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Adenomatous polyposis coli tumor suppressor homolog 2

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APC, CAN, Ubiquitin, APC1, Cdc27
Papers using APC2 antibodies
Roles of Armadillo, a Drosophila catenin, during central nervous system development.
Katoh Masaru, In PLoS ONE, 1997
... Fly APC2 constructs and transgenic flies were generated as ...
Papers on APC2
Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features.
Noda et al., Doha, Qatar. In Cell Rep, 03 Apr 2015
We conducted an etiological study on two siblings with Sotos features without mutations in NSD1 and detected a homozygous frameshift mutation in the APC2 gene by whole-exome sequencing, which resulted in the loss of function of cytoskeletal regulation in neurons.
Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide.
McCormick et al., Northbrook, United States. In Plos One, Dec 2014
Rat OSCC also demonstrated increased methylation of the first exon of APC2; the increased methylation was correlated with down-regulation of this tumor suppressor gene.
SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
Peters et al., Vienna, Austria. In Embo J, Dec 2014
A transcriptome-wide analysis revealed that SNW1 or PRPF8 depletion affects the splicing of specific introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC/C subunit APC2.
Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex.
McCartney et al., Pittsburgh, United States. In Mol Biol Cell, Dec 2014
Here we show that a novel N-terminal coil, the APC self-association domain (ASAD), found in vertebrate and invertebrate APCs, directly mediates self-association of Drosophila APC2 and plays an essential role in the assembly and stability of the destructosome that regulates β-cat degradation in Drosophila and human cells.
Ca(2+) regulation of mitochondrial function in neurons.
Satrústegui et al., Madrid, Spain. In Biochim Biophys Acta, Oct 2014
Two Ca(2+)-regulated mitochondrial metabolite transporters are expressed in neurons, the aspartate-glutamate exchanger ARALAR/AGC1/Slc25a12, a component of the malate-aspartate shuttle, and the ATP-Mg/Pi exchanger SCaMC-3/APC2/Slc25a23, with S0.5 for Ca(2+) of 300nM and 3.4μM, respectively.
The pubic midline exposure for symphyseal open reduction and plate fixation.
Routt et al., Newark, United States. In J Orthop Traumatol, Sep 2014
The injury pattern was APC2 in 18, APC3 in 3, LC2 in 2, LC3 in 1 and VS in 1 patient(s) [anterior posterior compression (APC), lateral compression (LC), vertical shear (VS)].
Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signaling.
Roberts et al., Lancaster, United States. In Genetics, Aug 2014
In addition, we generate an APC2 mutant lacking all β-catenin-binding sites (including the 15Rs) and find that a direct β-catenin/APC interaction is also not essential for β-catenin destruction, although it increases destruction complex efficiency in certain developmental contexts.
miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling.
Klusmann et al., Hannover, Germany. In Genes Dev, May 2014
In addition, down-regulation of tumor suppressor genes adenomatous polyposis coli (APC)/APC2 stabilizes active β-catenin and enhances Wnt signaling.
The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.
Zhang et al., Chapel Hill, United States. In Cell Cycle, 2013
We demonstrate that APC2, a scaffold subunit of APC/C, binds to Mdm2 and is required for Mdm2 polyubiquitination and proteasomal degradation.
The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex.
Lee et al., Nashville, United States. In Biol Open, 2013
dMCPH1 levels are increased in Drosophila morula (APC2) mutant embryos, consistent with dMCPH1 being an APC substrate in vivo.
Drosophila apc regulates delamination of invasive epithelial clusters.
Noselli et al., Nice, France. In Dev Biol, 2012
Data show that a loss of function for dapc1 or both dapc1 and dapc2 (dapc) in ovary border (BC) and adjacent follicle cells impaired BC delamination, and this mutant phenotype can be rescued upon overexpression of either dapc1 or dapc2.
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.
Peifer et al., Chapel Hill, United States. In Mol Biol Cell, 2012
These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling.
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
Noda et al., Okazaki, Japan. In J Neurosci, 2012
Lack of adenomatosis polyposis coli 2 induces severe laminary defects in some regions of the mouse brain, including the cerebral cortex and cerebellum.
Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.
Rishi et al., Detroit, United States. In J Biol Chem, 2011
anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonists are novel regulators of cell growth and apoptosis
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.
Huang et al., New York City, United States. In J Cell Biol, 2011
It proposes a role for APC/C(Cdh1) in modulating the status of PCNA monoubiquitination and UV DNA repair before S phase entry.
ASPP: a new family of oncogenes and tumour suppressor genes.
Lu et al., London, United Kingdom. In Br J Cancer, 2007
They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1).
Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin.
Peifer et al., Chapel Hill, United States. In Nat Cell Biol, 2001
Zeste-white 3 kinase, which can phosphorylate Armadillo and APC, is also crucial for spindle positioning and regulates the localization of APC2-Armadillo complexes.
Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing.
Goerdt et al., Mannheim, Germany. In Skin Pharmacol Appl Skin Physiol, 2001
Thus, APC2 represent a hitherto neglected, but indispensable major pathway of APC activation and function.
The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy.
Kalinski et al., Amsterdam, Netherlands. In Clin Exp Allergy, 1999
Here, we will discuss the concept that antigen-presenting cells (APC) provide Th cells not only with antigen and costimulatory signals, but also with a polarizing signal (signal 3).
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Kirschner et al., Boston, United States. In Science, 1998
The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned.
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