GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Adenomatous polyposis coli
APC, Adenomatous Polyposis Coli, Adenomatous Polyposis Coli Protein
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
APC
antibodies
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Supplier
In PLoS ONE, 2010
... -FITC (eBioscience, San Diego, USA), ICOS-PE (BD clone DX29, BD Biosciences, Oxford, UK) and IL-17A-APC-A (eBioscience clone eBio64DEC17, eBioscience, San ...
Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cells
Supplier
In The Indian Journal of Medical Research, 2010
... peridinin chlorophyll protein (PerCP)-Cy5.5 labelled CD127, and fluorescein isothiocyanate (FITC)-labelled CD57 or CD38 and allophycocyanin (APC) labelled HLA-DR (Becton Dickinson, USA) ...
B cell memory and the role of apoptosis in its formation
Supplier
In Frontiers in Immunology, 2010
... Anti-CD20-FITC, anti-CD38-APC, and IgG1-APC control were purchased from BD Biosciences (Le Pont de Claix, ...
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
Supplier
In PLoS ONE, 2009
... Alexa Fluor® 647-conjugated anti-human CD34 antibody, PE-conjugated anti-human CD38 antibody, Alexa Fluor® 488-conjugated anti-mouse Sca-1, APC-conjugated anti-c-Kit were purchased from BioLegend (San Diego, CA) ...
The CD300 molecules regulate monocyte and dendritic cell functions.
more suppliersSupplier
In PLoS ONE, 2008
... and APC anti-IL-2 (clone MQ1-17H12), FITC anti-IL-4 (clone MP4-25D2), FITC anti-IL-17a (clone eBio84DEC17), PE-Cy7 and APC anti-TNF-α (clone Mab11) from eBioscience, Alexa 647 anti-Eomes (clone ...
Papers on
APC
Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.
New
Impact
San Francisco, United States. In Nat Immunol, 10 Apr 2013
Priming of T cells takes place via an immunological synapse formed with an antigen-presenting cell (APC).
Glucocorticoids Induce Effector T Cell Depolarization via ERM Proteins, Thereby Impeding Migration and APC Conjugation.
New
Würzburg, Germany. In J Immunol, 08 Apr 2013
Glucocorticoids (GCs) repress lymphocyte function by controlling gene expression.
Benznidazole treatment reduces the induction of indoleamine 2, 3-dioxygenase (IDO) enzymatic activity in Chagas disease symptomatic patients.
New
Granada, Spain. In Parasite Immunol, 08 Apr 2013
The enzyme indoleamine 2,3-dioxigenase (IDO) is critical for the regulation of immune responses in pro-tolerogenic APC.
The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells.
New
Impact
Boston, United States. In Immunity, 21 Mar 2013
Both stable and unstable modes of cognate T cell-APC interactions have been observed in vivo, but the functional significance of unstable, serial contacts has remained unclear.
Restriction of intestinal stem cell expansion and the regenerative response by YAP.
New
Impact
Boston, United States. In Nature, 03 Feb 2013
We find that cytoplasmic YAP restricts elevated Wnt signalling independently of the AXIN-APC-GSK-3β complex partly by limiting the activity of dishevelled (DVL).
Role of TAZ as mediator of Wnt signaling.
New
Impact
Padova, Italy. In Cell, Jan 2013
In the absence of Wnt activity, the components of the β-catenin destruction complex--APC, Axin, and GSK3--are also required to keep TAZ at low levels.
[Enhancement of hypoxia tolerance and survival rate of daphnia in severe hypoxia based on acidic preconditioning].
New
Chengdu, China. In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, Dec 2012
Here we found that acidic preconditioning (APC) could significantly increase the survival rate of daphnia pulex, a freshwater invertebrate, during severe hypoxic insult.
Gas2l3, a Novel Constriction Site-Associated Protein Whose Regulation Is Mediated by the APC/C(Cdh1) Complex.
New
Ramat Gan, Israel. In Plos One, Dec 2012
Using cell-free systems from both frog eggs and human cells, we show that the Gas2l3 protein is targeted for ubiquitin-mediated proteolysis by the APC/C(cdh1) complex, but not by the APC/C(cdc20) complex, and is phosphorylated by Cdk1 in mitosis.
APC and DNA demethylation in cell fate specification and intestinal cancer.
Review
New
Salt Lake City, United States. In Adv Exp Med Biol, Dec 2012
Most cases of colon cancer are initiated by mutation or loss of the tumor suppressor gene adenomatous polyposis coli (APC).
Genetics, inheritance and strategies for prevention in populations at high risk of colorectal cancer (CRC).
Review
New
Newcastle upon Tyne, United Kingdom. In Recent Results Cancer Res, Dec 2012
Familial Adenomatous Polyposis (FAP) due to loss of the APC gene and Lynch syndrome or Hereditary Non-Polyposis Colon Cancer (HNPCC) due to breakdown in MisMatch Repair are the principal syndromes of broader interest and both have been the subject of chemoprevention trials.
Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients.
New
London, United Kingdom. In Gastroenterol Res Pract, Dec 2012
. Familial adenomatous polyposis (FAP) patients have a germline mutation in the adenomatous polyposis coli () gene.
Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.
New
Impact
Dresden, Germany. In Cell, Nov 2012
We show that an extended prophase I additionally requires the suppression of latent, mitotic cell-cycle controls by the anaphase-promoting complex (APC/C) and its meiosis-specific activator Ama1, which trigger the degradation of M phase regulators and Ndd1, a subunit of a mitotic transcription factor.
Promoter methylation of tumor-related genes in gastric carcinogenesis.
Review
New
Shenyang, China. In Histol Histopathol, Oct 2012
A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied.
Genetic testing by cancer site: stomach.
Review
New
Stanford, United States. In Cancer J, Jul 2012
In addition to this syndrome, gastric cancer risk is elevated in Lynch syndrome associated with germline mutations in DNA mismatch repair genes and microsatellite instability, in hereditary breast and ovarian cancer syndrome due to germline BRCA1 and BRCA2 mutations, in familial adenomatous polyposis caused by germline APC mutations, in Li-Fraumeni syndrome due to germline p53 mutations, in Peutz-Jeghers syndrome associated with germline STK11 mutations, and in juvenile polyposis syndrome associated with germline mutations in the SMAD4 and BMPR1A genes.
Increased variance in germline allele-specific expression of APC associates with colorectal cancer.
GeneRIF
Chieti, Italy. In Gastroenterology, 2012
Patients with colorectal cancer have a larger variance in germline levels of allele-specific expression in APC than controls; large distances from the mean ASE were associated with risk for common forms of CRC.
The C-terminus of Apc does not influence intestinal adenoma development or progression.
GeneRIF
Oxford, United Kingdom. In J Pathol, 2012
We conclude that the C-terminus of APC does not influence intestinal adenoma development or progression.
Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients.
Review
Quito, Ecuador. In Cochrane Database Syst Rev, 2011
Human recombinant activated protein C (APC) has been introduced to reduce the high risk of death associated with severe sepsis or septic shock.
Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68.
GeneRIF
Yokohama, Japan. In Structure, 2011
The armadillo domain of APC forms a superhelix with a positively charged groove. The tyrosine-rich domain of Sam68 is bound in a bent conformation to the APC groove.
Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.
GeneRIF
Cambridge, United States. In Proc Natl Acad Sci U S A, 2011
active Wnt/beta-catenin signaling is required for maintenance of colorectal tumor xenografts harboring APC mutations
The genetics of familial adenomatous polyposis (FAP) and MutYH-associated polyposis (MAP).
More papers using
APC
antibodies
Review
GeneRIF
Brussels, Belgium. In Acta Gastroenterol Belg, 2011
Adenomatous polyposis is caused by autosomal dominantly inherited mutations in the APC (Adenomatous polyposis coli) gene, a tumour suppressor gene that controls beta-catenin turnover in the Wnt pathway.
siRNA and innate immunity
Supplier
In Molecular Therapy. Nucleic Acids, 2008
Then, cells were washed with phosphate-buffered saline and analyzed in the APC channel with a fluorescence-activated cell sorting canto II (BD Biosciences, Franklin Lakes, NJ) ...
Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma.
Supplier
In PLoS ONE, 2008
... FITC conjugated CD326 (EpCAM) and CD271 (p75NTR), and allophycocyanin (APC) conjugated CD133 antibodies were from Miltenyi Biotec.
Intravital imaging of metastatic behavior through a mammary imaging window
Supplier
In Molecular Imaging and Biology, 2007
... Goat antimouse APC was purchased from Cedarlane (Ontario, CA, USA) ...
Stabilization of β-catenin induces pancreas tumor formation
Supplier
In Journal of Oncology, 2007
... CD44-PE, CD24-FITC, anti-EpCAM-PerCP-Cy5.5, and anti-c-Myc antibody from BD Biosciences (San Jose, CA) and CD44-APC-Cy7 and CD24-APC from Biolegend (San Diego, CA) ...
NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models
Supplier
In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007
... anti-human CD235a (clone GA-R2, BD Biosciences, USA), phycoerythrin-CY7 (PE-CY7)-CD45 (clone HI30, BD Biosciences), and allophycocyanin (APC)-conjugated CD133/2 (Miltenyi Biotec GMBH, Germany) ...
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
Supplier
In Annals of Hematology, 2006
... Purified mouse anti-human STAT5 (pY694), CD11b-PE, CD14-FITC, and CD15-APC were purchased from BD Biosciences (Breda, the Netherlands) ...
HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.
Supplier
In PLoS Pathogens, 2006
... flow cytometry, an IgG2a antibody isotype control and a goat, anti-mouse IgG antibody conjugated to allophycocyanin (APC) was obtained from BioLegend (San Diego, CA); phycoerythrin ...
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Supplier
In PLoS Biology, 2006
... cytometry: CD4-APC (L3T4), CD25-FITC (PC61.5),
Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals
Supplier
In Journal of Biomedicine and Biotechnology, 2005
... APC-labeled anti-human IFN-γ antibody was purchased from eBioscience (Hatfield, UK) ...
Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation.
Supplier
In PLoS ONE, 2005
... Kit receptor was immunostained with the APC- anti-mouse CD117 antibody (eBioscience).
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.
Supplier
In PLoS ONE, 2005
... cytometry analysis was performed after staining with anti-GL7-FITC, anti-CD95-PE, anti-CD19-APC, anti-IgG1 biotin and anti-IgG3 antibodies, APC-streptavidin and 7-AAD (all from BD Biosciences) in a FACSCanto flow cytometer ...
An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.
Supplier
In PLoS ONE, 2004
... CD4-allophycocyanin (rat IgG2a, clone RM4-5, BD Biosciences), CD19-PE-Cyanin7 (rat IgG2a, clone 1D3, BD Biosciences), and CD8-APC-Cyanin7 (rat IgG2a, clone 53-6.7,
BiTEs: bispecific antibody constructs with unique anti-tumor activity
Supplier
In British Journal of Cancer, 2004
... Fluorescein isothiocyanate-anti-lineage cocktail 1 mAb, PerCP-anti-CD4 mAb, APC-anti-CD8 mAb, PE-anti-CD69 mAb, PE-anti-CD25 mAb, FITC-anti-granzyme B mAb, PE-anti-Fas ligand mAb and streptavidin-APC were purchased from BD Biosciences (San Jose, CA, USA) ...
CD8+ T cells in autoimmunity
Supplier
In Indian Journal of Human Genetics, 2004
... antibodies: Anti-human GITR FITC mAb, anti-human CD8 PE mAb, purified phopspho-specific JNK mAb, goat anti-mouse APC mAb and purified anti-human CD3mAb were purchased from BD Biosciences (San Jose, CA, USA) ...
Soluble MHC-peptide complexes induce rapid death of CD8+ CTL
Supplier
In PLoS Biology, 2004
... APC-labeled anti-mouse IL2 antibody, JES6-5H4, and APC-labeled anti-mouse IL4 antibody, 11H11, were from BD Biosciences.
Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions.
Supplier
In PLoS ONE, 2003
... conjugated anti-human CD45RO (UCHL1), PE-Cy5 conjugated anti-human CD19 (HIB19), PE-Cy7 conjugated anti-human IFNγ (4S.B3), and APC-conjugated streptavidin were obtained from eBioscience (San Diego, CA) ...
Proteins released from degenerating neurons are surrogate markers for acute brain damage.
Supplier
In PLoS ONE, 2003
... anti-β-galactosidase (MP Biomedicals), monoclonal mouse anti-GAPDH and NeuN (Chemicon), mouse anti-fodrin (Affinity Research Products), mouse anti-APC (CC1, Abcam), mouse anti-CD11b (OX42, Serotec), ...
Chemokines: key regulators of mononuclear cell recruitment in atherosclerotic vascular disease
Supplier
In Acta Orthopaedica, 2003
... Grand Island, NY) and stained with a combination of CD45-fluorescein isothiocyanate (FITC), CD34-phycoerythrin (PE), and CXCR4-allophycocyanin (APC) monoclonal antibodies (BD Biosciences Pharmigen, San Diego, CA) ...
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Supplier
In PLoS ONE, 2003
... Antibodies against c-Kit (APC-conjugated, 2B8, eBioscience), Sca-1 (PE-conjugated, D7, eBioscience) ...
Adherence to a Mediterranean diet and survival in a Greek population
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... conjugated with PE that is directed against P-selectin expressed on the platelet surface, and anti-CD14-allophycocyanin (APC) antibody (Becton Dickinson), an mAb which recognizes ...
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Supplier
In PLoS ONE, 2002
... Antibodies for flow cytometric analysis were purchased at Immunotools (CD13, CD34, CD45, all APC labelled), NatuTec/eBiosience (CD44, CD90, CD105, all ...
The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting.
Supplier
In Genome Biology, 2001
... isothiocyanate (FITC), CD69-phosphatidylethanolamine (PE), CD8- peridinin chlorophyll protein (PerCP) and 1G12 indirectly labeled with Allophycocyanin (APC), then sorted with a Becton Dickinson (Franklin Lakes, NJ) FACVantage ...
Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells
Supplier
In The Journal of Experimental Medicine, 2001
... followed by anti-IgG2a FITC (Biosystems), and anti-CXCR3 CyChrome, anti-CD45RA APC, and anti-CCR4 biotin followed by streptavidin-APC-Cy7 (BD Biosciences).
SOCS proteins: negative regulators of cytokine signaling.
Supplier
In PLoS ONE, 2000
... and 1 µl for per fixed and unfixed sample), CD45RA-pacifc blue (BioLegend, Cat.304118, 5 µl per sample), CD110-APC (BD Biosciences, Cat ...
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
Supplier
In The Journal of Experimental Medicine, 2000
... cells dissociated from d 10 hEBs were stained with human PECAM-1 or Flk-1-FITC (BD Biosciences) and CD45-APC (Becton Dickinson), followed by 7-AAD (Immunotech) ...
The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development
Supplier
In The Journal of Experimental Medicine, 1998
... Monoclonal antibodies to CD10, CD11c, CD14, CD19, and CD123 conjugated to PE, PerCP, PeCy7, APC, or APCCy7 were purchased from Becton Dickinson.
Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene
Supplier
In PLoS ONE, 1996
CD11c-FITC (clone N418), CD11b-PE (clone M1/70), and Gr-1-APC (clone RB6-8C5) were from eBioscience (San Diego, CA, USA) ...
Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium
Supplier
In The Journal of Cell Biology, 1995
... (Clontech or MBL), rabbit anti-APC pAb specific for COOH-terminal 20 amino acids of human APC (APC(C-20); Santa Cruz Biotechnology, Inc.), mouse anti-APC mAb ...
Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
Supplier
In The Journal of Cell Biology, 1995
... Two different anti-APC antibodies were used for this study; anti-APC (C-20), which was obtained from Santa Cruz Biotechnology, Inc., was used for ...
Cell surface proteins of chicken hematopoietic progenitors, thrombocytes and eosinophils detected by novel monoclonal antibodies.
Supplier
In PLoS ONE, 1991
... anti-rat or rabbit IgG (Invitrogen, Burlington ON), biotinylated goat anti-rat IgG (Southern Biotech, Birmingham AL), APC conjugated goat anti-mouse Ig or streptavidin (BD Biosciences, Mississauga ON), and horseradish ...
Hierarchical grouping to optimize an objective function
Supplier
In PLoS ONE, 1962
... After 16 h of stimulation, cells were incubated with directly conjugated anti-CD4-APC/Cy7 (BD Biosciences, San Jose, CA), anti-CD8-Alexa405 ...
Colorimetric method for determination of sugars and related substances
Supplier
In PLoS ONE, 1955
... The CD14+ cell population was more than 98% pure as assessed by flow cytometry (anti-CD14 APC-conjugated MAb, eBioscience).
