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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Adenomatous polyposis coli

APC, Adenomatous Polyposis Coli, Adenomatous Polyposis Coli Protein
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, E-cadherin, PCNA
Papers using APC antibodies
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
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Unutmaz Derya, In PLoS ONE, 2010
... -FITC (eBioscience, San Diego, USA), ICOS-PE (BD clone DX29, BD Biosciences, Oxford, UK) and IL-17A-APC-A (eBioscience clone eBio64DEC17, eBioscience, San ...
Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cells
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Kurapati Sravya et al., In The Indian Journal of Medical Research, 2010
... peridinin chlorophyll protein (PerCP)-Cy5.5 labelled CD127, and fluorescein isothiocyanate (FITC)-labelled CD57 or CD38 and allophycocyanin (APC) labelled HLA-DR (Becton Dickinson, USA) ...
B cell memory and the role of apoptosis in its formation
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Pellat-Deceunynck Catherine et al., In Frontiers in Immunology, 2010
... Anti-CD20-FITC, anti-CD38-APC, and IgG1-APC control were purchased from BD Biosciences (Le Pont de Claix, ...
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
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Cotterill Sue, In PLoS ONE, 2009
... Alexa Fluor® 647-conjugated anti-human CD34 antibody, PE-conjugated anti-human CD38 antibody, Alexa Fluor® 488-conjugated anti-mouse Sca-1, APC-conjugated anti-c-Kit were purchased from BioLegend (San Diego, CA) ...
The CD300 molecules regulate monocyte and dendritic cell functions.
Supplier
Unutmaz Derya, In PLoS ONE, 2008
... and APC anti-IL-2 (clone MQ1-17H12), FITC anti-IL-4 (clone MP4-25D2), FITC anti-IL-17a (clone eBio84DEC17), PE-Cy7 and APC anti-TNF-α (clone Mab11) from eBioscience, Alexa 647 anti-Eomes (clone ...
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Papers on APC
Deep sequencing with intronic capture enables identification of an APC exon 10 inversion in a patient with polyposis.
New
Pritchard et al., Seattle, United States. In Genet Med, 27 Apr 2014
We report the case of a 40-year-old woman with adenomatous colon polyps too numerous to count and who had a complex inversion spanning the entire exon 10 in APC (the gene encoding for adenomatous polyposis coli), causing exon skipping and resulting in a frameshift and premature protein truncation.Methods:In this study, we employed complete APC gene sequencing using high-coverage next-generation sequencing by ColoSeq, analysis with BreakDancer and SLOPE software, and confirmatory transcript analysis.Results:ColoSeq identified a complex small genomic rearrangement consisting of an inversion that results in translational skipping of exon 10 in the APC gene.
Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillations.
New
Brandeis et al., Jerusalem, Israel. In Cell Cycle, 26 Apr 2014
Cdk1 deactivates itself by activating the APC/C, consequently generating embryonic cell cycle oscillations.
Heat treatment improves antigen-specific T cell activation after protein delivery by several but not all yeast genera.
New
Breinig et al., Saarbrücken, Germany. In Vaccine, 24 Apr 2014
Here, we investigated the distribution of major yeast cell wall components such as mannan, β-glucan and chitin of four different and likewise biotechnologically relevant yeasts (Saccharomyces, Pichia, Kluyveromyces and Schizosaccharomyces) and analyzed the influence of heat-treatment on β-1,3-glucan exposure at the outer yeast cell surface as well as the amount of yeast induced reactive oxygen species (ROS) production by antigen presenting cells (APC) in human blood.
Telomeres, telomerase and colorectal cancer.
Review
New
De Rossi et al., Padova, Italy. In World J Gastroenterol, 28 Mar 2014
The erosion of telomeres, mainly because of cell proliferation, may be accelerated by specific alterations in the genes involved in CRC, such as APC and MSH2.
Nuclear pores protect genome integrity by assembling a premitotic and mad1-dependent anaphase inhibitor.
New
Impact
Jallepalli et al., New York City, United States. In Cell, 27 Mar 2014
Under current models, unattached kinetochores transduce the SAC by catalyzing the intramitotic production of a diffusible inhibitor of APC/C(Cdc20) (the anaphase-promoting complex/cyclosome and its coactivator Cdc20, a large ubiquitin ligase).
Detection of an activated JAK3 variant and a Xq26.3 microdeletion causing loss of PHF6 and miR-424 expression in myelodysplastic syndromes by combined targeted next generation sequencing and SNP array analysis.
New
Gattenlöhner et al., Gießen, Germany. In Pathol Res Pract, 23 Mar 2014
In addition to the detection of mutations known to be associated with MDS in NRAS, KRAS, MPL, NPM1, IDH1, PTPN11, APC and MET, single nucleotide variants so far unrelated to MDS in STK11 (n=1), KDR (n=3), ATM (n=1) and JAK3 (n=2) were identified.
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis.
Review
New
Wei et al., Boston, United States. In Biochim Biophys Acta, 22 Mar 2014
UNLABELLED: The Anaphase Promoting Complex/Cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that primarily governs cell cycle progression.
Anticancer Potency Studies of Coordination Driven Self-Assembled Arene-Ru-Based Metalla-Bowls.
New
Chi et al., Ulsan, South Korea. In Chembiochem, 13 Mar 2014
In particular, in colorectal cancer cells, expression of the cancer suppressor genes APC and p53 was increased following exposure to 6.
Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration.
New
Impact
de Sauvage et al., San Francisco, United States. In Cell Stem Cell, 06 Mar 2014
Interestingly though, we found that crypts deficient for Lgr5(+) cells are competent to undergo hyperplasia upon loss of Apc.
Is cancer vaccination feasible at older age?
Review
New
Jahangir et al., Ben Mehidi, Algeria. In Exp Gerontol, 05 Mar 2014
Major immune defects at older age are lack of naïve T cells, impaired activation pathways of T cells and antigen-presenting cells (APC), and age-related changes in the tumor microenvironment (TME).
Visualizing how T cells collect activation signals in vivo.
Review
New
Bousso et al., Paris, France. In Curr Opin Immunol, 28 Feb 2014
Additionally, the development of more sophisticated fluorescent tools has permitted not only to visualize T cell-APC contacts but also to probe their functional impact on T cell activation.
The central role of antigen presentation in islets of Langerhans in autoimmune diabetes.
Review
New
Unanue et al., Saint Louis, United States. In Curr Opin Immunol, 28 Feb 2014
The islet APC present exogenous peptides derived from secretory granules of the β-cell, giving rise to unique peptide-MHC complexes (pMHC) that activate those non-conventional T cells that bypass thymus selection.
Defining stem cell dynamics in models of intestinal tumor initiation.
New
Impact
Winton et al., Cambridge, United Kingdom. In Science, Dec 2013
We quantified the competitive advantage of Apc loss, Kras activation, and P53 mutations in the mouse intestine.
ERF115 controls root quiescent center cell division and stem cell replenishment.
New
Impact
De Veylder et al., Gent, Belgium. In Science, Dec 2013
ERF115 marks QC cell division but is restrained through proteolysis by the APC/C(CCS52A2) ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression.
Kinetic framework of spindle assembly checkpoint signalling.
New
Impact
Gerlich et al., Vienna, Austria. In Nat Cell Biol, Nov 2013
We identify two mechanisms by which cells can bypass the SAC: first, single unattached chromosomes inhibit the anaphase-promoting complex/cyclosome (APC/C) less efficiently than a full complement of unattached chromosomes; second, because of the relatively slow kinetics of re-imposing APC/C inhibition during metaphase, cells were unresponsive to chromosome detachment up to several minutes before anaphase onset.
The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.
GeneRIF
De Mey et al., Illkirch-Graffenstaden, France. In J Cell Biol, 2012
tumor suppressor Apc controls planar cell polarities central to gut homeostasis
Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas.
Impact
GeneRIF
Syngal et al., Boston, United States. In Jama, 2012
Among patients with multiple colorectal adenomas, pathogenic APC and MUTYH mutation prevalence varied considerably by adenoma count, including within those with a classic polyposis phenotype.
Perinatal detection of familial adenomatous polyposis.
GeneRIF
Hueppchen et al., Baltimore, United States. In Obstet Gynecol, 2012
A case of familial adenomatous polyposis in which neonatal and maternal cytomolecular analysis revealed APC gene disruption at 5q22.2.
Epiretinal membrane and retinal pigment epithelial lesions in a young child and detection of de novo APC mutation.
GeneRIF
Shields et al., In Arch Ophthalmol, 2012
We describe a child with epiretinal membrane and characteristic retinal pigment epithelial lesions that led to detection of an APC mutation and at-risk status for Familial adenomatous polyposis. .
Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.
GeneRIF
Narayan et al., Gainesville, United States. In Neoplasia, 2012
These studies demonstrate a novel role for APC in the suppression of Fen1 activity in the BER pathway
More papers using APC antibodies
siRNA and innate immunity
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Brinkmann Ulrjch et al., In Molecular Therapy. Nucleic Acids, 2008
Then, cells were washed with phosphate-buffered saline and analyzed in the APC channel with a fluorescence-activated cell sorting canto II (BD Biosciences, Franklin Lakes, NJ) ...
Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma.
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Tang Dean G., In PLoS ONE, 2008
... FITC conjugated CD326 (EpCAM) and CD271 (p75NTR), and allophycocyanin (APC) conjugated CD133 antibodies were from Miltenyi Biotec.
Stabilization of β-catenin induces pancreas tumor formation
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Fontana Joseph A. et al., In Journal of Oncology, 2007
... CD44-PE, CD24-FITC, anti-EpCAM-PerCP-Cy5.5, and anti-c-Myc antibody from BD Biosciences (San Jose, CA) and CD44-APC-Cy7 and CD24-APC from Biolegend (San Diego, CA) ...
Intravital imaging of metastatic behavior through a mammary imaging window
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van de Water Bob et al., In Molecular Imaging and Biology, 2007
... Goat antimouse APC was purchased from Cedarlane (Ontario, CA, USA) ...
NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models
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Ratajczak Mariusz Z et al., In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2007
... anti-human CD235a (clone GA-R2, BD Biosciences, USA), phycoerythrin-CY7 (PE-CY7)-CD45 (clone HI30, BD Biosciences), and allophycocyanin (APC)-conjugated CD133/2 (Miltenyi Biotec GMBH, Germany) ...
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
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Vellenga Edo et al., In Annals of Hematology, 2006
... Purified mouse anti-human STAT5 (pY694), CD11b-PE, CD14-FITC, and CD15-APC were purchased from BD Biosciences (Breda, the Netherlands) ...
HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.
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Hope Thomas J., In PLoS Pathogens, 2006
... flow cytometry, an IgG2a antibody isotype control and a goat, anti-mouse IgG antibody conjugated to allophycocyanin (APC) was obtained from BioLegend (San Diego, CA); phycoerythrin ...
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
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Marrack Philippa, In PLoS Biology, 2006
... cytometry: CD4-APC (L3T4), CD25-FITC (PC61.5),
Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals
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Pamphilon Derwood et al., In Journal of Biomedicine and Biotechnology, 2005
... APC-labeled anti-human IFN-γ antibody was purchased from eBioscience (Hatfield, UK) ...
Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation.
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Najbauer Joseph, In PLoS ONE, 2005
... Kit receptor was immunostained with the APC- anti-mouse CD117 antibody (eBioscience).
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.
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Feldmesser Marta, In PLoS ONE, 2005
... cytometry analysis was performed after staining with anti-GL7-FITC, anti-CD95-PE, anti-CD19-APC, anti-IgG1 biotin and anti-IgG3 antibodies, APC-streptavidin and 7-AAD (all from BD Biosciences) in a FACSCanto flow cytometer ...
BiTEs: bispecific antibody constructs with unique anti-tumor activity
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Morse M A et al., In British Journal of Cancer, 2004
... Fluorescein isothiocyanate-anti-lineage cocktail 1 mAb, PerCP-anti-CD4 mAb, APC-anti-CD8 mAb, PE-anti-CD69 mAb, PE-anti-CD25 mAb, FITC-anti-granzyme B mAb, PE-anti-Fas ligand mAb and streptavidin-APC were purchased from BD Biosciences (San Jose, CA, USA) ...
An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.
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Rénia Laurent, In PLoS ONE, 2004
... CD4-allophycocyanin (rat IgG2a, clone RM4-5, BD Biosciences), CD19-PE-Cyanin7 (rat IgG2a, clone 1D3, BD Biosciences), and CD8-APC-Cyanin7 (rat IgG2a, clone 53-6.7,
CD8+ T cells in autoimmunity
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Chakraborty Nitya G. et al., In Indian Journal of Human Genetics, 2004
... antibodies: Anti-human GITR FITC mAb, anti-human CD8 PE mAb, purified phopspho-specific JNK mAb, goat anti-mouse APC mAb and purified anti-human CD3mAb were purchased from BD Biosciences (San Jose, CA, USA) ...
Soluble MHC-peptide complexes induce rapid death of CD8+ CTL
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Marrack Philippa, In PLoS Biology, 2004
... APC-labeled anti-mouse IL2 antibody, JES6-5H4, and APC-labeled anti-mouse IL4 antibody, 11H11, were from BD Biosciences.
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
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Alberola-Ila Jose, In PLoS ONE, 2003
... Antibodies against c-Kit (APC-conjugated, 2B8, eBioscience), Sca-1 (PE-conjugated, D7, eBioscience) ...
Chemokines: key regulators of mononuclear cell recruitment in atherosclerotic vascular disease
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Ochi Mitsuo et al., In Acta Orthopaedica, 2003
... Grand Island, NY) and stained with a combination of CD45-fluorescein isothiocyanate (FITC), CD34-phycoerythrin (PE), and CXCR4-allophycocyanin (APC) monoclonal antibodies (BD Biosciences Pharmigen, San Diego, CA) ...
Proteins released from degenerating neurons are surrogate markers for acute brain damage.
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Di Giovanni Simone, In PLoS ONE, 2003
... anti-β-galactosidase (MP Biomedicals), monoclonal mouse anti-GAPDH and NeuN (Chemicon), mouse anti-fodrin (Affinity Research Products), mouse anti-APC (CC1, Abcam), mouse anti-CD11b (OX42, Serotec), ...
Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions.
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Unutmaz Derya, In PLoS ONE, 2003
... conjugated anti-human CD45RO (UCHL1), PE-Cy5 conjugated anti-human CD19 (HIB19), PE-Cy7 conjugated anti-human IFNγ (4S.B3), and APC-conjugated streptavidin were obtained from eBioscience (San Diego, CA) ...
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
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Covas Dimas Tadeu, In PLoS ONE, 2002
... Antibodies for flow cytometric analysis were purchased at Immunotools (CD13, CD34, CD45, all APC labelled), NatuTec/eBiosience (CD44, CD90, CD105, all ...
Adherence to a Mediterranean diet and survival in a Greek population
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Li Chi-Yuan et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... conjugated with PE that is directed against P-selectin expressed on the platelet surface, and anti-CD14-allophycocyanin (APC) antibody (Becton Dickinson), an mAb which recognizes ...
The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting.
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Goodnow Christopher C et al., In Genome Biology, 2001
... isothiocyanate (FITC), CD69-phosphatidylethanolamine (PE), CD8- peridinin chlorophyll protein (PerCP) and 1G12 indirectly labeled with Allophycocyanin (APC), then sorted with a Becton Dickinson (Franklin Lakes, NJ) FACVantage ...
Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells
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Geginat Jens et al., In The Journal of Experimental Medicine, 2001
... followed by anti-IgG2a FITC (Biosystems), and anti-CXCR3 CyChrome, anti-CD45RA APC, and anti-CCR4 biotin followed by streptavidin-APC-Cy7 (BD Biosciences).
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
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Bhatia Mickie et al., In The Journal of Experimental Medicine, 2000
... cells dissociated from d 10 hEBs were stained with human PECAM-1 or Flk-1-FITC (BD Biosciences) and CD45-APC (Becton Dickinson), followed by 7-AAD (Immunotech) ...
SOCS proteins: negative regulators of cytokine signaling.
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Hartl Dominik, In PLoS ONE, 2000
... and 1 µl for per fixed and unfixed sample), CD45RA-pacifc blue (BioLegend, Cat.304118, 5 µl per sample), CD110-APC (BD Biosciences, Cat ...
The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development
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Blom Bianca et al., In The Journal of Experimental Medicine, 1998
... Monoclonal antibodies to CD10, CD11c, CD14, CD19, and CD123 conjugated to PE, PerCP, PeCy7, APC, or APCCy7 were purchased from Becton Dickinson.
Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene
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Barsh Gregory S., In PLoS ONE, 1996
CD11c-FITC (clone N418), CD11b-PE (clone M1/70), and Gr-1-APC (clone RB6-8C5) were from eBioscience (San Diego, CA, USA) ...
Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium
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Tsukita Shoichiro et al., In The Journal of Cell Biology, 1995
... (Clontech or MBL), rabbit anti-APC pAb specific for COOH-terminal 20 amino acids of human APC (APC(C-20); Santa Cruz Biotechnology, Inc.), mouse anti-APC mAb ...
Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
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Hall Alan et al., In The Journal of Cell Biology, 1995
... Two different anti-APC antibodies were used for this study; anti-APC (C-20), which was obtained from Santa Cruz Biotechnology, Inc., was used for ...
Cell surface proteins of chicken hematopoietic progenitors, thrombocytes and eosinophils detected by novel monoclonal antibodies.
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Bhatia Mick, In PLoS ONE, 1991
... anti-rat or rabbit IgG (Invitrogen, Burlington ON), biotinylated goat anti-rat IgG (Southern Biotech, Birmingham AL), APC conjugated goat anti-mouse Ig or streptavidin (BD Biosciences, Mississauga ON), and horseradish ...
Hierarchical grouping to optimize an objective function
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Hoshino Yoshihiko, In PLoS ONE, 1962
... After 16 h of stimulation, cells were incubated with directly conjugated anti-CD4-APC/Cy7 (BD Biosciences, San Jose, CA), anti-CD8-Alexa405 ...
Colorimetric method for determination of sugars and related substances
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Kovats Susan, In PLoS ONE, 1955
... The CD14+ cell population was more than 98% pure as assessed by flow cytometry (anti-CD14 APC-conjugated MAb, eBioscience).
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