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N-acylaminoacyl-peptide hydrolase

APH, OPH, acylpeptide hydrolase, D3F15S2, DNF15S2
This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using APH antibodies
New mRNAs are preferentially translated during vesicular stomatitis virus infection.
Mohr Ian, In PLoS Pathogens, 2007
... Caspase activity was prevented by incubation with 60 µM Q-VD-Oph (Calbiochem) or Z-VAD fmk (Bachem).
Chromatin immunoprecipitation: optimization, quantitative analysis and data normalization.
Bryk Mary, In PLoS ONE, 2006
... Seedlings were treated for 48 h at 25°C with or without varying concentrations of APH (Wako Chemicals USA, Inc., Richmond, VA, ...
Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons
Deshmukh Mohanish et al., In The Journal of Cell Biology, 1999
... Q-VD-OPH was obtained from MP Biomedicals.
Papers on APH
Synaptic localization of acylpeptide hydrolase in adult rat telencephalon.
Pancetti et al., Coquimbo, Chile. In Neurosci Lett, 2012
ACPH protein levels are significantly increased at the synapse; ACPH is preferentially located at the pre-synaptic side
Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review.
Lottaz et al., Leuven, Belgium. In Plos One, 2010
Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4).
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