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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Adenomatous polyposis coli

APC, Adenomatous Polyposis Coli, Adenomatous Polyposis Coli Protein
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, p53, E-cadherin
Papers using APC antibodies
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
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Unutmaz Derya, In PLoS ONE, 2010
... -FITC (eBioscience, San Diego, USA), ICOS-PE (BD clone DX29, BD Biosciences, Oxford, UK) and IL-17A-APC-A (eBioscience clone eBio64DEC17, eBioscience, San ...
Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cells
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Kurapati Sravya et al., In The Indian Journal of Medical Research, 2010
... peridinin chlorophyll protein (PerCP)-Cy5.5 labelled CD127, and fluorescein isothiocyanate (FITC)-labelled CD57 or CD38 and allophycocyanin (APC) labelled HLA-DR (Becton Dickinson, USA) ...
B cell memory and the role of apoptosis in its formation
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Pellat-Deceunynck Catherine et al., In Frontiers in Immunology, 2010
... Anti-CD20-FITC, anti-CD38-APC, and IgG1-APC control were purchased from BD Biosciences (Le Pont de Claix, ...
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
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Cotterill Sue, In PLoS ONE, 2009
... Alexa Fluor® 647-conjugated anti-human CD34 antibody, PE-conjugated anti-human CD38 antibody, Alexa Fluor® 488-conjugated anti-mouse Sca-1, APC-conjugated anti-c-Kit were purchased from BioLegend (San Diego, CA) ...
The CD300 molecules regulate monocyte and dendritic cell functions.
Supplier
Unutmaz Derya, In PLoS ONE, 2008
... and APC anti-IL-2 (clone MQ1-17H12), FITC anti-IL-4 (clone MP4-25D2), FITC anti-IL-17a (clone eBio84DEC17), PE-Cy7 and APC anti-TNF-α (clone Mab11) from eBioscience, Alexa 647 anti-Eomes (clone ...
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Papers on APC
Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.
New
Krappmann et al., München, Germany. In Oncogene, Feb 2016
By a proteomic approach we identified recruitment of β-catenin and its destruction complex consisting of APC, AXIN1, CK1α and GSK3β to oncogenic CARMA1.
Phosphatidylinositol 4-Phosphate 5-Kinase β Controls Recruitment of Lipid Rafts into the Immunological Synapse.
New
Viola et al., Milano, Italy. In J Immunol, Feb 2016
UNASSIGNED: Phosphatidylinositol 4,5-biphosphate (PIP2) is critical for T lymphocyte activation serving as a substrate for the generation of second messengers and the remodeling of actin cytoskeleton necessary for the clustering of lipid rafts, TCR, and costimulatory receptors toward the T:APC interface.
Characteristics of DNA methylation changes induced by traffic-related air pollution.
New
Xu et al., Hangzhou, China. In Mutat Res Genet Toxicol Environ Mutagen, Feb 2016
Global DNA methylation (LINE-1 and Alu) and specific gene methylation (p16(CDKN2A), APC, and iNOS) in the DNA from blood and lung tissues were quantified by pyrosequencing.
Mcl-1 dynamics influence mitotic slippage and death in mitosis.
New
Taylor et al., Manchester, United Kingdom. In Oncotarget, Feb 2016
However, this degradation does not require the activity of either APC/C-Cdc20, FBW7 or MULE, three separate E3 ubiquitin ligases implicated in targeting Mcl-1 for degradation.
Cockroach Allergen Exposure and Risk of Asthma.
Review
New
Gao et al., Baltimore, United States. In Allergy, Jan 2016
Protease-activated receptor (PAR)-2, Toll-like receptor (TLR), and C-type lectin receptors have been suggested to be important for the penetration of cockroach allergens through epithelial cells to mediate allergen uptake, dendritic cell maturation, antigen presenting cell (APC) function in T cell polarization, and cytokine production.
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche.
New
Impact
Wang et al., New York City, United States. In Cancer Cell, Jan 2016
Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin.
Germline Mutations in Predisposition Genes in Pediatric Cancer.
New
Impact
Downing et al., Memphis, United States. In N Engl J Med, Jan 2016
The most commonly mutated genes in the affected patients were TP53 (in 50 patients), APC (in 6), BRCA2 (in 6), NF1 (in 4), PMS2 (in 4), RB1 (in 3), and RUNX1 (in 3).
Controlling the response to DNA damage by the APC/C-Cdh1.
Review
New
van Vugt et al., Groningen, Netherlands. In Cell Mol Life Sci, Jan 2016
An important player in the regulation of mitotic cyclins is the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase.
Combination cancer immunotherapies tailored to the tumour microenvironment.
Review
New
Teng et al., Australia. In Nat Rev Clin Oncol, Dec 2015
These strategies include eliminating the bulk of tumour cells to provoke tumour-antigen release and antigen-presenting cell (APC) function, using adjuvants to enhance APC function, and using agents that enhance effector-cell activity.
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
New
Impact
Lapidot et al., Israel. In Nat Med, Nov 2015
Conversely, bone marrow blood vessels provide a microenvironment enriched with activated protein C (aPC) that retains EPCR(+) LT-HSCs by limiting NO generation, reducing Cdc42 activity and enhancing integrin VLA4 affinity and adhesion.
Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.
New
Impact
Wrana et al., Toronto, Canada. In Nature, Nov 2015
Consistent with key roles for regenerative signalling in tumorigenesis, we further demonstrate that Yap inactivation abolishes adenomas in the Apc(Min) mouse model of colon cancer, and that Yap-driven expansion of Apc(-/-) organoids requires the Egfr module of the Yap regenerative program.
Engineering activated protein C to maximize therapeutic efficacy.
Review
New
Preston et al., Dublin, Ireland. In Biochem Soc Trans, Sep 2015
The anticoagulant-activated protein C (APC) acts not solely as a crucial regulator of thrombus formation following vascular injury, but also as a potent signalling enzyme with important functions in the control of both acute and chronic inflammatory disease.
Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.
New
Impact
Romagnolo et al., Paris, France. In Nat Cell Biol, Aug 2015
Here, we show that autophagy is activated in the intestinal epithelium in murine and human colorectal cancer and that the conditional inactivation of Atg7 in intestinal epithelial cells inhibits the formation of pre-cancerous lesions in Apc(+/-) mice by enhancing anti-tumour responses.
FAP Associated Papillary Thyroid Carcinoma: A Peculiar Subtype of Familial Nonmedullary Thyroid Cancer.
Review
Cetta, Milano, Italy. In Patholog Res Int, 2014
We give evidence that this extracolonic manifestation of FAP is determined by the same germline mutation of the APC gene responsible for colonic polyps and cancer but also shows some unusual features (F : M ratio = 80 : 1, absence of LOH for APC in the thyroid tumoral tissue, and indolent biological behaviour, despite frequent multicentricity and lymph nodal involvement), suggesting that the APC gene confers only a generic susceptibility to thyroid cancer, but perhaps other factors, namely, modifier genes, sex-related factors, or environmental factors, are also required for its phenotypic expression.
An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics.
Carman et al., In J Vis Exp, 2014
Herein a basic approach to implement endothelial cells as a novel and physiologic 'planar cellular APC model' for improved imaging and interrogation of fundamental antigenic signaling processes will be described.
The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.
GeneRIF
De Mey et al., Illkirch-Graffenstaden, France. In J Cell Biol, 2012
tumor suppressor Apc controls planar cell polarities central to gut homeostasis
Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas.
Impact
GeneRIF
Syngal et al., Boston, United States. In Jama, 2012
Among patients with multiple colorectal adenomas, pathogenic APC and MUTYH mutation prevalence varied considerably by adenoma count, including within those with a classic polyposis phenotype.
Perinatal detection of familial adenomatous polyposis.
GeneRIF
Hueppchen et al., Baltimore, United States. In Obstet Gynecol, 2012
A case of familial adenomatous polyposis in which neonatal and maternal cytomolecular analysis revealed APC gene disruption at 5q22.2.
Epiretinal membrane and retinal pigment epithelial lesions in a young child and detection of de novo APC mutation.
GeneRIF
Shields et al., In Arch Ophthalmol, 2012
We describe a child with epiretinal membrane and characteristic retinal pigment epithelial lesions that led to detection of an APC mutation and at-risk status for Familial adenomatous polyposis. .
Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.
GeneRIF
Narayan et al., Gainesville, United States. In Neoplasia, 2012
These studies demonstrate a novel role for APC in the suppression of Fen1 activity in the BER pathway
More papers using APC antibodies
siRNA and innate immunity
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Brinkmann Ulrjch et al., In Molecular Therapy. Nucleic Acids, 2008
Then, cells were washed with phosphate-buffered saline and analyzed in the APC channel with a fluorescence-activated cell sorting canto II (BD Biosciences, Franklin Lakes, NJ) ...
Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma.
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Tang Dean G., In PLoS ONE, 2008
... FITC conjugated CD326 (EpCAM) and CD271 (p75NTR), and allophycocyanin (APC) conjugated CD133 antibodies were from Miltenyi Biotec.
Stabilization of β-catenin induces pancreas tumor formation
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Fontana Joseph A. et al., In Journal of Oncology, 2007
... CD44-PE, CD24-FITC, anti-EpCAM-PerCP-Cy5.5, and anti-c-Myc antibody from BD Biosciences (San Jose, CA) and CD44-APC-Cy7 and CD24-APC from Biolegend (San Diego, CA) ...
Intravital imaging of metastatic behavior through a mammary imaging window
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van de Water Bob et al., In Molecular Imaging and Biology, 2007
... Goat antimouse APC was purchased from Cedarlane (Ontario, CA, USA) ...
NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models
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Ratajczak Mariusz Z et al., In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007
... anti-human CD235a (clone GA-R2, BD Biosciences, USA), phycoerythrin-CY7 (PE-CY7)-CD45 (clone HI30, BD Biosciences), and allophycocyanin (APC)-conjugated CD133/2 (Miltenyi Biotec GMBH, Germany) ...
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
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Vellenga Edo et al., In Annals of Hematology, 2006
... Purified mouse anti-human STAT5 (pY694), CD11b-PE, CD14-FITC, and CD15-APC were purchased from BD Biosciences (Breda, the Netherlands) ...
HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.
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Hope Thomas J., In PLoS Pathogens, 2006
... flow cytometry, an IgG2a antibody isotype control and a goat, anti-mouse IgG antibody conjugated to allophycocyanin (APC) was obtained from BioLegend (San Diego, CA); phycoerythrin ...
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
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Marrack Philippa, In PLoS Biology, 2006
... cytometry: CD4-APC (L3T4), CD25-FITC (PC61.5),
Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals
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Pamphilon Derwood et al., In Journal of Biomedicine and Biotechnology, 2005
... APC-labeled anti-human IFN-γ antibody was purchased from eBioscience (Hatfield, UK) ...
Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation.
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Najbauer Joseph, In PLoS ONE, 2005
... Kit receptor was immunostained with the APC- anti-mouse CD117 antibody (eBioscience).
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.
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Feldmesser Marta, In PLoS ONE, 2005
... cytometry analysis was performed after staining with anti-GL7-FITC, anti-CD95-PE, anti-CD19-APC, anti-IgG1 biotin and anti-IgG3 antibodies, APC-streptavidin and 7-AAD (all from BD Biosciences) in a FACSCanto flow cytometer ...
BiTEs: bispecific antibody constructs with unique anti-tumor activity
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Morse M A et al., In British Journal of Cancer, 2004
... Fluorescein isothiocyanate-anti-lineage cocktail 1 mAb, PerCP-anti-CD4 mAb, APC-anti-CD8 mAb, PE-anti-CD69 mAb, PE-anti-CD25 mAb, FITC-anti-granzyme B mAb, PE-anti-Fas ligand mAb and streptavidin-APC were purchased from BD Biosciences (San Jose, CA, USA) ...
An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.
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Rénia Laurent, In PLoS ONE, 2004
... CD4-allophycocyanin (rat IgG2a, clone RM4-5, BD Biosciences), CD19-PE-Cyanin7 (rat IgG2a, clone 1D3, BD Biosciences), and CD8-APC-Cyanin7 (rat IgG2a, clone 53-6.7,
CD8+ T cells in autoimmunity
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Chakraborty Nitya G. et al., In Indian Journal of Human Genetics, 2004
... antibodies: Anti-human GITR FITC mAb, anti-human CD8 PE mAb, purified phopspho-specific JNK mAb, goat anti-mouse APC mAb and purified anti-human CD3mAb were purchased from BD Biosciences (San Jose, CA, USA) ...
Soluble MHC-peptide complexes induce rapid death of CD8+ CTL
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Marrack Philippa, In PLoS Biology, 2004
... APC-labeled anti-mouse IL2 antibody, JES6-5H4, and APC-labeled anti-mouse IL4 antibody, 11H11, were from BD Biosciences.
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
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Alberola-Ila Jose, In PLoS ONE, 2003
... Antibodies against c-Kit (APC-conjugated, 2B8, eBioscience), Sca-1 (PE-conjugated, D7, eBioscience) ...
Chemokines: key regulators of mononuclear cell recruitment in atherosclerotic vascular disease
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Ochi Mitsuo et al., In Acta Orthopaedica, 2003
... Grand Island, NY) and stained with a combination of CD45-fluorescein isothiocyanate (FITC), CD34-phycoerythrin (PE), and CXCR4-allophycocyanin (APC) monoclonal antibodies (BD Biosciences Pharmigen, San Diego, CA) ...
Proteins released from degenerating neurons are surrogate markers for acute brain damage.
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Di Giovanni Simone, In PLoS ONE, 2003
... anti-β-galactosidase (MP Biomedicals), monoclonal mouse anti-GAPDH and NeuN (Chemicon), mouse anti-fodrin (Affinity Research Products), mouse anti-APC (CC1, Abcam), mouse anti-CD11b (OX42, Serotec), ...
Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions.
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Unutmaz Derya, In PLoS ONE, 2003
... conjugated anti-human CD45RO (UCHL1), PE-Cy5 conjugated anti-human CD19 (HIB19), PE-Cy7 conjugated anti-human IFNγ (4S.B3), and APC-conjugated streptavidin were obtained from eBioscience (San Diego, CA) ...
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
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Covas Dimas Tadeu, In PLoS ONE, 2002
... Antibodies for flow cytometric analysis were purchased at Immunotools (CD13, CD34, CD45, all APC labelled), NatuTec/eBiosience (CD44, CD90, CD105, all ...
Adherence to a Mediterranean diet and survival in a Greek population
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Li Chi-Yuan et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... conjugated with PE that is directed against P-selectin expressed on the platelet surface, and anti-CD14-allophycocyanin (APC) antibody (Becton Dickinson), an mAb which recognizes ...
The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting.
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Goodnow Christopher C et al., In Genome Biology, 2001
... isothiocyanate (FITC), CD69-phosphatidylethanolamine (PE), CD8- peridinin chlorophyll protein (PerCP) and 1G12 indirectly labeled with Allophycocyanin (APC), then sorted with a Becton Dickinson (Franklin Lakes, NJ) FACVantage ...
Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells
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Geginat Jens et al., In The Journal of Experimental Medicine, 2001
... followed by anti-IgG2a FITC (Biosystems), and anti-CXCR3 CyChrome, anti-CD45RA APC, and anti-CCR4 biotin followed by streptavidin-APC-Cy7 (BD Biosciences).
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
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Bhatia Mickie et al., In The Journal of Experimental Medicine, 2000
... cells dissociated from d 10 hEBs were stained with human PECAM-1 or Flk-1-FITC (BD Biosciences) and CD45-APC (Becton Dickinson), followed by 7-AAD (Immunotech) ...
SOCS proteins: negative regulators of cytokine signaling.
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Hartl Dominik, In PLoS ONE, 2000
... and 1 µl for per fixed and unfixed sample), CD45RA-pacifc blue (BioLegend, Cat.304118, 5 µl per sample), CD110-APC (BD Biosciences, Cat ...
The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development
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Blom Bianca et al., In The Journal of Experimental Medicine, 1998
... Monoclonal antibodies to CD10, CD11c, CD14, CD19, and CD123 conjugated to PE, PerCP, PeCy7, APC, or APCCy7 were purchased from Becton Dickinson.
Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene
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Barsh Gregory S., In PLoS ONE, 1996
CD11c-FITC (clone N418), CD11b-PE (clone M1/70), and Gr-1-APC (clone RB6-8C5) were from eBioscience (San Diego, CA, USA) ...
Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium
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Tsukita Shoichiro et al., In The Journal of Cell Biology, 1995
... (Clontech or MBL), rabbit anti-APC pAb specific for COOH-terminal 20 amino acids of human APC (APC(C-20); Santa Cruz Biotechnology, Inc.), mouse anti-APC mAb ...
Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
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Hall Alan et al., In The Journal of Cell Biology, 1995
... Two different anti-APC antibodies were used for this study; anti-APC (C-20), which was obtained from Santa Cruz Biotechnology, Inc., was used for ...
Cell surface proteins of chicken hematopoietic progenitors, thrombocytes and eosinophils detected by novel monoclonal antibodies.
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Bhatia Mick, In PLoS ONE, 1991
... anti-rat or rabbit IgG (Invitrogen, Burlington ON), biotinylated goat anti-rat IgG (Southern Biotech, Birmingham AL), APC conjugated goat anti-mouse Ig or streptavidin (BD Biosciences, Mississauga ON), and horseradish ...
Hierarchical grouping to optimize an objective function
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Hoshino Yoshihiko, In PLoS ONE, 1962
... After 16 h of stimulation, cells were incubated with directly conjugated anti-CD4-APC/Cy7 (BD Biosciences, San Jose, CA), anti-CD8-Alexa405 ...
Colorimetric method for determination of sugars and related substances
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Kovats Susan, In PLoS ONE, 1955
... The CD14+ cell population was more than 98% pure as assessed by flow cytometry (anti-CD14 APC-conjugated MAb, eBioscience).
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