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Apoptotic peptidase activating factor 1

Apaf-1, Apoptotic Protease-Activating Factor 1, Axl, Ark
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using Apaf-1 antibodies
Using process diagrams for the graphical representation of biological networks
Supplier
Levchenko Andre, In PLoS Biology, 2004
... Antibodies were obtained as follows: cPARP, cleaved C3, XIAP, Bid, and Apaf-1 (BD Biosciences); C6, C8, and PARP ...
Growing roles for the mTOR pathway
Supplier
Wang Aiyuan et al., In Molecular Cancer, 2004
... EGFR (immunoprecipitation), phosphotyrosine (PY99), p53 and PCNA and polyclonal antibodies to EGFR, ERBB4, MET and AXL were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis
Supplier
Auberger Patrick et al., In Oncotarget, 2003
... Anti-HSP90, anti-HSP60, anti-tubulin and anti-AXL antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
Supplier
Slack Ruth S. et al., In The Journal of Cell Biology, 2000
... Apaf1-deficient transgenic mice have been described ...
Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1
Supplier
Dulak Jozef et al., In Genetic Vaccines and Therapy, 1997
... Proliferating cell nuclear antigen (PCNA) recognizing primary antibodies (clone PC10) and Animal Research Kit (ARK) Peroxidase were procured from DAKO (Gdynia, Poland) ...
Papers on Apaf-1
AXL and acquired resistance to EGFR inhibitors.
Impact
GeneRIF
Ashworth et al., In Nat Genet, 2012
mechanism of acquired resistance to EGFR inhibitors through the induction of AXL and its ligand GAS6 in NSCLC
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.
Impact
GeneRIF
Bivona et al., Cleveland, United States. In Nat Genet, 2012
increased activation of AXL and evidence for epithelial-to-mesenchymal transition in multiple in vitro and in vivo EGFR-mutant lung cancer models with acquired resistance to erlotinib in the absence of the EGFR p.Thr790Met alteration or MET activation
Targeted Casp8AP2 methylation increases drug resistance in mesenchymal stem cells and cancer cells.
GeneRIF
Leu et al., Taiwan. In Biochem Biophys Res Commun, 2012
These data demonstrate that methylation within the Casp8AP2 promoter correlates with the development of drug resistance and might serve as a biomarker and treatment target for drug resistance in cancer cells.
Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening.
GeneRIF
Korshunov et al., Rochester, United States. In Am J Pathol, 2012
Axl contributes to carotid remodeling not only by inhibition of apoptosis but also via regulation of immune heterogeneity of vascular cells, cytokine/chemokine expression, and extracellular matrix remodeling.
Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.
GeneRIF
Prieto et al., Bloomington, United States. In Plos One, 2011
Overexpression of Tyro3 in the Rat2 cell line that expresses Axl, but not Mer or Tyro3, resulted in a 5 fold increase in cell proliferation.
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