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Apolipoprotein L, 2

APOL3, APOL2, apolipoprotein L, 2, apoL-II
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: apolipoprotein L-I, CAN, SET, MHA, POLYMERASE
Papers on APOL3
Recent progress in the genetics of diabetic microvascular complications.
Review
New
Chuang et al., Taipei, Taiwan. In World J Diabetes, Jul 2015
However, most of the identified risk loci could not be replicated by independent studies with a few exceptions including those in ELMO1, FRMD3, CARS, MYO16/IRS2, and APOL3-MYH9 genes.
Re-Sequencing of the APOL1-APOL4 and MYH9 Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression.
Langefeld et al., Winston-Salem, United States. In Am J Nephrol, 2014
Eleven variants, including a rare APOL3 Gln58Ter null variant (rs11089781), were genotyped in a replication panel of 1,571 AA ESKD cases and 1,334 controls.
Copy Number Variation at the APOL1 Locus.
Pollak et al., Cambridge, United States. In Plos One, 2014
8 samples sequenced in the 1000 Genomes Project showed increased coverage over a ~100kb region that includes APOL2, APOL1 and part of MYH9, suggesting the presence of APOL1 copy number greater than 2. We reasoned that such duplications should be enriched in apparent G1 heterozygotes with kidney disease.
A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation.
Sarwal et al., Paris, France. In Sci Transl Med, 2014
A panel of seven Abs (CD40, PTPRO, CGB5, FAS, P2RY11, SNRPB2, and APOL2) could predict posttransplant FSGS recurrence with 92% accuracy.
Obestatin and Nt8U influence glycerolipid metabolism and PPAR gamma signaling in mice.
Manjappara et al., Mysore, India. In Int J Biochem Cell Biol, 2014
Nt8U upregulated genes implicated in the same two pathways but with lesser significance and also upregulated APOL2.
Analysis of coding variants identified from exome sequencing resources for association with diabetic and non-diabetic nephropathy in African Americans.
Bowden et al., Winston-Salem, United States. In Hum Genet, 2014
In African Americans, SNPs in OR2L8, OR2AK2, C6orf167 (MMS22L), LIMK2, APOL3, APOL2, and APOL1 were nominally associated (P = 1.8 × 10(-4)-0.044).
Genome-wide association study of degenerative bony changes of the temporomandibular joint.
Inoue et al., Tokyo, Japan. In Oral Dis, 2014
According to in silico predictions of the 41 SNPs, two intronic SNPs of APOL3 (rs80575) and MRC2 (rs2460300) may fall within regulatory elements and affect DNA-protein interactions.
MYH9 and APOL1 gene polymorphisms and the risk of CKD in patients with lupus nephritis from an admixture population.
Woronik et al., São Paulo, Brazil. In Plos One, 2013
MYH9 rs4821480, rs2032487, rs4821481 and rs3752462, APOL 1rs73885319, rs16996616, rs60910145, rs71785313, and APOL3 rs11089781 gene polymorphisms were determined.
Mitochondrial proteomic analysis of human host cells infected with H3N2 swine influenza virus.
Zhou et al., Hangzhou, China. In J Proteomics, 2013
We further demonstrated that apolipoprotein L2 was upregulated in the cytoplasm and translocated to mitochondria during virus infection.
Pathway analysis of a genome-wide association study in schizophrenia.
Song et al., Seoul, South Korea. In Gene, 2013
Two of 15 candidate genes are known genes associated with schizophrenia: KCNQ2 and APOL2.
Copy number variation of individual cattle genomes using next-generation sequencing.
Liu et al., Beltsville, United States. In Genome Res, 2012
In contrast, genes related to pathogen- and parasite-resistance, such as CATHL4 and ULBP17, were highly duplicated in the Nelore individual relative to the taurine cattle, while genes involved in lipid transport and metabolism, including APOL3 and FABP2, were highly duplicated in the beef breeds.
Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions.
Wang et al., Oslo, Norway. In J Cell Mol Med, 2011
Genes overexpressed in ovarian/peritoneal carcinoma included SPON1, RBP1, MFGE8, TM4SF12, MMP7, KLK5/6/7, FOLR1/3,PAX8, APOL2 and NRCAM.
A novel anti-apoptotic role for apolipoprotein L2 in IFN-γ-induced cytotoxicity in human bronchial epithelial cells.
GeneRIF
Wong et al., Singapore, Singapore. In J Cell Physiol, 2011
Results reveal a novel function for ApoL2 in conferring anti-apoptotic ability of human bronchial epithelium to the cytotoxic effects of IFN-gamma, in maintaining airway epithelial layer integrity.
Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.
Johansson et al., Umeå, Sweden. In Plos Genet, 2010
Nonetheless, deletion of DPB3 and DPB4 elevates spontaneous frameshift and base substitution rates in vivo, to the same extent as the loss of Pol ε proofreading activity in a pol2-4 strain.
Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus.
Ostrander et al., Bethesda, United States. In Hum Mol Genet, 2010
We now refine this locus to a 15 kb interval, spanning Apolipoprotein L3 (APOL3), using family-based association analyses of 150 total prostate cancer (PC) cases from two independent family collections with 506 unrelated population controls.
Replication of a genome-wide association study of panic disorder in a Japanese population.
Sasaki et al., Tokyo, Japan. In J Hum Genet, 2010
We also conducted haplotype analyses of SNPs in the APOL3 and CLU genes.
Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia.
GeneRIF
Tsuang et al., Tokyo, Japan. In Schizophr Res, 2008
An association of APOL1, 2 and 4 with schizophrenia was establised.
The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.
GeneRIF
Horrevoets et al., Amsterdam, Netherlands. In Genomics, 2002
APOL2 has been found only in humans and African green monkeys
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