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Adenomatous polyposis coli

APC, Adenomatous Polyposis Coli, Adenomatous Polyposis Coli Protein
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, p53, E-cadherin
Papers using APC antibodies
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Unutmaz Derya, In PLoS ONE, 2010
... -FITC (eBioscience, San Diego, USA), ICOS-PE (BD clone DX29, BD Biosciences, Oxford, UK) and IL-17A-APC-A (eBioscience clone eBio64DEC17, eBioscience, San ...
Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cells
Kurapati Sravya et al., In The Indian Journal of Medical Research, 2010
... peridinin chlorophyll protein (PerCP)-Cy5.5 labelled CD127, and fluorescein isothiocyanate (FITC)-labelled CD57 or CD38 and allophycocyanin (APC) labelled HLA-DR (Becton Dickinson, USA) ...
B cell memory and the role of apoptosis in its formation
Pellat-Deceunynck Catherine et al., In Frontiers in Immunology, 2010
... Anti-CD20-FITC, anti-CD38-APC, and IgG1-APC control were purchased from BD Biosciences (Le Pont de Claix, ...
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
Cotterill Sue, In PLoS ONE, 2009
... Alexa Fluor® 647-conjugated anti-human CD34 antibody, PE-conjugated anti-human CD38 antibody, Alexa Fluor® 488-conjugated anti-mouse Sca-1, APC-conjugated anti-c-Kit were purchased from BioLegend (San Diego, CA) ...
The CD300 molecules regulate monocyte and dendritic cell functions.
Unutmaz Derya, In PLoS ONE, 2008
... and APC anti-IL-2 (clone MQ1-17H12), FITC anti-IL-4 (clone MP4-25D2), FITC anti-IL-17a (clone eBio84DEC17), PE-Cy7 and APC anti-TNF-α (clone Mab11) from eBioscience, Alexa 647 anti-Eomes (clone ...
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Papers on APC
Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.
Sharma et al., Gainesville, United States. In Life Sci, 15 Nov 2015
It is suggested that colonic tumors or cell lines harbor truncated adenomatous polyposis coli (APC) without DNA repair inhibitory (DRI)-domain.
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
Lapidot et al., Israel. In Nat Med, 12 Nov 2015
Conversely, bone marrow blood vessels provide a microenvironment enriched with activated protein C (aPC) that retains EPCR(+) LT-HSCs by limiting NO generation, reducing Cdc42 activity and enhancing integrin VLA4 affinity and adhesion.
Effects of methoxypoly (Ethylene glycol) mediated immunocamouflage on leukocyte surface marker detection, cell conjugation, activation and alloproliferation.
Scott et al., Vancouver, Canada. In Biomaterials, 09 Nov 2015
UNASSIGNED: Tissue rejection occurs subsequent to the recognition of foreign antigens via receptor-ligand contacts between APC (antigen presenting cells) and T cells, resulting in initialization of signaling cascades and T cell proliferation.
Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages.
Lindon et al., Cambridge, United Kingdom. In Mol Biol Cell, 07 Nov 2015
The ubiquitin ligase called the Anaphase Promoting Complex/Cyclosome (APC/C) controls mitotic exit.
Contribution of APC and MUTYH mutations to familial adenomatous polyposis susceptibility in Hungary.
Olah et al., Budapest, Hungary. In Fam Cancer, 07 Nov 2015
FAP is caused either by monoallelic mutations in the adenomatous polyposis coli gene APC, or by biallelic germline mutations of MUTYH, this latter usually presenting with milder phenotype.
The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles to negatively regulate Wnt signaling.
McCartney et al., Pittsburgh, United States. In Mol Biol Cell, 07 Nov 2015
UNASSIGNED: The tumor suppressor Adenomatous polyposis coli (APC) plays a key role in regulating the canonical Wnt signaling pathway as an essential component of the ß-catenin destruction complex.
High-resolution Melting Analysis for Gene Scanning of Adenomatous Polyposis Coli (APC) Gene With Oral Squamous Cell Carcinoma Samples.
Chang et al., Taiwan. In Appl Immunohistochem Mol Morphol, 01 Nov 2015
BACKGROUND: There have been many different mutations reported for the large adenomatous polyposis coli (APC) tumor suppressor gene.
Breast cancer cells: Modulation by melatonin and the ubiquitin-proteasome system - A review.
Reiter et al., Winnipeg, Canada. In Mol Cell Endocrinol, 09 Oct 2015
Three other ubiquitin ligases, SCF(Skp2), E6AP and APC, interact directly with ERα at the ERE and AP-1 promoters of ERα target genes.
Regulatory dendritic cells in autoimmunity: A comprehensive review.
Cao et al., Shanghai, China. In J Autoimmun, 30 Sep 2015
Dendritic cells (DCs) are professional antigen-presenting cells (APC) with significant phenotypic heterogeneity and functional plasticity.
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Ting et al., Chapel Hill, United States. In Nat Med, Aug 2015
Tumor burden was also higher in Aim2(-/-)/Apc(Min/+) than in APC(Min/+) mice.
Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.
Romagnolo et al., Paris, France. In Nat Cell Biol, Aug 2015
Here, we show that autophagy is activated in the intestinal epithelium in murine and human colorectal cancer and that the conditional inactivation of Atg7 in intestinal epithelial cells inhibits the formation of pre-cancerous lesions in Apc(+/-) mice by enhancing anti-tumour responses.
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
Barford et al., Cambridge, United Kingdom. In Nature, Jul 2015
The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit.
RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
Roose et al., San Francisco, United States. In Nat Cell Biol, Jun 2015
Genetic Rasgrp1 depletion from mice with either an activating mutation in KRas or with aberrant Wnt signalling due to a mutation in Apc resulted in both cases in exacerbated Ras-ERK signalling and cell proliferation.
Choice and Design of Adjuvants for Parenteral and Mucosal Vaccines.
Schijns et al., Wageningen, Netherlands. In Vaccines (basel), Dec 2014
Adjuvants, for example, are used to promote the immunogenicity of antigens in vaccines, by inducing a pro-inflammatory environment that enables the recruitment and promotion of the infiltration of phagocytic cells, particularly antigen-presenting cells (APC), to the injection site.
Human Immunodeficiencies Related to Defective APC/T Cell Interaction.
Benvenuti et al., Rozzano, Italy. In Front Immunol, Dec 2014
In vivo live-cell imaging of APC-T cell interactions combined to functional studies unveiled that T cell fate is dictated, in large part, by the stability of the initial contact.
The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.
De Mey et al., Illkirch-Graffenstaden, France. In J Cell Biol, 2012
tumor suppressor Apc controls planar cell polarities central to gut homeostasis
Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas.
Syngal et al., Boston, United States. In Jama, 2012
Among patients with multiple colorectal adenomas, pathogenic APC and MUTYH mutation prevalence varied considerably by adenoma count, including within those with a classic polyposis phenotype.
Perinatal detection of familial adenomatous polyposis.
Hueppchen et al., Baltimore, United States. In Obstet Gynecol, 2012
A case of familial adenomatous polyposis in which neonatal and maternal cytomolecular analysis revealed APC gene disruption at 5q22.2.
Epiretinal membrane and retinal pigment epithelial lesions in a young child and detection of de novo APC mutation.
Shields et al., In Arch Ophthalmol, 2012
We describe a child with epiretinal membrane and characteristic retinal pigment epithelial lesions that led to detection of an APC mutation and at-risk status for Familial adenomatous polyposis. .
Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.
Narayan et al., Gainesville, United States. In Neoplasia, 2012
These studies demonstrate a novel role for APC in the suppression of Fen1 activity in the BER pathway
More papers using APC antibodies
siRNA and innate immunity
Brinkmann Ulrjch et al., In Molecular Therapy. Nucleic Acids, 2008
Then, cells were washed with phosphate-buffered saline and analyzed in the APC channel with a fluorescence-activated cell sorting canto II (BD Biosciences, Franklin Lakes, NJ) ...
Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma.
Tang Dean G., In PLoS ONE, 2008
... FITC conjugated CD326 (EpCAM) and CD271 (p75NTR), and allophycocyanin (APC) conjugated CD133 antibodies were from Miltenyi Biotec.
Stabilization of β-catenin induces pancreas tumor formation
Fontana Joseph A. et al., In Journal of Oncology, 2007
... CD44-PE, CD24-FITC, anti-EpCAM-PerCP-Cy5.5, and anti-c-Myc antibody from BD Biosciences (San Jose, CA) and CD44-APC-Cy7 and CD24-APC from Biolegend (San Diego, CA) ...
Intravital imaging of metastatic behavior through a mammary imaging window
van de Water Bob et al., In Molecular Imaging and Biology, 2007
... Goat antimouse APC was purchased from Cedarlane (Ontario, CA, USA) ...
NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models
Ratajczak Mariusz Z et al., In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007
... anti-human CD235a (clone GA-R2, BD Biosciences, USA), phycoerythrin-CY7 (PE-CY7)-CD45 (clone HI30, BD Biosciences), and allophycocyanin (APC)-conjugated CD133/2 (Miltenyi Biotec GMBH, Germany) ...
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
Vellenga Edo et al., In Annals of Hematology, 2006
... Purified mouse anti-human STAT5 (pY694), CD11b-PE, CD14-FITC, and CD15-APC were purchased from BD Biosciences (Breda, the Netherlands) ...
HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.
Hope Thomas J., In PLoS Pathogens, 2006
... flow cytometry, an IgG2a antibody isotype control and a goat, anti-mouse IgG antibody conjugated to allophycocyanin (APC) was obtained from BioLegend (San Diego, CA); phycoerythrin ...
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Marrack Philippa, In PLoS Biology, 2006
... cytometry: CD4-APC (L3T4), CD25-FITC (PC61.5),
Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals
Pamphilon Derwood et al., In Journal of Biomedicine and Biotechnology, 2005
... APC-labeled anti-human IFN-γ antibody was purchased from eBioscience (Hatfield, UK) ...
Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation.
Najbauer Joseph, In PLoS ONE, 2005
... Kit receptor was immunostained with the APC- anti-mouse CD117 antibody (eBioscience).
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.
Feldmesser Marta, In PLoS ONE, 2005
... cytometry analysis was performed after staining with anti-GL7-FITC, anti-CD95-PE, anti-CD19-APC, anti-IgG1 biotin and anti-IgG3 antibodies, APC-streptavidin and 7-AAD (all from BD Biosciences) in a FACSCanto flow cytometer ...
BiTEs: bispecific antibody constructs with unique anti-tumor activity
Morse M A et al., In British Journal of Cancer, 2004
... Fluorescein isothiocyanate-anti-lineage cocktail 1 mAb, PerCP-anti-CD4 mAb, APC-anti-CD8 mAb, PE-anti-CD69 mAb, PE-anti-CD25 mAb, FITC-anti-granzyme B mAb, PE-anti-Fas ligand mAb and streptavidin-APC were purchased from BD Biosciences (San Jose, CA, USA) ...
An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.
Rénia Laurent, In PLoS ONE, 2004
... CD4-allophycocyanin (rat IgG2a, clone RM4-5, BD Biosciences), CD19-PE-Cyanin7 (rat IgG2a, clone 1D3, BD Biosciences), and CD8-APC-Cyanin7 (rat IgG2a, clone 53-6.7,
CD8+ T cells in autoimmunity
Chakraborty Nitya G. et al., In Indian Journal of Human Genetics, 2004
... antibodies: Anti-human GITR FITC mAb, anti-human CD8 PE mAb, purified phopspho-specific JNK mAb, goat anti-mouse APC mAb and purified anti-human CD3mAb were purchased from BD Biosciences (San Jose, CA, USA) ...
Soluble MHC-peptide complexes induce rapid death of CD8+ CTL
Marrack Philippa, In PLoS Biology, 2004
... APC-labeled anti-mouse IL2 antibody, JES6-5H4, and APC-labeled anti-mouse IL4 antibody, 11H11, were from BD Biosciences.
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Alberola-Ila Jose, In PLoS ONE, 2003
... Antibodies against c-Kit (APC-conjugated, 2B8, eBioscience), Sca-1 (PE-conjugated, D7, eBioscience) ...
Chemokines: key regulators of mononuclear cell recruitment in atherosclerotic vascular disease
Ochi Mitsuo et al., In Acta Orthopaedica, 2003
... Grand Island, NY) and stained with a combination of CD45-fluorescein isothiocyanate (FITC), CD34-phycoerythrin (PE), and CXCR4-allophycocyanin (APC) monoclonal antibodies (BD Biosciences Pharmigen, San Diego, CA) ...
Proteins released from degenerating neurons are surrogate markers for acute brain damage.
Di Giovanni Simone, In PLoS ONE, 2003
... anti-β-galactosidase (MP Biomedicals), monoclonal mouse anti-GAPDH and NeuN (Chemicon), mouse anti-fodrin (Affinity Research Products), mouse anti-APC (CC1, Abcam), mouse anti-CD11b (OX42, Serotec), ...
Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions.
Unutmaz Derya, In PLoS ONE, 2003
... conjugated anti-human CD45RO (UCHL1), PE-Cy5 conjugated anti-human CD19 (HIB19), PE-Cy7 conjugated anti-human IFNγ (4S.B3), and APC-conjugated streptavidin were obtained from eBioscience (San Diego, CA) ...
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Covas Dimas Tadeu, In PLoS ONE, 2002
... Antibodies for flow cytometric analysis were purchased at Immunotools (CD13, CD34, CD45, all APC labelled), NatuTec/eBiosience (CD44, CD90, CD105, all ...
Adherence to a Mediterranean diet and survival in a Greek population
Li Chi-Yuan et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... conjugated with PE that is directed against P-selectin expressed on the platelet surface, and anti-CD14-allophycocyanin (APC) antibody (Becton Dickinson), an mAb which recognizes ...
The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting.
Goodnow Christopher C et al., In Genome Biology, 2001
... isothiocyanate (FITC), CD69-phosphatidylethanolamine (PE), CD8- peridinin chlorophyll protein (PerCP) and 1G12 indirectly labeled with Allophycocyanin (APC), then sorted with a Becton Dickinson (Franklin Lakes, NJ) FACVantage ...
Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells
Geginat Jens et al., In The Journal of Experimental Medicine, 2001
... followed by anti-IgG2a FITC (Biosystems), and anti-CXCR3 CyChrome, anti-CD45RA APC, and anti-CCR4 biotin followed by streptavidin-APC-Cy7 (BD Biosciences).
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
Bhatia Mickie et al., In The Journal of Experimental Medicine, 2000
... cells dissociated from d 10 hEBs were stained with human PECAM-1 or Flk-1-FITC (BD Biosciences) and CD45-APC (Becton Dickinson), followed by 7-AAD (Immunotech) ...
SOCS proteins: negative regulators of cytokine signaling.
Hartl Dominik, In PLoS ONE, 2000
... and 1 µl for per fixed and unfixed sample), CD45RA-pacifc blue (BioLegend, Cat.304118, 5 µl per sample), CD110-APC (BD Biosciences, Cat ...
The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development
Blom Bianca et al., In The Journal of Experimental Medicine, 1998
... Monoclonal antibodies to CD10, CD11c, CD14, CD19, and CD123 conjugated to PE, PerCP, PeCy7, APC, or APCCy7 were purchased from Becton Dickinson.
Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene
Barsh Gregory S., In PLoS ONE, 1996
CD11c-FITC (clone N418), CD11b-PE (clone M1/70), and Gr-1-APC (clone RB6-8C5) were from eBioscience (San Diego, CA, USA) ...
Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium
Tsukita Shoichiro et al., In The Journal of Cell Biology, 1995
... (Clontech or MBL), rabbit anti-APC pAb specific for COOH-terminal 20 amino acids of human APC (APC(C-20); Santa Cruz Biotechnology, Inc.), mouse anti-APC mAb ...
Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
Hall Alan et al., In The Journal of Cell Biology, 1995
... Two different anti-APC antibodies were used for this study; anti-APC (C-20), which was obtained from Santa Cruz Biotechnology, Inc., was used for ...
Cell surface proteins of chicken hematopoietic progenitors, thrombocytes and eosinophils detected by novel monoclonal antibodies.
Bhatia Mick, In PLoS ONE, 1991
... anti-rat or rabbit IgG (Invitrogen, Burlington ON), biotinylated goat anti-rat IgG (Southern Biotech, Birmingham AL), APC conjugated goat anti-mouse Ig or streptavidin (BD Biosciences, Mississauga ON), and horseradish ...
Hierarchical grouping to optimize an objective function
Hoshino Yoshihiko, In PLoS ONE, 1962
... After 16 h of stimulation, cells were incubated with directly conjugated anti-CD4-APC/Cy7 (BD Biosciences, San Jose, CA), anti-CD8-Alexa405 ...
Colorimetric method for determination of sugars and related substances
Kovats Susan, In PLoS ONE, 1955
... The CD14+ cell population was more than 98% pure as assessed by flow cytometry (anti-CD14 APC-conjugated MAb, eBioscience).
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