gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


apelin, apelin-13
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: SRA, Insulin, V1a, HAD, Angiotensin II
Papers on apelin
Search for Genetic Variant in the Apelin (APLN) Gene by Resequencing and Association Study in European Subjects.
Baroni et al., Roma, Italy. In Genet Test Mol Biomarkers, Feb 2016
The first aim of this study was to search for sequence variants in the apelin gene (APLN), located on chromosome Xq25-q26.1 that may associate with serum levels of apelin.
Apelin: An Endogenous Peptide Essential for Cardiomyogenic Differentiation of Mesenchymal Stem Cells via Activating Extracellular Signal-Regulated Kinase 1/2 and 5.
Gao et al., Beijing, China. In Cell Biol Int, Feb 2016
UNASSIGNED: Growing evidence has shown that apelin/APJ system functions as a critical mediator of cardiac development as well as cardiovascular function.
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
Klabusay et al., Brno, Czech Republic. In Vascul Pharmacol, Jan 2016
Apelin is a peptide known to have a vital role in cardiovascular diseases.
Apelin/APJ signaling in hypoxia-related diseases.
Li et al., Hengyang, China. In Clin Chim Acta, Jan 2016
The regulatory peptide apelin is the endogenous ligand for the orphan G protein-coupled receptor APJ.
Combinatorial Treatment with Apelin-13 Enhances the Therapeutic Efficacy of a Preconditioned Cell-Based Therapy for Peripheral Ischemia.
Hamano et al., Ube, Japan. In Sci Rep, Dec 2015
In this study, we examined whether apelin-13, a regulator of vessel maturation, could be an effective promoter of therapeutic angiogenesis, following severe limb ischemia.
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
Davenport et al., Cambridge, United Kingdom. In Trends Pharmacol Sci, Sep 2015
Apelin and its G protein-coupled receptor (GPCR) have emerged as a key signalling pathway in the cardiovascular system.
Exercise associated hormonal signals as powerful determinants of an effective fat mass loss.
Penesova et al., In Endocr Regul, Jul 2015
Moreover, we are also describing the response of some other substances to exercise, such as myokines [irisin, apelin, brain-derived neurotrophic factor (BDNF), myostatin, and fibroblast growth factor 21 (FGF21)].
APJ receptor A445C gene polymorphism in Turkish patients with coronary artery disease.
Genç et al., Kütahya, Turkey. In Int J Clin Exp Med, 2014
Apelin is a novel endogenous peptide with inotropic and vasodilatory properties and is the ligand for the angiotensin receptor-like 1 (APJ) receptor.
The Apelin-APJ System in the Evolution of Heart Failure.
Vida-Simiti et al., Cluj-Napoca / Kolozsvár, Romania. In Clujul Med, 2014
The apelin-APJ system is a newly discovered molecular pathway and the RAAS counterbalance is its principal effect.
Electroacupuncture with different current intensities to treat knee osteoarthritis: a single-blinded controlled study.
Wang et al., Shanghai, China. In Int J Clin Exp Med, 2014
Plasma TNFα, IL-1β, IL-6, and apelin levels were also assessed by enzyme immunoassay (ELA) before and after treatment.
An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.
Chun et al., New Haven, United States. In Nat Med, 2013
Here we describe a microRNA (miRNA)-dependent association between apelin (APLN) and fibroblast growth factor 2 (FGF2) signaling in pulmonary artery endothelial cells (PAECs).
Direct identification of ligand-receptor interactions on living cells and tissues.
Wollscheid et al., Zürich, Switzerland. In Nat Biotechnol, 2012
We validated this ligand-based, receptor-capture (LRC) technology using insulin, transferrin, apelin, epidermal growth factor, the therapeutic antibody trastuzumab and two DARPins targeting ErbB2.
Apelin enhances cardiac neovascularization after myocardial infarction by recruiting aplnr+ circulating cells.
Duckers et al., Rotterdam, Netherlands. In Circ Res, 2012
We conclude that apelin functions as a new and potent chemoattractant for circulating cKit+/Flk1+/Aplnr+ cells during early myocardial repair, providing myocardial protection against ischemic damage by improving neovascularization via paracine action.
APJ acts as a dual receptor in cardiac hypertrophy.
Ruiz-Lozano et al., Los Angeles, United States. In Nature, 2012
In contrast, mice lacking apelin (the endogenous APJ ligand) remain sensitive, suggesting an apelin-independent function of APJ.
APELIN promotes hematopoiesis from human embryonic stem cells.
Elefanty et al., Australia. In Blood, 2012
APELIN promotes hematopoiesis from human embryonic stem cells.
Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat.
Lesage et al., Villeneuve-d'Ascq, France. In Peptides, 2012
At term, plasma levels of apelin were not modulated by maternal hypertension but APJ expression was increased in placenta and lung but reduced in heart.
The adipokine apelin and human uterine contractility.
Morrison et al., Galway, Ireland. In Am J Obstet Gynecol, 2012
Apelin exerted an inhibitory effect on spontaneous and oxytocin-induced contractions in human myometrium.
Apelin, plasmatic osmolality and hypotension in dialyzed patients.
Buemi et al., Messina, Italy. In Blood Purif, 2011
The arginine-vasopressin / apelin balance changes with plasmatic osmolality variations induced by hemodialytic sessions and could represent a physiopathological marker of arterial hypo- and hypertension.
A mesoderm-derived precursor for mesenchymal stem and endothelial cells.
Slukvin et al., Madison, United States. In Cell Stem Cell, 2011
Using human embryonic stem cells directed toward mesendodermal differentiation, we show that mesenchymal stem/stromal cells (MSCs) originate from a population of mesodermal cells identified by expression of apelin receptor.
International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function.
Davenport et al., Cambridge, United Kingdom. In Pharmacol Rev, 2010
It was designated an "orphan" receptor until 1998, when its endogenous ligand was identified and named apelin (for APJ endogenous ligand).
share on facebooktweetadd +1mail to friends