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Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4

This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APOBEC-1, APOBEC2, APOBEC3, APOBEC3G, APOBEC3A
Papers on APOBEC4
APOBECs and virus restriction.
Dudley et al., Minneapolis, United States. In Virology, May 2015
APOBEC1 and activation-induced cytosine deaminase (AID) have specialized functions in RNA editing and antibody gene diversification, respectively, whereas APOBEC2 and APOBEC4 appear to have different functions.
APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma.
Morgan et al., Little Rock, United States. In Nat Commun, 2014
Loss of MAF or MAFB expression results in decreased APOBEC3B and APOBEC4 expression, indicating a transcriptional control mechanism.
The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population.
Shen et al., Nanjing, China. In Sci Rep, 2014
APOBEC (Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) enzymes may involve in mutagenic processes in multiple cancer types, including lung cancer.
Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast.
Pavlov et al., Omaha, United States. In Biochemistry (mosc), 2011
The functions of APOBEC4, APOBEC5, and other deaminases recently discovered by bioinformatics approaches are unknown.
APOBEC deaminases-mutases with defensive roles for immunity.
Chen et al., Los Angeles, United States. In Sci China C Life Sci, 2009
Studies indicate the APOBEC family consists of 11 members: APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and APOBEC- 4 (Apo4).
Dissecting APOBEC3G substrate specificity by nucleoside analog interference.
Le Grice et al., Frederick, United States. In J Biol Chem, 2009
The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminase genes encode a set of enzymes including APOBEC1 (A1), APOBEC2 (A2), APOBEC4 (A4), and APOBEC3A-H (A3A-H).
[Vertebrate immunity: mutator proteins and their evolution].
Pavlov et al., In Genetika, 2007
The functions of APOBEC2 and APOBEC4 have not been yet determined.
HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of action.
Goncalves et al., Lisbon, Portugal. In Mol Immunol, 2007
APOBEC3G is member of a homologous family of proteins with cytidine deaminase activity expressed with characteristic tissue specificity, that in humans consist of APOBEC1, APOBEC2, APOBEC3A-H, APOBEC4 and the activation-induced deaminase (AID), a B lymphoid protein necessary for somatic hypermutation, gene conversion and class switch recombination.
APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis.
Koonin et al., Bethesda, United States. In Cell Cycle, 2005
APOBEC4 is expressed primarily in testis which suggests the possibility that it is an editing enzyme for mRNAs involved in spermatogenesis
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