012
APOA2 m265 genotype may be associated with eating behaviours and dietary modulation of plasma ghrelin.
Search for breast cancer biomarkers in fractionated serum samples by protein profiling with SELDI-TOF MS.
van Gils et al., Utrecht, Netherlands. In J Clin Lab Anal, 2012
Seven of these were tentatively identified as apolipoprotein C-II (m/z 8,909), oxidized apolipoprotein C-II (m/z 8,925), apolipoprotein C-III (m/z 8,746), fragment of coagulation factor XIIIa (m/z 3,959), heterodimer of apolipoprotein A-I and apolipoprotein A-II (m/z 45,435), hemoglobin B-chain (m/z 15,915), and post-translational modified hemoglobin (m/z 15,346).
ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis.
GeneRIF
Higuchi et al., Matsumoto, Japan. In J Lipid Res, 2011
ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis.
Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction.
GeneRIF
Ordovas et al., Boston, United States. In Int J Obes (lond), 2011
a gene-diet interaction involving the APOA2 -265T>C SNP and saturated fat intake determines body weight in a Mediterranean and an Asian populations
Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function.
GeneRIF
Nakayama et al., Chiba, Japan. In J Immunol, 2011
Exacerbated hepatitis is observed in ApoA-II-deficient mice, indicating that ApoA-II plays a suppressive role in concanavalin A-induced hepatitis under physiological conditions.
Apolipoproteins and amyloid fibril formation in atherosclerosis.
Review
Howlett et al., Melbourne, Australia. In Protein Cell, 2011
A number of plasma apolipoproteins, including apolipoprotein (apo) A-I, apoA-II, apoC-II and apoE are implicated in amyloid formation or influence amyloid formation by other proteins.
The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans.
Review
Millar et al., Philadelphia, United States. In Atherosclerosis, 2010
Fibrates also increase HDL apoA-I and apoA-II levels by enhancing apoA-I and apoA-II production, although this is partially counteracted by increasing fractional catabolism of these apolipoproteins.
HDL metabolism in context: looking on the bright side.
Review
Chan et al., Perth, Australia. In Curr Opin Lipidol, 2008
RECENT FINDINGS: HDL-apoA-I and apoA-II may be better predictors of cardiovascular disease than HDL-cholesterol.
High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase.
Impact
Shaul et al., Dallas, United States. In Nat Med, 2001
In contrast, eNOS is not activated by purified forms of the major HDL apolipoproteins ApoA-I and ApoA-II or by low-density lipoprotein.
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23.
Impact
Peltonen et al., Helsinki, Finland. In Nat Genet, 1998
One marker, D1S104, adjacent to the apolipoprotein A-II (APOA2) gene on chromosome 1, revealed a lod score of Z = 3.50 assuming a dominant mode of inheritance.
Protein composition determines the anti-atherogenic properties of HDL in transgenic mice.
Impact
Rubin et al., Berkeley, United States. In Nature, 1993
High-density lipoprotein (HDL) contains two major proteins, apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II), comprising about 70% and 20% of the total HDL protein mass, respectively.
Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.
Impact
Lusis et al., Los Angeles, United States. In Science, 1993
The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II).
A multicenter comparison of lovastatin and cholestyramine therapy for severe primary hypercholesterolemia. The Lovastatin Study Group III.
Impact
In Jama, 1988
Cholestyramine resin treatment had no significant effect on very low-density lipoprotein cholesterol and apolipoprotein A-II levels and produced a median 11% increase in plasma triglyceride concentration; in contrast, administration of either 20 or 40 mg of lovastatin twice a day was associated with median reductions in very low-density lipoprotein cholesterol levels (-34% and -31%, respectively) and plasma triglyceride levels (-21% and -27%, respectively) and median increases in levels of apolipoprotein A-II (8% and 13%, respectively).
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