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Apolipoprotein C-IV

apoC-IV, APOC4, apolipoprotein C-IV
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: apolipoprotein E, Apolipoprotein C-I, Apo, HDL, Apolipoprotein C-III
Papers on apoC-IV
Genetic basis of dyslipidemia in disease precipitation of coronary artery disease (CAD) associated type 2 diabetes mellitus (T2DM).
Ramteke et al., Allahābād, India. In Diabetes Metab Res Rev, Oct 2015
Taq 1B polymorphism of cholesterol ester transfer protein (CETP) gene contributes to the development of atherosclerosis, whereas haplotypes of APOA5, APOC3, APOC4, and APOC5 genes are in the same cluster and are independently associated with high plasma triglyceride level, CAD and T2DM.
The association of APOC4 polymorphisms with premature coronary artery disease in a Chinese Han population.
Xiong et al., Dongguan, China. In Lipids Health Dis, 2014
We herein genotyped four single nucleotide polymorphisms (SNPs) in lipid metabolism-related genes (rs1132899 and rs5167 in APOC4, rs1801693 and rs7765781 in LPA), aimed to shed light on the influence of these SNPs on individual susceptibility to early-onset CAD.
Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.
Malloy et al., San Francisco, United States. In Jama Neurol, 2014
The patient's apoC-III and apoC-IV levels were decreased in very low-density lipoproteins.
Evaluation of links between high-density lipoprotein genetics, functionality, and aortic valve stenosis risk in humans.
Tardif et al., Montréal, Canada. In Arterioscler Thromb Vasc Biol, 2014
APPROACH AND RESULTS: A total of 1435 single nucleotide polymorphisms in genes associated with HDL cholesterol levels (in or around GALNT2, LPL, ABCA1, APOA5, SCARB1, LIPC, CETP, LCAT, LIPG, APOC4, and PLTP) were genotyped in 382 patients with echocardiography-confirmed AVS (aortic jet velocity ≥2.5 m/s) and 401 controls.
A novel estrogen-regulated avian apolipoprotein.
Hermann et al., London, United Kingdom. In Biochimie, 2013
In search for mammalian counterparts of Apo-IV, alignment of the sequence of the novel chicken protein with those of different mammalian apolipoproteins revealed stretches with limited similarity to regions of ApoC-IV and possibly with ApoE from various mammalian species.
Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans.
Cha et al., Taejŏn, South Korea. In Bmc Complement Altern Med, 2013
By analyzing TE and non-TE type (each 2,664 subjects) populations classified on the basis of Sasang constitutional medicine, we found that the minor allele effects of three variants enriched in TE type had a harmful influence on lipid risk (near apolipoprotein A-V (APOA5)-APOA4-APOC3-APOA1 on increased triglyceride: p = 8.90 × 10(-11), in APOE-APOC1-APOC4 on increased low-density lipoprotein cholesterol: p = 1.63 × 10(-5), and near endothelial lipase gene on decreased high-density lipoprotein cholesterol: p = 4.28 × 10(-3)), whereas those of three variants (near angiopoietin-like 3 gene, APOA5-APOA4-APOC3-APOA1, and near lipoprotein lipase gene on triglyceride and high-density lipoprotein cholesterol) associated in non-TE type had neutral influences because of a compensating effect.
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.
Ballantyne et al., München, Germany. In Eur Heart J, 2012
Variants at six loci were associated with Lp-PLA2 activity (PLA2G7, APOC1, CELSR2, LDL, ZNF259, SCARB1), among which the strongest signals were at rs4420638, near the APOE-APOC1-APOC4-APOC2 cluster [P = 4.9 × 10(-30); log Lp-PLA2 difference per allele (beta): -0.054].
Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate.
Arnett et al., Birmingham, United States. In Plos One, 2011
Suggestive associations with fenofibrate response were observed for markers in or near PDE3A, MOSC1, FLJ36070, CETP, the APOE-APOC1-APOC4-APOC2, and CILP2.
Genetic variation in APOE cluster region and Alzheimer's disease risk.
Pastor et al., Pamplona, Spain. In Neurobiol Aging, 2011
We report the fine mapping/sequencing results of promoter and regulatory regions of APOE cluster genes (APOE, APOC1, APOC4, APOC2, and TOMM40) in Alzheimer's disease (AD) risk as well as in the progression from mild cognitive impairment (MCI) to AD. Long-range sequencing in 29 MCI subjects who progressed to dementia revealed 7 novel variants.
Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions.
Gafencu et al., Bucureşti, Romania. In J Biol Chem, 2011
The experiments showed that the promoters of all genes of the apoE/apoCI/apoCIV/apoCII gene cluster are enhanced by multienhancer 2 (ME.2), a regulatory region that is located 15.9 kb downstream of the apoE gene.
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
Whitfield et al., Brisbane, Australia. In Bmc Med Genet, 2010
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.
Brousseau et al., Boston, United States. In J Lipid Res, 2010
After adjustment for multiple testing within each gene, single-nucleotide polymorphisms (SNP) significantly associated with case status were identified in the genes encoding LIPC (rs4775065, P < 0.0001); CETP (rs5882, P = 0.0002); RXRA (rs11185660, P = 0.0021); ABCA1 (rs2249891, P = 0.0126); ABCC6 (rs150468, P = 0.0206; rs212077, P = 0.0443); CUBN (rs7893395, P = 0.0246); APOA2 (rs3813627, P = 0.0324); SELP (rs732314, P = 0.0376); and APOC4 (rs10413089, P = 0.0425).
APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men.
Drenos et al., London, United Kingdom. In Mol Med, 2010
This study examines the association between APOE/C1/C4/C2 gene cluster variation using tagging single nucleotide polymorphisms and plasma lipid concentration along with risk of coronary heart disease in a prospective cohort.
Identification of endogenous control genes for normalisation of real-time quantitative PCR data in colorectal cancer.
Miller et al., Galway, Ireland. In Bmc Mol Biol, 2009
RESULTS: The expression of thirteen candidate EC genes: B2M, HPRT, GAPDH, ACTB, PPIA, HCRT, SLC25A23, DTX3, APOC4, RTDR1, KRTAP12-3, CHRNB4 and MRPL19 were analysed in a cohort of 64 colorectal tumours and tumour associated normal specimens.
Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis.
Li et al., Providence, United States. In J Hepatol, 2008
ApoC-IV overexpression may perturb lipid metabolism leading to lipid accumulation. HCV core protein may modulate ApoC-IV expression through Ku antigen and PPARgamma/RXRalpha complex.
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
Edwards et al., Los Angeles, United States. In J Biol Chem, 2002
regulated expression of gene cluster in macrophages
Transcriptional regulation of the human apolipoprotein genes.
Kardassis et al., Boston, United States. In Front Biosci, 2001
ApoE/ApoCI/ApoCIV/ApoCII Cluster. 1.
Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus.
Taylor et al., San Francisco, United States. In Genomics, 1995
Includes the observation of APOC4-APOC2 read-through transcription
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