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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Apolipoprotein A-Ia

apolipoprotein A-I, apoA-I
Top mentioned proteins: HDL, Apo, fibrillin-1, HAD, CAN
Papers on apolipoprotein A-I
Pentraxin 3 promotes oxLDL uptake and inhibits cholesterol efflux from macrophage-derived foam cells.
New
Ruan et al., Wuhan, China. In Exp Mol Pathol, 24 Apr 2014
To evaluate the role of specific signaling pathways, human THP-1 cells were pre-treated with inhibitors of the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2), phosphatidylinositide 3-kinases (PI3-K), and p38 mitogen-activated protein kinase (MAPK) pathways (PD98059, LY294002, and SB203580, respectively), and then exposed to oxLDL for the uptake assay or oxLDL and [(3)H]-cholesterol and apolipoprotein A-I (apoA-I) for the cholesterol efflux assay.
Twelve weeks of smoking cessation therapy with varenicline increases the serum levels of apolipoprotein A-I only in the success group.
New
Kugiyama et al., Tokyo, Japan. In J Cardiol, 24 Apr 2014
RESULTS: Serum apolipoprotein A-I (apoA-I) and high-density lipoprotein cholesterol (HDL-C) levels significantly increased from baseline to 12 weeks in the success group (apoA-I: 151.7±28.0 vs. 158.6±27.3mg/dL,
L-4F Inhibits Lipopolysaccharide-Mediated Activation of Primary Human Neutrophils.
New
Gupta et al., Birmingham, United States. In Inflammation, 20 Apr 2014
UNLABELLED: Human apolipoprotein A-I (apoA-I) mimetic L-4F inhibits acute inflammation in endotoxemic animals.
Urinary peptidomics identifies potential biomarkers for major depressive disorder.
New
Xie et al., Chongqing, China. In Psychiatry Res, 12 Apr 2014
Moreover, the protein precursors of four of the five peptides were identified by tandem mass spectrometric analysis: serum albumin, apolipoprotein A-I, protein AMBP, and basement membrane-specific heparan sulfate proteoglycan core protein.
Searching for a successful HDL-based treatment strategy.
Review
New
Fogelman et al., In Biochim Biophys Acta, Jan 2014
This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I-mimetic peptides.
Involvement of ATP-binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease.
New
Al-Jafari et al., Riyadh, Saudi Arabia. In Biomed Rep, Nov 2013
Adenosine triphosphate (ATP)-binding cassette A1 (ABCA1) belongs to the superfamily of membrane proteins that function as a key factor in the regulation of plasma high-density lipoprotein cholesterol (HDL-C) and the metabolism of apolipoprotein A-I (Apo AI).
Molecular regulation of cholesterol metabolism: HDL-based intervention through drugs and diet.
Review
New
Sala et al., Padova, Italy. In Indian J Exp Biol, Nov 2013
Pharmacological interventions mainly involve the use of molecules capable of interfering with high-density lipoprotien (HDL) metabolism and the reverse cholesterol transport (RCT) through genetic control of apolipoprotein A-I (ApoA-I), agonism at liver X-receptor alpha (LXRalpha), or inhibition of cholesteryl ester transport protein (CETP), scavenger receptor BI(SR-BI), and ecto F0F1ATPase/synthase. Nutritional interventions are based on the use of fibres, phytosterols, and probiotics acting through interference with absorption and reabsorption of cholesterol by enterocyte and hepatocyte specific transporters, thus influencing RCT final step.
Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis.
New
Impact
Melbye et al., Copenhagen, Denmark. In Jama, Sep 2013
P = 1.9 × 10(-10)), is located 301 bases downstream of the apolipoprotein A-I (APOA1) gene and is correlated (r2 between 0.46 and 0.80) with SNPs previously found to be associated with levels of circulating cholesterol.
The angiopoietin-like protein 3: a hepatokine with expanding role in metabolism.
Review
New
Maranghi et al., Roma, Italy. In Curr Opin Lipidol, Aug 2013
Their findings indicate that in humans, ANGPTL3 has a broader action on apoB and apoA-I-containing lipoproteins, as well as on free fatty acid and adipose tissue metabolism.
Control of angiogenesis by AIBP-mediated cholesterol efflux.
New
Impact
Miller et al., San Diego, United States. In Nature, Jul 2013
To prevent cholesterol overload, ATP-binding cassette (ABC) transporters mediate cholesterol efflux from the cells to apolipoprotein A-I (apoA-I) and the apoA-I-containing high-density lipoprotein (HDL).
Diagnosis and management of familial dyslipoproteinemias.
Review
New
Kwiterovich, Baltimore, United States. In Curr Cardiol Rep, Jun 2013
In the reverse cholesterol pathway, deletions or nonsense mutations in apoA-I or ABCA1 transporter disrupt the formation of the nascent HDL particle.
Role of HDL dysfunction in end-stage renal disease: a double-edged sword.
Review
New
Kalantar-Zadeh et al., Orange, United States. In J Ren Nutr, May 2013
Clinical and laboratory studies have revealed that ESRD is associated with significantly reduced serum apolipoprotein A-I (ApoA-I) and HDL-C level as well as altered HDL composition.
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival.
Impact
Singh-Jasuja et al., Tübingen, Germany. In Nat Med, 2012
Furthermore, among six predefined populations of myeloid-derived suppressor cells, two were prognostic for overall survival, and among over 300 serum biomarkers, we identified apolipoprotein A-I (APOA1) and chemokine (C-C motif) ligand 17 (CCL17) as being predictive for both immune response to IMA901 and overall survival.
Lipid-related markers and cardiovascular disease prediction.
Impact
Danesh et al., In Jama, 2012
OBJECTIVE: To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction.
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.
Impact
Rader et al., Philadelphia, United States. In N Engl J Med, 2011
RESULTS: The levels of HDL cholesterol and apolipoprotein A-I were significant determinants of cholesterol efflux capacity but accounted for less than 40% of the observed variation.
Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles.
GeneRIF
Sakmar et al., New York City, United States. In J Mol Biol, 2008
The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.
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