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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Apolipoprotein A-Ia

apolipoprotein A-I, apoA-I
Top mentioned proteins: HDL, CAN, Apo, fibrillin-1, HAD
Papers on apolipoprotein A-I
A laboratory exercise to illustrate protein-membrane interactions.
Lohmeier-Vogel et al., Calgary, Canada. In Biochem Mol Biol Educ, 12 Dec 2015
Students first purify His6 -tagged human apolipoprotein A-I (apoA-I) with Ni-NTA affinity resin in a simple batch protocol and prepare multilamellar vesicles (MLV) from pre-dried phospholipid films.
Insulin resistance determines a differential response to changes in dietary fat modification on metabolic syndrome risk factors: the LIPGENE study.
Lopez-Miranda et al., Córdoba, Spain. In Am J Clin Nutr, 11 Dec 2015
MetS subjects with a low to medium HOMA-IR exhibited reduced blood pressure, triglyceride, and LDL cholesterol levels after the LFHCC n-3 diet and increased apolipoprotein A-I concentrations after consumption of the HMUFA and HSFA diets (all P < 0.05).
Plasma-derived and synthetic high density lipoproteins inhibit tissue factor in endothelial cells and monocytes.
Gomaraschi et al., Milano, Italy. In Biochem J, 10 Dec 2015
Synthetic HDL fully retain the ability to inhibit TF expression in a dose-dependent manner; lipid-free apoA-I was not effective nor was sphingosine-1-phosphate involved.
Mycoplasma gallisepticum (HS strain) surface lipoprotein pMGA interacts with host apolipoprotein A-I during infection in chicken.
Peng et al., Wuhan, China. In Appl Microbiol Biotechnol, 09 Dec 2015
This host protein was further identified by mass spectrometry as chicken apolipoprotein A-I (ApoA-I).
Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?
Gursky et al., Boston, United States. In J Mol Biol, 09 Dec 2015
UNASSIGNED: ApoA-I, the major protein of plasma high-density lipoprotein, removes cellular cholesterol and protects against atherosclerosis.
Therapeutic applications of reconstituted HDL: When structure meets function.
Kontush et al., Paris, France. In Pharmacol Ther, 04 Dec 2015
Currently available rHDL formulations developed for clinical use contain apolipoprotein A-I (apoA-I) and one of the major lipid components of HDL, either phosphatidylcholine or sphingomyelin.
Mitochondrial regulation of macrophage cholesterol homeostasis.
Graham, Glasgow, United Kingdom. In Free Radic Biol Med, 25 Oct 2015
Certainly, overexpression of StAR and TSPO proteins can enhance macrophage cholesterol efflux to apoA-I and/or HDL, while perturbations in mitochondrial function, or changes in the expression of mitochondrial fusion proteins, alter the efficiency of cholesterol efflux.
Dysfunctional HDL and atherosclerotic cardiovascular disease.
Webb et al., New York City, United States. In Nat Rev Cardiol, Oct 2015
The proinflammatory enzyme myeloperoxidase induces both oxidative modification and nitrosylation of specific residues on plasma and arterial apolipoprotein A-I to render HDL dysfunctional, which results in impaired ABCA1 macrophage transport, the activation of inflammatory pathways, and an increased risk of coronary artery disease.
Non-clinical development of CER-001.
Barbaras, France. In Front Pharmacol, Dec 2014
Cerenis Therapeutics has developed CER-001, a negatively charged lipoprotein complex consisting of phospholipid and recombinant human apoA-I that mimics the structure and function of natural HDL.
Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights.
Gursky et al., Boston, United States. In Adv Exp Med Biol, Dec 2014
Misfolding of apoA-I, apoA-II, and serum amyloid A (SAA) causes systemic amyloidoses, apoE4 is a critical risk factor in Alzheimer's disease, and apolipoprotein misfolding is also implicated in cardiovascular disease.
Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis.
Melbye et al., Copenhagen, Denmark. In Jama, 2013
P = 1.9 × 10(-10)), is located 301 bases downstream of the apolipoprotein A-I (APOA1) gene and is correlated (r2 between 0.46 and 0.80) with SNPs previously found to be associated with levels of circulating cholesterol.
Control of angiogenesis by AIBP-mediated cholesterol efflux.
Miller et al., San Diego, United States. In Nature, 2013
To prevent cholesterol overload, ATP-binding cassette (ABC) transporters mediate cholesterol efflux from the cells to apolipoprotein A-I (apoA-I) and the apoA-I-containing high-density lipoprotein (HDL).
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival.
Singh-Jasuja et al., Tübingen, Germany. In Nat Med, 2012
Furthermore, among six predefined populations of myeloid-derived suppressor cells, two were prognostic for overall survival, and among over 300 serum biomarkers, we identified apolipoprotein A-I (APOA1) and chemokine (C-C motif) ligand 17 (CCL17) as being predictive for both immune response to IMA901 and overall survival.
Lipid-related markers and cardiovascular disease prediction.
Danesh et al., In Jama, 2012
OBJECTIVE: To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction.
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.
Rader et al., Philadelphia, United States. In N Engl J Med, 2011
RESULTS: The levels of HDL cholesterol and apolipoprotein A-I were significant determinants of cholesterol efflux capacity but accounted for less than 40% of the observed variation.
Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles.
Sakmar et al., New York City, United States. In J Mol Biol, 2008
The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.
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