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Anaphase promoting complex subunit 4

APC4, Cut20, lid1
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APC, Ubiquitin, APC5, APC1, Cdc27
Papers using APC4 antibodies
Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.
Supplier
Mossman Karen L., In PLoS Pathogens, 2010
Santa Cruz and 610454, BD); anti-APC8 (6114, Biolegend); anti-APC4 (A301-176A, Bethyl laboratories); anti-APC5 (A301-026A, Bethyl ...
Papers on APC4
Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
New
Barford et al., London, United Kingdom. In J Mol Biol, Nov 2015
Here, we describe the crystal structures of Apc4 and the N-terminal domain of Apc5 (Apc5(N)).
Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5.
New
Spector et al., San Diego, United States. In J Virol, Jul 2015
Viral proteins UL97 and UL21a, respectively, affect the APC/C by phosphorylation of APC/C coactivator Cdh1 and by inducing the degradation of subunits APC4 and APC5, which along with APC1 form the APC/C platform subcomplex.
In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
New
Okazawa et al., Tokyo, Japan. In Mol Psychiatry, Apr 2015
Exogenous Apc4, a hub protein in the network of affected genes, recovered the cell cycle, proliferation, and cell phenotypes of NSPCs caused by Pqbp1-cKO.
The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa.
Liu et al., Fuzhou, China. In Acta Crystallogr D Biol Crystallogr, 2015
Tle4 consists of two domains: a conserved α/β-hydrolase domain and an unusual cap domain in which two lid regions (lid1 and lid2) display a closed conformation that buries the catalytic triad in a deep funnel.
Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe.
Gould et al., Nashville, United States. In G3 (bethesda), 2014
We found that deletion of ubp8, encoding the Spt-Ada-Gcn5-Acetyl transferase (SAGA) complex associated DUB, suppressed temperature-sensitive phenotypes of APC/C mutants cut9-665, lid1-6, cut4-533, and slp1-362.
MicroRNA-452 contributes to the docetaxel resistance of breast cancer cells.
Zhao et al., Xuzhou, China. In Tumour Biol, 2014
The relationship of miRNA-452 and its predictive target gene "anaphase-promoting complex 4" (APC4) was analyzed by RT-qPCR and Western blot.MiRNA-452 showed significantly higher expression (78.9-folds) in MCF-7/DOC cells compared to parental MCF-7 cells.
Calcium-independent opening of lid1 of a family I.3 lipase by a single Asp to Arg mutation at the calcium-binding site.
Kanaya et al., Suita, Japan. In Protein Eng Des Sel, 2014
MIS38 (PML) has two lids, lid1 and lid2, which are open when it exhibits activity.
The Arabidopsis anaphase-promoting complex/cyclosome subunit 1 is critical for both female gametogenesis and embryogenesis(F).
Qu et al., Beijing, China. In J Integr Plant Biol, 2013
All of these defects are similar to those previously identified in apc4.
Nutritionally driven differential gene expression leads to heterochronic brain development in honeybee castes.
Simões et al., Ribeirão Preto, Brazil. In Plos One, 2012
Analyzing brains from L3 through L5S1 larvae, we identified 21 genes with caste-specific transcription patterns (e.g., APC-4, GlcAT-P, fax, kr-h1 and shot), which encode proteins that are potentially involved in the development of brain tissues through controlling the cell proliferation rate (APC4, kr-h1) and fasciculation (GlcAT-P, fax, and shot).
A minimal anaphase promoting complex/cyclosome (APC/C) in Trypanosoma brucei.
Wang et al., San Francisco, United States. In Plos One, 2012
AP1 turned out to be a homologue of APC4.
Requirement of lid2 for interfacial activation of a family I.3 lipase with unique two lid structures.
Kanaya et al., Ōsaka, Japan. In Febs J, 2012
MIS38 (PML) is characterized by the presence of two lids (lid1 and lid2) that greatly change conformation upon substrate binding.
The Arabidopsis APC4 subunit of the anaphase-promoting complex/cyclosome (APC/C) is critical for both female gametogenesis and embryogenesis.
Qu et al., Beijing, China. In Plant J, 2012
APC4 is proposed to be a connector in the APC/C in yeast and animals.
Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.
Yu et al., Saint Louis, United States. In Plos Pathog, 2011
Importantly, we determined that expression of pUL21a was necessary and sufficient for proteasome-dependent degradation of APC subunits APC4 and APC5.
Structural basis for the subunit assembly of the anaphase-promoting complex.
Impact
Barford et al., London, United Kingdom. In Nature, 2011
Our structure explains how this TPR sub-complex, together with additional scaffolding subunits (Apc1, Apc4 and Apc5), coordinate the juxtaposition of the catalytic and substrate recognition module (Apc2, Apc11 and Apc10 (also known as Doc1)), and TPR-phosphorylation sites, relative to co-activator, regulatory proteins and substrates.
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
GeneRIF
Spector et al., San Diego, United States. In J Virol, 2010
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
GeneRIF
Cross et al., Freiburg, Germany. In Oncogene, 2010
Studies indicate that APC/C(Cdh1) is required to maintain genomic stability.
Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.
GeneRIF
Gould et al., Nashville, United States. In Eukaryot Cell, 2005
Data suggest that Dim1p participates in pre-mRNA splicing, and in the nuclear export of lid1(+) mRNA.
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Impact
Kirschner et al., Boston, United States. In Science, 1998
The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned.
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