Targeting JAK kinase in solid tumors: emerging opportunities and challenges.
Melbourne, Australia. In Oncogene, 18 Jun 2015
Emerging data with small molecule JAK-specific adenosine triphosphate-binding analogs corroborate genetic findings and suggest that interference with the JAK/STAT3 pathway may suppress the growth of the most common forms of sporadic colon cancers that arise from mutations of the APC tumor suppressor gene.
HuangQi Decoction Improves Renal Tubulointerstitial Fibrosis in Mice by Inhibiting the Up-Regulation of Wnt/β-Catenin Signaling Pathway.
Shanghai, China. In Cell Physiol Biochem, 18 Jun 2015
RESULTS: In UUO mice models, expression levels of Wnt3,4, Frizzled4, LRP5,6, β-catenin, LEF-1, TCF-1, Snail, MMP2,7 genes were positively correlated with the degree of renal tubulointerstitial fibrosis, while expression levels of GSK-3β, Axin, APC, CK1 were negatively correlated.
Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure.
Paris, France. In Nature, 11 Jun 2015
In the early stage of mouse colon tumour development in the Notch(+)Apc(+/1638N) mouse model, we observed mechanistic pressure stress in the non-tumorous epithelial cells caused by hyper-proliferative adjacent crypts overexpressing active Notch, which is associated with increased Ret and β-catenin signalling.
Targeting Cdc20 as a novel cancer therapeutic strategy.
More papers using
Suzhou, China. In Pharmacol Ther, 04 May 2015
UNASSIGNED: The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub-complexes, APC(Cdc20) and APC(Cdh1), respectively.
siRNA and innate immunity
In Molecular Therapy. Nucleic Acids, 2008
Then, cells were washed with phosphate-buffered saline and analyzed in the APC channel with a fluorescence-activated cell sorting canto II (BD Biosciences, Franklin Lakes, NJ) ... CD8+ T cells in autoimmunity
In Indian Journal of Human Genetics, 2004
... antibodies: Anti-human GITR FITC mAb, anti-human CD8 PE mAb, purified phopspho-specific JNK mAb, goat anti-mouse APC mAb and purified anti-human CD3mAb were purchased from BD Biosciences (San Jose, CA, USA) ...