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Adenomatous polyposis coli tumor suppressor homolog 2

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APC, CAN, Ubiquitin, APC1, Cdc27
Papers using APC2 antibodies
Roles of Armadillo, a Drosophila catenin, during central nervous system development.
Katoh Masaru, In PLoS ONE, 1997
... Fly APC2 constructs and transgenic flies were generated as ...
Papers on APC2
The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles to negatively regulate Wnt signaling.
McCartney et al., Pittsburgh, United States. In Mol Biol Cell, 07 Nov 2015
UNASSIGNED: The tumor suppressor Adenomatous polyposis coli (APC) plays a key role in regulating the canonical Wnt signaling pathway as an essential component of the ß-catenin destruction complex.
The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients.
Karimipoor et al., Tehrān, Iran. In Adv Med Sci, 30 Sep 2015
APC7 and APC2 subunits of the APC/C complex are involved in the substrate recognition and the catalytic reaction, respectively.
RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.
Schulman et al., Vienna, Austria. In Proc Natl Acad Sci U S A, May 2015
On the opposite side of the APC, the dynamic catalytic core contains the cullin-like subunit APC2 and its RING partner APC11, which collaborates with the E2 UBCH10 (UBE2C) to ubiquitinate substrates.
MiR-939 promotes the proliferation of human ovarian cancer cells by repressing APC2 expression.
Ji-hong et al., Guangzhou, China. In Biomed Pharmacother, Apr 2015
Therefore, it was speculated that adenomatous polyposis coli 2 (APC2) could play important roles in activating the Wnt/β-catenin pathway.
Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features.
Noda et al., Doha, Qatar. In Cell Rep, Apr 2015
We conducted an etiological study on two siblings with Sotos features without mutations in NSD1 and detected a homozygous frameshift mutation in the APC2 gene by whole-exome sequencing, which resulted in the loss of function of cytoskeletal regulation in neurons.
Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide.
McCormick et al., Northbrook, United States. In Plos One, Dec 2014
Rat OSCC also demonstrated increased methylation of the first exon of APC2; the increased methylation was correlated with down-regulation of this tumor suppressor gene.
Association of aberrant DNA methylation in Apc(min/+) mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq.
Kong et al., United States. In Cell Biosci, Dec 2014
The identification of certain differentially methylated molecules in the EMT and Wnt/β-catenin pathways, such as APC2 (adenomatosis polyposis coli 2), SFRP2 (secreted frizzled-related protein 2), and DKK3 (dickkopf-related protein 3), was consistent with previous publications.
DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway.
Zhou et al., Suzhou, China. In Int J Biol Sci, Dec 2014
Our study further reveals that DNA-PKcs interacts with APC/C core component APC2 and its co-activator Cdh1.
Genome-wide copy-number variation study of psychosis in Alzheimer's disease.
Feingold et al., Pittsburgh, United States. In Transl Psychiatry, Dec 2014
The most interesting finding was the presence of a genome-wide significant duplication in the APC2 gene on chromosome 19, which was protective against developing AD+P (odds ratio=0.42;
SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
Peters et al., Vienna, Austria. In Embo J, Dec 2014
A transcriptome-wide analysis revealed that SNW1 or PRPF8 depletion affects the splicing of specific introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC/C subunit APC2.
Drosophila apc regulates delamination of invasive epithelial clusters.
Noselli et al., Nice, France. In Dev Biol, 2012
Data show that a loss of function for dapc1 or both dapc1 and dapc2 (dapc) in ovary border (BC) and adjacent follicle cells impaired BC delamination, and this mutant phenotype can be rescued upon overexpression of either dapc1 or dapc2.
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.
Peifer et al., Chapel Hill, United States. In Mol Biol Cell, 2012
These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling.
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
Noda et al., Okazaki, Japan. In J Neurosci, 2012
Lack of adenomatosis polyposis coli 2 induces severe laminary defects in some regions of the mouse brain, including the cerebral cortex and cerebellum.
Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.
Rishi et al., Detroit, United States. In J Biol Chem, 2011
anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonists are novel regulators of cell growth and apoptosis
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.
Huang et al., New York City, United States. In J Cell Biol, 2011
It proposes a role for APC/C(Cdh1) in modulating the status of PCNA monoubiquitination and UV DNA repair before S phase entry.
ASPP: a new family of oncogenes and tumour suppressor genes.
Lu et al., London, United Kingdom. In Br J Cancer, 2007
They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1).
Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin.
Peifer et al., Chapel Hill, United States. In Nat Cell Biol, 2001
Zeste-white 3 kinase, which can phosphorylate Armadillo and APC, is also crucial for spindle positioning and regulates the localization of APC2-Armadillo complexes.
Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing.
Goerdt et al., Mannheim, Germany. In Skin Pharmacol Appl Skin Physiol, 2001
Thus, APC2 represent a hitherto neglected, but indispensable major pathway of APC activation and function.
The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy.
Kalinski et al., Amsterdam, Netherlands. In Clin Exp Allergy, 1999
Here, we will discuss the concept that antigen-presenting cells (APC) provide Th cells not only with antigen and costimulatory signals, but also with a polarizing signal (signal 3).
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Kirschner et al., Boston, United States. In Science, 1998
The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned.
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