Obesity is associated with gene expression and imaging markers of iron accumulation in skeletal muscle.
Girona, Spain. In J Clin Endocrinol Metab, Feb 2016
Design, setting, patients and outcome measures: Markers of iron accumulation were measured in 3 different territories: Iron gene markers (TFRC1, TF, SLC11A2, FTL, FTH1 and SLC40A1) were studied in abdominal rectus abdominis (cohort 1, n=26) and quadriceps (cohort 2, n= 13) muscle using real time PCR, while paravertebral muscle R2* signal (as surrogate of iron content) (cohort 3, n=43) was evaluated by means of MRI.
Hierarchical Organization of Organic Dyes and Protein Cages into Photoactive Crystals.
Finland. In Acs Nano, Jan 2016
Toward this end, a hierarchical organization process has been designed in which (a) a supramolecular complex is formed between octacationic zinc Pc (1) and a tetraanionic pyrene (2) derivatives, driven by electrostatic and π-π interactions, and (b) the resulting tetracationic complex acts as a molecular glue that binds to the outer surface anionic patches of the apoferritin (aFt) protein cage, inducing cocrystallization.
Coupling heme and iron metabolism via ferritin H chain.
Portugal. In Antioxid Redox Signal, 2014
While heme catabolism by heme oxygenase-1 (HO-1) prevents programmed cell death, this cytoprotective effect requires the co-expression of ferritin H (heart/heavy) chain (FTH), which controls the pro-oxidant effect of labile Fe released from the protoporphyrin IX ring of heme.
GAPDH in anesthesia.
Kansas City, United States. In Adv Exp Med Biol, 2012
The binding site of inhaled anesthetics is described from literature reports on model proteins, such as human serum albumin and apoferritin.
Discovery of Novel General Anesthetics Using Apoferritin as a Surrogate System
Bethesda, United States. In Unknown Journal, 2012
A surrogate approach was recently developed, where the iron-binding protein apoferritin, was demonstrated to possess not only strong binding capacity for many general anesthetics, but also to have a structural architecture highly resembling that of the GABAA receptor transmembrane region.