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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Oct 2014.

Apolipoprotein A-Ia

apolipoprotein A-I, apoA-I
Top mentioned proteins: HDL, Apo, CAN, HAD, fibrillin-1
Papers on apolipoprotein A-I
Defective functionality of HDL particles in familial apolipoprotein A-I deficiency: relevance of alterations in HDL lipidome and proteome.
New
Kontush et al., São Paulo, Brazil. In J Lipid Res, 23 Nov 2014
Homozygotes displayed undetectable plasma levels of apoA-I and reduced levels of HDL-cholesterol and apoC-III (5.4% and 42.6% of controls, respectively).
Minimum Amino Acid Residues of an α-Helical Peptide Leading to Lipid Nanodisc Formation.
New
Kitamoto et al., In J Oleo Sci, 21 Nov 2014
In order to identify the minimum number of amino acid residues of an amphiphilic α-helical peptide that leads to nanodisc formation, seven peptides differing in lengths (22-, 18-, 14-, 12-, 10-, 8-, and 6-mers) that mimic and modify the C-terminal domain of apoA-I (residues 220-241) were synthesized.
Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance.
New
Yu et al., In Cardiovasc Diabetol, 20 Nov 2014
UNLABELLED: BackgroundTo directly compare traditional lipid ratios (total cholesterol [TC]/high density lipoprotein cholesterol [HDL-C], non-HDL-C/HDL-C, low density lipoprotein cholesterol [LDL-C]/HDL-C, and triglycerides [TG]/HDL-C), apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio, visceral adiposity index (VAI), lipid accumulation product (LAP), and the product of TG and fasting glucose (TyG) for strength and independence as risk factors for insulin resistance (IR).MethodsWe conducted a cross-sectional analysis of 7629 Chinese adults using data from the China Health and Nutrition Survey 2009.ResultsFor all lipid ratios (traditional lipid ratios and apoB/apoA-I), among both sexes, TG/HDL-C explained the most additional percentage of variation in HOMA-IR (2.9% in men, and 2.3% in women); for all variables of interest, the variability in HOMA-IR explained by VAI and TG/HDL-C were comparable; TyG had the most significant association with HOMA-IR, which explained 9.1% for men and 7.8% for women of the variability in HOMA-IR.
Impact of Cigarette Smoking Cessation on High-Density Lipoprotein Functionality.
New
Saku et al., Fukuoka, Japan. In Circ J, 16 Nov 2014
After smoking cessation, HDL-C, apoA-I levels and HDL subfractions were not significantly different from the respective baseline values.
Paraoxonase 1 and HDL maturation.
Review
New
Menini et al., Vallejo, United States. In Clin Chim Acta, 24 Oct 2014
The crucial phase will be achieved when human kinetic studies (both in the fasting and the post-prandial state) on HDL -PON1, apoA-I and lipids fate in the circulation are carried out.
ATP-Binding Cassette Transporter A1: From metabolism to neurodegeneration.
Review
New
Lefterov et al., Pittsburgh, United States. In Neurobiol Dis, Jun 2014
UNLABELLED: ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE).
Searching for a successful HDL-based treatment strategy.
Review
New
Fogelman et al., In Biochim Biophys Acta, Jan 2014
This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I-mimetic peptides.
ApoA-I/HDL Generation and Intracellular Cholesterol Transport through Cytosolic Lipid-Protein Particles in Astrocytes.
Review
New
Michikawa et al., Nagoya, Japan. In J Lipids, Dec 2013
Exogenous apolipoprotein A-I (apoA-I) associates with ATP-binding cassette transporter A1 (ABCA1) on the cell surface of astrocytes like various peripheral cells and enhances the translocation of newly synthesized cholesterol from the endoplasmic reticulum/Golgi apparatus (ER/Golgi) to the cytosol.
Residual macrovascular risk in 2013: what have we learned?
Review
New
Residual Risk Reduction Initiative (R3i) et al., Basel, Switzerland. In Cardiovasc Diabetol, Dec 2013
The Residual Risk Reduction Initiative (R3i) has previously highlighted atherogenic dyslipidaemia, defined as the imbalance between proatherogenic triglyceride-rich apolipoprotein B-containing-lipoproteins and antiatherogenic apolipoprotein A-I-lipoproteins (as in high-density lipoprotein, HDL), as an important modifiable contributor to lipid-related residual cardiovascular risk, especially in insulin-resistant conditions.
Effects of miR-33a-5P on ABCA1/G1-Mediated Cholesterol Efflux under Inflammatory Stress in THP-1 Macrophages.
New
Ruan et al., Chongqing, China. In Plos One, Dec 2013
ApoA-I-mediated cholesterol efflux was examined using the fluorescent sterol (BODIPY-cholesterol).
Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis.
New
Impact
Melbye et al., Copenhagen, Denmark. In Jama, Sep 2013
P = 1.9 × 10(-10)), is located 301 bases downstream of the apolipoprotein A-I (APOA1) gene and is correlated (r2 between 0.46 and 0.80) with SNPs previously found to be associated with levels of circulating cholesterol.
Control of angiogenesis by AIBP-mediated cholesterol efflux.
New
Impact
Miller et al., San Diego, United States. In Nature, Jul 2013
To prevent cholesterol overload, ATP-binding cassette (ABC) transporters mediate cholesterol efflux from the cells to apolipoprotein A-I (apoA-I) and the apoA-I-containing high-density lipoprotein (HDL).
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival.
Impact
Singh-Jasuja et al., Tübingen, Germany. In Nat Med, 2012
Furthermore, among six predefined populations of myeloid-derived suppressor cells, two were prognostic for overall survival, and among over 300 serum biomarkers, we identified apolipoprotein A-I (APOA1) and chemokine (C-C motif) ligand 17 (CCL17) as being predictive for both immune response to IMA901 and overall survival.
Lipid-related markers and cardiovascular disease prediction.
Impact
Danesh et al., In Jama, 2012
OBJECTIVE: To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction.
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.
Impact
Rader et al., Philadelphia, United States. In N Engl J Med, 2011
RESULTS: The levels of HDL cholesterol and apolipoprotein A-I were significant determinants of cholesterol efflux capacity but accounted for less than 40% of the observed variation.
Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles.
GeneRIF
Sakmar et al., New York City, United States. In J Mol Biol, 2008
The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.
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