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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Adenomatosis polyposis coli down-regulated 1

APCDD1, Drapc1
This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: HAIR, ACID, OUT, soluble NSF attachment protein, TCF
Papers on APCDD1
The role of APCDD1 in epithelial rearrangement in tooth morphogenesis.
New
Kim et al., Taegu, South Korea. In Histochem Cell Biol, Oct 2015
Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development.
The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells.
New
Morsczeck et al., Regensburg, Germany. In Biochem Biophys Res Commun, Mar 2015
In hair follicle cells APCDD1 inhibits the canonical WNT/β-Catenin pathway and its inactivation is associated with an autosomal dominant form of hair loss.
[Alopecia and hypotrichosis in childhood: clinical features and diagnosis].
Betz, Bonn, Germany. In Hautarzt, 2014
These include other keratin genes for monilethrix, the HR gene for atrichia congenita, the genes CDSN, APCDD1 and SNRPE for the autosomal dominant form of hypotrichosis simplex, and the genes DSG4, LIPH and LPAR6 for the autosomal recessive forms of hypotrichosis as well as U2HR for hypotrichosis type Marie Unna.
Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study.
HOMED-BP study group et al., Ōsaka, Japan. In Pharmacogenomics, 2013
RESULTS: SNPs in PICALM, TANC2, NUMA1 and APCDD1 were found to be associated with CCB responses and those in ABCC9 and YIPF1 were found to be associated with ARB response with replication.
Secreted and transmembrane wnt inhibitors and activators.
Review
Niehrs et al., Heidelberg, Germany. In Cold Spring Harb Perspect Biol, 2013
Wnt inhibitors belong to small protein families, including sFRP, Dkk, WIF, Wise/SOST, Cerberus, IGFBP, Shisa, Waif1, APCDD1, and Tiki1.
Reverse differentiation as a gene filtering tool in genome expression profiling of adipogenesis for fat marker gene selection and their analysis.
Ringe et al., Berlin, Germany. In Plos One, 2012
We identified APCDD1, CHI3L1, RARRES1 and SEMA3G as potential adipogenic-specific genes.
The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations.
Park et al., Seoul, South Korea. In Hum Genet, 2012
Among the 44 validation SNPs, two SNPs (rs11080466 and rs11663246) near the APCDD1, NAPG and FAM38B genes in the 18p11.22
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex.
Impact
GeneRIF
Christiano et al., New York City, United States. In Nature, 2010
APCDD1 is a novel inhibitor of the Wnt signalling pathway with an essential role in human hair growth
Systematic identification of placental epigenetic signatures for the noninvasive prenatal detection of Edwards syndrome.
GeneRIF
Chim et al., Hong Kong, Hong Kong. In Plos One, 2009
Data show that the methylated VAPA-APCDD1 DNA in maternal plasma is predominantly derived from the fetus, and this novel fetal epigenetic marker in maternal plasma is useful for the noninvasive detection of fetal trisomy 18.
Transposition-based method for the rapid generation of gene-targeting vectors to produce Cre/Flp-modifiable conditional knock-out mice.
Savilahti et al., Helsinki, Finland. In Plos One, 2008
We demonstrate the applicability of the methodology by modifying two mouse genes, Chd22 and Drapc1.
Target genes of the WNT/beta-catenin pathway in Wilms tumors.
Gessler et al., Würzburg, Germany. In Genes Chromosomes Cancer, 2006
Among these, PITX2, APCDD1, and two members of the endothelin axis (EDN3 and EDNRA) are directly activated downstream targets of the WNT/beta-catenin pathway that may enhance proliferation of these tumor cells.
Genomic sequence analysis of a potential QTL region for fat trait on pig chromosome 6.
Kim et al., Suwŏn, South Korea. In Genomics, 2006
By searching the NCBI GenBank using BLASTX and BLASTN, this 909-kb segment was found to contain eight genes, RAB31, TXNDC2, VAPA, APCDD1, NAPG, FAM38B, C18orf30, and C18orf58, and one putative gene (DN119777).
Comprehensive survey of carapacial ridge-specific genes in turtle implies co-option of some regulatory genes in carapace evolution.
Kuratani et al., Kōbe, Japan. In Evol Dev, 2005
We identified orthologs of Sp5, cellular retinoic acid-binding protein-I (CRABP-I), adenomatous polyposis coli down-regulated 1 (APCDD1), and lymphoid enhancer-binding factor-1 (LEF-1).
Drapc1 expression during mouse embryonic development.
GeneRIF
Partanen et al., Helsinki, Finland. In Gene Expr Patterns, 2004
mouse Drapc1 is a novel in vivo target gene of Wnt/beta-catenin signaling pathway
Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis.
Nakamura et al., Tokyo, Japan. In Cancer Res, 2002
These experiments identified a novel human gene, termed APCDD1, that was down-regulated in the cancer cells by exogenous wild-type APC; its expression was also reduced in response to transduction of AXIN1.
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