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Anaphase promoting complex subunit 1

APC1, Tsg24
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: APC, APC2, CAN, Ubiquitin, PCNA
Papers on APC1
Identification of new highly selective inhibitors of the human ADP/ATP carriers by molecular docking and in vitro transport assays.
New
Pierri et al., Bari, Italy. In Biochem Pharmacol, Dec 2015
We also demonstrated that chebulinic acid and suramin are "highly selective" AAC2 inhibitors, since they poorly inhibit other human mitochondrial carriers (namely ORC1, APC1 and AGC1).
Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5.
New
Spector et al., San Diego, United States. In J Virol, Jul 2015
Viral proteins UL97 and UL21a, respectively, affect the APC/C by phosphorylation of APC/C coactivator Cdh1 and by inducing the degradation of subunits APC4 and APC5, which along with APC1 form the APC/C platform subcomplex.
Drosophila homologues of adenomatous polyposis coli (APC) and the formin diaphanous collaborate by a conserved mechanism to stimulate actin filament assembly.
McCartney et al., Waltham, United States. In J Biol Chem, 2013
RESULTS: Despite limited sequence homology between the vertebrate and Drosophila APC Basic domains, Drosophila APC1 collaborates with Dia to stimulate actin assembly in vitro.
The Arabidopsis anaphase-promoting complex/cyclosome subunit 1 is critical for both female gametogenesis and embryogenesis(F).
Qu et al., Beijing, China. In J Integr Plant Biol, 2013
Our data thus suggest that APC1, an essential component of APC/C, plays a synergistic role with APC4 both in female gametogenesis and in embryogenesis.
A minimal anaphase promoting complex/cyclosome (APC/C) in Trypanosoma brucei.
Wang et al., San Francisco, United States. In Plos One, 2012
The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for proteolytic destruction.
Drosophila apc regulates delamination of invasive epithelial clusters.
GeneRIF
Noselli et al., Nice, France. In Dev Biol, 2012
Data show that a loss of function for dapc1 or both dapc1 and dapc2 (dapc) in ovary border (BC) and adjacent follicle cells impaired BC delamination, and this mutant phenotype can be rescued upon overexpression of either dapc1 or dapc2.
Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo.
McCartney et al., Pittsburgh, United States. In Genetics, 2012
The tumor suppressor Adenomatous polyposis coli (APC) negatively regulates Wnt signaling through its activity in the destruction complex.
Evidence that the spindle assembly checkpoint does not regulate APC(Fzy) activity in Drosophila female meiosis.
GeneRIF
Swan et al., Windsor, Canada. In Genome, 2012
spindle assembly checkpoint is not responsible for the inability of APC(Fzy) to target cyclin B and promote anaphase in metaphase II arrested eggs from cort mutant females
A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila.
Goldstein et al., San Diego, United States. In Mol Biol Cell, 2011
In addition we identified adenomatous polyposis coli 1 (APC1) as an interaction partner of KHC in controlling directed transport and modulating kinesin function in neurons.
Cubism and the cell cycle: the many faces of the APC/C.
Impact
GeneRIF
Pines, Cambridge, United Kingdom. In Nat Rev Mol Cell Biol, 2011
Studies indicate that the APC/C is tightly regulated by its co-activators and by the spindle assembly checkpoint.
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.
GeneRIF
Hershko et al., Haifa, Israel. In J Biol Chem, 2011
the ability of Emi1 to inhibit APC/C is negatively regulated by CDKs
Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle.
GeneRIF
Moncada et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2011
Data demonstrate that PFKFB3 is essential for cell division and that it is regulated by APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP.
Dynamic regulation of Oct1 during mitosis by phosphorylation and ubiquitination.
Tantin et al., Salt Lake City, United States. In Plos One, 2010
Ubiquitination requires the anaphase-promoting complex, and we further show that the anaphase-promoting complex large subunit APC1 and Oct1(pS335) interact.
Apoptin: therapeutic potential of an early sensor of carcinogenic transformation.
Review
Impact
Noteborn et al., Leiden, Netherlands. In Annu Rev Pharmacol Toxicol, 2007
Apoptin targets include DEDAF, Nur77, Nmi, Hippi, and the potential drug target APC1.
Cytoskeletal connections: building strong cells in new ways.
Review
Peifer et al., Chapel Hill, United States. In Curr Biol, 2003
New findings reveal that the cytoskeletal linker protein Short stop works with EB1 and APC1 to help carry out this function.
Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing.
Review
Goerdt et al., Mannheim, Germany. In Skin Pharmacol Appl Skin Physiol, 2001
The Th1/Th2 paradigm has stimulated extensive research into the mechanisms underlying T-cell polarization; alternative activation of antigen-presenting cells (APCs) has turned out to be the corresponding concept APC polarization.
The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy.
Review
Kalinski et al., Amsterdam, Netherlands. In Clin Exp Allergy, 1999
Here, we will discuss the concept that antigen-presenting cells (APC) provide Th cells not only with antigen and costimulatory signals, but also with a polarizing signal (signal 3).
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Impact
Kirschner et al., Boston, United States. In Science, 1998
The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).
The APC1 concept of type I diabetes.
Review
Kolb et al., Düsseldorf, Germany. In Autoimmunity, 1997
The functional state of APCs during preferential stimulation of Th1 reactivities (APC1 state) is characterized by the release of TNFalpha, IL-12 and/or IL-18.
Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae.
Impact
Nasmyth et al., Vienna, Austria. In Science, 1996
Two additional subunits of the budding yeast APC were identified: The largest subunit, encoded by the APC1 gene, is conserved between fungi and vertebrates and shows similarity to BIMEp from Aspergillus nidulans.
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