The Role of the Single Deaminase Domain APOBEC3A in Virus Restriction, Retrotransposition, DNA Damage and Cancer.
Denver, United States. In J Gen Virol, Nov 2015
UNASSIGNED: The apolipoprotein mRNA editing catalytic peptide 3 (APOBEC3; A3) proteins are a family of seven are cytidine deaminases (A3A, A3B, A3C, A3D, A3F, A3G, and A3H) that restrict certain viral infections.
The eQTL-missense polymorphisms of APOBEC3H are associated with lung cancer risk in a Han Chinese population.
Nanjing, China. In Sci Rep, 2014
To test this hypothesis, we systematically screened predicted deleterious polymorphisms in the exon regions of 10 APOBEC core genes (APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, APOBEC3H, and APOBEC4) and evaluated them with a case-control study including 1200 cases and 1253 controls.
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.
San Francisco, United States. In Nature, 2012
CBF-β, which normally functions in concert with RUNX DNA binding proteins, allows the reconstitution of a recombinant six-protein assembly that elicits specific polyubiquitination activity with APOBEC3G, but not the related deaminase APOBEC3A.
Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs".
Dortmund, Germany. In Arch Toxicol, 2011
These SNPs are located next to the following genes: MYC, TP63, PSCA, the TERT-CLPTM1L locus, FGFR3, TACC3, NAT2, CBX6, APOBEC3A, CCNE1, and UGT1A.
An overview of cytidine deaminases.
London, United Kingdom. In Int J Hematol, 2006
This motif is present in APOBEC family members including activation-induced cytidine deaminase (AID), APOBEC2, and APOBEC3A through APOBEC3G.