APOBEC3 Proteins in Viral Immunity.
Philadelphia, United States. In J Immunol, Dec 2015
Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons.
The Role of the Single Deaminase Domain APOBEC3A in Virus Restriction, Retrotransposition, DNA Damage and Cancer.
Denver, United States. In J Gen Virol, Nov 2015
UNASSIGNED: The apolipoprotein mRNA editing catalytic peptide 3 (APOBEC3; A3) proteins are a family of seven are cytidine deaminases (A3A, A3B, A3C, A3D, A3F, A3G, and A3H) that restrict certain viral infections.
APOBEC3 Interference during Replication of Viral Genomes.
Liège, Belgium. In Viruses, Jun 2015
In this review, we describe the mechanisms of APOBEC3 editing during viral replication, the viral strategies that prevent APOBEC3 activity and the consequences of APOBEC3 modulation on viral fitness and host genome integrity.
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.
London, United Kingdom. In Nature, 2013
For the pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include widely expressed restriction factors, such as APOBEC3 proteins, TRIM5-α, BST2 (refs 4, 5) and SAMHD1 (refs 6, 7), as well as additional factors that are stimulated by type 1 interferon (IFN).