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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

ApoER2, apolipoprotein E receptor 2, LRP8
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: VLDLR, Scr, apolipoprotein E, CAN, V1a
Papers on ApoER2
Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis.
Swedish Bipolar Study Group et al., Kunming, China. In Mol Neurobiol, Jan 2016
However, the role of its downstream signaling molecule, the low-density lipoprotein receptor-related protein 8 (LRP8) in these illnesses is still unclear.
Anti-β2 glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two receptors: apolipoprotein E receptor 2' and glycoprotein I bα.
Liu et al., Harbin, China. In Front Med, Dec 2015
We examined the involvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I ba) in platelet activation induced by the anti-β2GPI /β2GPI complex.
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.
Chan et al., Boston, United States. In Cell Rep, Dec 2015
MicroRNA-130/301 controlled a PPAR?-APOE-LRP8 axis, promoting collagen deposition and LOX-dependent remodeling and further upregulating YAP/TAZ via a mechanoactive feedback loop.
ApoE Receptor 2 mediates trophoblast dysfunction and pregnancy complications induced by antiphospholipid antibodies in mice.
Mineo et al., Utrecht, Netherlands. In Arthritis Rheumatol, Nov 2015
We sought to determine if the LDL receptor family member apoE receptor 2 (apoER2) mediates trophoblast dysfunction and pregnancy complications induced by aPL.
LRP receptor family member associated bone disease.
Johnson et al., Kansas City, United States. In Rev Endocr Metab Disord, Jun 2015
In this review we discuss some of the most recent reports (in the past 2 years) highlighting the involvement of the members of the LRP family (LRP5, LRP6, LRP4, and more recently LRP8) in the maintenance of bone and their implications in bone diseases.
Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development.
Winckler et al., Charlottesville, United States. In Front Cell Neurosci, 2014
We focus our discussion on endocytic accessory proteins (EAPs) (such as numb and disabled) and how they regulate endocytosis and subsequent post-endocytic trafficking of their cognate receptors (such as Notch, TrkB, β-APP, VLDLR, and ApoER2).
Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling.
Alberi et al., Fribourg, Switzerland. In Front Cell Neurosci, 2014
We observe that Notch1 is a postsynaptic receptor with functional interactions with the Reelin receptor, apolipoprotein E receptor 2 (ApoER2) and the ionotropic receptor, N-methyl-D-aspartate receptor (NMDAR).
Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms.
Kim et al., Jacksonville, United States. In Mol Cells, 2014
In this review, we summarize current understanding of apoE function in the brain, with a particular emphasis on its role in synaptic plasticity and the underlying cellular and molecular mechanisms, involving low-density lipoprotein receptor-related protein 1 (LRP1), syndecan, and LRP8/ApoER2.
Receptors involved in cell activation by antiphospholipid antibodies.
de Moerloose et al., Genève, Switzerland. In Thromb Res, 2013
Members of the TLR family and the platelet receptor apolipoprotein E receptor 2' (apoER2'), a receptor belonging to the low-density lipoprotein receptor (LDL-R) family, as well as GPIbα, were identified as putative candidates for aPLA recognition.
Selenium homeostasis and antioxidant selenoproteins in brain: implications for disorders in the central nervous system.
Sies et al., Düsseldorf, Germany. In Arch Biochem Biophys, 2013
Presumably, astrocytes secrete Sepp1, which is subsequently taken up by neurons via the apolipoprotein E receptor 2 (ApoER2).
Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis.
Tavazoie et al., New York City, United States. In Cell, 2012
Cancer-secreted ApoE suppresses invasion and metastatic endothelial recruitment (MER) by engaging melanoma cell LRP1 and endothelial cell LRP8 receptors, respectively, while DNAJA4 promotes ApoE expression.
Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2).
Burk et al., Nashville, United States. In J Biol Chem, 2012
apoER2-mediated uptake of long isoform Sepp1 is responsible for selenium distribution to tissues throughout the body.
Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia.
Kalaydjieva et al., Perth, Australia. In Am J Med Genet B Neuropsychiatr Genet, 2012
Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.
Genetic variant R952Q in LRP8 is associated with increased plasma triglyceride levels in patients with early-onset CAD and MI.
Wang et al., Cleveland, United States. In Ann Hum Genet, 2012
genetic variant R952Q of LRP8 is associated with increased plasma TG levels in patients who are overweight and have premature CAD/MI and history of smoking.
Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2.
Yang et al., Nashville, United States. In J Biol Chem, 2012
activation of VLDLR and apoER2 by reelin and apoE induces ABCA1 expression and cholesterol efflux via a Dab1-PI3K-PKCzeta-Sp1 signaling cascade.
ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.
Herz et al., Tampa, United States. In J Neurosci, 2011
ApoER2 plays a pivotal role in the development of the rod bipolar pathway and maintenance of retinal synaptic connectivity.
Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.
Acker-Palmer et al., Frankfurt am Main, Germany. In Nature, 2011
The secreted glycoprotein Reelin (also known as RELN) guides migration of neurons by binding to two lipoprotein receptors, the very-low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2, also known as LRP8).
Interaction of reelin signaling and Lis1 in brain development.
Clark et al., Houston, United States. In Nat Genet, 2003
Reln encodes an extracellular protein that regulates layer formation by interacting with VLDLR and ApoER2 (Lrp8) receptors, thereby phosphorylating the Dab1 signaling molecule.
Reelin promotes peripheral synapse elimination and maturation.
D'Arcangelo et al., Houston, United States. In Science, 2003
Unlike layer formation, neuromuscular junction development requires a function of Reelin that is not mediated by Disabled1 or very-low-density lipoprotein receptors and apolipoprotein E receptor 2 receptors but by a distinct mechanism involving its protease activity.
Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations.
Walsh et al., Boston, United States. In Nat Genet, 2000
RELN encodes a large (388 kD) secreted protein that acts on migrating cortical neurons by binding to the very low density lipoprotein receptor (VLDLR), the apolipoprotein E receptor 2 (ApoER2; refs 9-11 ), alpha3beta1 integrin and protocadherins.
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