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Anaphase promoting complex subunit 5

APC5, rmc1, Apc5p
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008] (from NCBI)
Top mentioned proteins: APC, Ubiquitin, CAN, APC4, PCNA
Papers using APC5 antibodies
Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.
Supplier
Mossman Karen L., In PLoS Pathogens, 2010
Santa Cruz and 610454, BD); anti-APC8 (6114, Biolegend); anti-APC4 (A301-176A, Bethyl laboratories); anti-APC5 (A301-026A, Bethyl laboratories); anti-geminin (sc-13015, Santa ...
Papers on APC5
Effects of Long-Term Odanacatib Treatment on Bone Gene Expression in Ovariectomized Adult Rhesus Monkeys - Differentiation from Alendronate.
New
Duong et al., United States. In J Bone Miner Res, Dec 2015
APC5, TNFRSF11A, CTSK, ITGB3 and CALCR), consistent with previous findings on the effects of this agent in enhancing the number of non-resorbing osteoclasts.
Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5.
New
Spector et al., San Diego, United States. In J Virol, Jul 2015
Viral proteins UL97 and UL21a, respectively, affect the APC/C by phosphorylation of APC/C coactivator Cdh1 and by inducing the degradation of subunits APC4 and APC5, which along with APC1 form the APC/C platform subcomplex.
The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation.
Harkness et al., Saskatoon, Canada. In Genetics, 2014
Our two-hybrid screen utilizing Apc5 as bait recovered the lifespan determinant Fob1 as prey.
Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation.
Lin et al., Houston, United States. In Cell Cycle, 2012
We also identify an APC/C subunit APC5 that binds to E2F1 and is essential for E2F1 ubiquitination.
Ruthenium methylimidazole complexes induced apoptosis in lung cancer A549 cells through intrinsic mitochondrial pathway.
He et al., Guangzhou, China. In Biochimie, 2012
Ruthenium(II) methylimidazole complexes, with the general formula [Ru(MeIm)(4)(N⌢N)](2+) (N⌢N = tip (RMC1), iip (RMC2), dppz (RMC3), dpq (RMC4); MeIm = 1-methylimidazole, tip = 2-(thiophene-2-yl)-1H-imidazo [4,5-f] [1,10]phenanthroline, iip = 2-(1H-imidazol-4-yl)-1H-imidazo [4,5-f] [1,10]phenanthroline, dppz = dipyrido[3,2-a:2',3'-c]phenazine, dpq = pyrazino [2,3-f] [1,10]phenanthroline), were synthesized and characterized.
Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.
Yu et al., Saint Louis, United States. In Plos Pathog, 2011
Importantly, we determined that expression of pUL21a was necessary and sufficient for proteasome-dependent degradation of APC subunits APC4 and APC5.
The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex.
Harkness et al., Saskatoon, Canada. In Plos Genet, 2011
Here we show the Anaphase-Promoting Complex (APC) genetically interacts with the Fkh pathway, likely working in a linear pathway under normal conditions, as fkh1Δ fkh2Δ post-mitotic survival is epistatic to that observed in apc5(CA) mutants.
Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder.
Ressler et al., Atlanta, United States. In Am J Med Genet B Neuropsychiatr Genet, 2011
CpG sites in five genes (TPR, CLEC9A, APC5, ANXA2, and TLR8) were differentially methylated in subjects with PTSD.
Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans.
Gönczy et al., Lausanne, Switzerland. In Genetics, 2010
Here, we report the characterization of a novel allele of the APC5 component SUCH-1 in Caenorhabditis elegans.
Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis.
Golden et al., Bethesda, United States. In Genetics, 2010
We have recovered a gain-of-function allele in an APC5 subunit of the anaphase promoting complex/cyclosome.
Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast.
Harkness et al., Saskatoon, Canada. In Cell Div, 2010
Here, the apc5CA mutant background is used to study a previously uncharacterized functional antagonistic genetic interaction between Gcn5 and Hda1 that is not detected in APC5 cells.
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
GeneRIF
Spector et al., San Diego, United States. In J Virol, 2010
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression.
GeneRIF
Harkness et al., Saskatoon, Canada. In Eukaryot Cell, 2010
APC is required for histone synthesis and histone metabolism in mitotically active cells as shown by its interaction with Elp3/Gcn5.
The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
GeneRIF
Cross et al., Freiburg, Germany. In Oncogene, 2010
Studies indicate that APC/C(Cdh1) is required to maintain genomic stability.
Cross-talk between APC/C and CBP/p300.
Review
Fuchs et al., Philadelphia, United States. In Cancer Biol Ther, 2006
In a recent report, it is shown that APC/C interacts with transcription co-activators, CBP and p300, via its APC5 and APC7 subunits.
The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
Impact
GeneRIF
Gallimore et al., Birmingham, United Kingdom. In Nature, 2006
APC5 and APC7 suppress E1A-mediated transformation in a CBP/p300-dependent manner, indicating that these components of the APC/C may be targeted during cellular transformation
Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae.
GeneRIF
Harkness et al., Saskatoon, Canada. In Eukaryot Cell, 2005
Apc5p and Rsp5p have roles in an intracellular signaling pathway in Saccharomyces cerevisiae
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Impact
Kirschner et al., Boston, United States. In Science, 1998
The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned.
Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.
Impact
Nasmyth et al., Vienna, Austria. In Science, 1998
Apc2p, Apc5p, and the RING-finger protein Apc11p are conserved from yeast to humans.
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