An atomic structure of human γ-secretase.
Beijing, China. In Nature, Oct 2015
Component protein APH-1 serves as a scaffold, anchoring the lone transmembrane helix from nicastrin and supporting the flexible conformation of PS1.
Three-dimensional structure of human γ-secretase.
Beijing, China. In Nature, 2014
The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage.
Structural biology of presenilin 1 complexes.
Cambridge, United Kingdom. In Mol Neurodegener, 2013
Subsequent work has shown that the presenilin proteins are the catalytic subunits of a hetero-tetrameric complex containing APH1, nicastrin and PEN-2.
The γ-secretase complex: from structure to function.
Xiamen, China. In Front Cell Neurosci, 2013
γ-secretase is a high molecular weight complex minimally composed of four components: presenilins (PS), nicastrin, anterior pharynx defective 1 (APH-1), and presenilin enhancer 2 (PEN-2).