gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Adenomatous polyposis coli tumor suppressor homolog 2

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APC, CAN, Ubiquitin, APC1, Armadillo
Papers using APC2 antibodies
Roles of Armadillo, a Drosophila catenin, during central nervous system development.
Katoh Masaru, In PLoS ONE, 1997
... Fly APC2 constructs and transgenic flies were generated as ...
Papers on APC2
The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells.
Fuller et al., Stanford, United States. In Development, Jan 2014
Germline specific overexpression of Adenomatous Polyposis Coli 2 (APC2) rescued GSC loss in chic hypomorphs, suggesting an additive role of APC2 and F-actin in maintaining the adherens junctions that anchor GSCs to the niche.
Drosophila-Cdh1 (Rap/Fzr) a regulatory subunit of APC/C is required for synaptic morphology, synaptic transmission and locomotion.
Venkatesh et al., New York City, United States. In Int J Dev Neurosci, Nov 2013
In the Drosophila peripheral nervous system (PNS), APC2, a ligase subunit of the APC/C complex has been shown to regulate synaptic bouton size and activity (van Roessel et al., 2004).
APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation.
Peifer et al., Chapel Hill, United States. In Development, Oct 2013
Mutations in the tumor suppressor adenomatous polyposis coli (APC) initiate most colon cancers and have also been suggested to promote disease progression through increased CIN, but the mechanistic role of APC in preventing CIN remains controversial.
Discs large links spindle orientation to apical-basal polarity in Drosophila epithelia.
St Johnston et al., Cambridge, United Kingdom. In Curr Biol, Oct 2013
Previous work has implicated the apical polarity factor aPKC, the junctional protein APC2, and basal integrins in epithelial spindle orientation, but the underlying mechanisms remain unclear.
Regulation of nuclear envelope dynamics via APC/C is necessary for the progression of semi-open mitosis in Schizosaccharomyces japonicus.
Niki et al., Mishima, Japan. In Genes Cells, Sep 2013
In anaphase-promoting complex/cyclosome (APC/C) mutants of Sz. japonicus, the nuclear envelope remained relatively intact during anaphase, resulting in impaired semi-open mitosis.
Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer.
Hosseini et al., Shīrāz, Iran. In Mol Biol Rep, May 2013
Then we compared the frequency of their methylation changes with the results of our previously reported K-ras gene mutation, APC2 and p16 methylation.
Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.
Behrens et al., Erlangen, Germany. In Plos One, 2012
We show here that colon cancer cell lines express also the paralog APC-like (APCL or APC2).
Drosophila apc regulates delamination of invasive epithelial clusters.
Noselli et al., Nice, France. In Dev Biol, 2012
Data show that a loss of function for dapc1 or both dapc1 and dapc2 (dapc) in ovary border (BC) and adjacent follicle cells impaired BC delamination, and this mutant phenotype can be rescued upon overexpression of either dapc1 or dapc2.
Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxicity in Drosophila.
Liévens et al., Marseille, France. In Neurobiol Dis, 2012
Similarly, overexpression of one Armadillo/β-Catenin destruction complex component (Axin, APC2 or Shaggy/GSK-3β) increases the lifespan of HD flies.
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.
Peifer et al., Chapel Hill, United States. In Mol Biol Cell, 2012
These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling.
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
Noda et al., Okazaki, Japan. In J Neurosci, 2012
Lack of adenomatosis polyposis coli 2 induces severe laminary defects in some regions of the mouse brain, including the cerebral cortex and cerebellum.
Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells.
Waterman et al., Bethesda, United States. In Plos One, 2011
By analyzing fluorescent EB3 dynamics with automated tracking, we found that RNAi treatments targeting p150(glued), APC2, spastin, EB1, Op18, or MARK2 blocked Rac1-mediated MT growth in lamellipodia.
Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.
Rishi et al., Detroit, United States. In J Biol Chem, 2011
anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonists are novel regulators of cell growth and apoptosis
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.
Huang et al., New York City, United States. In J Cell Biol, 2011
It proposes a role for APC/C(Cdh1) in modulating the status of PCNA monoubiquitination and UV DNA repair before S phase entry.
ASPP: a new family of oncogenes and tumour suppressor genes.
Lu et al., London, United Kingdom. In Br J Cancer, 2007
They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1).
Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin.
Peifer et al., Chapel Hill, United States. In Nat Cell Biol, 2001
Zeste-white 3 kinase, which can phosphorylate Armadillo and APC, is also crucial for spindle positioning and regulates the localization of APC2-Armadillo complexes.
Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing.
Goerdt et al., Mannheim, Germany. In Skin Pharmacol Appl Skin Physiol, 2001
Thus, APC2 represent a hitherto neglected, but indispensable major pathway of APC activation and function.
The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy.
Kalinski et al., Amsterdam, Netherlands. In Clin Exp Allergy, 1999
Here, we will discuss the concept that antigen-presenting cells (APC) provide Th cells not only with antigen and costimulatory signals, but also with a polarizing signal (signal 3).
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Kirschner et al., Boston, United States. In Science, 1998
The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned.
share on facebooktweetadd +1mail to friends