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Apolipoprotein B receptor

apoB48R, apolipoprotein B48 receptor, apolipoprotein B48 receptor gene
Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, THP, Insulin, PPAR, apolipoprotein E
Papers on apoB48R
A common 16p11.2 inversion underlies the joint susceptibility to asthma and obesity.
Pérez-Jurado et al., Barcelona, Spain. In Am J Hum Genet, 2014
Inversion alleles strongly correlate with expression levels of neighboring genes, especially TUFM (p = 3.0 × 10(-40)) that encodes a mitochondrial protein regulator of energy balance and inhibitor of type 1 interferon, and other candidates for asthma (IL27) and obesity (APOB48R and SH2B1).
The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells.
Bermudez et al., Sevilla, Spain. In J Nutr Biochem, 2013
In this study, we investigated the relevance of monounsaturated fatty acid (MUFA) and saturated fatty acid (SFA) in postprandial TRL in affecting the transcriptional activity of the apolipoprotein-B48 receptor (ApoB48R) and its functionality in human monocyte/macrophage cells.
Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention.
Hinney et al., Essen, Germany. In Exp Clin Endocrinol Diabetes, 2013
A gene in close proximity, apolipoprotein B48 receptor gene (APOB48R), is tagged by the same SNP(s).We analyzed 454 overweight and obese children and adolescents (10.8±2.6 years, BMI-SDS 2.4±0.5;
Triglyceride-rich lipoprotein regulates APOB48 receptor gene expression in human THP-1 monocytes and macrophages.
GeneRIF
Muriana et al., Sevilla, Spain. In J Nutr, 2012
These findings suggest that APOB48R represents a molecular target of postprandial lipoproteins via PPAR-dependent pathways in human monocytes and macrophages and advance an important link between postprandial metabolism of dietary fats and atherogenesis.
A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes.
GeneRIF
Muriana et al., Sevilla, Spain. In Am J Clin Nutr, 2011
investigation of apoB48R gene transcription in circulating monocytes: increase in apoB48R gene transcription following high-fat meal
Perilipin and adipophilin expression in lipid loaded macrophages.
Lindholm et al., Malmö, Sweden. In Biochem Biophys Res Commun, 2007
Lipid droplets were isolated and major proteins identified by mass spectrometry, among them the apolipoprotein B-48 receptor that has not previously been recognized in this context.
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity.
Saltiel et al., Ann Arbor, United States. In Diabetes, 2007
Additionally, expression of Apoe was decreased, whereas genes important in lipid metabolism, such as Pparg, Adfp, Srepf1, and Apob48r, were increased in the recruited macrophages.
Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages.
Yaqoob et al., Reading, United Kingdom. In Atherosclerosis, 2005
Expression of LDL receptor related protein (LRP) and apolipoprotein B48 receptor (apoB48R) was also examined in both differentiating monocytes, and monocyte-derived macrophages, incubated with TRL.
Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism.
GeneRIF
Yoshida et al., Tokyo, Japan. In Arterioscler Thromb Vasc Biol, 2005
Atherogenic remnant lipoproteins induced macrophage foam cell formation via apoB48R, indicating a potential role of apoB48R in atherosclerosis.
Association of nucleotide variations in the apolipoprotein B48 receptor gene (APOB48R) with hypercholesterolemia.
GeneRIF
Emi et al., Tokyo, Japan. In J Hum Genet, 2004
Nucleotide variations in the apolipoprotein B48 receptor gene is associated with hypercholesterolemia
Postprandial hyperlipidemia and atherosclerosis.
Review
Tanaka, Yokohama, Japan. In J Atheroscler Thromb, 2003
A novel apolipoprotein B48 receptor incorporating remnant lipoproteins into macrophages in arterial wall was discovered and the structure of the gene of the receptor was clarified.
PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor.
Bradley et al., Tokyo, Japan. In J Lipid Res, 2003
Certain triglyceride-rich lipoproteins (TRLs), specifically chylomicrons, dyslipemic VLDLs, and their remnants, are atherogenic and can induce monocyte-macrophage foam cell formation in vitro via the apolipoprotein B-48 receptor (apoB-48R).
The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor.
Bradley et al., Birmingham, United States. In J Lipid Res, 2002
Previously we cloned the human macrophage apolipoprotein B-48 receptor (ApoB-48R) and documented its expression in human atherosclerotic foam cells (1).
A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis.
Gianturco et al., Birmingham, United States. In Proc Natl Acad Sci U S A, 2000
TG-rich lipoprotein uptake by the apoB48R rapidly converts macrophages and apoB48R-transfected Chinese hamster ovary cells in vitro into lipid-filled foam cells, as seen in atherosclerotic lesions.
[Human apolipoprotein B48 receptor].
Review
Tanaka, Tokyo, Japan. In Nihon Rinsho, 1999
Unique candidate receptor membrane binding proteins, MBP 200 and 235, were identified in human monocyte-macrophages.
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