Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure.
Paris, France. In Nature, 02 Aug 2015
In the early stage of mouse colon tumour development in the Notch(+)Apc(+/1638N) mouse model, we observed mechanistic pressure stress in the non-tumorous epithelial cells caused by hyper-proliferative adjacent crypts overexpressing active Notch, which is associated with increased Ret and β-catenin signalling.
Molecular and genetic aspects of odontogenic tumors: a review.
India. In Iran J Basic Med Sci, Jun 2015
This audit speaks to experiences and cooperation of the molecular and genetic variations connected to the development and movement of odontogenic tumors which incorporate oncogenes, tumor-silencer genes, APC gene, retinoblastoma genes, DNA repair genes, onco-viruses, development components, telomerase, cell cycle controllers, apoptosis-related elements, and regulators/conttrollers of tooth development.
Targeting JAK kinase in solid tumors: emerging opportunities and challenges.
Melbourne, Australia. In Oncogene, Jun 2015
Emerging data with small molecule JAK-specific adenosine triphosphate-binding analogs corroborate genetic findings and suggest that interference with the JAK/STAT3 pathway may suppress the growth of the most common forms of sporadic colon cancers that arise from mutations of the APC tumor suppressor gene.
Associations Between Inflammatory Markers, Hemostatic Markers, and Microvascular Complications in 182 Chinese Patients With Type 2 Diabetes Mellitus.
Hangzhou, China. In Lab Med, Dec 2014
Based on logistic regression analysis, the highest-tertile groups of fibrinogen, FVII, and FVIII, corresponded to a greater risk of high CRP, whereas risk of high IL-6 was significantly greater in the groups with highest-tertile values for fibrinogen, FVII, TAT III, PAI-1, and activated protein C (APC).
The Novel PKCθ from Benchtop to Clinic.
Beirut, Lebanon. In J Immunol Res, Dec 2014
This isozyme, however, is unique in that it translocates to the immunological synapse between a T cell and an antigen-presenting cell (APC) upon T cell receptor-peptide MHC recognition.
Generation and Validation of miR-142 Knock Out Mice.
More papers using
Gießen, Germany. In Plos One, Dec 2014
At embryonic day 18.5, miR-142-null lungs display increased Wnt signaling associated with the up-regulation of Apc and p300, two previously reported targets of miR-142-3p and -5p, respectively.
siRNA and innate immunity
In Molecular Therapy. Nucleic Acids, 2008
Then, cells were washed with phosphate-buffered saline and analyzed in the APC channel with a fluorescence-activated cell sorting canto II (BD Biosciences, Franklin Lakes, NJ) ... CD8+ T cells in autoimmunity
In Indian Journal of Human Genetics, 2004
... antibodies: Anti-human GITR FITC mAb, anti-human CD8 PE mAb, purified phopspho-specific JNK mAb, goat anti-mouse APC mAb and purified anti-human CD3mAb were purchased from BD Biosciences (San Jose, CA, USA) ...