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Adenomatous polyposis coli tumor suppressor homolog 2

APC2, APCL
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APC, CAN, Ubiquitin, APC1, Cdc27
Papers using APC2 antibodies
Roles of Armadillo, a Drosophila catenin, during central nervous system development.
Supplier
Katoh Masaru, In PLoS ONE, 1997
... Fly APC2 constructs and transgenic flies were generated as ...
Papers on APC2
Ca(2+) regulation of mitochondrial function in neurons.
New
Satrústegui et al., Madrid, Spain. In Biochim Biophys Acta, 31 Oct 2014
Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4μM, respectively.
SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
New
Peters et al., Vienna, Austria. In Embo J, 25 Oct 2014
A transcriptome-wide analysis revealed that SNW1 or PRPF8 depletion affects the splicing of specific introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC/C subunit APC2.
Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex.
New
McCartney et al., Pittsburgh, United States. In Mol Biol Cell, 10 Oct 2014
Here we show that a novel N-terminal coil, the APC Self-Association Domain (ASAD), found in vertebrate and invertebrate APCs, directly mediates self-association of Drosophila APC2 and plays an essential role in the assembly and stability of the destructosome that regulates ß-cat degradation in Drosophila and human cells.
The pubic midline exposure for symphyseal open reduction and plate fixation.
New
Routt et al., Newark, United States. In J Orthop Traumatol, 30 Sep 2014
The injury pattern was APC2 in 18, APC3 in 3, LC2 in 2, LC3 in 1 and VS in 1 patient(s) [anterior posterior compression (APC), lateral compression (LC), vertical shear (VS)].
The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.
New
Zhang et al., Chapel Hill, United States. In Cell Cycle, Aug 2014
We demonstrate that APC2, a scaffold subunit of APC/C, binds to Mdm2 and is required for Mdm2 polyubiquitination and proteasomal degradation.
Testing Models of the APC Tumor Suppressor/β-catenin Interaction Reshapes Our View of the Destruction Complex in Wnt Signaling.
New
Roberts et al., Marshall Islands. In Genetics, Jul 2014
In addition, we generate an APC2 mutant lacking all β-catenin binding-sites (including the 15Rs) and find that a direct β-catenin/APC interaction is also not essential for β-catenin destruction, although it increases destruction complex efficiency in certain developmental contexts.
miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling.
New
Klusmann et al., Hannover, Germany. In Genes Dev, May 2014
In addition, down-regulation of tumor suppressor genes adenomatous polyposis coli (APC)/APC2 stabilizes active β-catenin and enhances Wnt signaling.
The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells.
New
Fuller et al., Stanford, United States. In Development, Jan 2014
Germline specific overexpression of Adenomatous Polyposis Coli 2 (APC2) rescued GSC loss in chic hypomorphs, suggesting an additive role of APC2 and F-actin in maintaining the adherens junctions that anchor GSCs to the niche.
different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli.
New
Wenzel et al., Erlangen, Germany. In Plos One, Dec 2013
Wnt signalling is prevented by the proteosomal degradation of β-catenin, which occurs in a destruction complex containing adenomatous polyposis coli (APC), APC-like (APCL), Axin and Axin2.
The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex.
New
Lee et al., Nashville, United States. In Biol Open, Dec 2013
dMCPH1 levels are increased in Drosophila morula (APC2) mutant embryos, consistent with dMCPH1 being an APC substrate in vivo.
Drosophila apc regulates delamination of invasive epithelial clusters.
GeneRIF
Noselli et al., Nice, France. In Dev Biol, 2012
Data show that a loss of function for dapc1 or both dapc1 and dapc2 (dapc) in ovary border (BC) and adjacent follicle cells impaired BC delamination, and this mutant phenotype can be rescued upon overexpression of either dapc1 or dapc2.
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.
GeneRIF
Peifer et al., Chapel Hill, United States. In Mol Biol Cell, 2012
These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling.
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
GeneRIF
Noda et al., Okazaki, Japan. In J Neurosci, 2012
Lack of adenomatosis polyposis coli 2 induces severe laminary defects in some regions of the mouse brain, including the cerebral cortex and cerebellum.
Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.
GeneRIF
Rishi et al., Detroit, United States. In J Biol Chem, 2011
anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonists are novel regulators of cell growth and apoptosis
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.
GeneRIF
Huang et al., New York City, United States. In J Cell Biol, 2011
It proposes a role for APC/C(Cdh1) in modulating the status of PCNA monoubiquitination and UV DNA repair before S phase entry.
ASPP: a new family of oncogenes and tumour suppressor genes.
Review
Lu et al., London, United Kingdom. In Br J Cancer, 2007
They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1).
Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin.
Impact
Peifer et al., Chapel Hill, United States. In Nat Cell Biol, 2001
Zeste-white 3 kinase, which can phosphorylate Armadillo and APC, is also crucial for spindle positioning and regulates the localization of APC2-Armadillo complexes.
Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing.
Review
Goerdt et al., Mannheim, Germany. In Skin Pharmacol Appl Skin Physiol, 2001
Thus, APC2 represent a hitherto neglected, but indispensable major pathway of APC activation and function.
The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy.
Review
Kalinski et al., Amsterdam, Netherlands. In Clin Exp Allergy, 1999
Here, we will discuss the concept that antigen-presenting cells (APC) provide Th cells not only with antigen and costimulatory signals, but also with a polarizing signal (signal 3).
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Impact
Kirschner et al., Boston, United States. In Science, 1998
The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned.
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