DNA Editing by APOBECs: A Genomic Preserver and Transformer.
Ramat Gan, Israel. In Trends Genet, Jan 2016
The unique AID (activation-induced cytidine deaminase)/APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide) family comprises proteins that alter DNA sequences by converting deoxycytidines to deoxyuridines through deamination.
Genomic spectra of biliary tract cancer.
Tokyo, Japan. In Nat Genet, Sep 2015
Gradient spectra of mutational signatures with a higher burden of the APOBEC-associated mutation signature were observed in gallbladder cancer and ECC.
AID/APOBEC deaminases and cancer.
Salzburg, Austria. In Oncoscience, 2014
Common non-random mutations comprise DNA strand-biased mutation showers and mutations restricted to certain DNA motifs, which recently have become attributed to the activity of the AID/APOBEC family of DNA deaminases.
Hypermutation in human cancer genomes: footprints and mechanisms.
In Nat Rev Cancer, 2014
This major expansion of cancer mutation data sets has provided unprecedented statistical power for the analysis of mutation spectra, which has confirmed several classical sources of mutation in cancer, highlighted new prominent mutation sources (such as apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) enzymes) and empowered the search for cancer drivers.