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Anaphase promoting complex subunit 7
APC7, anaphase-promoting complex subunit 7
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008] (from
NCBI)
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Top mentioned proteins:
APC, Ubiquitin, Cdc27, PCNA, V1a
Papers on
APC7
The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients.
New
Tehrān, Iran. In Adv Med Sci, Sep 2015
APC7 and APC2 subunits of the APC/C complex are involved in the substrate recognition and the catalytic reaction, respectively.
Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.
New
Memphis, United States. In J Mol Biol, May 2015
The Arc Lamp contains the small subunits APC16, CDC26, and APC13, and tetratricopeptide repeat (TPR) proteins (APC7, APC3, APC6, and APC8) that homodimerize and stack with quasi-2-fold symmetry.
The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix.
London, United Kingdom. In J Mol Biol, 2013
In metazoans, there are four canonical tetratricopeptide repeat (TPR) proteins that form homo-dimers (Apc3/Cdc27, Apc6/Cdc16, Apc7 and Apc8/Cdc23).
Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C).
London, United Kingdom. In Biochem J, 2013
Additional density present in the human APC/C structure, proximal to Apc3/Cdc27 of the TPR lobe, is assigned to the TPR subunit Apc7, a subunit specific to vertebrate APC/C.
The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.
Pittsburgh, United States. In Plos One, 2012
One of the most frequent candidates was the anaphase promoting complex protein 7 (APC7 or AnapC7), which interacted with both IL-17RC and IL-17RA.
The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
GeneRIF
Freiburg, Germany. In Oncogene, 2010
Studies indicate that APC/C(Cdh1) is required to maintain genomic stability.
Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants.
Rio de Janeiro, Brazil. In Bmc Plant Biol, 2009
The absence of subunit APC7 from the genome of some green algae species and as well as from early metazoan lineages, could mean that APC7 is not required for APC function in unicellular organisms and it may be a result of duplication of another tetratricopeptide (TPR) subunit.
Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7.
GeneRIF
Seoul, South Korea. In J Biol Chem, 2009
The crystal structure of quad mutant of nApc7 (N-terminal fragment, residues 1-147) of human Apc7 at a resolution of 2.5 A, is reported.
Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast.
GeneRIF
Suwŏn, South Korea. In Hum Pathol, 2009
Expression of ANAPC7 in fibroadenomas and phylloides tumors of breast is reported.
Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster.
Szeged, Hungary. In J Cell Sci, 2007
In this study we demonstrate that the Drosophila APC/C associates with a new TPR protein, a genuine orthologue of the vertebrate Apc7 subunit that is not found in yeasts.
Cross-talk between APC/C and CBP/p300.
Review
Philadelphia, United States. In Cancer Biol Ther, 2006
In a recent report, it is shown that APC/C interacts with transcription co-activators, CBP and p300, via its APC5 and APC7 subunits.
The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
Impact
GeneRIF
Birmingham, United Kingdom. In Nature, 2006
APC5 and APC7 suppress E1A-mediated transformation in a CBP/p300-dependent manner, indicating that these components of the APC/C may be targeted during cellular transformation
Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships.
GeneRIF
Wŏnju, South Korea. In Breast Cancer Res, 2004
dysregulation of APC activity, possibly through downregulation of APC7, may be associated with tumorigenesis in breast cancer
Mitotic regulation of the human anaphase-promoting complex by phosphorylation.
Vienna, Austria. In Embo J, 2004
Of these, 32 sites are clustered in parts of Apc1 and the tetratricopeptide repeat (TPR) subunits Cdc27, Cdc16, Cdc23 and Apc7.
TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.
Vienna, Austria. In Curr Biol, 2003
In vitro, the C termini of CDC20 and CDH1 bind to the closely related TPR subunits APC3 and APC7.
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Impact
Boston, United States. In Science, 1998
The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned.
